| Retrocopy Name | PGK2 |
 |
| Species | Homo sapiens | |
| Coordinates (hg38) | chr6:49785940-49787187 UCSC | |
| Coordinates (T2T) | chr6:49627907-49629154 UCSC | |
| Coordinates (hg19) | chr6:49753653-49754900 UCSC | |
| Strand | - | |
| Parental Sequence | NM_000291.4 | |
| Parental seq. overlap | 1067 bp | |
| Parental seq. overlap (%) | 22.2% | |
| Genomic Region |
Intergenic |
|
| Retrocopy Summary | PGK2, located on chr6:49785940-49787187, is a retrocopy of the parental gene PGK1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes. |
| Gene Name | PGK1 |
| Full Name | phosphoglycerate kinase 1 |
| Also known as | HEL-S-68p|MIG10|PGKA |
| Coordinate | chrX:78104248-78129295 |
| Strand | + |
| Gene summary | The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014] |
| Species | Scientific Name | Retrocopy | |
 |
Chimpanzee | Pan troglodytes | PGK1P1 |
 |
Bonobo | Pan paniscus | PGK1P1 |
 |
Gorilla | Gorilla gorilla | PGK1P1 |
 |
Orangutan | Pongo abelii | PGK1P1 |
 |
Gibbon | Nomascus leucogenys | PGK1P2 |
 |
Green monkey | Chlorocebus sabaeus | PGK1P3 |
 |
Crab-eating macaque | Macaca fascicularis | PGK1P1 |
 |
Rhesus | Macaca mulatta | PGK1P1 |
 |
Golden snub-nosed monkey | Rhinopithecus roxellana | PGK1P3 |
 |
Marmoset | Callithrix jacchus | PGK1P2 |
 |
Mouse lemur | Microcebus murinus | PGK1P1 |
 |
Rabbit | Oryctolagus cuniculus | PGK1P3 |
 |
Pig | Sus scrofa | PGK1P1 |
 |
Cow | Bos taurus | PGK1P1 |
 |
Sheep | Ovis aries | PGK1P1 |
 |
Horse | Equus caballus | PGK1P1 |
 |
Dog | Canis familiaris | PGK1P2 |
 |
Cat | Felis catus | PGK1P2 |
 |
Pale spear-nosed bat | Phyllostomus discolor | PGK1P3 |
 |
Velvety free-tailed bat | Molossus molossus | PGK1P2 |
 |
Greater mouse-eared bat | Myotis myotis | PGK1P2 |
 |
Greater horseshoe bat | Rhinolophus ferrumequinum | PGK1P2 |
 |
Egyptian rousette | Rousettus aegyptiacus | PGK1P1 |
 |
Baboon | Papio anubis | Without Homology |
 |
Mouse | Mus musculus | Without Homology |
 |
Rat | Rattus norvegicus | Without Homology |
 |
Chinese hamster | Cricetulus griseus | Without Homology |
 |
Dolphin | Tursiops truncatus | Without Homology |
 |
Panda | Ailuropoda melanoleuca | Without Homology |
 |
Kuhl's pipistrelle | Pipistrellus kuhlii | Without Homology |
 |
Sloth | Choloepus didactylus | Without Homology |
 |
Tasmanian Devil | Sarcophilus harrisii | Without Homology |
 |
Opossum | Monodelphis domestica | Without Homology |
 |
Platypus | Ornithorhynchus anatinus | Without Homology |
 |
Chicken | Gallus gallus | Without Homology |
 |
Turkey | Meleagris gallopavo | Without Homology |
 |
Zebra Finch | Taeniopygia guttata | Without Homology |
 |
Budgerigar | Melopsittacus undulatus | Without Homology |
 |
Painted Turtle | Chrysemys picta | Without Homology |
 |
Lizard | Anolis Carolinensis | Without Homology |
 |
Frog | Xenopus tropicalis | Without Homology |
 |
Zebrafish | Danio rerio | Without Homology |
 |
Drosophila | Drosophila melanogaster | Without Homology |
| >PGK2 |
