Summary

Gene Name	SELENOT
Specie	Homo sapiens
Full Name	selenoprotein T
Also known as	SELT
Coordinate	chr3:150603321-150630436
Strand	+
Gene summary	This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5. [provided by RefSeq, Sep 2017]

Retrocopy(s) from SELENOT

Retroname	Coord	Strand	Genomic Region	ENSG
SELENOTP1	chr9:6278595-6281989	+	Intergenic	ENSG00000233846	UCSC

Expression

Transcript Sequences

>NM_016275.5

GCAGTCTGTCTGAGGGCGGCCGAAGTGGCTGGCTCATTTAAGATGAGGCTTCTGCTGCTTCTCCTAGTGGCGGCGTCTGCGATGGTCCGGAGCGAGGCCTCGGCCAATCTGGGCGGCGTGCCCAGCAAGAGATTAAAGATGCAGTACGCCACGGGGCCGCTGCTCAAGTTCCAGATTTGTGTTTCCTGAGGTTATAGGCGGGTGTTTGAGGAGTACATGCGGGTTATTAGCCAGCGGTACCCAGACATCCGCATTGAAGGAGAGAATTACCTCCCTCAACCAATATATAGACACATAGCATCTTTCCTGTCAGTCTTCAAACTAGTATTAATAGGCTTAATAATTGTTGGCAAGGATCCTTTTGCTTTCTTTGGCATGCAAGCTCCTAGCATCTGGCAGTGGGGCCAAGAAAATAAGGTTTATGCATGTATGATGGTTTTCTTCTTGAGCAACATGATTGAGAACCAGTGTATGTCAACAGGTGCATTTGAGATAACTTTAAATGATGTACCTGTGTGGTCTAAGCTGGAATCTGGTCACCTTCCATCCATGCAACAACTTGTTCAAATTCTTGACAATGAAATGAAGCTCAATGTGCATATGGATTCAATCCCACACCATCGATCATAGCACCACCTATCAGCACTGAAAACTCTTTTGCATTAAGGGATCATTGCAAGAGCAGCGTGACTGACATTATGAAGGCCTGTACTGAAGACAGCAAGCTGTTAGTACAGACCAGATGCTTTCTTGGCAGGCTCGTTGTACCTCTTGGAAAACCTCAATGCAAGATAGTGTTTCAGTGCTGGCATATTTTGGAATTCTGCACATTCATGGAGTGCAATAATACTGTATAGCTTTCCCCACCTCCCACAAAATCACCCAGTTAATGTGTGTGTGTGTTTTTTTTTTAAGGTAAACATTACTACTTGTAACTTTTTTTCTTAGTCATATTTGAAAAAGTAGAAAATTGAGTTACAATTTGATTTTTTTTCCAAAGATGTCTGTTAAATCTGTTGTGCTTTTATATGAATATTTGTTTTTTATAGTTTAAAATTGATCCTTTGGGAATCCAGTTGAAGTTCCCAAATACTTTATAAGAGTTTATCAGACATCTCTAATTTGGCCATGTCCAGTTTATACAGTTTACAAAATATAGCAGATGCAAGATTATGGGGGAAATCCTATATTCAGAGTACTCTATAAATTTTtgtgtatgtgtgtatgtgcgtgtgATTACCAGAGAACTACTAAAAAAACCAACTGCTTTTTAAATCCTATTGTGTAGTTAAAGTGTCATGCCTTGACCAATCTAATGAATTGATTAATTAACTGGGCCTTTATACTTAACTAAATAAAAAACTAAGCAGATATGAGTTAAATTTAAAAGTTTCAATTTATTGCTCAGTGTACCTGTTAACATTATATTTAACAATTGCTTAAATTTTTGTTTTTGATTTATGGATAATTTCTTAAGAGTACACACTTTAGATACACAAATAATCGTTCATTTACCATCTTTAGGATCATTGAAACTCATCTCACTAAAGAAAGTTCACTTGAACCTCTTTATAGCATTGATACTAGGTGAACAGAAATTACCTGACTAATAATTTGTCTAACATCATATATCAGAATTTTATTGTATATGATGAACAAAACTTAAAATTTTTTAAATTTAATTTTTAAATACTGTTTCAGAGTTCTAAAAAGGCAGTTTTTTAAAAAACTTAAGTTGATAAAAACTGTAAGAATAATTTAGCAGAAATAGAACCAGAATGTAGAAGAGTAGTCATGTAACAGCAGTAATAACATACTTCAGCTTCCATATAGGAATAGAAGTGGTAGAGCCAAAAGTGATTTAGGAAAAGTTATAAGGTAcaggttgagtatcccttttccaaaaatgcttgggacaagaagtatttcagatttcataatttttttcaaagtttggaatatttgcattatacttaccagttgggcatcccaaatctgaaatctgaaatgttccatgagcatttcctttgagtgtcatgttggcactcaaaaaggttcAACATTGAGTCCACTTAACACTTAGGTGTTAGAAGACCTAACTTTCTGTAACAATTAACCTTATACTTTGTTTGTCATCGAATATTTGTTGAATGCATGTCAGGTAATGGTCTTGATTGTGATAGCTTCAAGGTGGAACATACTGTAATCTCCAGATGCTAGGAAGTTAGTCTAATAATTCACTGCAGAAAATTGATTAAGTGGCTGTCCTTTTAATTAAGAGTGTGGAGTCATAAACTTAAGTTCTTCATATAGTGACAAGAGTCCTTAGAGATTGTTATTCAAGTTCCTTAGAAATTGTTATTTAGGTATAATATCATCTTGTCTTTGACTAGAGCTTGAAACCTTGTTATCTGATTGTGTACCACTCCAAATTCCCTGCCTTCTGCAAGTTGAATGTCTTGCTGAATGTGTCTAGGGGTTCATCTTCAGTAATCGACATTCCACTAGTGCCATAGTTAACTTCATGACATGTAGACATTCAAAACTTGAGCCTTGGATGTTCCTGTGGACCTGACAGTTAAAAATATAAAGAACCTAGGATTCAATTCCAACTTTCTCTGTTTGCCTTGGGTTGAATAACTTATCTTTTGGAGAATAGCTTTAAGTGGCTTAGACACTGATAAAATTCAGCTGTGTTGTTGACGCTCATCTCTTTTGTCTTACGCTTAGCCATATTTAAATCTTGAATTTAATAGAGTCTAGTGAAAAAAATGAGTGGGAAGAATGAATATAAAAGTAATAATATAAGGAAAAAGGGAAAGTAAACTATTTAGAATGTAGTTTTGTTATATTCCCAGCATTTCAATATTTATTAGTTACTTGTAAATTACTGTGGCTGTGTAGTTTATAAATGTCTGTGCACTATATTAATTAGAAGACCATAGAACATGCCAGCAGGTTGGCTAATGCTATGGGGGTTTTTACCACAGTTGCCATTGTGGAAGAAATTATTTGGTACATTAATAAAAAAAGTTGGTAAAACATGGTTTTATACCTCAGTGTATAAGATGTGCAAGACAAATATGCTTATTTCCTTTTCTAGAATATAAGTGATATTATTTGCTTATGACACTAACACTATTAATGACAGGAGTCAATCAGCCTTTACAGCTATCAAAATATAATGAGATCCCAATGATGATTCTTTTTTACTTTGAATGTTAATTAGTTTGGGACTTTGATTGGCTGGCAAACATTTTATCATTGTCAGAATTTAATTTAGATTTCAAAAATAGCTTACAGGATTTTAAACATGGTGTGGTATTCTAAAGCCTTTTTTTTAAAAAAAGAGATCTTTTTGAGAGAAACAAATGAGGATTGTAAAGTTTGGGGACTTACCTCTGTAGCATTGTGAAAATAAACTTTGATTAAGCTGA