| Gene Name | PSMD8 |
|
| Specie | Homo sapiens | |
| Full Name | proteasome 26S subunit, non-ATPase 8 | |
| Also known as | HEL-S-91n|HIP6|HYPF|Nin1p|Rpn12|S14|p31 | |
| Coordinate | chr19:38374571-38383824 | |
| Strand | + | |
| Gene summary | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| PSMD8P1 | chr1:154414275-154415187 | - |
Intragenic |
ENSG00000228264 | UCSC |
| PSMD8P2 | chr18:856526-857421 | + |
Intergenic |
ENSG00000264179 | UCSC |
| >NM_002812.5 |
| GAGTGACGACAGAGGCGGAGCTCCAACTGACATGTTCATTAAGGGCAGGGCTCCGAGGGCGCCACCTCGAGAGCGACGGCGGGCTACCCGGGGCGGGCTGAGGCAGGTTGTAGCCCCGCCCCGGGCCTTGGGCTCCACCTCTCGGCCCCACTTCCGCCGGGCAAGCGTTTGTAGGCGGCGCTGCCGTAAATCAGGCGGTCTGCTTGCCGCATCACGCAAGATGGCGGCCGCGGCGGTGAACGGGGCGGCAGGCTTCTCGAGCTCCGGGCCCGCGGCAACCTCGGGCGCTGTTCTGCAGGCCGCGACCGGCATGTACGAGCAACTCAAGGGCGAGTGGAACCGTAAAAGCCCCAATCTTAGCAAGTGCGGGGAAGAGCTGGGTCGACTCAAGCTAGTTCTTCTGGAGCTCAACTTCTTGCCAACCACAGGGACCAAGCTGACCAAACAGCAGCTAATTCTGGCCCGTGACATACTGGAGATCGGGGCCCAATGGAGCATCCTACGCAAGGACATCCCCTCCTTCGAGCGCTACATGGCCCAGCTCAAATGCTACTACTTTGATTACAAGGAGCAGCTCCCCGAGTCAGCCTATATGCACCAGCTCTTGGGCCTCAACCTCCTCTTCCTGCTGTCCCAGAACCGGGTGGCTGAGTTCCACACGGAGTTGGAGCGGCTGCCTGCCAAGGACATACAGACCAATGTCTACATCAAGCACCCAGTGTCCCTGGAGCAATACCTGATGGAGGGCAGCTACAACAAAGTGTTCCTGGCCAAGGGTAACATCCCCGCCGAGAGCTACACCTTCTTCATTGACATCCTGCTCGACACTATCAGGGATGAGATCGCTGGGTGCATCGAGAAGGCCTACGAGAAAATCCTTTTCACTGAGGCCACCCGGATCCTCTTCTTCAACACACCCAAAAAGATGACAGACTACGCCAAGAAGCGAGGGTGGGTCCTGGGCCCCAACAACTACTACAGTTTTGCCAGCCAGCAGCAGAAGCCGGAAGACACCACCATTCCCTCCACAGAACTGGCCAAACAGGTCATCGAGTATGCCCGGCAGCTGGAGATGATCGTCTGAGCCCCCCGGGCACTGGGTGGGGCAGGGCACGAGTTATTTAAAACAGTTACACTGCAGGGTTTCGCCCAATAAAGGTGGACTGACATTCCCTCTTCCAGGCCCTTGTCTCCCCAGTTGGGACGGCAGAGAGACAAGTTCTTATATCTGAAGAACTTGGAGGTTTTGGGGCATTCAGGAGTTGGAGATAGCCTCCAACTGGGTCAGCCTCTGTCTGGTGGGCATTGCTCAGGGTCTCAAACATGGACGCCCACTGTGGGGCCCCAGCAGCACTGTGGCCTGCAGGAGGGCATGGCCCCAGGTAGGGGGACTGTTCTAGCCAGCTGTGGACACATAGGAATGCTGGACCAGGGTACCAGATTTTTTCAACAAAGGGGGTGAAGTGTCCTACTAAAAAGAATAAATGTTGGCAGTGAATTAAACAATTTTTCAAATGA |