| ATGTCTCTTTCTAAGAAGTTGACTTTAGACAAACTGGATGTTAGAGGGAAGCGAGTCATCATGAGAGTAGACTTCAATGTTCCCATGAAGAAGAACCAGATTACAAACAACCAGAGGATCAAGGCTTCCATCCCAAGCATCAAGTACTGCCTGGACAATGGAGCCAAGGCAGTAGTTCTTATGAGTCATCTAGGTCGGCCTGATGGTGTTCCCATGCCTGACAAATATTCCTTAGCACCTGTTGCTGTTGAGCTCAAATCCTTGCTGGGCAAGGATGTTCTGTTCCTGAAGGACTGTGTAGGCGCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTCCTGGTTCAGTCATCCTGCTGGAGAACCTGCGCTTTCATGTGGAGGAAGAAGGGAAGGGCCAAGATCCCTCTGGAAAGAAGATTAAAGCTGAGCCAGATAAAATAGAAGCCTTCCGAGCATCACTTTCCAAGCTAGGGGACGTCTATGTCAATGATGCTTTTGGCACTGCACACCGCGCTCATAGTTCCATGGTGGGAGTGAATCTGCCCCATAAAGCATCCGGATTCTTGATGAAGAAGGAACTAGATTACTTTGCTAAAGCCTTGGAAAACCCAGTGAGACCCTTTCTGGCTATACTTGGTGGAGCCAAAGTGGCAGACAAGATCCAACTTATCAAAAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTATACCTTCCTTAAGGTACTCAACAACATGGAGATTGGTGCTTCCCTGTTTGATGAAGAGGGAGCCAAGATCGTTAAAGATATCATGGCCAAAGCACAAAAGAATGGTGTAAGGATTACTTTTCCTGTTGATTTTGTTACTGGGGACAAGTTTGACGAGAACGCTCAGGTTGGAAAAGCCACTGTAGCATCTGGCATATCTCCTGGCTGGATGGGTTTGGACTGTGGTCCTGAGAGCAACAAGAATCATGCTCAAGTTGTGGCTCAAGCAAGGCTAATTGTTTGGAATGGGCCGTTAGGAGTATTTGAATGGGATGCCTTTGCTAAGGGAACCAAAGCCCTCATGGATGAAATTGTGAAAGCCACTTCCAAGGGCTGCATCACTGTTATAGGGGGTGGAGACACTGCTACTTGCTGTGCCAAATGGAACACTGAAGATAAAGTCAGCCATGTCAGCACTGGAGGCGGTGCCAGTCTAGAGCTTCTGGAAGGTAAAATCCTTCCTGGAGTAGAGGCCCTCAGCAAC |
| >NM_000291.4 |
| GTTCCGCATTCTGCAAGCCTCCGGAGCGCACGTCGGCAGTCGGCTCCCTCGTTGACCGAATCACCGACCTCTCTCCCCAGCTGTATTTCCAAAATGTCGCTTTCTAACAAGCTGACGCTGGACAAGCTGGACGTTAAAGGGAAGCGGGTCGTTATGAGAGTCGACTTCAATGTTCCTATGAAGAACAACCAGATAACAAACAACCAGAGGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGAGCCACCTAGGCCGGCCTGATGGTGTGCCCATGCCTGACAAGTACTCCTTAGAGCCAGTTGCTGTAGAACTCAAATCTCTGCTGGGCAAGGATGTTCTGTTCTTGAAGGACTGTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCCGCTTTCATGTGGAGGAAGAAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTTCACTTTCCAAGCTAGGGGATGTCTATGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCACAGAAGGCTGGTGGGTTTTTGATGAAGAAGGAGCTGAACTACTTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGGCCATCCTGGGCGGAGCTAAAGTTGCAGACAAGATCCAGCTCATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCCTTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGAAGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTTCTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTGTGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTAGGGGCTGCATCACCATCATAGGTGGTGGAGACACTGCCACTTGCTGTGCCAAATGGAACACGGAGGATAAAGTCAGCCATGTGAGCACTGGGGGTGGTGCCAGTTTGGAGCTCCTGGAAGGTAAAGTCCTTCCTGGGGTGGATGCTCTCAGCAATATTTAGTACTTTCCTGCCTTTTAGTTCCTGTGCACAGCCCCTAAGTCAACTTAGCATTTTCTGCATCTCCACTTGGCATTAGCTAAAACCTTCCATGTCAAGATTCAGCTAGTGGCCAAGAGATGCAGTGCCAGGAACCCTTAAACAGTTGCACAGCATCTCAGCTCATCTTCACTGCACCCTGGATTTGCATACATTCTTCAAGATCCCATTTGAATTTTTTAGTGACTAAACCATTGTGCATTCTAGAGTGCATATATTTATATTTTGCCTGTTAAAAAGAAAGTGAGCAGTGTTAGCTTAGTTCTCTTTTGATGTAGGTTATTATGATTAGCTTTGTCACTGTTTCACTACTCAGCATGGAAACAAGATGAAATTCCATTTGTAGGTAGTGAGACAAAATTGATGATCCATTAAGTAAACAATAAAAGTGTCCATTGAAACCGTGATTTTTTTTTTTTTCCTGTCATACTTTGTTAGGAAGGGTGAGAATAGAATCTTGAGGAACGGATCAGATGTCTATATTGCTGAATGCAAGAAGTGGGGCAGCAGCAGTGGAGAGATGGGACAATTAGATAAATGTCCATTCtttatcaagggcctactttatggcagacattgtgctagTGCTTTTATTCTAACttttatttttatcagttacacatgatcataatttaaaaagtcaaggcttataacaaaaaagccccagcccattcctcccattcaagattcccactccccagaggtgaccactttcaactcttgagtttttcaggtatatacctccatgtttctaagtaatatgcttatattgttcacttcttttttttttattttttaaagaaatctatttcataccatggaggaaggctctgttccacatatatttccacttcttcattctctcggtatagttttgtcacaattatagattagatcaaaagtctacataactaatacagctgagctatgtagtatgctatgattaaatttacttatgtaacttttattgtctttggcattaacagtgtttcaaaaaattttctgtgtatacccatcagtgattcattcccaaatcttctagaagcataagtgtctcaatatattaaaacatattgaataatccttgttagagttatccctgcaggagtccttagtgctcctttatccaatttgtacttgatgccctctaggcagggtgtacagctagctgttgctctggtatttcctataaccttcttggggatttcttttacctcctgtgttagactcctgttttctggattcccccttttccctctttcttggtctactttttgtagaacacaagactctactagcttcctgagaaagggtgcctgggaggcaaaatctctaagactttgtaagtctgaaaatgtctttattcgacccttatacttgattcctagtttggctatatatagaattttagcctgagtatcactttttgagactcgaagccactgtttcattgtcACTATTGAGAATCTAAATGGCCATTCGGATTCTTTCATCATCTTTATAATTTTACCTTCCTATTTCTTTCCTGTCCTTTTAATGGAGTTTTGGGAGAGAGCAGAGGTAAACATGATTTGAAAAAGCCATGTCTGACCAGAAATTCTGTGCTGGAAAGATATGTATTTCACCTTTagggacaaagaaataaacttttggacaggaccacagagctagtaagtaacagcagggattcaagtccaggtttgtctggttccagtggctgatgcttttccaatgtgcctccgtccctGACATGATGCTTCTAGGCTATAGATGCTTCTAGACTCTATCCCTGACATGATGCTTCTAGACTATTTTGTTTAACCCTGGATAGAATAGCAAAAGAAAATTTTGGTGGTTGCTCTAAACAAAACAGAAATTTGAAAGCTCAAGTTTTTTCTTCATTTGTATTTTAGTTAATACTGTACCCATATTTGTAGTTAATTTTAAATTGTACCATGTTTCTGCATACCTCTATGGGTACTCAGGAATTCTAGTCCAATTTTTGTGACTTTTTCCTACTGATTACCTTTCCTCCAACGTTTTAAAAATTATTTCAAATGGAACTGAAAGAAGCATAAACTCCCATAAACCCAGCACCTAGACTCTACAATTGCCAACATTATCTATCCAACAATCTCTGACTGTACCTTTTAAGTACTTTCTACTGGACTGTTTCCAGGATCACCCCTCATTTATTTGGGTTGTTAACCTAAAGAATGAATGGGGGAATCTCCAGTCATAAACAACTTGTCAATTAGGCAAATATTTGAGTTCCTTCTATGTGCTTAAAGACGTGATAGAGGGAATATAAGAGCATTTATGTTCTGAAGGAATTTTTAACCTAACCAAAGAAGATAGTAGATAACTTGTGTGCATATAAGCTAGAACAGTATAAGGggccgggcatggtggcttacgcctgtaatcccaggactttgggaggccaaggcgggcagatcacctgtcaggagtttgggaccagcctggccaacatggtgaaaccccgtttctaccaaaaatacaaaaattagccgggcgtggtggcgtgtgccactgtagtcccagctattcagaaggctgaggcaggagaatcacttgaacccgggaggtggaggttgcagtgagctgagatcacgctactgcattcctgcttgggcgacagagtgagactctgcctcaaaacaaaaaCCCCACAAAACAGTATAAGGATGTGCTTTCTAATTTGGAATTATGAATTATTGGTAAAATATTGCAAAGGTGTATGCTTTAAGTTGTAAATTCACCTTTAACCCTAGACTATATATGTGTGTTTATATGCAGAAAAAAATAATTCCCATGTCGTAAGTGAACAATTTGGTTCTTTAGCTCAGTGTTTTCCTGTTTTCTTCATTTCCAAAATTTCCCTCTAGCACAGGGGTTTACACATGATCAAaaaggagtatacaatgaagacaccttcctcagtcccctacctaccagtttccctccccagaagcaacctctggaagaccagtttcttTCAATCTAAGGCTATTTAATATACATTAAGAggccgggcgcagtggctcacgcctgtaatcccaacaacactttgggaggcccaggcaggcgggtcatgaggtcaggagattgagaccatcctggctaacacggtgaaaccctgtctctactaaaaatacaaaaaattagctgggcgtgatggtgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacctgggaagcggagctcgcagtgagccgagatcacgccactgcactccagcctgggcaacagtgagactctgCATAAAGAGCATACCCATGTGTGTACctatctatctatctatctatctatctatctatctatctatctGTATATAGATATATTAAAATGTAAATGGTGGCA |
| PMID - Link | Title |
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