RCPedia: Rtcs

Summary

Retrocopy Name	MDM4P1	Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chrX:17934051-17934351 UCSC
Coordinates (T2T)	chrX:17516659-17516959 UCSC
Coordinates (hg19)	chrX:17952171-17952471 UCSC
Strand	+
Parental Sequence	NM_001278516.2
Parental seq. overlap	248 bp
Parental seq. overlap (%)	2.5%
Genomic Region	Intergenic
Retrocopy Summary	MDM4P1, located on chrX:17934051-17934351, is a retrocopy of the parental gene MDM4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	MDM4
Full Name	MDM4 regulator of p53
Also known as	BMFS6\|HDMX\|MDMX\|MRP1
Coordinate	chr1:204516377-204558120
Strand	+
Gene summary	This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	MDM4P1
Bonobo	Pan paniscus	MDM4P1
Gorilla	Gorilla gorilla	MDM4P1
Gibbon	Nomascus leucogenys	MDM4P1
Crab-eating macaque	Macaca fascicularis	MDM4P1
Rhesus	Macaca mulatta	MDM4P1
Baboon	Papio anubis	MDM4P1
Golden snub-nosed monkey	Rhinopithecus roxellana	MDM4P1
Marmoset	Callithrix jacchus	MDM4P2
Horse	Equus caballus	MDM4P1
Velvety free-tailed bat	Molossus molossus	MDM4P1
Orangutan	Pongo abelii	Without Homology
Green monkey	Chlorocebus sabaeus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>MDM4P1
GTGACTTGTGGGTTTGGAATGAGTCAATACTGGAGCAGATAGGTGTTGGAATAAAAGTAGGAGCTACTGCTACTGATAAAACCAGCAAAAAAGTAGGGAATGTGAGGTGATTGATGTGGGAAAAAATGACCTTGAGGACTCTCCACCCTTAAAAGATTACACAGATATTGAAGTTACTTCTGAGGATGTGTGGTAGTGTTACTGAGTATAAGAAATTTAACCTTCCAAACAGGAGGTGTTTCTGTTGCAGGGCCTTGAGGAAAGATTGGTATTCAGACTCTTCTAAGTTAACCCATTCTCT

>NM_001278516.2
ATTACTCGCCATTTCAAAATGCTGCCGAGGCCCTAGGATCTGTGACTGCCACCCCTCCCCCCACCCGGGCTCGGCGGGGGAGCGACTCATGGAGCTGCCGTAAGTTTTACCAACAGACTGCAGTTTCTTCACTACCAAAATGACATCATTTTCCACCTCTGCTCAGTGTTCAACATCTGACAGTGCTTGCAGGATCTCTCCTGGACAAATCAATCAGGTACGACCAAAACTGCCGCTTTTGAAGATTTTGCATGCAGCAGGTGCGCAAGGTGAAATGTTCACTGTTAAAGAGGTCATGCACTATTTAGGTCAGTACATAATGGTGAAGCAACTTTATGATCAGCAGGAGCAGCATATGGTATATTGTGGTGGAGATCTTTTGGGAGAACTACTGGGACGTCAGAGCTTCTCCGTGAAAGACCCAAGCCCTCTCTATGATATGCTAAGAAAGAATCTTGTCACTTTAGCCACTGCTACTACAGCAAAGTGCAGAGGAAAGTTCCACTTCCAGAAAAAGAACTACAGAAGACGATATCCCCACACTGCCTACCTCAGAGCATAAATGCATACATTCTAGAGAAGATGAAGACTTAATTGAAAATTTAGCCCAAGATGAAACATCTAGGCTGGACCTTGGATTTGAGGAGTGGGATGTAGCTGGCCTGCCTTGGTGGTTTTTAGGAAACTTGAGAAGCAACTATACACCTAGAAGTAATGGCTCAACTGATTTACAGACAAATCAGGATGTGGGTACTGCCATTGTTTCAGATACTACAGATGACTTGTGGTTTTTGAATGAGTCAGTATCAGAGCAGTTAGGTGTTGGAATAAAAGTTGAAGCTGCTGATACTGAACAAACAAGTGAAGAAGTAGGGAAAGTAAGTGACAAAAAGGTGATTGAAGTGGGAAAAAATGATGACCTGGAGGACTCTAAGTCCTTAAGTGATGATACCGATGTAGAGGTTACCTCTGAGGATGAGTGGCAGTGTACTGAATGCAAGAAATTTAACTCTCCAAGCAAGAGGTACTGTTTTCGTTGTTGGGCCTTGAGGAAGGATTGGTATTCAGATTGTTCAAAGTTAACCCATTCTCTCTCCACGTCTGATATCACTGCCATACCTGAAAAGGAAAATGAAGGAAATGATGTCCCTGATTGTCGAAGAACCATTTCGGCTCCTGTCGTTAGACCTAAAGATGCGTATATAAAGAAAGAAAACTCCAAACTTTTTGATCCCTGCAACTCAGTGGAATTCTTGGATTTGGCTCACAGTTCTGAAAGCCAAGAGACCATCTCAAGCATGGGAGAACAGTTAGATAACCTTTCTGAACAGAGAACAGATACAGAAAACATGGAGGATTGCCAGAATCTCTTGAAGCCATGTAGCTTATGTGAGAAAAGACCACGAGACGGGAACATTATTCATGGAAGGACGGGCCATCTTGTCACTTGTTTTCACTGTGCCAGAAGACTAAAGAAGGCTGGGGCTTCATGCCCTATTTGCAAGAAAGAGATTCAGCTGGTTATTAAGGTTTTTATAGCATAATGGTAGTACGAACATAAAAATGCATTTATTCCGTTCACTTACCACATTATTTGAAAATCAATCCTTTATTTAATTTTATTTCCAACCTGTCAGAGAATGTTCTTAGGCATCAAAATCCAAGGTAGCTGTAAGAAAAATACTGGAGCTAACAATGAAGAACAGAAGTAATCTGATTAGTCAAATTATTAAGTGCCATGGATTACTTTATGCAGCAGTCAGGTACATAGTTAGGTGAACCCAAAAGAAAAACTCTTGAAAACAAGAGATTTCTTCCATGCACATTTACAAtattgaggtataattaacatgataaagtgtttccttctaacgagttgtagaaatctgagtaaccacccaaaaaagcaatagaatgtttctgtcaccccaaaacactcccttctgcccctcttcagacagtccttcaGCTATTTCATGGCTCTCACCCTAGttttttttttttttgcacttttttttttCCGGGGGTATAGGGGAGGTGTGGGGCgacagggtctgtcttgttctgtctcccaggctgaagtgcagtgcagtggtatgatcatggctcactgcagccttggtttcctgggcataagtggtcttcccacttcagcctcctgagtagctgagactatagactagcataaccacactggctaattttttgtggagatgaagtctcactatgttgcccaggctggtctcgaactcctgggctcaaacaatcctcccgcctcagccttccaaattgctgggattatagtcatgaggcacctagtctggccCTTTTGCAAGACTTTAATCTGAAATCTAAATTTTTAAAATTTAAGTACTTACAAAGGATATACTATCCAACATATTGCatattatatatgtgctttaaagtttttttttttttttgagagacggtctcactttgtcatccaagctggagtgcagtggtgcaaacacggcccacctcctgggctcaagtgatcctccagcctcagcttccctcacaggcattcactatcactcccagctaattaaaataatttgtagacggtgtctcgttatgttgcccaggctggtctcgaactcctgggtttaagtgattcccccgcctcagcctcccaaagtgttgggcttacagccttgagccactatgcttggctcaaagatatttttatgaaagccctgggactatagatttagctgattaaatttatagaaaaagtcctgtcatataaactggcaaagtctgttcttaatttaattagccaaatcagacttaacttccgtcagaacatgtcttggttttaattcagataaaCACACAAACATACTTCTCTGGCACAGCCTTCAGAAGCATCAGtttttgttttgttttgttttgttttttgagacagggtcttgctctgtcgcccaggctggagtgcactggcacaatcacagttcactgcagcctcgacctcccagatccaagcaatcctcccacctaagcctcccaagtagctgggtctataggcgcgtgccaccaccatgcccagctgaattttgtattttttgtacagacagcattttgccatgttgcccaggctggtcccaaacttctagcctcaagcaaccctcctgcctcagcctctcaaagtgctaggattgcagtcctgagctactgcccccTACCCTCTTTGCGTCTTAGGAGTCATTTAGATTTTTTTTGAtccttttgtttagtgcctctggagctgcttacaccaaggcaatacgccttgatatactggatggttgagaggcagcctctttttttttttttttttttttttttttttggaggatagggagtatggctgttgtgaaaagggaggtaaagagaaatggtagatctgaagaggcctcatcagagcacatattttaggacaacacatatggaaattggacatctttaagttggtttccatagagctatgcatgtatccttacccccatgggaaaatgttggtgtgttctcaagggtatgcatgtgtcattttgaagaccaAGGCCCTAGAATTGTCAAACTTAAGGATCATAAAAATCATGAGGGTTGCTTGTTAAAAATGTCCAAACGTGCAGAGACTGATCTTTGAGATCTGGACCAGGAATTTGCATTTGAACAAGTGTTCCTGGAATCTCTATGCAAGTTTTATACAGAACATACTTTTGGAATCCTTGCCCTAGAcaggggtgtccaatcttttggcttccctggtccacaatggaagaagaattgtcttggaccacacataaaatacactaacactaacaatagctgatgagctaaaaaaaaaaaaaaaaaaaatcgtggaccgggcgtagtggctcacgcctgtaatcccaacactttgggagatcacctaggtcgggagtttgagaccagcctgaccgacatggagaaaccccatttttactaaaaatacaaaaaattagctgggcatggtggtgcatgcctgtagtcccagctactcaggaggctgaggcaggagaatcgcttgaacctgagagggggagattgcggtgagctgagattgcgccattgcaccccagcctgggcaacaatagcgaaactgtctcagaaaaaagaaaaaaaaaatcgcaaaaagaaaaatctcataatgtCGTTGTTGGtttttttttttttttttgagacagtctcactctgttgcccaggctggagtgcaatggcatgatctctgctcaccgcaacctctgcctcccgggttcaggtgattctcctgcctcagcctcccagatagctgggactacaggcacataccaccatgcctggctaatttttgtatttttagtagagatgggggtttcactgtgttggccaggctggtctcgaactcctgacctcatgatccacacacctcggcctcccaaagtcctgcgattacaggcgtgagctaccgcacccagccAAGTTGTAATTTTTAATAAAACTTAAGAAGTAAACATTTTACTTATGTTTATAGGTATTTGATCCTAAATTTGACACATCATTGCCCATGAAAGAATCCTCTTAGGCTGCTCAGCTTCACTCTTCCTGCTTGCCCACCGGGGTTTTTCACTGCTTCTGTTAGCACTAAGTACTTAGACGATCCTAAGATATGTGCTTGAGCCGAATTTCATCTTTACTTGTAGGAAACTTTAAACTATTTCttttcttttcttttttttttttttttacttgagatggagttttgctcttgtcgcccaggctggagtgcagtggagtgatctcggctcactgcaacctctgcctcccgggttcaaatgattctcctgcctcagcctcccaagtagctgggattacaggtgtgcaccaccatgtctggctaattttgtatttttagtagagatggtttcaccatgttggtcaggctggtctcgaactcctgacctcaggtcatccacccacctcagcctcgcaaagtgctgagattacaggcatgagccacagcgcccagcTTAAACTATTTTCTTGGTCTGTTTTTGATTTTCTTTTTTCCTTGCCACTGCGGTACAGATTTTTTTTACTCACTGCCACTAAACTAAAGCAAGGCATAGTTTATATGTGAAGTGTTCAGAGTTTACTGCTATAAGGAAACTTCCAAATACTGACATTTACCTTTTAGCTGTAGTTATTGGGACCATGTGCTCTGGTTTTCTGGAGACTGCCAAATTGCTCCCATTTTTCTGCATCCCACCTGGTTTCTTTCTGCATgtcccctttcactttcaaacctcttcatttggatgttaaattatatggtcaccTAGTTATAGGTAAGCCTTGTTCGAGTTGATATCTTGATTGTGAGGAAGGATCTGTGTCATTGGAGCTTGTTTCTGCTGCAACGTGCTGTAGACTATGAATAATGAAATCACACCACATTACCATCAGATTTCTTGTTTTAGTTGTCAAATTAATATTTATGATTGTTATCTTGGGCGAAAAGTTCAGAGCAGAGATGACAAATCATTAGAACAACGATGAATTTCAGTATTACGGCTAAAAAGTTCTTCTGTCTGAATATTAACTCACTCTCCTTCCAGTGTACTTCACAGTAATTGGTATGCTTTTTTATTTAATGCTTAAATCAAACTTTATAAAAATCTTAGACCAGATCTTTAATATGGTATGCCATTTCCCCAGTCTACCAATGGAATAGTATGGGTTTCTAATCCTAGGCTTGTACAATGGATTGGAGTTGAGCCATGCCAGCCTCCACACTGCCACTAACTTCTGTAATGTAAGATTGAGTCACTGCCAAGCATTTGAAATATGCAGTTGTGTTTTAATTATAATTTATGTATAGTTAGATGTATGTAGTGCATTGTGTGGTATTATTTGGTTTGTAAGAATTTATTTTTAAGGGTCAAGGTCATTTGTAACATTTTGTGTGTGTCAATTCAATGCAATGTTGGCTGCCTTTTGAAGTCTTTGATATATTGGTGAATATTCTTCTGATCTATAATACAAAGCTATGTAATGTTACCTCTTGACTCGCTTTTGAAAGGAAGACAATTGTTAACTAGATATTTGAGTTTTTTCCCCTCAGAATTATGTGAATTTCTGATATATGGCTTTAGATACTGTGAATCTGTTTTCCATTTAGTCAGTTATCTGCTTAAATTGTTCAGAACTATATCCTAACGAGCAATTAGTTCTGATGGTTCTCCCAGTCATGAGTGTGCATGTGTGCAAGCATGTTTTGATCCTGATGCTACCTTTGCTAAAAATGGCCATAGATTAGGAACTAGCTATGTTTTTAGAATCAAAGATGAACCGGTAAGCTGTCTCATGTACCAAACGTGAAATTTACAGTGTTTACAAATGTCTGGAATTTTGCACTGCCATAGGGAATGTTAAGGTTACTTGGCTGGAATTTATCAGACTTGTGAGTAAACAAGTTGAAGTTTAGCAGATGAGGGGGAATATTGAGGCCCCTAAGGCTAAACAAAATAATCAGTATCTGAGATAGTGGCTAATGTGGCTCCCCAGGCCTAATTTGGGAACAGTTTTTCCTGATTGCTTTGAGAAGTACTTTCTTTTGACAGAAATTTTCATTCTGCTTGCCATTGCTATATTCTCCCTTTATAGGAGCCATTGGATTTCTTTCCTTTTGTGGGAAATGTCCCATTAGCATTTTCAGATCTTTTGATGTGCACTAATGCCATTATTGGTAATGCCGTTATTGGTGAATACAGCATAGTTAAATAAACTGTTACAGTAAATCTACACTTGGATTTGCTGCACCTCTACCAATAGCCTTTTGAATGACTGAAAGTGTTAACAGAGAAAGAGGCATGTCTGCAGAAAGAGATAGCTAATATTTTTTGGTACTTTATCTGAAATCCAAGATGCTGCTTCCCCTGCAGGTTGTTTTCCTTCTTACGATCCTCATTGAATCCCCTCTGGGAGCACAGGACAGTTAGTAGAACTCTCCAtttctttttttttttttttagacggagtctctctctgtcgccccggctggagtgcagtggcgcgatctcggctcactgcaacctccgcctcccgggttcaccccattctcctgcctcagcctccctagtagctgggactataggcgcccgccaccacgcctggctaatttttgtatttttattggagacggggtttcaccgtcttagccaggatggtcttgatctcctgacctcgtgatctgcccacctcagcctcccaaagtactgggattacaggcgtgagccaccgcgcccggccGGAACTCTCCATTTCTTAAGGTAAAGAGGGTCAAGGATACCTAAAAAGGGTCAAATAATGCTAGAAGAGCAATTCCTCTTTCAGAGCAGTTGCTGTAATTTGGCAAATGCTTTATCGAAGATTGATATTAggctaggggcggtggcttacgcctgtaatcccagcactttgggaggccgaggtgggtggattgcctgagctcaggagttcgagaccagtctgaccagtatggtgaaaccctgtctctactaaaaatacaaaaattagccggtcgtggtggcgtgcacctgtagtcccagctacttggcaggttgagacaggagaatcgcttgaacctgggaggtggaggttgcagtgagccgagactgcaccactgcgctcccacctgggtgacagagactctgtctcaaaaaaaaGGACATTTATCATTATAACATCTTATTAGAGCCCCTAATTTCTTATCTGAAGGCACTGTTTTTTTTTTTAAACAGTTAAGTACTGATGTCAACAGACAAATATTTCTGATCAGATAGTCCCCTGTCAACAGTAGCAAATGTGGTTTCATAAAGTGGGAAGAAAACAGCATTTTAAAGTAACTTTTTgggagactgatttgagtaataataaaactctggtctcccTTAAGAAAAAAAAACCCTTCCACCTTTACTGTGTCATTTATATCCCCTTAGTTCCAAAGTTAATTATCTTATTTCTGGATATTGCTTTTATACCAAAGACCCTTATCAGCCCTTGTAACTACAGTATCTTTAGATAAGATTCCTCTTTCCAGTCAGTCCTGGGAAATGTTTCTGTTGCAGAGTTAGGCGGTAGATGGGAAGCTGTGATGGCAGAGCTACTATCTAATAAAGTAACAACTCGTAGTTGAGGCTTCCTTTCTGTGTGTGATGGGGGATAGGGAGTTAGCTCCCCTGTTGTCTCAGCACTAAGAAATTGAGGTCAggccaggcgcggtggttcactcctgttattccagcactggggtggccaaagtgggcagattgcttgcgctctggagctcgagaccagcctgggcaacatggtgaaaccctgtctctaccaaaaatacaaaaaaaaagctgggcatggtgggtgcatgcttgtcccagctactgaggaggctgaggtgggaggatcgcttgagcctgggaggtggaggttgcagtgagctgagatggcaccactgcaatccaaggtgggtgacagagacgctgtctcaaagaaaTTGAGGTCAGGCTTCCTTCTTACAGAATTATTTTTTTCTCTGTAGTTTGCCTCATTTTTTCACTTTCTTTTCAATGAGAATCGAAGTGTTTCTTTTGGGTTTTTTTTTCCCCCTTTTAAAATCAACAGGAAATGTTTCAAAGGAGGGATGAAATGCTTCTTGGCTTCCTCAGCACTTGGCAAGGTAGACCTCATAGCAACCTTGAATATGACTTTCTTTAGTCTCTAGCTATGCACTATTAAGTGCCTCTTGGGTAGAGGTAGAGTTAAGTATTGAGTgccagtcttgacgtccgtatgcctcagtttttctcatatataaaaagcagtatacatacctacccttttctacctcatcatttgttgtagggattaaatCCGGGAGAGCAATTCTGAAGCCTATAAATTTCCTTGAAGAGATCTAAGAACCTATTATGCTCTTGGTGTACCAAGCTCTGGGGTATATATTCAGAATACCTCATGTTCTGGAAGCTGAGCACTAGCTCCCCTTTATTGCCTGCCTGGCAGAGCCTGTTTGATTACTGCAGGCCCTTTTACCCATGCTTCTAGTTTAGGTATTCTTTCTTTGATATGAGGCTCTTGACCAGAAAAGAGTTCTTTCTCTAGGTGTTCTGAGAGAAGTTTGTAAATTTGGATAGTACATTCTATCCTGATAAAACCACCTTGCTGTGGTCTTGATGTACAAAAAAAAAttttttttttgagacagagtcttactctgtcacccaggctggaatgcagtggcgcaatcttggttcactgcaacccccgcctcctgggttcaagcgatcctcctgcctcaacctctcaagtagctgggactacaggcgtgcaccaccacacctggctaattttgtatttttagtagagacagggtttcaccatgttggccaggctggtcttgaactcctgacctcaggcgatctgcccgccttggcctcccaaagtactgggattacaggcgtgagcaactgctcctggccCAAAACATCTCTTTCTACATACACTTGAGTAGGTGGCATAAAATGCACTGTCAATATATAGAAAACATGAAATTTTCCAAATATTTCCGATCAGAGAATCACAAGAGCAGCAAATGTGGTTTCATCAAGTGGGAAGAAAGCAGCAATTTAAAATAACTTTTTgggagactgaattgagtaataataaaacttcagtctttcgctaataataataataataataataataaCAACAACTTATTGAATGTGGCCAGCTCACTAGATGAGGAAAGAGGAAGGCATTTTCTGCATTCTTGCCTAGTTTTCCTTATAAGCACCACTAAGTTAATAGCTCTGTCTTTTTGGTGTTTGCACTATGTAATGCTTTTAATACTTTTTAATTGTGCTTTTTTATGTATTAAATGTTTTTCCTTTTGCCA

>NM_001278516.2 

ATTACTCGCCATTTCAAAATGCTGCCGAGGCCCTAGGATCTGTGACTGCCACCCCTCCCCCCACCCGGGCTCGGCGGGGGAGCGACTCATGGAGCTGCCGTAAGTTTTACCAACAGACTGCAGTTTCTTCACTACCAAAATGACATCATTTTCCACCTCTGCTCAGTGTTCAACATCTGACAGTGCTTGCAGGATCTCTCCTGGACAAATCAATCAGGTACGACCAAAACTGCCGCTTTTGAAGATTTTGCATGCAGCAGGTGCGCAAGGTGAAATGTTCACTGTTAAAGAGGTCATGCACTATTTAGGTCAGTACATAATGGTGAAGCAACTTTATGATCAGCAGGAGCAGCATATGGTATATTGTGGTGGAGATCTTTTGGGAGAACTACTGGGACGTCAGAGCTTCTCCGTGAAAGACCCAAGCCCTCTCTATGATATGCTAAGAAAGAATCTTGTCACTTTAGCCACTGCTACTACAGCAAAGTGCAGAGGAAAGTTCCACTTCCAGAAAAAGAACTACAGAAGACGATATCCCCACACTGCCTACCTCAGAGCATAAATGCATACATTCTAGAGAAGATGAAGACTTAATTGAAAATTTAGCCCAAGATGAAACATCTAGGCTGGACCTTGGATTTGAGGAGTGGGATGTAGCTGGCCTGCCTTGGTGGTTTTTAGGAAACTTGAGAAGCAACTATACACCTAGAAGTAATGGCTCAACTGATTTACAGACAAATCAGGATGTGGGTACTGCCATTGTTTCAGATACTACAGATGACTTGTGGTTTTTGAATGAGTCAGTATCAGAGCAGTTAGGTGTTGGAATAAAAGTTGAAGCTGCTGATACTGAACAAACAAGTGAAGAAGTAGGGAAAGTAAGTGACAAAAAGGTGATTGAAGTGGGAAAAAATGATGACCTGGAGGACTCTAAGTCCTTAAGTGATGATACCGATGTAGAGGTTACCTCTGAGGATGAGTGGCAGTGTACTGAATGCAAGAAATTTAACTCTCCAAGCAAGAGGTACTGTTTTCGTTGTTGGGCCTTGAGGAAGGATTGGTATTCAGATTGTTCAAAGTTAACCCATTCTCTCTCCACGTCTGATATCACTGCCATACCTGAAAAGGAAAATGAAGGAAATGATGTCCCTGATTGTCGAAGAACCATTTCGGCTCCTGTCGTTAGACCTAAAGATGCGTATATAAAGAAAGAAAACTCCAAACTTTTTGATCCCTGCAACTCAGTGGAATTCTTGGATTTGGCTCACAGTTCTGAAAGCCAAGAGACCATCTCAAGCATGGGAGAACAGTTAGATAACCTTTCTGAACAGAGAACAGATACAGAAAACATGGAGGATTGCCAGAATCTCTTGAAGCCATGTAGCTTATGTGAGAAAAGACCACGAGACGGGAACATTATTCATGGAAGGACGGGCCATCTTGTCACTTGTTTTCACTGTGCCAGAAGACTAAAGAAGGCTGGGGCTTCATGCCCTATTTGCAAGAAAGAGATTCAGCTGGTTATTAAGGTTTTTATAGCATAATGGTAGTACGAACATAAAAATGCATTTATTCCGTTCACTTACCACATTATTTGAAAATCAATCCTTTATTTAATTTTATTTCCAACCTGTCAGAGAATGTTCTTAGGCATCAAAATCCAAGGTAGCTGTAAGAAAAATACTGGAGCTAACAATGAAGAACAGAAGTAATCTGATTAGTCAAATTATTAAGTGCCATGGATTACTTTATGCAGCAGTCAGGTACATAGTTAGGTGAACCCAAAAGAAAAACTCTTGAAAACAAGAGATTTCTTCCATGCACATTTACAAtattgaggtataattaacatgataaagtgtttccttctaacgagttgtagaaatctgagtaaccacccaaaaaagcaatagaatgtttctgtcaccccaaaacactcccttctgcccctcttcagacagtccttcaGCTATTTCATGGCTCTCACCCTAGttttttttttttttgcacttttttttttCCGGGGGTATAGGGGAGGTGTGGGGCgacagggtctgtcttgttctgtctcccaggctgaagtgcagtgcagtggtatgatcatggctcactgcagccttggtttcctgggcataagtggtcttcccacttcagcctcctgagtagctgagactatagactagcataaccacactggctaattttttgtggagatgaagtctcactatgttgcccaggctggtctcgaactcctgggctcaaacaatcctcccgcctcagccttccaaattgctgggattatagtcatgaggcacctagtctggccCTTTTGCAAGACTTTAATCTGAAATCTAAATTTTTAAAATTTAAGTACTTACAAAGGATATACTATCCAACATATTGCatattatatatgtgctttaaagtttttttttttttttgagagacggtctcactttgtcatccaagctggagtgcagtggtgcaaacacggcccacctcctgggctcaagtgatcctccagcctcagcttccctcacaggcattcactatcactcccagctaattaaaataatttgtagacggtgtctcgttatgttgcccaggctggtctcgaactcctgggtttaagtgattcccccgcctcagcctcccaaagtgttgggcttacagccttgagccactatgcttggctcaaagatatttttatgaaagccctgggactatagatttagctgattaaatttatagaaaaagtcctgtcatataaactggcaaagtctgttcttaatttaattagccaaatcagacttaacttccgtcagaacatgtcttggttttaattcagataaaCACACAAACATACTTCTCTGGCACAGCCTTCAGAAGCATCAGtttttgttttgttttgttttgttttttgagacagggtcttgctctgtcgcccaggctggagtgcactggcacaatcacagttcactgcagcctcgacctcccagatccaagcaatcctcccacctaagcctcccaagtagctgggtctataggcgcgtgccaccaccatgcccagctgaattttgtattttttgtacagacagcattttgccatgttgcccaggctggtcccaaacttctagcctcaagcaaccctcctgcctcagcctctcaaagtgctaggattgcagtcctgagctactgcccccTACCCTCTTTGCGTCTTAGGAGTCATTTAGATTTTTTTTGAtccttttgtttagtgcctctggagctgcttacaccaaggcaatacgccttgatatactggatggttgagaggcagcctctttttttttttttttttttttttttttttggaggatagggagtatggctgttgtgaaaagggaggtaaagagaaatggtagatctgaagaggcctcatcagagcacatattttaggacaacacatatggaaattggacatctttaagttggtttccatagagctatgcatgtatccttacccccatgggaaaatgttggtgtgttctcaagggtatgcatgtgtcattttgaagaccaAGGCCCTAGAATTGTCAAACTTAAGGATCATAAAAATCATGAGGGTTGCTTGTTAAAAATGTCCAAACGTGCAGAGACTGATCTTTGAGATCTGGACCAGGAATTTGCATTTGAACAAGTGTTCCTGGAATCTCTATGCAAGTTTTATACAGAACATACTTTTGGAATCCTTGCCCTAGAcaggggtgtccaatcttttggcttccctggtccacaatggaagaagaattgtcttggaccacacataaaatacactaacactaacaatagctgatgagctaaaaaaaaaaaaaaaaaaaatcgtggaccgggcgtagtggctcacgcctgtaatcccaacactttgggagatcacctaggtcgggagtttgagaccagcctgaccgacatggagaaaccccatttttactaaaaatacaaaaaattagctgggcatggtggtgcatgcctgtagtcccagctactcaggaggctgaggcaggagaatcgcttgaacctgagagggggagattgcggtgagctgagattgcgccattgcaccccagcctgggcaacaatagcgaaactgtctcagaaaaaagaaaaaaaaaatcgcaaaaagaaaaatctcataatgtCGTTGTTGGtttttttttttttttttgagacagtctcactctgttgcccaggctggagtgcaatggcatgatctctgctcaccgcaacctctgcctcccgggttcaggtgattctcctgcctcagcctcccagatagctgggactacaggcacataccaccatgcctggctaatttttgtatttttagtagagatgggggtttcactgtgttggccaggctggtctcgaactcctgacctcatgatccacacacctcggcctcccaaagtcctgcgattacaggcgtgagctaccgcacccagccAAGTTGTAATTTTTAATAAAACTTAAGAAGTAAACATTTTACTTATGTTTATAGGTATTTGATCCTAAATTTGACACATCATTGCCCATGAAAGAATCCTCTTAGGCTGCTCAGCTTCACTCTTCCTGCTTGCCCACCGGGGTTTTTCACTGCTTCTGTTAGCACTAAGTACTTAGACGATCCTAAGATATGTGCTTGAGCCGAATTTCATCTTTACTTGTAGGAAACTTTAAACTATTTCttttcttttcttttttttttttttttacttgagatggagttttgctcttgtcgcccaggctggagtgcagtggagtgatctcggctcactgcaacctctgcctcccgggttcaaatgattctcctgcctcagcctcccaagtagctgggattacaggtgtgcaccaccatgtctggctaattttgtatttttagtagagatggtttcaccatgttggtcaggctggtctcgaactcctgacctcaggtcatccacccacctcagcctcgcaaagtgctgagattacaggcatgagccacagcgcccagcTTAAACTATTTTCTTGGTCTGTTTTTGATTTTCTTTTTTCCTTGCCACTGCGGTACAGATTTTTTTTACTCACTGCCACTAAACTAAAGCAAGGCATAGTTTATATGTGAAGTGTTCAGAGTTTACTGCTATAAGGAAACTTCCAAATACTGACATTTACCTTTTAGCTGTAGTTATTGGGACCATGTGCTCTGGTTTTCTGGAGACTGCCAAATTGCTCCCATTTTTCTGCATCCCACCTGGTTTCTTTCTGCATgtcccctttcactttcaaacctcttcatttggatgttaaattatatggtcaccTAGTTATAGGTAAGCCTTGTTCGAGTTGATATCTTGATTGTGAGGAAGGATCTGTGTCATTGGAGCTTGTTTCTGCTGCAACGTGCTGTAGACTATGAATAATGAAATCACACCACATTACCATCAGATTTCTTGTTTTAGTTGTCAAATTAATATTTATGATTGTTATCTTGGGCGAAAAGTTCAGAGCAGAGATGACAAATCATTAGAACAACGATGAATTTCAGTATTACGGCTAAAAAGTTCTTCTGTCTGAATATTAACTCACTCTCCTTCCAGTGTACTTCACAGTAATTGGTATGCTTTTTTATTTAATGCTTAAATCAAACTTTATAAAAATCTTAGACCAGATCTTTAATATGGTATGCCATTTCCCCAGTCTACCAATGGAATAGTATGGGTTTCTAATCCTAGGCTTGTACAATGGATTGGAGTTGAGCCATGCCAGCCTCCACACTGCCACTAACTTCTGTAATGTAAGATTGAGTCACTGCCAAGCATTTGAAATATGCAGTTGTGTTTTAATTATAATTTATGTATAGTTAGATGTATGTAGTGCATTGTGTGGTATTATTTGGTTTGTAAGAATTTATTTTTAAGGGTCAAGGTCATTTGTAACATTTTGTGTGTGTCAATTCAATGCAATGTTGGCTGCCTTTTGAAGTCTTTGATATATTGGTGAATATTCTTCTGATCTATAATACAAAGCTATGTAATGTTACCTCTTGACTCGCTTTTGAAAGGAAGACAATTGTTAACTAGATATTTGAGTTTTTTCCCCTCAGAATTATGTGAATTTCTGATATATGGCTTTAGATACTGTGAATCTGTTTTCCATTTAGTCAGTTATCTGCTTAAATTGTTCAGAACTATATCCTAACGAGCAATTAGTTCTGATGGTTCTCCCAGTCATGAGTGTGCATGTGTGCAAGCATGTTTTGATCCTGATGCTACCTTTGCTAAAAATGGCCATAGATTAGGAACTAGCTATGTTTTTAGAATCAAAGATGAACCGGTAAGCTGTCTCATGTACCAAACGTGAAATTTACAGTGTTTACAAATGTCTGGAATTTTGCACTGCCATAGGGAATGTTAAGGTTACTTGGCTGGAATTTATCAGACTTGTGAGTAAACAAGTTGAAGTTTAGCAGATGAGGGGGAATATTGAGGCCCCTAAGGCTAAACAAAATAATCAGTATCTGAGATAGTGGCTAATGTGGCTCCCCAGGCCTAATTTGGGAACAGTTTTTCCTGATTGCTTTGAGAAGTACTTTCTTTTGACAGAAATTTTCATTCTGCTTGCCATTGCTATATTCTCCCTTTATAGGAGCCATTGGATTTCTTTCCTTTTGTGGGAAATGTCCCATTAGCATTTTCAGATCTTTTGATGTGCACTAATGCCATTATTGGTAATGCCGTTATTGGTGAATACAGCATAGTTAAATAAACTGTTACAGTAAATCTACACTTGGATTTGCTGCACCTCTACCAATAGCCTTTTGAATGACTGAAAGTGTTAACAGAGAAAGAGGCATGTCTGCAGAAAGAGATAGCTAATATTTTTTGGTACTTTATCTGAAATCCAAGATGCTGCTTCCCCTGCAGGTTGTTTTCCTTCTTACGATCCTCATTGAATCCCCTCTGGGAGCACAGGACAGTTAGTAGAACTCTCCAtttctttttttttttttttagacggagtctctctctgtcgccccggctggagtgcagtggcgcgatctcggctcactgcaacctccgcctcccgggttcaccccattctcctgcctcagcctccctagtagctgggactataggcgcccgccaccacgcctggctaatttttgtatttttattggagacggggtttcaccgtcttagccaggatggtcttgatctcctgacctcgtgatctgcccacctcagcctcccaaagtactgggattacaggcgtgagccaccgcgcccggccGGAACTCTCCATTTCTTAAGGTAAAGAGGGTCAAGGATACCTAAAAAGGGTCAAATAATGCTAGAAGAGCAATTCCTCTTTCAGAGCAGTTGCTGTAATTTGGCAAATGCTTTATCGAAGATTGATATTAggctaggggcggtggcttacgcctgtaatcccagcactttgggaggccgaggtgggtggattgcctgagctcaggagttcgagaccagtctgaccagtatggtgaaaccctgtctctactaaaaatacaaaaattagccggtcgtggtggcgtgcacctgtagtcccagctacttggcaggttgagacaggagaatcgcttgaacctgggaggtggaggttgcagtgagccgagactgcaccactgcgctcccacctgggtgacagagactctgtctcaaaaaaaaGGACATTTATCATTATAACATCTTATTAGAGCCCCTAATTTCTTATCTGAAGGCACTGTTTTTTTTTTTAAACAGTTAAGTACTGATGTCAACAGACAAATATTTCTGATCAGATAGTCCCCTGTCAACAGTAGCAAATGTGGTTTCATAAAGTGGGAAGAAAACAGCATTTTAAAGTAACTTTTTgggagactgatttgagtaataataaaactctggtctcccTTAAGAAAAAAAAACCCTTCCACCTTTACTGTGTCATTTATATCCCCTTAGTTCCAAAGTTAATTATCTTATTTCTGGATATTGCTTTTATACCAAAGACCCTTATCAGCCCTTGTAACTACAGTATCTTTAGATAAGATTCCTCTTTCCAGTCAGTCCTGGGAAATGTTTCTGTTGCAGAGTTAGGCGGTAGATGGGAAGCTGTGATGGCAGAGCTACTATCTAATAAAGTAACAACTCGTAGTTGAGGCTTCCTTTCTGTGTGTGATGGGGGATAGGGAGTTAGCTCCCCTGTTGTCTCAGCACTAAGAAATTGAGGTCAggccaggcgcggtggttcactcctgttattccagcactggggtggccaaagtgggcagattgcttgcgctctggagctcgagaccagcctgggcaacatggtgaaaccctgtctctaccaaaaatacaaaaaaaaagctgggcatggtgggtgcatgcttgtcccagctactgaggaggctgaggtgggaggatcgcttgagcctgggaggtggaggttgcagtgagctgagatggcaccactgcaatccaaggtgggtgacagagacgctgtctcaaagaaaTTGAGGTCAGGCTTCCTTCTTACAGAATTATTTTTTTCTCTGTAGTTTGCCTCATTTTTTCACTTTCTTTTCAATGAGAATCGAAGTGTTTCTTTTGGGTTTTTTTTTCCCCCTTTTAAAATCAACAGGAAATGTTTCAAAGGAGGGATGAAATGCTTCTTGGCTTCCTCAGCACTTGGCAAGGTAGACCTCATAGCAACCTTGAATATGACTTTCTTTAGTCTCTAGCTATGCACTATTAAGTGCCTCTTGGGTAGAGGTAGAGTTAAGTATTGAGTgccagtcttgacgtccgtatgcctcagtttttctcatatataaaaagcagtatacatacctacccttttctacctcatcatttgttgtagggattaaatCCGGGAGAGCAATTCTGAAGCCTATAAATTTCCTTGAAGAGATCTAAGAACCTATTATGCTCTTGGTGTACCAAGCTCTGGGGTATATATTCAGAATACCTCATGTTCTGGAAGCTGAGCACTAGCTCCCCTTTATTGCCTGCCTGGCAGAGCCTGTTTGATTACTGCAGGCCCTTTTACCCATGCTTCTAGTTTAGGTATTCTTTCTTTGATATGAGGCTCTTGACCAGAAAAGAGTTCTTTCTCTAGGTGTTCTGAGAGAAGTTTGTAAATTTGGATAGTACATTCTATCCTGATAAAACCACCTTGCTGTGGTCTTGATGTACAAAAAAAAAttttttttttgagacagagtcttactctgtcacccaggctggaatgcagtggcgcaatcttggttcactgcaacccccgcctcctgggttcaagcgatcctcctgcctcaacctctcaagtagctgggactacaggcgtgcaccaccacacctggctaattttgtatttttagtagagacagggtttcaccatgttggccaggctggtcttgaactcctgacctcaggcgatctgcccgccttggcctcccaaagtactgggattacaggcgtgagcaactgctcctggccCAAAACATCTCTTTCTACATACACTTGAGTAGGTGGCATAAAATGCACTGTCAATATATAGAAAACATGAAATTTTCCAAATATTTCCGATCAGAGAATCACAAGAGCAGCAAATGTGGTTTCATCAAGTGGGAAGAAAGCAGCAATTTAAAATAACTTTTTgggagactgaattgagtaataataaaacttcagtctttcgctaataataataataataataataataaCAACAACTTATTGAATGTGGCCAGCTCACTAGATGAGGAAAGAGGAAGGCATTTTCTGCATTCTTGCCTAGTTTTCCTTATAAGCACCACTAAGTTAATAGCTCTGTCTTTTTGGTGTTTGCACTATGTAATGCTTTTAATACTTTTTAATTGTGCTTTTTTATGTATTAAATGTTTTTCCTTTTGCCA

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