Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name STRADBP1
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:150512002-150514047  UCSC
Coordinates (T2T) chr7:151690369-151692414  UCSC
Coordinates (hg19) chr7:150209090-150211135  UCSC
Strand -
Parental Sequence NM_018571.6
Parental seq. overlap 1917 bp
Parental seq. overlap (%) 85.5%
Genomic Region Intergenic
Retrocopy Summary STRADBP1, located on chr7:150512002-150514047, is a retrocopy of the parental gene STRADB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name STRADB
Full Name STE20 related adaptor beta
Also known as ALS2CR2|CALS-21|ILPIP|ILPIPA|PAPK|PRO1038
Coordinate chr2:201451734-201480846
Strand +
Gene summary This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes STRADBP2
Bonobo Pan paniscus STRADBP2
Gorilla Gorilla gorilla STRADBP1
Orangutan Pongo abelii STRADBP1
Gibbon Nomascus leucogenys STRADBP1
Crab-eating macaque Macaca fascicularis STRADBP1
Rhesus Macaca mulatta STRADBP1
Baboon Papio anubis STRADBP1
Golden snub-nosed monkey Rhinopithecus roxellana STRADBP1
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>STRADBP1
AGAGTTCCAAGCCCACAGCCCCTGTCGCGGCCTTGCCACCCTCCAGCGCCCCACGCCAGGAGTGGGCCTAGAGCGCTCGCCTTGCCCCTCTGTGATCCGGGCTCCGGCACCCGCCCAGGTCCGCACCACTGGCAGCCTGTAGGGAGTCGCTGGCCGTCGTCGCCGCTAAGTAGGATATATCTGCATCTTCAAAGGAAGATAAAACAAAAGCCTTCTTTGGAATATTTGGATTTTTGTCACTTTCTGTGAGCTTTAGTTCAAGAACACAAGTTGAATCACTCAAACATGAAAAACAAGTCTGAAACCAGTATCCATCAATACTTGGTCGAAGAGCCAACCCTTTCCTGGTCGCCTCCATCCACTAGAGCCAGTGAAGTAGTATGTTCCGCCAACGTTTCTCACTACGAGCTCCAAGTAGAAATAGGAAGAGGATTTGACAAGTTGACTTCTGTCCATCTAGCACGGCATACTCCTACGGGAACGCTGGTAACTACAAAAATTACAAATCTGGAAAACGGCAATAAAGAACGCCTGAAAGTTTTACAGAAAGCCATGATTCTATCCCACTTTTTCCGGCATCCCAATATTACAACTTATTGGACAGTTTTCACTGTTGGCAGCTGGCTTTGGGTTATTTCTCCATTTATGGCCTATGGTTCAGCAAGACAACTCTTGAGGACCTATTTTCCTGAAGGAATGAGTAAAACTTTAATAAGAAACATTCTCTTTGGAGCAGTGAGAGGATTGAACTATCTCTACCAATATGGCTGTATTCACAGGAGAATTAAAGCCAGCCATATCCTCATTTCTGGTGATGGCCTAGTGACCCTCTCTGGCCTGTCCCATCTGCATAGTTTGGTTAAGCATGGACAGAGGCATAGGGCTGTGTATGATTTCCCACAGTTCAGCACATTAGTGCAGCCATGGCTGAGTCCAGAACTACTGAGACAGGATTTACATGGGTATAATGTGAAGTCAGATATTTACAGTGTTGGGATTACAACATGTGAATTAGCCAGTGGGCAGGTGCCTTTCCAGGACGTGCATAGAACTCAGATGCTGTTAACAGAAACTGAAAGGTCCCCCTTATAGCCCATTGGATATCAGTATTTTCCCTCAATCAGAATCCAAAATGAAAAATTCCCGGTCAGGTGTAGACTCTGGGATTGGAGCAAGTGTGCTTGTCTCCAGTGGAACTCACACAGTAAATAGTGACCGATTACACACACCATCCTCAAAAACCTTCTCTCCTGCCTTCTTTAGCTGGGTACAGCTGTGTTTGCAACAAGATCCGGAGAAAAGGCCATCAGCAAGCAGTTTATTGTCCCATGTTTTCTTCAAACAGATGAAAGAAGAAAGCCAGGATTCGGTACTTTCACTGTTGCCTCCTGCTTATAACAAGCCATCAATATCACTGCCTCCGGTGTTACCTTGGACTGAGCCAGAATGTGGTTTTCCTGATGAAAAAGATTCATATTGGGAATTCTAGCTAGGGCTGGCAAATCATCTTATGTCCTATATACTTGACACTTTCTCCTTGCTGCTTTTTCTTCTGTATTGCTAGGTACAAATACCAGAATTATACTTGAAAATACAGTTGGTGCACTGGAGAATCTATTCAAATCACTCTGTTCAAAGGGGCATCAGTTTGTAGTCCCTTTGGTTCACACAGAGTGCTATGACAACTCCAAGGAAACATCAGAACTACTAACCTAGCTAGTTAGTGTTATTTATTCAGGAAATTTTTCTAAGCTGTGGCTAACTGTCTTGATCTCTCAATATAATTTTTGAGCCAGTTAATTTTTTCAATATTTTGCTGTCCTCTTGGGAATGGTCCTTCAAAGGATAGTGCTTCTAAGTACATCTTCTTCTCCCAGATTGTCTGGCCTTTTTAATGAGCTATTGTTAAACCAACAGGCTAGTTTATCTTGCATCAGACCCTTTTATGGTAGAGGGAAAATGTCTTTACTTTCCCTTTTTCTTCTGTTAATACTTATGGTAACATCTAACTCAGCCTCACTCACATTAAGTGATTCGCTTGAAATG
>NM_018571.6
GTTCCCAGCGGGTAGCCTGGGACTGGTGCAGAGTTCCAAgcccacggccccggtcgcggcctcgccgccctcccgcgccccgcgccGGGAGCGGGCCTAGAGCGCTCGCCTCGCCCCTCCGCGAGCAGGGCTCTGGCGCCCGCCCCTGTCCGCACCGCTGGCAGCCTGAAGAGAGTCGCTGGCCGTGGTCGCCGCTAGGTAGGATATATCTGCATCTTGAAAGGAAGATAAAACAAAAGCCTTCTTTGGAATAGATGGATTTTTGTCACTTTCTGTGTGAACTAAAGTGATTCAATGTCTCTTTTGGATTGCTTCTGCACTTCAAGAACACAAGTTGAATCACTCAGACCTGAAAAACAGTCTGAAACCAGTATCCATCAATACTTGGTTGATGAGCCAACCCTTTCCTGGTCACGTCCATCCACTAGAGCCAGTGAAGTACTATGTTCCACCAACGTTTCTCACTATGAGCTCCAAGTAGAAATAGGAAGAGGATTTGACAACTTGACTTCTGTCCATCTTGCACGGCATACTCCCACAGGAACACTGGTAACTATAAAAATTACAAATCTGGAAAACTGCAATGAAGAACGCCTGAAAGCTTTACAGAAAGCCGTGATTCTATCCCACTTTTTCCGGCATCCCAATATTACAACTTATTGGACAGTTTTCACTGTTGGCAGCTGGCTTTGGGTTATTTCTCCATTTATGGCCTATGGTTCAGCAAGTCAACTCTTGAGGACCTATTTTCCTGAAGGAATGAGTGAAACTTTAATAAGAAACATTCTCTTTGGAGCCGTGAGAGGGTTGAACTATCTGCACCAAAATGGCTGTATTCACAGGAGTATTAAAGCCAGCCATATCCTCATTTCTGGTGATGGCCTAGTGACCCTCTCTGGCCTGTCCCATCTGCATAGTTTGGTTAAGCATGGACAGAGGCATAGGGCTGTGTATGATTTCCCACAGTTCAGCACATCAGTGCAGCCGTGGCTGAGTCCAGAACTACTGAGACAGGATTTACATGGGTATAATGTGAAGTCAGATATTTACAGTGTTGGGATTACAGCATGTGAATTAGCCAGTGGGCAGGTGCCTTTCCAGGACATGCATAGAACTCAGATGCTGTTACAGAAACTGAAAGGTCCTCCTTATAGCCCATTGGATATCAGTATTTTCCCTCAATCAGAATCCAGAATGAAAAATTCCCAGTCAGGTGTAGACTCTGGGATTGGAGAAAGTGTGCTTGTCTCCAGTGGAACTCACACAGTAAATAGTGACCGATTACACACACCATCCTCAAAAACTTTCTCTCCTGCCTTCTTTAGCTTGGTACAGCTCTGTTTGCAACAAGATCCTGAGAAAAGGCCATCAGCAAGCAGTTTATTGTCCCATGTTTTCTTCAAACAGATGAAAGAAGAAAGCCAGGATTCAATACTTTCACTGTTGCCTCCTGCTTATAACAAGCCATCAATATCATTGCCTCCAGTGTTACCTTGGACTGAGCCAGAATGTGATTTTCCTGATGAAAAAGACTCATACTGGGAATTCTAGGGCTGCCAAATCATTTTATGTCCTATATACTTGACACTTTCTCCTTGCTGCTTTTTCTTCTGTATTTCTAGGTACAAATACCAGAATTATACTTGAAAATACAGTTGGTGCACTGGAGAATCTATTATTTAAAACCACTCTGTTCAAAGGGGCACCAGTTTGTAGTCCCTCTGTTTCGCACAGAGTACTATGACAAGGAAACATCAGAATTACTAATCTAGCTAGTGTCATTTATTCTGGAATTTTTTTCTAAGCTGTGACTAACTCTTTTTATCTCTCAATATAATTTTTGAGCCAGTTAATTTTTTTCAGTATTTTGCTGTCCCTTGGGAATGGGCCCTCAGAGGACAGTGCTTCCAAGTACATCTTCTCCCAGATTCTCTGGCCTTTTTAATGAGCTATTGTTAAACCAACAGGCTAGTTTATCTTACATCAGACCCTTTTCTGGTAGAGGGAAAATGTTTGTGCTTTCCCTTTTTCTTCTGTTAATACTTATGGTAACACCTAACTGAGCCTCACTCACATTAAATGATTCACTTGAAATATATACAGAAATTGTAATTTGCTTTTTTTTAAACAAGGGGGCTAAAGTAACACTTTCCTACTTATGTAAATTATAGATCCTAAATTCACGCACCCCGTGGGAGCTCAATAAAGATTTACTGAATTGA

Publications

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