Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PRKCIP1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:101534635-101539446  UCSC
Coordinates (T2T) chrX:99979268-99984077  UCSC
Coordinates (hg19) chrX:100789622-100794433  UCSC
Strand -
Parental Sequence NM_002740.6
Parental seq. overlap 2505 bp
Parental seq. overlap (%) 37.9%
Genomic Region Intergenic
Retrocopy Summary PRKCIP1, located on chrX:101534635-101539446, is a retrocopy of the parental gene PRKCI. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PRKCI
Full Name protein kinase C iota
Also known as DXS1179E|PKCI|nPKC-iota
Coordinate chr3:170222424-170305977
Strand +
Gene summary This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PRKCIP1
Bonobo Pan paniscus PRKCIP1
Gorilla Gorilla gorilla PRKCIP1
Orangutan Pongo abelii PRKCIP1
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PRKCIP1
CTTTTGGAGCCTTCAACTTCACTTTGAGAAACACCTTCTTCAGGTTATTCTTTATGTTTGTCCTGTGGTTAAATATTAGAGTATTCATGATAAAACATTTTGAGAGGGGTAAGCAGTGAGTTATTACCCACAATTTAAAGCAAATTTTGAATGAATCTTTAAGTTGGGTGTCTACCTTCCCACCAGCCCCCCAAGAAAACCTCTCAGTAGTTTCTATCAATAATGTGCAAAATGATGAGCATTTTTCTATGATGAGGTTTTAACCATTATTCAGGGTGGTCTTTATGGTGTATATTTTATACAGAAATGCATTATAAATGTTTTTAATTGTGTTCTGTTTTTTGCAGTCTTTAAGTGCCATGCCAATTGTTTTTATATTCTATAGAAGTTCGCTCAAAATACTCAACAGGGGAATGCGCAGCGGACAGTCAGAATGGTTGGAATTTTGGCGTTCTAAGAAAAACTACTTTGCATAAGCATGTGGTCAGATCATTTTGTGCATATGCAGCCTGGATTGGATGTTAAGTAAATGCTTGTTCAGTGCCGATACATTTACTTAAATCTGTTTTTATTTTTGTCATGTAGAATACTACTGGGGTCATCACAATGTAATCTGTATTTCTGTACCTTTTTTTTTTACTTCGAAGTCTTTAAATTAAATGTATAATACCCAAGTCACAGTATCAGCTCTTTCAGTGAGTTTTTATTAACTGGATAACACATGTAACACATAGTAGAATACATTTCAGAGGCAGAGTTCCTTGGATTATTTTTTATTAATATTAGTGTTTAGCAGTTTATTTAAGGGGGTGCCAAATATAGCATCCTTCTGTTGTTTATTTTAAATATTTTTTAATGAAAAGGGACTTAAAAAGTAACCATGATCATCTAAATTACTTAAAGTTTTTTAATCTTAGTAAAACTTAATTTTAGGAAAGTGTCCTAGTTTAAATTTCAAATGTTTCAAAATTTGTAGGCATTTAATAAATTATCTTTTTTTGGAGGGGTGGATGCTACATTTCATTGGAAATGTCATTTTTCCAAAGTTTCTAGCTGTGTACTCTCTTTCCTTCAAATAACATAAGTCTGAAAGCAATGAAAACCTCAAAGGAAAATGTTTATATACATGCACATGTTTATTTAATATGTTTCTCTTAACATCTGAAACTTGTTTTAAAACAAAAAGCAGTATTCACTTCAAATCATAAACTTAGAATTCTGTATCTCATGTCAGAAATATGTTATGGCCTTGCTTTTAAGTGGTGCTGTTTCCCACAGGGCAATGTTAATATATATACTGCAAAAGACCAAGGATGCAGTTGAATGGAAGATTACTCAGTATATAGAAAGGAAAAAAACAGAAATTTAAAATAGATACAGCAAAGTACAGTGGTAATATTTTTATTTCCTATTGGAGAGTGAATCCCCACAGTTGCTTTTGTGACTTGATTCAAATGAGGCACTCATTATTGTTATCAAACTTGTAAAAGCATTCCATGTATTCAGTGGAGGCAGAATGTATAATATTTTTTCCTTACAATTTAGTATACAGGAAAATTATTTATTTTTAAGTAGGGTATCTTAATTATGCTCATTTCTCCCCCTAAACCACATTATCTATATGATTGGACCCTGTTTATAGAGTCTTTAGTGAAATCAGAAAAATCAAGTAGGCATGAATAAATGTTCAGGCCAAATTGGGAAATTCTTCTTGAGTTAAAAAACAGACACTTTTTATTATGAATCAGATTGCAAATCATTGGCTGCTTGGGCGAGGCGACCCTTGGGTCGGCGTTGCGGGTGAGGTGGGCAGGTAGGTGGGCGGATGGCCGCGGTTCTCCGACAGGCGCGGGCGGCGGGGTCTCCCACGGCGTCCGAAGCCCCCTCCCCGCACCCCCGGCCTCCAGCGTTGAGGCGGGGGAGTGAGGAGATGCCGACCCAGAGGGACAGCAGCACCATGTCCCACAGGGTTGCAGGCGGCTGCAGTGGGGACCATTCCCACCAGGTCTGGGTGAAAGCCTACTACCGCGGGGATATCATGATAACACATTTTGAACCTTCTGTCTCCTTTGAGGGCCTTTACAATGTGGTTCGAGACATGTTCTTTTGACAACGAACAGCTCTTCACCATGAAATGGATAGACGAGGAAGGAGACCCGTGTACAGTATCATCTCAGTTGGAGTTAGAAGAAGCCTTTACACTTTATGAGCTAAACAAGGACTCTGAACTCTTGATTCATGTGTTCCCTTGTGTACCAGAACGTCCCGGGATGCCTTGTCCAAGAGAAGATAAATCCATCTACCGTAGAGGTGCACGCCACTGGAGAAAGCTTTATTGTGCCAATGGACACACTTTTCAAGCCAAGTGCTTCAACAGGCGTGCTGACTGTGCCATCTGCACAGACTGAATATGGGGACTTGGATGCCAAGGATATAAGTGTATCAACTGCAAACTCTTGGTTCATAAGAAGTGCCATAAACTCCTCACAATTGAATGTGGGCGGCATTCTTTGCCACTGGAACCAATGATGCCCATGGATCAGTCATCCATGCATTCTGACCATGCACAGACAGTAATTCCATATAATCCTTCAAGTCATGAGAGTTTGGATCAAGTTGGTGAAGAAAAAGAGGCAATGAACACCAGAGAAAGTGGCAAAGCTTCATCCAGTCTAGGTCTTCAGGATTTTGATTTGCTCCAGGTAATAGGAAGAGGAAGTTAAGCCAAAGTACTGTTGGTTCCATTAAAAAAAAAAAAAAAACAGATCGTATTTATGCAATGAAAGTTGTGAAAAAAGAGCTTGTTAATGATGATGAGGATATTGATTGGGTGCAGACAGAGAAACATGTGTTTGAGCAGGCATCCAATCATCCTTTCCTTGTTGGGCTGCAGTCTTGCTTTCAGACAGAAAGCAGATTGTTCTTTGTTATAGAGTATGTAAATGGAGGAGACCTAATGTTTCATATGCAGCGACAAAGAAAACTTCCTGAAGAACATGCCAGATTTTACTCTGCAGAAATCAGTCTAGCATTCAATTATCTTCATGAGTGAGGGATAATTTATAGAGATTTGAAACTGGACAATGTATTACTGGACTCTGAAGGCCACATTAAACTCACTGACTACGGCATGTGTTAAGGAAGGATTACGGCCAGGAGATACAACCAGCACTTTCTGTGGTACTCCTAATTACATTGCTCCTGAAATTTTAAGAGGAGGAGATTATGGTTTCAGTGTTGACTGGTGGGCTCTTGGAGTGCTAATGTTTGAGACGATGGCAGGAAGGACTCCATTTGATACTGTTGGGAGCTCCGATAACCCTGACCAGAACACAGAGGATTCTCTCTTCCAAGTTATTGTGGAAAAACAAATTCACATACCACGTTCTCTGTCTGGAAAAGCTGCAAGTGTTCTGAAGAGTTTTCTTAACAAGGACCCTAAGAAACGACTGGGTTGTCATCCTCAAACAGGATTTGCTGATATTCAGGGACACCCGTTCTTCCAAAATGTTGATTGGGATATGATGGAGCAAAAACAGGTGGTATCTCCCTTTAAACCAAATATTTCTGGGGAATTTGGTTTGGACAACTTTGATTCTCAGTTTACTAATGAACCTGTCTAGCTCACTCCAGATGTCGATGACATTGTGAGAAAGATTGATCAGTCTGAATTTGAAGGTTTTGAGTATATCAATCCTCTTTTGATGTCTGCAGAAGAATGTGTCCGATCCTCATTTTTCAACCATGTATTCTACTCATGTTGCCATTTAATGCATGGATAAACTTGCTGCCAGCCTGGATACAATTAACCATTTTATATTTGCCACCTACAAAAAAACACCCAGTATCTTCTCTCGTAGACTACATGAATCAATTATTACATCTTTTTTACTATGAAAAATAAATTAATACTAGCTTCCAGACAATCATGTCAAAATTTAGTTGAACTGGTTTTTCAGTTTTTAAAAGGCCTACAGATGAGTAATGAAGTTATCTTTTTTGTTTAAAAAAAAAACAAAGAAAACCACTGCATTTAAAAAGTATCAGTTGCATTAAGGCACATAGTGGGATTACATCATAAACCTCCCATAATTTTTGTCATTCTGTGTTAAATCACTTCAGGGTTTAATTTTGAAATAAAAGATTAATATAAAATGCAACAACTTTTTATATTACCTATTAGTTTTGGAGTTCTTTATGTTTAAAAATTCGGGTGTAAATTTTATTGCCTTGGATAAATAAATTATCGATTTTTTAAGGCAGCAGTTACTAAATTGGTAATAGAAGATGCTGCTTGCTTAAAATTGGGAAATGCAg
>NM_002740.6
GACGCAGGAGGTGTCTTGGGCCCGGGCGGCTGTAGAGGCGGCGGCGCCTACGGGCAGTGGGAGGAGCCGCGCGGTTCCGGCTGCTCCGGCGAGGCGACCCTTGGGTCGGCGCTGCGGGCGAGGTGGGCAGGTAGGTGGGCGGACGGCCGCGGTTCTCCGGCAAGCGCAGGCGGCGGAGTCCCCCACGGCGCCCGAAGCGCCCCCCCGCACCCCCGGCCTCCAGCGTTGAGGCGGGGGAGTGAGGAGATGCCGACCCAGAGGGACAGCAGCACCATGTCCCACACGGTCGCAGGCGGCGGCAGCGGGGACCATTCCCACCAGGTCCGGGTGAAAGCCTACTACCGCGGGGATATCATGATAACACATTTTGAACCTTCCATCTCCTTTGAGGGCCTTTGCAATGAGGTTCGAGACATGTGTTCTTTTGACAACGAACAGCTCTTCACCATGAAATGGATAGATGAGGAAGGAGACCCGTGTACAGTATCATCTCAGTTGGAGTTAGAAGAAGCCTTTAGACTTTATGAGCTAAACAAGGATTCTGAACTCTTGATTCATGTGTTCCCTTGTGTACCAGAACGTCCTGGGATGCCTTGTCCAGGAGAAGATAAATCCATCTACCGTAGAGGTGCACGCCGCTGGAGAAAGCTTTATTGTGCCAATGGCCACACTTTCCAAGCCAAGCGTTTCAACAGGCGTGCTCACTGTGCCATCTGCACAGACCGAATATGGGGACTTGGACGCCAAGGATATAAGTGCATCAACTGCAAACTCTTGGTTCATAAGAAGTGCCATAAACTCGTCACAATTGAATGTGGGCGGCATTCTTTGCCACAGGAACCAGTGATGCCCATGGATCAGTCATCCATGCATTCTGACCATGCACAGACAGTAATTCCATATAATCCTTCAAGTCATGAGAGTTTGGATCAAGTTGGTGAAGAAAAAGAGGCAATGAACACCAGGGAAAGTGGCAAAGCTTCATCCAGTCTAGGTCTTCAGGATTTTGATTTGCTCCGGGTAATAGGAAGAGGAAGTTATGCCAAAGTACTGTTGGTTCGATTAAAAAAAACAGATCGTATTTATGCAATGAAAGTTGTGAAAAAAGAGCTTGTTAATGATGATGAGGATATTGATTGGGTACAGACAGAGAAGCATGTGTTTGAGCAGGCATCCAATCATCCTTTCCTTGTTGGGCTGCATTCTTGCTTTCAGACAGAAAGCAGATTGTTCTTTGTTATAGAGTATGTAAATGGAGGAGACCTAATGTTTCATATGCAGCGACAAAGAAAACTTCCTGAAGAACATGCCAGATTTTACTCTGCAGAAATCAGTCTAGCATTAAATTATCTTCATGAGCGAGGGATAATTTATAGAGATTTGAAACTGGACAATGTATTACTGGACTCTGAAGGCCACATTAAACTCACTGACTACGGCATGTGTAAGGAAGGATTACGGCCAGGAGATACAACCAGCACTTTCTGTGGTACTCCTAATTACATTGCTCCTGAAATTTTAAGAGGAGAAGATTATGGTTTCAGTGTTGACTGGTGGGCTCTTGGAGTGCTCATGTTTGAGATGATGGCAGGAAGGTCTCCATTTGATATTGTTGGGAGCTCCGATAACCCTGACCAGAACACAGAGGATTATCTCTTCCAAGTTATTTTGGAAAAACAAATTCGCATACCACGTTCTCTGTCTGTAAAAGCTGCAAGTGTTCTGAAGAGTTTTCTTAATAAGGACCCTAAGGAACGATTGGGTTGTCATCCTCAAACAGGATTTGCTGATATTCAGGGACACCCGTTCTTCCGAAATGTTGATTGGGATATGATGGAGCAAAAACAGGTGGTACCTCCCTTTAAACCAAATATTTCTGGGGAATTTGGTTTGGACAACTTTGATTCTCAGTTTACTAATGAACCTGTCCAGCTCACTCCAGATGACGATGACATTGTGAGGAAGATTGATCAGTCTGAATTTGAAGGTTTTGAGTATATCAATCCTCTTTTGATGTCTGCAGAAGAATGTGTCTGATCCTCATTTTTCAACCATGTATTCTACTCATGTTGCCATTTAATGCATGGATAAACTTGCTGCAAGCCTGGATACAATTAACCATTTTATATTTGCCACCTACAAAAAAACACCCAATATCTTCTCTTGTAGACTATATGAATCAATTATTACATCTGTTTTACTATGAAAAAAAAATTAATACTACTAGCTTCCAGACAATCATGTCAAAATTTAGTTGAACTGGTTTTTCAGTTTTTAAAAGGCCTACAGATGAGTAATGAAGTTATCTTTTTTGTTTAAAAAAAAAAAAAACACTGCATTAAAAAAGTATCTGTTGCATTAAGGCACATAGTGGGATTACATCATAAACCTCCCATAATTTTTGTCATTCTGTGTTAAATCATTTCAGGGTTTAATTTTGAAATAAAAGATTAATATAAAATGCAACAACTTTTTATATTACCTATTAGTTTTGGAGTTCTTTATGTTTAAAAATTCAGGTGTAAATTTTATTGCCTTGGATAAATAAATTATTGATCTTTTTTAAGGCAGCAGTTATTAAATTGGTAATAGAAGATGCTGCTTGCTTAGAATTGGGAAATTCggctgggtgcagtgactcaatgcctgtgatcccagtactttgggaggttgaggcgggcagatcacttgaggtcaggagtttgagattggcctggtcaacatggtgaaatcctgtctctactaaaaatacaaaaattagctgggcatggtggcacatacctgtaatcccagctactcgggaggctgaaacaggagaatcgcttgaacccaggagatggagttggcagtgagccaagattagcctgggcaacagtgagtgagactcggtctcaaacaaaaaCCAAATTGGGAAATTCTTCTTGAGTTAAAAAAGACACTTTTTATTATGAATCAGATTCCAAATCATTAACTATTTTTGCAAAACTGGCACAAGTGGTTTTTCTTTTTAAGTATATTAACAGGGTAGCTCCTGAGCCTTTCCCTTTATTGGAAACTTTAACTGCAGTGTTAATATATACACTGCAAAAGACCAAGGATGCAGTTGAATGGAAAATTACTCAGTGTATAGAAAGGAAAAAAACCAGAAATTTAAAATAGATACAGAAAAGTACACTGGTAATATTTTTATTTCCTATTGGAGAGTGAATCCCCACAGTTGCTTTTTGTGACTTGATTCAAATGAGGCACTCATTATTGTTACCAAACTTGTAAAAGCATTCCATGTATTCAGTGGAGGCAGAATGTATAATATTTTTTCCTTATAATTTAGCATACAGGAAAAGTATTTATTTTTTAAGTAGGGTATCTTAATTATGCTCATTTCTTCCCCTAAACCACATTATCTATATGATTGGACCCTTTAGTGAAATCAGAAAAATAAAGTAGGCATGAATAAATGTTCAGGacacacacatacactcacacacatcacaGTATCAGCTCTTTCAGTGAGTTTTTATTAACTAGATAACACATGTAATACATAGTAGAATACATTTCAGAGGCAGAGTTCCTCGGATTATTTTTTATGGATATTAGTGTTCAGCAGCTTATTATTTAAAGGGGTGCCAAATATAGCATCCTTCTGTTGTTTATTTTAAATATATTTTTAATGAAAAGGGACTTAAAAAGTAAACATGATTATCTAAATTACTTAAAATTTTTTAATCTTAGTAAAAATTTTAGGAAAGTTATCTAGTTTAAATTTCAAATGTTTTAAAATTTGTAGGCATTTAATAAATTATCTTTTTTTGGAGGGGTGGATGCTGCATTTCATTGGAAATGTCATTTTTCCAAAGTTTCTAGCTATATACTCTCTTTCCTTCAAATAACATAAGTCTGAAAGCAATGAAAACGTCAAAGGAAAATGTTTATATACATCCACATGTTTATTTAATATGTTTCTCTTAACACCTGAAACTTGTTTTAAAACAAAAAGCAGTATTCACTTCAAATCATAAACTTAGAATTCTGTATCTCATGTCAGAAATATGTTTATGGCCTTGCTTTTAAGTGGTGCTGTTTCCCATAGGGcattagttctcagattttggaatgtgaaataatcacctaggaagttggtttaaaatgcacactagtgagcccaccttagacttCTTTTGGGGCCTTCGACCTCACTTTGAGAAATACCTTCTTCAGGTTATTCTTTATGTTTGTCCTGTGGTTAAATATTAGAGTATTCATGATAAAACATTTTGAGAAGGGGTAAGCAGTGAGTTATTACCCACAATTTAAAGCAAATTTTGAATGAATCTTTAAGTTAGGTATCTACCTTCCCACCAGCCCCCCAAAAAACCTCTCAGTAGTTTCTTTCAGTGTACAAAATGATGAGCATTTTTCTATGATGAGGTTTTAACCATTATTCAGGGTGGTCTTTTGTTTTTAAATCTTTTTTTAACTAATAAGATTTACGGTGTGTATTTTATACAGAAATGCATTATAAATGTTTTTAATTGTGTTCTGTTTTTTGCAGTCTTTAAGTGCCATGCCAATTGTTCTTATATTCTATAGAAGTTCGCTCAAAATACTCAACAGGGGAATAGGCAGCGGACAGTCAGAATGGTTGGAATTTTGGCTTTCTAAGAAAAACTTTATTTTGCATAAGCATGTGGTCAGATCATTTTGTGCATATGCAGCCTGGATTGGATGTTAAGTAAATGCTTGTTCAGTGCCGGTACATTTACTTAAATCTGTTTTTATTTTTGTCATGTAGAATACTACTGTGGTCATCATAATGTAATCTATTTCTGTACCTTTTTTTTTTTTTTTTACTTTGAAGTCTTTAAATAAAATGTATAATACCCA

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