Summary

Gene Name	PGK1
Specie	Homo sapiens
Full Name	phosphoglycerate kinase 1
Also known as	HEL-S-68p|MIG10|PGKA
Coordinate	chrX:78104248-78129295
Strand	+
Gene summary	The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]

Retrocopy(s) from PGK1

Retroname	Coord	Strand	Genomic Region	ENSG
PGK1P2	chr19:12559484-12561270	+	Intergenic	ENSG00000213290	UCSC
PGK2	chr6:49785940-49787187	-	Intergenic	ENSG00000170950	UCSC
PGK1P1	chrX:68070080-68071845	-	Intragenic	ENSG00000228328	UCSC

Expression

Transcript Sequences

>NM_000291.4

GTTCCGCATTCTGCAAGCCTCCGGAGCGCACGTCGGCAGTCGGCTCCCTCGTTGACCGAATCACCGACCTCTCTCCCCAGCTGTATTTCCAAAATGTCGCTTTCTAACAAGCTGACGCTGGACAAGCTGGACGTTAAAGGGAAGCGGGTCGTTATGAGAGTCGACTTCAATGTTCCTATGAAGAACAACCAGATAACAAACAACCAGAGGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGAGCCACCTAGGCCGGCCTGATGGTGTGCCCATGCCTGACAAGTACTCCTTAGAGCCAGTTGCTGTAGAACTCAAATCTCTGCTGGGCAAGGATGTTCTGTTCTTGAAGGACTGTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCCGCTTTCATGTGGAGGAAGAAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTTCACTTTCCAAGCTAGGGGATGTCTATGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCACAGAAGGCTGGTGGGTTTTTGATGAAGAAGGAGCTGAACTACTTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGGCCATCCTGGGCGGAGCTAAAGTTGCAGACAAGATCCAGCTCATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCCTTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGAAGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTTCTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTGTGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTAGGGGCTGCATCACCATCATAGGTGGTGGAGACACTGCCACTTGCTGTGCCAAATGGAACACGGAGGATAAAGTCAGCCATGTGAGCACTGGGGGTGGTGCCAGTTTGGAGCTCCTGGAAGGTAAAGTCCTTCCTGGGGTGGATGCTCTCAGCAATATTTAGTACTTTCCTGCCTTTTAGTTCCTGTGCACAGCCCCTAAGTCAACTTAGCATTTTCTGCATCTCCACTTGGCATTAGCTAAAACCTTCCATGTCAAGATTCAGCTAGTGGCCAAGAGATGCAGTGCCAGGAACCCTTAAACAGTTGCACAGCATCTCAGCTCATCTTCACTGCACCCTGGATTTGCATACATTCTTCAAGATCCCATTTGAATTTTTTAGTGACTAAACCATTGTGCATTCTAGAGTGCATATATTTATATTTTGCCTGTTAAAAAGAAAGTGAGCAGTGTTAGCTTAGTTCTCTTTTGATGTAGGTTATTATGATTAGCTTTGTCACTGTTTCACTACTCAGCATGGAAACAAGATGAAATTCCATTTGTAGGTAGTGAGACAAAATTGATGATCCATTAAGTAAACAATAAAAGTGTCCATTGAAACCGTGATTTTTTTTTTTTTCCTGTCATACTTTGTTAGGAAGGGTGAGAATAGAATCTTGAGGAACGGATCAGATGTCTATATTGCTGAATGCAAGAAGTGGGGCAGCAGCAGTGGAGAGATGGGACAATTAGATAAATGTCCATTCtttatcaagggcctactttatggcagacattgtgctagTGCTTTTATTCTAACttttatttttatcagttacacatgatcataatttaaaaagtcaaggcttataacaaaaaagccccagcccattcctcccattcaagattcccactccccagaggtgaccactttcaactcttgagtttttcaggtatatacctccatgtttctaagtaatatgcttatattgttcacttcttttttttttattttttaaagaaatctatttcataccatggaggaaggctctgttccacatatatttccacttcttcattctctcggtatagttttgtcacaattatagattagatcaaaagtctacataactaatacagctgagctatgtagtatgctatgattaaatttacttatgtaacttttattgtctttggcattaacagtgtttcaaaaaattttctgtgtatacccatcagtgattcattcccaaatcttctagaagcataagtgtctcaatatattaaaacatattgaataatccttgttagagttatccctgcaggagtccttagtgctcctttatccaatttgtacttgatgccctctaggcagggtgtacagctagctgttgctctggtatttcctataaccttcttggggatttcttttacctcctgtgttagactcctgttttctggattcccccttttccctctttcttggtctactttttgtagaacacaagactctactagcttcctgagaaagggtgcctgggaggcaaaatctctaagactttgtaagtctgaaaatgtctttattcgacccttatacttgattcctagtttggctatatatagaattttagcctgagtatcactttttgagactcgaagccactgtttcattgtcACTATTGAGAATCTAAATGGCCATTCGGATTCTTTCATCATCTTTATAATTTTACCTTCCTATTTCTTTCCTGTCCTTTTAATGGAGTTTTGGGAGAGAGCAGAGGTAAACATGATTTGAAAAAGCCATGTCTGACCAGAAATTCTGTGCTGGAAAGATATGTATTTCACCTTTagggacaaagaaataaacttttggacaggaccacagagctagtaagtaacagcagggattcaagtccaggtttgtctggttccagtggctgatgcttttccaatgtgcctccgtccctGACATGATGCTTCTAGGCTATAGATGCTTCTAGACTCTATCCCTGACATGATGCTTCTAGACTATTTTGTTTAACCCTGGATAGAATAGCAAAAGAAAATTTTGGTGGTTGCTCTAAACAAAACAGAAATTTGAAAGCTCAAGTTTTTTCTTCATTTGTATTTTAGTTAATACTGTACCCATATTTGTAGTTAATTTTAAATTGTACCATGTTTCTGCATACCTCTATGGGTACTCAGGAATTCTAGTCCAATTTTTGTGACTTTTTCCTACTGATTACCTTTCCTCCAACGTTTTAAAAATTATTTCAAATGGAACTGAAAGAAGCATAAACTCCCATAAACCCAGCACCTAGACTCTACAATTGCCAACATTATCTATCCAACAATCTCTGACTGTACCTTTTAAGTACTTTCTACTGGACTGTTTCCAGGATCACCCCTCATTTATTTGGGTTGTTAACCTAAAGAATGAATGGGGGAATCTCCAGTCATAAACAACTTGTCAATTAGGCAAATATTTGAGTTCCTTCTATGTGCTTAAAGACGTGATAGAGGGAATATAAGAGCATTTATGTTCTGAAGGAATTTTTAACCTAACCAAAGAAGATAGTAGATAACTTGTGTGCATATAAGCTAGAACAGTATAAGGggccgggcatggtggcttacgcctgtaatcccaggactttgggaggccaaggcgggcagatcacctgtcaggagtttgggaccagcctggccaacatggtgaaaccccgtttctaccaaaaatacaaaaattagccgggcgtggtggcgtgtgccactgtagtcccagctattcagaaggctgaggcaggagaatcacttgaacccgggaggtggaggttgcagtgagctgagatcacgctactgcattcctgcttgggcgacagagtgagactctgcctcaaaacaaaaaCCCCACAAAACAGTATAAGGATGTGCTTTCTAATTTGGAATTATGAATTATTGGTAAAATATTGCAAAGGTGTATGCTTTAAGTTGTAAATTCACCTTTAACCCTAGACTATATATGTGTGTTTATATGCAGAAAAAAATAATTCCCATGTCGTAAGTGAACAATTTGGTTCTTTAGCTCAGTGTTTTCCTGTTTTCTTCATTTCCAAAATTTCCCTCTAGCACAGGGGTTTACACATGATCAAaaaggagtatacaatgaagacaccttcctcagtcccctacctaccagtttccctccccagaagcaacctctggaagaccagtttcttTCAATCTAAGGCTATTTAATATACATTAAGAggccgggcgcagtggctcacgcctgtaatcccaacaacactttgggaggcccaggcaggcgggtcatgaggtcaggagattgagaccatcctggctaacacggtgaaaccctgtctctactaaaaatacaaaaaattagctgggcgtgatggtgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacctgggaagcggagctcgcagtgagccgagatcacgccactgcactccagcctgggcaacagtgagactctgCATAAAGAGCATACCCATGTGTGTACctatctatctatctatctatctatctatctatctatctatctGTATATAGATATATTAAAATGTAAATGGTGGCA