Summary

Gene Name	STRADB
Specie	Homo sapiens
Full Name	STE20 related adaptor beta
Also known as	ALS2CR2|CALS-21|ILPIP|ILPIPA|PAPK|PRO1038
Coordinate	chr2:201451734-201480846
Strand	+
Gene summary	This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Retrocopy(s) from STRADB

Retroname	Coord	Strand	Genomic Region	ENSG
STRADBP2	chr1:48435701-48437896	+	Intragenic	ENSG00000235105	UCSC
STRADBP1	chr7:150512002-150514047	-	Intergenic	ENSG00000213205	UCSC

Expression

Transcript Sequences

>NM_018571.6

GTTCCCAGCGGGTAGCCTGGGACTGGTGCAGAGTTCCAAgcccacggccccggtcgcggcctcgccgccctcccgcgccccgcgccGGGAGCGGGCCTAGAGCGCTCGCCTCGCCCCTCCGCGAGCAGGGCTCTGGCGCCCGCCCCTGTCCGCACCGCTGGCAGCCTGAAGAGAGTCGCTGGCCGTGGTCGCCGCTAGGTAGGATATATCTGCATCTTGAAAGGAAGATAAAACAAAAGCCTTCTTTGGAATAGATGGATTTTTGTCACTTTCTGTGTGAACTAAAGTGATTCAATGTCTCTTTTGGATTGCTTCTGCACTTCAAGAACACAAGTTGAATCACTCAGACCTGAAAAACAGTCTGAAACCAGTATCCATCAATACTTGGTTGATGAGCCAACCCTTTCCTGGTCACGTCCATCCACTAGAGCCAGTGAAGTACTATGTTCCACCAACGTTTCTCACTATGAGCTCCAAGTAGAAATAGGAAGAGGATTTGACAACTTGACTTCTGTCCATCTTGCACGGCATACTCCCACAGGAACACTGGTAACTATAAAAATTACAAATCTGGAAAACTGCAATGAAGAACGCCTGAAAGCTTTACAGAAAGCCGTGATTCTATCCCACTTTTTCCGGCATCCCAATATTACAACTTATTGGACAGTTTTCACTGTTGGCAGCTGGCTTTGGGTTATTTCTCCATTTATGGCCTATGGTTCAGCAAGTCAACTCTTGAGGACCTATTTTCCTGAAGGAATGAGTGAAACTTTAATAAGAAACATTCTCTTTGGAGCCGTGAGAGGGTTGAACTATCTGCACCAAAATGGCTGTATTCACAGGAGTATTAAAGCCAGCCATATCCTCATTTCTGGTGATGGCCTAGTGACCCTCTCTGGCCTGTCCCATCTGCATAGTTTGGTTAAGCATGGACAGAGGCATAGGGCTGTGTATGATTTCCCACAGTTCAGCACATCAGTGCAGCCGTGGCTGAGTCCAGAACTACTGAGACAGGATTTACATGGGTATAATGTGAAGTCAGATATTTACAGTGTTGGGATTACAGCATGTGAATTAGCCAGTGGGCAGGTGCCTTTCCAGGACATGCATAGAACTCAGATGCTGTTACAGAAACTGAAAGGTCCTCCTTATAGCCCATTGGATATCAGTATTTTCCCTCAATCAGAATCCAGAATGAAAAATTCCCAGTCAGGTGTAGACTCTGGGATTGGAGAAAGTGTGCTTGTCTCCAGTGGAACTCACACAGTAAATAGTGACCGATTACACACACCATCCTCAAAAACTTTCTCTCCTGCCTTCTTTAGCTTGGTACAGCTCTGTTTGCAACAAGATCCTGAGAAAAGGCCATCAGCAAGCAGTTTATTGTCCCATGTTTTCTTCAAACAGATGAAAGAAGAAAGCCAGGATTCAATACTTTCACTGTTGCCTCCTGCTTATAACAAGCCATCAATATCATTGCCTCCAGTGTTACCTTGGACTGAGCCAGAATGTGATTTTCCTGATGAAAAAGACTCATACTGGGAATTCTAGGGCTGCCAAATCATTTTATGTCCTATATACTTGACACTTTCTCCTTGCTGCTTTTTCTTCTGTATTTCTAGGTACAAATACCAGAATTATACTTGAAAATACAGTTGGTGCACTGGAGAATCTATTATTTAAAACCACTCTGTTCAAAGGGGCACCAGTTTGTAGTCCCTCTGTTTCGCACAGAGTACTATGACAAGGAAACATCAGAATTACTAATCTAGCTAGTGTCATTTATTCTGGAATTTTTTTCTAAGCTGTGACTAACTCTTTTTATCTCTCAATATAATTTTTGAGCCAGTTAATTTTTTTCAGTATTTTGCTGTCCCTTGGGAATGGGCCCTCAGAGGACAGTGCTTCCAAGTACATCTTCTCCCAGATTCTCTGGCCTTTTTAATGAGCTATTGTTAAACCAACAGGCTAGTTTATCTTACATCAGACCCTTTTCTGGTAGAGGGAAAATGTTTGTGCTTTCCCTTTTTCTTCTGTTAATACTTATGGTAACACCTAACTGAGCCTCACTCACATTAAATGATTCACTTGAAATATATACAGAAATTGTAATTTGCTTTTTTTTAAACAAGGGGGCTAAAGTAACACTTTCCTACTTATGTAAATTATAGATCCTAAATTCACGCACCCCGTGGGAGCTCAATAAAGATTTACTGAATTGA