Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SELENOTP1
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:6278595-6281989  UCSC
Coordinates (T2T) chr9:6283649-6287043  UCSC
Coordinates (hg19) chr9:6278595-6281989  UCSC
Strand +
Parental Sequence NM_016275.5
Parental seq. overlap 3077 bp
Parental seq. overlap (%) 89.1%
Genomic Region Intergenic
Retrocopy Summary SELENOTP1, located on chr9:6278595-6281989, is a retrocopy of the parental gene SELENOT. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SELENOT
Full Name selenoprotein T
Also known as SELT
Coordinate chr3:150603321-150630436
Strand +
Gene summary This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5. [provided by RefSeq, Sep 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SELENOTP1
Bonobo Pan paniscus SELENOTP1
Gorilla Gorilla gorilla SELENOTP1
Orangutan Pongo abelii SELENOTP1
Gibbon Nomascus leucogenys SELENOTP1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SELENOTP1
GAGTGGCGGTGTCTGTGATGGTCCGGAGCGAGGCCTCGGCCAATCTGGGTGGCGTGCCCAGCGAGATTAAAGATGCAGTACGCCACGGGGCCACTGCTCAAGTTCCAGATTTGTGTTTCCTGAGGTTATAGGCGGGTGTTTGAGGAGTACATGTGGGTTACTAGCCAGGGGTACCCAGACATCCGTATTGAAGGAGAGAATTACCTCCCTCAACCAATGTATAGACACATAGCATCTTTCCTGTCAGTCTTCAAACTAGTATTAATAGGCTTAATAATTGTTGGCAAGGATCCTTTTGCTTTCTTTGGCATGCAAGCTCCTAGCATCTGGCAGTGGGGCCAAGAAAATAAGGTCTATGCATGTATGATGGTTTTCTTCTTGAGCAACATGATTGAGAACCAGTGTATGTCAACAGGTGCATTTGAGATAACTTTAAATGATGTACCTGTGTGGTCTAAGCTGGAATCCGGTCACCTTCCATCCATGCAACAGCTTGTTCAAATTCTTGACAATGAAATGAAGCTCAATGTGCATATGGATTCAATCCCACACCATCGATCATAGCACCACCTATCAGCACTGAAAACTCTTTTGCATTAAGGGATCATTCCAAGAGCAGCTTGACTGACATTATGAAGGCCTGTACTGAAGAGAGCAAGCTGTTAGTACAGACCAAATGCTTTCTTAGCATGCTCGTTGTACCTCTTGGAAAACCTCAATGCAAGATAGCTTTTCCGTGCTGGCATATTTTGGAATTCTTCACATTCATGGAGTGCAATAATACTGTATAGCTTTCCCCACCCCCCACACAATCACCCAGTTAATGTGTGTTTTTTTTTAAGGTAGACATTACTACTTGTAACTTTTTTCCTTAGTCGTATTTGAAAAAGTAGAAAATTGAGTTACAATTTGATTTTTTTTCCAAAGATGTCTGTTAAATCTGTTGTGCTTTTATATGAATATTTGTTTTTTATAGTTTAAAATTCATCCTTTGGGAATCCAGTTGAAGTTCCCAAATACTTTATAAGAGTTTATCAGACATCTCTAATTTGGCCATGTCCAGTTTATATAGTTTACAAAATACAGCAGATGCAAGATTATGGGGGAAATCCTATATTCAGAGTACTCTACAAATTTTATTACCAGAGAACTACTAAAAAAACCAACTGCTTTTTAAATCCTATTGTGTAGTTCAAGTGTCATGCCTTGACCAATCTAATGAATTGATTAATTAACTGGGCCTTTATACTTAACTAAATAAAAAACTAAGCAGATATGAGTTAAATTTAAAAGTTTCAATTTATTGCTCAATGTTCCTGTTAACATTATATTTAACAATTGCTTAAATTTTTGTTTTTGATTTATGGATAATTTCTTAAGAGTACACACTTTAGACACACAAATAATGGTTCATTTACCATCTTTAGGATCATTGAAACTCATCTCACTAAAGAAAGTTCACTTGAAGCTCTTTATAGCATTGATACTAGGTGAACAGAAATTACCTGGCTAATAATTTGTCTAACATCATATATCAGAATTGTATTGTATATGATGAACAAAACTTAAAATTTTTTTAATTTAATTTTTAAATACTGTTTCAGAGTTCTAAAAAGGCAGTTTTTTAAAAAACTTAAATTGATAAAGACTGTAAGAATAATTTAGCAGAAATAGAACCACAATGTAGAAAAATAGTCATGTAACAGCAGTAATAACATACTTCAGCTTCCATATAGGGATAGAAGTGGTAGAGCCAAAAGTTATAAGGAAGTTATAAGGTAAACATTGAGTCCACTTAACACTTAGGTGTTAGGAGACCTAACTTTCTGTAACCTTATAATTAATTAACCTTATACTTTGTTTGTCATCGAATATTTGTTGAATGCATGTCAGGTAATAGTCTTGATTGTGATAGCTTCAAGGTGGAACATACTGTAATCTCCAGATGCTAGGAAGTTAGTCTAATAATTCACTGCAGAAAATTGATTAAATGGCTGTCCTTTTAATTAAGATTATGGAGCCATTAACTTAAGTTCTTCATATAGTGACAAGAGTCCTTAGAGATTGTTATTCAAGTTCCTTAGAAATTGTTATTTAGGTATAATATCATCTTGTCTTCGACTAGAGCTTGAAACCTTGTTATCTGATTGTGTACCACTCCAAATTCCCTGCCTTCTGCAAGTTGAATGTCTTGCTGAATGTGTCTAGGGGTTCATCTTCAGTAATCGACATTCCACTAGTGCCAGTTAACtCCAGTTAACTTCATGACATGTAGACATTCAAAACTTGAGCCTTGGATGTTCCTGTGGACCTGACAGTTAAAAATATAAAGAACCTAAGATTCAAATCCAACTTTCTCTGTTTGCCTTGGGTTGAATAACTTATCTTTTGGAGAACAGCTTTAAGTGCCTTGGACACTGATAAAATTCAGCTATATTGTTGACACTCATCTCTTTTGTCTTATGCTTAGCCATATTTAAATCTTAAATTTAATAGAGTCTAGTGAAAAAATGAGTGGGAAGAATGAATATAAAAGTAATAATATAAGGAAAAAGGGAAAGTAAACTATTTAGAATGTAGTTTTGTTATATTCCCAGCATTTCAATATTTATTAGTTACTTGTAAATTACTGTGGCTGTGTAGCTTATAAATGTCTGTGCACTATATTAATTAGAAGACCATAGAACATGCCAGCAGGTTGGCTAATGCTATGGGGGATTTTACCACAGTTGCCATTGTGGAAGAAATTATTTGGTACATTAATAAAAAAAGTTGGTAAAACATGGTTTTATACCTCAGTGTATAAGATGTACAAGACAAATATGCTTATTTCTTTTTCTAGAATGTAAGTGATATTATTTGCTTATGACACTAACACTAGGAATGACAGAAGTCAATCAGCCTTTACAGCTATCAAAATATAATGAGATCCCAATGATGATTCTTTTTTACTTTGAATGTTAATTAGTTTGGGACTTTGATTGGCTGGCAAACATTTTATCATTGTCAGAATTTAATTTAGATTTCAAAAATAGCTTGCAGGATTTTAAACATGGTGTGGTATTCTAAAGCCTTTTTTTAAAAAAAGAGATCTTTTTGAGAGAAACAAATGAGCATTGTAAAGTTTGGGGACTTACCTCTGCAGCACTGTGAAAATAAACTTTTATTAAGCTGA
>NM_016275.5
GCAGTCTGTCTGAGGGCGGCCGAAGTGGCTGGCTCATTTAAGATGAGGCTTCTGCTGCTTCTCCTAGTGGCGGCGTCTGCGATGGTCCGGAGCGAGGCCTCGGCCAATCTGGGCGGCGTGCCCAGCAAGAGATTAAAGATGCAGTACGCCACGGGGCCGCTGCTCAAGTTCCAGATTTGTGTTTCCTGAGGTTATAGGCGGGTGTTTGAGGAGTACATGCGGGTTATTAGCCAGCGGTACCCAGACATCCGCATTGAAGGAGAGAATTACCTCCCTCAACCAATATATAGACACATAGCATCTTTCCTGTCAGTCTTCAAACTAGTATTAATAGGCTTAATAATTGTTGGCAAGGATCCTTTTGCTTTCTTTGGCATGCAAGCTCCTAGCATCTGGCAGTGGGGCCAAGAAAATAAGGTTTATGCATGTATGATGGTTTTCTTCTTGAGCAACATGATTGAGAACCAGTGTATGTCAACAGGTGCATTTGAGATAACTTTAAATGATGTACCTGTGTGGTCTAAGCTGGAATCTGGTCACCTTCCATCCATGCAACAACTTGTTCAAATTCTTGACAATGAAATGAAGCTCAATGTGCATATGGATTCAATCCCACACCATCGATCATAGCACCACCTATCAGCACTGAAAACTCTTTTGCATTAAGGGATCATTGCAAGAGCAGCGTGACTGACATTATGAAGGCCTGTACTGAAGACAGCAAGCTGTTAGTACAGACCAGATGCTTTCTTGGCAGGCTCGTTGTACCTCTTGGAAAACCTCAATGCAAGATAGTGTTTCAGTGCTGGCATATTTTGGAATTCTGCACATTCATGGAGTGCAATAATACTGTATAGCTTTCCCCACCTCCCACAAAATCACCCAGTTAATGTGTGTGTGTGTTTTTTTTTTAAGGTAAACATTACTACTTGTAACTTTTTTTCTTAGTCATATTTGAAAAAGTAGAAAATTGAGTTACAATTTGATTTTTTTTCCAAAGATGTCTGTTAAATCTGTTGTGCTTTTATATGAATATTTGTTTTTTATAGTTTAAAATTGATCCTTTGGGAATCCAGTTGAAGTTCCCAAATACTTTATAAGAGTTTATCAGACATCTCTAATTTGGCCATGTCCAGTTTATACAGTTTACAAAATATAGCAGATGCAAGATTATGGGGGAAATCCTATATTCAGAGTACTCTATAAATTTTtgtgtatgtgtgtatgtgcgtgtgATTACCAGAGAACTACTAAAAAAACCAACTGCTTTTTAAATCCTATTGTGTAGTTAAAGTGTCATGCCTTGACCAATCTAATGAATTGATTAATTAACTGGGCCTTTATACTTAACTAAATAAAAAACTAAGCAGATATGAGTTAAATTTAAAAGTTTCAATTTATTGCTCAGTGTACCTGTTAACATTATATTTAACAATTGCTTAAATTTTTGTTTTTGATTTATGGATAATTTCTTAAGAGTACACACTTTAGATACACAAATAATCGTTCATTTACCATCTTTAGGATCATTGAAACTCATCTCACTAAAGAAAGTTCACTTGAACCTCTTTATAGCATTGATACTAGGTGAACAGAAATTACCTGACTAATAATTTGTCTAACATCATATATCAGAATTTTATTGTATATGATGAACAAAACTTAAAATTTTTTAAATTTAATTTTTAAATACTGTTTCAGAGTTCTAAAAAGGCAGTTTTTTAAAAAACTTAAGTTGATAAAAACTGTAAGAATAATTTAGCAGAAATAGAACCAGAATGTAGAAGAGTAGTCATGTAACAGCAGTAATAACATACTTCAGCTTCCATATAGGAATAGAAGTGGTAGAGCCAAAAGTGATTTAGGAAAAGTTATAAGGTAcaggttgagtatcccttttccaaaaatgcttgggacaagaagtatttcagatttcataatttttttcaaagtttggaatatttgcattatacttaccagttgggcatcccaaatctgaaatctgaaatgttccatgagcatttcctttgagtgtcatgttggcactcaaaaaggttcAACATTGAGTCCACTTAACACTTAGGTGTTAGAAGACCTAACTTTCTGTAACAATTAACCTTATACTTTGTTTGTCATCGAATATTTGTTGAATGCATGTCAGGTAATGGTCTTGATTGTGATAGCTTCAAGGTGGAACATACTGTAATCTCCAGATGCTAGGAAGTTAGTCTAATAATTCACTGCAGAAAATTGATTAAGTGGCTGTCCTTTTAATTAAGAGTGTGGAGTCATAAACTTAAGTTCTTCATATAGTGACAAGAGTCCTTAGAGATTGTTATTCAAGTTCCTTAGAAATTGTTATTTAGGTATAATATCATCTTGTCTTTGACTAGAGCTTGAAACCTTGTTATCTGATTGTGTACCACTCCAAATTCCCTGCCTTCTGCAAGTTGAATGTCTTGCTGAATGTGTCTAGGGGTTCATCTTCAGTAATCGACATTCCACTAGTGCCATAGTTAACTTCATGACATGTAGACATTCAAAACTTGAGCCTTGGATGTTCCTGTGGACCTGACAGTTAAAAATATAAAGAACCTAGGATTCAATTCCAACTTTCTCTGTTTGCCTTGGGTTGAATAACTTATCTTTTGGAGAATAGCTTTAAGTGGCTTAGACACTGATAAAATTCAGCTGTGTTGTTGACGCTCATCTCTTTTGTCTTACGCTTAGCCATATTTAAATCTTGAATTTAATAGAGTCTAGTGAAAAAAATGAGTGGGAAGAATGAATATAAAAGTAATAATATAAGGAAAAAGGGAAAGTAAACTATTTAGAATGTAGTTTTGTTATATTCCCAGCATTTCAATATTTATTAGTTACTTGTAAATTACTGTGGCTGTGTAGTTTATAAATGTCTGTGCACTATATTAATTAGAAGACCATAGAACATGCCAGCAGGTTGGCTAATGCTATGGGGGTTTTTACCACAGTTGCCATTGTGGAAGAAATTATTTGGTACATTAATAAAAAAAGTTGGTAAAACATGGTTTTATACCTCAGTGTATAAGATGTGCAAGACAAATATGCTTATTTCCTTTTCTAGAATATAAGTGATATTATTTGCTTATGACACTAACACTATTAATGACAGGAGTCAATCAGCCTTTACAGCTATCAAAATATAATGAGATCCCAATGATGATTCTTTTTTACTTTGAATGTTAATTAGTTTGGGACTTTGATTGGCTGGCAAACATTTTATCATTGTCAGAATTTAATTTAGATTTCAAAAATAGCTTACAGGATTTTAAACATGGTGTGGTATTCTAAAGCCTTTTTTTTAAAAAAAGAGATCTTTTTGAGAGAAACAAATGAGGATTGTAAAGTTTGGGGACTTACCTCTGTAGCATTGTGAAAATAAACTTTGATTAAGCTGA

Publications

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