| Gene Name | MDM4 |
|
| Specie | Homo sapiens | |
| Full Name | MDM4 regulator of p53 | |
| Also known as | BMFS6|HDMX|MDMX|MRP1 | |
| Coordinate | chr1:204516377-204558120 | |
| Strand | + | |
| Gene summary | This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| MDM4P1 | chrX:17934051-17934351 | + |
Intergenic |
ENSG00000225066 | UCSC |
| >NM_001278516.2 |
| ATTACTCGCCATTTCAAAATGCTGCCGAGGCCCTAGGATCTGTGACTGCCACCCCTCCCCCCACCCGGGCTCGGCGGGGGAGCGACTCATGGAGCTGCCGTAAGTTTTACCAACAGACTGCAGTTTCTTCACTACCAAAATGACATCATTTTCCACCTCTGCTCAGTGTTCAACATCTGACAGTGCTTGCAGGATCTCTCCTGGACAAATCAATCAGGTACGACCAAAACTGCCGCTTTTGAAGATTTTGCATGCAGCAGGTGCGCAAGGTGAAATGTTCACTGTTAAAGAGGTCATGCACTATTTAGGTCAGTACATAATGGTGAAGCAACTTTATGATCAGCAGGAGCAGCATATGGTATATTGTGGTGGAGATCTTTTGGGAGAACTACTGGGACGTCAGAGCTTCTCCGTGAAAGACCCAAGCCCTCTCTATGATATGCTAAGAAAGAATCTTGTCACTTTAGCCACTGCTACTACAGCAAAGTGCAGAGGAAAGTTCCACTTCCAGAAAAAGAACTACAGAAGACGATATCCCCACACTGCCTACCTCAGAGCATAAATGCATACATTCTAGAGAAGATGAAGACTTAATTGAAAATTTAGCCCAAGATGAAACATCTAGGCTGGACCTTGGATTTGAGGAGTGGGATGTAGCTGGCCTGCCTTGGTGGTTTTTAGGAAACTTGAGAAGCAACTATACACCTAGAAGTAATGGCTCAACTGATTTACAGACAAATCAGGATGTGGGTACTGCCATTGTTTCAGATACTACAGATGACTTGTGGTTTTTGAATGAGTCAGTATCAGAGCAGTTAGGTGTTGGAATAAAAGTTGAAGCTGCTGATACTGAACAAACAAGTGAAGAAGTAGGGAAAGTAAGTGACAAAAAGGTGATTGAAGTGGGAAAAAATGATGACCTGGAGGACTCTAAGTCCTTAAGTGATGATACCGATGTAGAGGTTACCTCTGAGGATGAGTGGCAGTGTACTGAATGCAAGAAATTTAACTCTCCAAGCAAGAGGTACTGTTTTCGTTGTTGGGCCTTGAGGAAGGATTGGTATTCAGATTGTTCAAAGTTAACCCATTCTCTCTCCACGTCTGATATCACTGCCATACCTGAAAAGGAAAATGAAGGAAATGATGTCCCTGATTGTCGAAGAACCATTTCGGCTCCTGTCGTTAGACCTAAAGATGCGTATATAAAGAAAGAAAACTCCAAACTTTTTGATCCCTGCAACTCAGTGGAATTCTTGGATTTGGCTCACAGTTCTGAAAGCCAAGAGACCATCTCAAGCATGGGAGAACAGTTAGATAACCTTTCTGAACAGAGAACAGATACAGAAAACATGGAGGATTGCCAGAATCTCTTGAAGCCATGTAGCTTATGTGAGAAAAGACCACGAGACGGGAACATTATTCATGGAAGGACGGGCCATCTTGTCACTTGTTTTCACTGTGCCAGAAGACTAAAGAAGGCTGGGGCTTCATGCCCTATTTGCAAGAAAGAGATTCAGCTGGTTATTAAGGTTTTTATAGCATAATGGTAGTACGAACATAAAAATGCATTTATTCCGTTCACTTACCACATTATTTGAAAATCAATCCTTTATTTAATTTTATTTCCAACCTGTCAGAGAATGTTCTTAGGCATCAAAATCCAAGGTAGCTGTAAGAAAAATACTGGAGCTAACAATGAAGAACAGAAGTAATCTGATTAGTCAAATTATTAAGTGCCATGGATTACTTTATGCAGCAGTCAGGTACATAGTTAGGTGAACCCAAAAGAAAAACTCTTGAAAACAAGAGATTTCTTCCATGCACATTTACAAtattgaggtataattaacatgataaagtgtttccttctaacgagttgtagaaatctgagtaaccacccaaaaaagcaatagaatgtttctgtcaccccaaaacactcccttctgcccctcttcagacagtccttcaGCTATTTCATGGCTCTCACCCTAGttttttttttttttgcacttttttttttCCGGGGGTATAGGGGAGGTGTGGGGCgacagggtctgtcttgttctgtctcccaggctgaagtgcagtgcagtggtatgatcatggctcactgcagccttggtttcctgggcataagtggtcttcccacttcagcctcctgagtagctgagactatagactagcataaccacactggctaattttttgtggagatgaagtctcactatgttgcccaggctggtctcgaactcctgggctcaaacaatcctcccgcctcagccttccaaattgctgggattatagtcatgaggcacctagtctggccCTTTTGCAAGACTTTAATCTGAAATCTAAATTTTTAAAATTTAAGTACTTACAAAGGATATACTATCCAACATATTGCatattatatatgtgctttaaagtttttttttttttttgagagacggtctcactttgtcatccaagctggagtgcagtggtgcaaacacggcccacctcctgggctcaagtgatcctccagcctcagcttccctcacaggcattcactatcactcccagctaattaaaataatttgtagacggtgtctcgttatgttgcccaggctggtctcgaactcctgggtttaagtgattcccccgcctcagcctcccaaagtgttgggcttacagccttgagccactatgcttggctcaaagatatttttatgaaagccctgggactatagatttagctgattaaatttatagaaaaagtcctgtcatataaactggcaaagtctgttcttaatttaattagccaaatcagacttaacttccgtcagaacatgtcttggttttaattcagataaaCACACAAACATACTTCTCTGGCACAGCCTTCAGAAGCATCAGtttttgttttgttttgttttgttttttgagacagggtcttgctctgtcgcccaggctggagtgcactggcacaatcacagttcactgcagcctcgacctcccagatccaagcaatcctcccacctaagcctcccaagtagctgggtctataggcgcgtgccaccaccatgcccagctgaattttgtattttttgtacagacagcattttgccatgttgcccaggctggtcccaaacttctagcctcaagcaaccctcctgcctcagcctctcaaagtgctaggattgcagtcctgagctactgcccccTACCCTCTTTGCGTCTTAGGAGTCATTTAGATTTTTTTTGAtccttttgtttagtgcctctggagctgcttacaccaaggcaatacgccttgatatactggatggttgagaggcagcctctttttttttttttttttttttttttttttggaggatagggagtatggctgttgtgaaaagggaggtaaagagaaatggtagatctgaagaggcctcatcagagcacatattttaggacaacacatatggaaattggacatctttaagttggtttccatagagctatgcatgtatccttacccccatgggaaaatgttggtgtgttctcaagggtatgcatgtgtcattttgaagaccaAGGCCCTAGAATTGTCAAACTTAAGGATCATAAAAATCATGAGGGTTGCTTGTTAAAAATGTCCAAACGTGCAGAGACTGATCTTTGAGATCTGGACCAGGAATTTGCATTTGAACAAGTGTTCCTGGAATCTCTATGCAAGTTTTATACAGAACATACTTTTGGAATCCTTGCCCTAGAcaggggtgtccaatcttttggcttccctggtccacaatggaagaagaattgtcttggaccacacataaaatacactaacactaacaatagctgatgagctaaaaaaaaaaaaaaaaaaaatcgtggaccgggcgtagtggctcacgcctgtaatcccaacactttgggagatcacctaggtcgggagtttgagaccagcctgaccgacatggagaaaccccatttttactaaaaatacaaaaaattagctgggcatggtggtgcatgcctgtagtcccagctactcaggaggctgaggcaggagaatcgcttgaacctgagagggggagattgcggtgagctgagattgcgccattgcaccccagcctgggcaacaatagcgaaactgtctcagaaaaaagaaaaaaaaaatcgcaaaaagaaaaatctcataatgtCGTTGTTGGtttttttttttttttttgagacagtctcactctgttgcccaggctggagtgcaatggcatgatctctgctcaccgcaacctctgcctcccgggttcaggtgattctcctgcctcagcctcccagatagctgggactacaggcacataccaccatgcctggctaatttttgtatttttagtagagatgggggtttcactgtgttggccaggctggtctcgaactcctgacctcatgatccacacacctcggcctcccaaagtcctgcgattacaggcgtgagctaccgcacccagccAAGTTGTAATTTTTAATAAAACTTAAGAAGTAAACATTTTACTTATGTTTATAGGTATTTGATCCTAAATTTGACACATCATTGCCCATGAAAGAATCCTCTTAGGCTGCTCAGCTTCACTCTTCCTGCTTGCCCACCGGGGTTTTTCACTGCTTCTGTTAGCACTAAGTACTTAGACGATCCTAAGATATGTGCTTGAGCCGAATTTCATCTTTACTTGTAGGAAACTTTAAACTATTTCttttcttttcttttttttttttttttacttgagatggagttttgctcttgtcgcccaggctggagtgcagtggagtgatctcggctcactgcaacctctgcctcccgggttcaaatgattctcctgcctcagcctcccaagtagctgggattacaggtgtgcaccaccatgtctggctaattttgtatttttagtagagatggtttcaccatgttggtcaggctggtctcgaactcctgacctcaggtcatccacccacctcagcctcgcaaagtgctgagattacaggcatgagccacagcgcccagcTTAAACTATTTTCTTGGTCTGTTTTTGATTTTCTTTTTTCCTTGCCACTGCGGTACAGATTTTTTTTACTCACTGCCACTAAACTAAAGCAAGGCATAGTTTATATGTGAAGTGTTCAGAGTTTACTGCTATAAGGAAACTTCCAAATACTGACATTTACCTTTTAGCTGTAGTTATTGGGACCATGTGCTCTGGTTTTCTGGAGACTGCCAAATTGCTCCCATTTTTCTGCATCCCACCTGGTTTCTTTCTGCATgtcccctttcactttcaaacctcttcatttggatgttaaattatatggtcaccTAGTTATAGGTAAGCCTTGTTCGAGTTGATATCTTGATTGTGAGGAAGGATCTGTGTCATTGGAGCTTGTTTCTGCTGCAACGTGCTGTAGACTATGAATAATGAAATCACACCACATTACCATCAGATTTCTTGTTTTAGTTGTCAAATTAATATTTATGATTGTTATCTTGGGCGAAAAGTTCAGAGCAGAGATGACAAATCATTAGAACAACGATGAATTTCAGTATTACGGCTAAAAAGTTCTTCTGTCTGAATATTAACTCACTCTCCTTCCAGTGTACTTCACAGTAATTGGTATGCTTTTTTATTTAATGCTTAAATCAAACTTTATAAAAATCTTAGACCAGATCTTTAATATGGTATGCCATTTCCCCAGTCTACCAATGGAATAGTATGGGTTTCTAATCCTAGGCTTGTACAATGGATTGGAGTTGAGCCATGCCAGCCTCCACACTGCCACTAACTTCTGTAATGTAAGATTGAGTCACTGCCAAGCATTTGAAATATGCAGTTGTGTTTTAATTATAATTTATGTATAGTTAGATGTATGTAGTGCATTGTGTGGTATTATTTGGTTTGTAAGAATTTATTTTTAAGGGTCAAGGTCATTTGTAACATTTTGTGTGTGTCAATTCAATGCAATGTTGGCTGCCTTTTGAAGTCTTTGATATATTGGTGAATATTCTTCTGATCTATAATACAAAGCTATGTAATGTTACCTCTTGACTCGCTTTTGAAAGGAAGACAATTGTTAACTAGATATTTGAGTTTTTTCCCCTCAGAATTATGTGAATTTCTGATATATGGCTTTAGATACTGTGAATCTGTTTTCCATTTAGTCAGTTATCTGCTTAAATTGTTCAGAACTATATCCTAACGAGCAATTAGTTCTGATGGTTCTCCCAGTCATGAGTGTGCATGTGTGCAAGCATGTTTTGATCCTGATGCTACCTTTGCTAAAAATGGCCATAGATTAGGAACTAGCTATGTTTTTAGAATCAAAGATGAACCGGTAAGCTGTCTCATGTACCAAACGTGAAATTTACAGTGTTTACAAATGTCTGGAATTTTGCACTGCCATAGGGAATGTTAAGGTTACTTGGCTGGAATTTATCAGACTTGTGAGTAAACAAGTTGAAGTTTAGCAGATGAGGGGGAATATTGAGGCCCCTAAGGCTAAACAAAATAATCAGTATCTGAGATAGTGGCTAATGTGGCTCCCCAGGCCTAATTTGGGAACAGTTTTTCCTGATTGCTTTGAGAAGTACTTTCTTTTGACAGAAATTTTCATTCTGCTTGCCATTGCTATATTCTCCCTTTATAGGAGCCATTGGATTTCTTTCCTTTTGTGGGAAATGTCCCATTAGCATTTTCAGATCTTTTGATGTGCACTAATGCCATTATTGGTAATGCCGTTATTGGTGAATACAGCATAGTTAAATAAACTGTTACAGTAAATCTACACTTGGATTTGCTGCACCTCTACCAATAGCCTTTTGAATGACTGAAAGTGTTAACAGAGAAAGAGGCATGTCTGCAGAAAGAGATAGCTAATATTTTTTGGTACTTTATCTGAAATCCAAGATGCTGCTTCCCCTGCAGGTTGTTTTCCTTCTTACGATCCTCATTGAATCCCCTCTGGGAGCACAGGACAGTTAGTAGAACTCTCCAtttctttttttttttttttagacggagtctctctctgtcgccccggctggagtgcagtggcgcgatctcggctcactgcaacctccgcctcccgggttcaccccattctcctgcctcagcctccctagtagctgggactataggcgcccgccaccacgcctggctaatttttgtatttttattggagacggggtttcaccgtcttagccaggatggtcttgatctcctgacctcgtgatctgcccacctcagcctcccaaagtactgggattacaggcgtgagccaccgcgcccggccGGAACTCTCCATTTCTTAAGGTAAAGAGGGTCAAGGATACCTAAAAAGGGTCAAATAATGCTAGAAGAGCAATTCCTCTTTCAGAGCAGTTGCTGTAATTTGGCAAATGCTTTATCGAAGATTGATATTAggctaggggcggtggcttacgcctgtaatcccagcactttgggaggccgaggtgggtggattgcctgagctcaggagttcgagaccagtctgaccagtatggtgaaaccctgtctctactaaaaatacaaaaattagccggtcgtggtggcgtgcacctgtagtcccagctacttggcaggttgagacaggagaatcgcttgaacctgggaggtggaggttgcagtgagccgagactgcaccactgcgctcccacctgggtgacagagactctgtctcaaaaaaaaGGACATTTATCATTATAACATCTTATTAGAGCCCCTAATTTCTTATCTGAAGGCACTGTTTTTTTTTTTAAACAGTTAAGTACTGATGTCAACAGACAAATATTTCTGATCAGATAGTCCCCTGTCAACAGTAGCAAATGTGGTTTCATAAAGTGGGAAGAAAACAGCATTTTAAAGTAACTTTTTgggagactgatttgagtaataataaaactctggtctcccTTAAGAAAAAAAAACCCTTCCACCTTTACTGTGTCATTTATATCCCCTTAGTTCCAAAGTTAATTATCTTATTTCTGGATATTGCTTTTATACCAAAGACCCTTATCAGCCCTTGTAACTACAGTATCTTTAGATAAGATTCCTCTTTCCAGTCAGTCCTGGGAAATGTTTCTGTTGCAGAGTTAGGCGGTAGATGGGAAGCTGTGATGGCAGAGCTACTATCTAATAAAGTAACAACTCGTAGTTGAGGCTTCCTTTCTGTGTGTGATGGGGGATAGGGAGTTAGCTCCCCTGTTGTCTCAGCACTAAGAAATTGAGGTCAggccaggcgcggtggttcactcctgttattccagcactggggtggccaaagtgggcagattgcttgcgctctggagctcgagaccagcctgggcaacatggtgaaaccctgtctctaccaaaaatacaaaaaaaaagctgggcatggtgggtgcatgcttgtcccagctactgaggaggctgaggtgggaggatcgcttgagcctgggaggtggaggttgcagtgagctgagatggcaccactgcaatccaaggtgggtgacagagacgctgtctcaaagaaaTTGAGGTCAGGCTTCCTTCTTACAGAATTATTTTTTTCTCTGTAGTTTGCCTCATTTTTTCACTTTCTTTTCAATGAGAATCGAAGTGTTTCTTTTGGGTTTTTTTTTCCCCCTTTTAAAATCAACAGGAAATGTTTCAAAGGAGGGATGAAATGCTTCTTGGCTTCCTCAGCACTTGGCAAGGTAGACCTCATAGCAACCTTGAATATGACTTTCTTTAGTCTCTAGCTATGCACTATTAAGTGCCTCTTGGGTAGAGGTAGAGTTAAGTATTGAGTgccagtcttgacgtccgtatgcctcagtttttctcatatataaaaagcagtatacatacctacccttttctacctcatcatttgttgtagggattaaatCCGGGAGAGCAATTCTGAAGCCTATAAATTTCCTTGAAGAGATCTAAGAACCTATTATGCTCTTGGTGTACCAAGCTCTGGGGTATATATTCAGAATACCTCATGTTCTGGAAGCTGAGCACTAGCTCCCCTTTATTGCCTGCCTGGCAGAGCCTGTTTGATTACTGCAGGCCCTTTTACCCATGCTTCTAGTTTAGGTATTCTTTCTTTGATATGAGGCTCTTGACCAGAAAAGAGTTCTTTCTCTAGGTGTTCTGAGAGAAGTTTGTAAATTTGGATAGTACATTCTATCCTGATAAAACCACCTTGCTGTGGTCTTGATGTACAAAAAAAAAttttttttttgagacagagtcttactctgtcacccaggctggaatgcagtggcgcaatcttggttcactgcaacccccgcctcctgggttcaagcgatcctcctgcctcaacctctcaagtagctgggactacaggcgtgcaccaccacacctggctaattttgtatttttagtagagacagggtttcaccatgttggccaggctggtcttgaactcctgacctcaggcgatctgcccgccttggcctcccaaagtactgggattacaggcgtgagcaactgctcctggccCAAAACATCTCTTTCTACATACACTTGAGTAGGTGGCATAAAATGCACTGTCAATATATAGAAAACATGAAATTTTCCAAATATTTCCGATCAGAGAATCACAAGAGCAGCAAATGTGGTTTCATCAAGTGGGAAGAAAGCAGCAATTTAAAATAACTTTTTgggagactgaattgagtaataataaaacttcagtctttcgctaataataataataataataataataaCAACAACTTATTGAATGTGGCCAGCTCACTAGATGAGGAAAGAGGAAGGCATTTTCTGCATTCTTGCCTAGTTTTCCTTATAAGCACCACTAAGTTAATAGCTCTGTCTTTTTGGTGTTTGCACTATGTAATGCTTTTAATACTTTTTAATTGTGCTTTTTTATGTATTAAATGTTTTTCCTTTTGCCA 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