Summary

Gene Name	PRKCI
Specie	Homo sapiens
Full Name	protein kinase C iota
Also known as	DXS1179E|PKCI|nPKC-iota
Coordinate	chr3:170222424-170305977
Strand	+
Gene summary	This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

Retrocopy(s) from PRKCI

Retroname	Coord	Strand	Genomic Region	ENSG
PRKCIP1	chrX:101534635-101539446	-	Intergenic	ENSG00000237682	UCSC

Expression

Transcript Sequences

>NM_002740.6

GACGCAGGAGGTGTCTTGGGCCCGGGCGGCTGTAGAGGCGGCGGCGCCTACGGGCAGTGGGAGGAGCCGCGCGGTTCCGGCTGCTCCGGCGAGGCGACCCTTGGGTCGGCGCTGCGGGCGAGGTGGGCAGGTAGGTGGGCGGACGGCCGCGGTTCTCCGGCAAGCGCAGGCGGCGGAGTCCCCCACGGCGCCCGAAGCGCCCCCCCGCACCCCCGGCCTCCAGCGTTGAGGCGGGGGAGTGAGGAGATGCCGACCCAGAGGGACAGCAGCACCATGTCCCACACGGTCGCAGGCGGCGGCAGCGGGGACCATTCCCACCAGGTCCGGGTGAAAGCCTACTACCGCGGGGATATCATGATAACACATTTTGAACCTTCCATCTCCTTTGAGGGCCTTTGCAATGAGGTTCGAGACATGTGTTCTTTTGACAACGAACAGCTCTTCACCATGAAATGGATAGATGAGGAAGGAGACCCGTGTACAGTATCATCTCAGTTGGAGTTAGAAGAAGCCTTTAGACTTTATGAGCTAAACAAGGATTCTGAACTCTTGATTCATGTGTTCCCTTGTGTACCAGAACGTCCTGGGATGCCTTGTCCAGGAGAAGATAAATCCATCTACCGTAGAGGTGCACGCCGCTGGAGAAAGCTTTATTGTGCCAATGGCCACACTTTCCAAGCCAAGCGTTTCAACAGGCGTGCTCACTGTGCCATCTGCACAGACCGAATATGGGGACTTGGACGCCAAGGATATAAGTGCATCAACTGCAAACTCTTGGTTCATAAGAAGTGCCATAAACTCGTCACAATTGAATGTGGGCGGCATTCTTTGCCACAGGAACCAGTGATGCCCATGGATCAGTCATCCATGCATTCTGACCATGCACAGACAGTAATTCCATATAATCCTTCAAGTCATGAGAGTTTGGATCAAGTTGGTGAAGAAAAAGAGGCAATGAACACCAGGGAAAGTGGCAAAGCTTCATCCAGTCTAGGTCTTCAGGATTTTGATTTGCTCCGGGTAATAGGAAGAGGAAGTTATGCCAAAGTACTGTTGGTTCGATTAAAAAAAACAGATCGTATTTATGCAATGAAAGTTGTGAAAAAAGAGCTTGTTAATGATGATGAGGATATTGATTGGGTACAGACAGAGAAGCATGTGTTTGAGCAGGCATCCAATCATCCTTTCCTTGTTGGGCTGCATTCTTGCTTTCAGACAGAAAGCAGATTGTTCTTTGTTATAGAGTATGTAAATGGAGGAGACCTAATGTTTCATATGCAGCGACAAAGAAAACTTCCTGAAGAACATGCCAGATTTTACTCTGCAGAAATCAGTCTAGCATTAAATTATCTTCATGAGCGAGGGATAATTTATAGAGATTTGAAACTGGACAATGTATTACTGGACTCTGAAGGCCACATTAAACTCACTGACTACGGCATGTGTAAGGAAGGATTACGGCCAGGAGATACAACCAGCACTTTCTGTGGTACTCCTAATTACATTGCTCCTGAAATTTTAAGAGGAGAAGATTATGGTTTCAGTGTTGACTGGTGGGCTCTTGGAGTGCTCATGTTTGAGATGATGGCAGGAAGGTCTCCATTTGATATTGTTGGGAGCTCCGATAACCCTGACCAGAACACAGAGGATTATCTCTTCCAAGTTATTTTGGAAAAACAAATTCGCATACCACGTTCTCTGTCTGTAAAAGCTGCAAGTGTTCTGAAGAGTTTTCTTAATAAGGACCCTAAGGAACGATTGGGTTGTCATCCTCAAACAGGATTTGCTGATATTCAGGGACACCCGTTCTTCCGAAATGTTGATTGGGATATGATGGAGCAAAAACAGGTGGTACCTCCCTTTAAACCAAATATTTCTGGGGAATTTGGTTTGGACAACTTTGATTCTCAGTTTACTAATGAACCTGTCCAGCTCACTCCAGATGACGATGACATTGTGAGGAAGATTGATCAGTCTGAATTTGAAGGTTTTGAGTATATCAATCCTCTTTTGATGTCTGCAGAAGAATGTGTCTGATCCTCATTTTTCAACCATGTATTCTACTCATGTTGCCATTTAATGCATGGATAAACTTGCTGCAAGCCTGGATACAATTAACCATTTTATATTTGCCACCTACAAAAAAACACCCAATATCTTCTCTTGTAGACTATATGAATCAATTATTACATCTGTTTTACTATGAAAAAAAAATTAATACTACTAGCTTCCAGACAATCATGTCAAAATTTAGTTGAACTGGTTTTTCAGTTTTTAAAAGGCCTACAGATGAGTAATGAAGTTATCTTTTTTGTTTAAAAAAAAAAAAAACACTGCATTAAAAAAGTATCTGTTGCATTAAGGCACATAGTGGGATTACATCATAAACCTCCCATAATTTTTGTCATTCTGTGTTAAATCATTTCAGGGTTTAATTTTGAAATAAAAGATTAATATAAAATGCAACAACTTTTTATATTACCTATTAGTTTTGGAGTTCTTTATGTTTAAAAATTCAGGTGTAAATTTTATTGCCTTGGATAAATAAATTATTGATCTTTTTTAAGGCAGCAGTTATTAAATTGGTAATAGAAGATGCTGCTTGCTTAGAATTGGGAAATTCggctgggtgcagtgactcaatgcctgtgatcccagtactttgggaggttgaggcgggcagatcacttgaggtcaggagtttgagattggcctggtcaacatggtgaaatcctgtctctactaaaaatacaaaaattagctgggcatggtggcacatacctgtaatcccagctactcgggaggctgaaacaggagaatcgcttgaacccaggagatggagttggcagtgagccaagattagcctgggcaacagtgagtgagactcggtctcaaacaaaaaCCAAATTGGGAAATTCTTCTTGAGTTAAAAAAGACACTTTTTATTATGAATCAGATTCCAAATCATTAACTATTTTTGCAAAACTGGCACAAGTGGTTTTTCTTTTTAAGTATATTAACAGGGTAGCTCCTGAGCCTTTCCCTTTATTGGAAACTTTAACTGCAGTGTTAATATATACACTGCAAAAGACCAAGGATGCAGTTGAATGGAAAATTACTCAGTGTATAGAAAGGAAAAAAACCAGAAATTTAAAATAGATACAGAAAAGTACACTGGTAATATTTTTATTTCCTATTGGAGAGTGAATCCCCACAGTTGCTTTTTGTGACTTGATTCAAATGAGGCACTCATTATTGTTACCAAACTTGTAAAAGCATTCCATGTATTCAGTGGAGGCAGAATGTATAATATTTTTTCCTTATAATTTAGCATACAGGAAAAGTATTTATTTTTTAAGTAGGGTATCTTAATTATGCTCATTTCTTCCCCTAAACCACATTATCTATATGATTGGACCCTTTAGTGAAATCAGAAAAATAAAGTAGGCATGAATAAATGTTCAGGacacacacatacactcacacacatcacaGTATCAGCTCTTTCAGTGAGTTTTTATTAACTAGATAACACATGTAATACATAGTAGAATACATTTCAGAGGCAGAGTTCCTCGGATTATTTTTTATGGATATTAGTGTTCAGCAGCTTATTATTTAAAGGGGTGCCAAATATAGCATCCTTCTGTTGTTTATTTTAAATATATTTTTAATGAAAAGGGACTTAAAAAGTAAACATGATTATCTAAATTACTTAAAATTTTTTAATCTTAGTAAAAATTTTAGGAAAGTTATCTAGTTTAAATTTCAAATGTTTTAAAATTTGTAGGCATTTAATAAATTATCTTTTTTTGGAGGGGTGGATGCTGCATTTCATTGGAAATGTCATTTTTCCAAAGTTTCTAGCTATATACTCTCTTTCCTTCAAATAACATAAGTCTGAAAGCAATGAAAACGTCAAAGGAAAATGTTTATATACATCCACATGTTTATTTAATATGTTTCTCTTAACACCTGAAACTTGTTTTAAAACAAAAAGCAGTATTCACTTCAAATCATAAACTTAGAATTCTGTATCTCATGTCAGAAATATGTTTATGGCCTTGCTTTTAAGTGGTGCTGTTTCCCATAGGGcattagttctcagattttggaatgtgaaataatcacctaggaagttggtttaaaatgcacactagtgagcccaccttagacttCTTTTGGGGCCTTCGACCTCACTTTGAGAAATACCTTCTTCAGGTTATTCTTTATGTTTGTCCTGTGGTTAAATATTAGAGTATTCATGATAAAACATTTTGAGAAGGGGTAAGCAGTGAGTTATTACCCACAATTTAAAGCAAATTTTGAATGAATCTTTAAGTTAGGTATCTACCTTCCCACCAGCCCCCCAAAAAACCTCTCAGTAGTTTCTTTCAGTGTACAAAATGATGAGCATTTTTCTATGATGAGGTTTTAACCATTATTCAGGGTGGTCTTTTGTTTTTAAATCTTTTTTTAACTAATAAGATTTACGGTGTGTATTTTATACAGAAATGCATTATAAATGTTTTTAATTGTGTTCTGTTTTTTGCAGTCTTTAAGTGCCATGCCAATTGTTCTTATATTCTATAGAAGTTCGCTCAAAATACTCAACAGGGGAATAGGCAGCGGACAGTCAGAATGGTTGGAATTTTGGCTTTCTAAGAAAAACTTTATTTTGCATAAGCATGTGGTCAGATCATTTTGTGCATATGCAGCCTGGATTGGATGTTAAGTAAATGCTTGTTCAGTGCCGGTACATTTACTTAAATCTGTTTTTATTTTTGTCATGTAGAATACTACTGTGGTCATCATAATGTAATCTATTTCTGTACCTTTTTTTTTTTTTTTTACTTTGAAGTCTTTAAATAAAATGTATAATACCCA