Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PSMD8P2
Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr18:856526-857421  UCSC
Coordinates (T2T) chr18:1010828-1011723  UCSC
Coordinates (hg19) chr18:856527-857422  UCSC
Strand +
Parental Sequence NM_002812.5
Parental seq. overlap 799 bp
Parental seq. overlap (%) 52.4%
Genomic Region Intergenic
Retrocopy Summary PSMD8P2, located on chr18:856526-857421, is a retrocopy of the parental gene PSMD8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PSMD8
Full Name proteasome 26S subunit, non-ATPase 8
Also known as HEL-S-91n|HIP6|HYPF|Nin1p|Rpn12|S14|p31
Coordinate chr19:38374571-38383824
Strand +
Gene summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PSMD8P2
Bonobo Pan paniscus PSMD8P2
Gorilla Gorilla gorilla PSMD8P2
Orangutan Pongo abelii PSMD8P2
Gibbon Nomascus leucogenys PSMD8P1
Green monkey Chlorocebus sabaeus PSMD8P1
Crab-eating macaque Macaca fascicularis PSMD8P2
Rhesus Macaca mulatta PSMD8P2
Baboon Papio anubis PSMD8P2
Golden snub-nosed monkey Rhinopithecus roxellana PSMD8P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PSMD8P2
CTACCCAAGTCAGCCTACATGCACCAGCTCTTGGGCCTCAACCTCCTCTTCCTGCTGTCCCAGGATTAGGTGGCTGAGTTCCACATGGAGTTGGAGTGGCTGCCTGCCACGGACACACAGACCAATGCCTACATCAAGCGCCCTGTGTCCCTGGAGCCATACCTGATGGAGGGCGGCTACAACAAGGTGTTCCTGGCCAAGGGTAACATCCCTGCCAAGAGCTACACCTTCATCCACATCCTGCTTGACACTATCAGGGATGAGATGGCTGGGTGCATTGAGAAGGCCTATGAGAAAATCCTTTTCACCAAGGCCACCTGGATCCTCTTCCTCAACACACCCAAACAGATGATGGACAACACCAAGAAGTGAGGGTGGGTCCTGGGCCCCAACAACTACTACAGTTTTGCCAGCCAGCAGCAGAAGCTGGAAGACACCACCATTCCAAGTTGAGTATGCCTGGCAGCCCACCAGGCACTGGGTGGGGCAGGGCATACGTTATTTAAAACAGTTACAGTGCAGGGTTTCCTCTAATAAAGGTGGATTGACATTCTGTCTTCCAGGCCCTTATCTCCCCATTTGGAATGGTGAGGAGCCAAGTTCTTATATCTGAGATAGATAAGTTTTGGGGCCCTCAGGGGATGGAGATAACACCCTCCAACTGGGTCAGCCTCTGTCTGATGGCCATTGCTCAGGGTCTCAAACACAGATGGCCACCGTAGAGCCCCAGCAGCACTGTGGCCTACAGGAGAGCATGGCCCCAGGTAGGGGGATGTTCCAGCCAGCTGTGGACACACAGGAATGCTGGGCCAGGGTACCAGATATTTTTCAACAAAGGGGGTGAAGTGTCCCATTAAAAAAAAGTTGGCAATGAATTAAGCAATTTTTCA
>NM_002812.5
GAGTGACGACAGAGGCGGAGCTCCAACTGACATGTTCATTAAGGGCAGGGCTCCGAGGGCGCCACCTCGAGAGCGACGGCGGGCTACCCGGGGCGGGCTGAGGCAGGTTGTAGCCCCGCCCCGGGCCTTGGGCTCCACCTCTCGGCCCCACTTCCGCCGGGCAAGCGTTTGTAGGCGGCGCTGCCGTAAATCAGGCGGTCTGCTTGCCGCATCACGCAAGATGGCGGCCGCGGCGGTGAACGGGGCGGCAGGCTTCTCGAGCTCCGGGCCCGCGGCAACCTCGGGCGCTGTTCTGCAGGCCGCGACCGGCATGTACGAGCAACTCAAGGGCGAGTGGAACCGTAAAAGCCCCAATCTTAGCAAGTGCGGGGAAGAGCTGGGTCGACTCAAGCTAGTTCTTCTGGAGCTCAACTTCTTGCCAACCACAGGGACCAAGCTGACCAAACAGCAGCTAATTCTGGCCCGTGACATACTGGAGATCGGGGCCCAATGGAGCATCCTACGCAAGGACATCCCCTCCTTCGAGCGCTACATGGCCCAGCTCAAATGCTACTACTTTGATTACAAGGAGCAGCTCCCCGAGTCAGCCTATATGCACCAGCTCTTGGGCCTCAACCTCCTCTTCCTGCTGTCCCAGAACCGGGTGGCTGAGTTCCACACGGAGTTGGAGCGGCTGCCTGCCAAGGACATACAGACCAATGTCTACATCAAGCACCCAGTGTCCCTGGAGCAATACCTGATGGAGGGCAGCTACAACAAAGTGTTCCTGGCCAAGGGTAACATCCCCGCCGAGAGCTACACCTTCTTCATTGACATCCTGCTCGACACTATCAGGGATGAGATCGCTGGGTGCATCGAGAAGGCCTACGAGAAAATCCTTTTCACTGAGGCCACCCGGATCCTCTTCTTCAACACACCCAAAAAGATGACAGACTACGCCAAGAAGCGAGGGTGGGTCCTGGGCCCCAACAACTACTACAGTTTTGCCAGCCAGCAGCAGAAGCCGGAAGACACCACCATTCCCTCCACAGAACTGGCCAAACAGGTCATCGAGTATGCCCGGCAGCTGGAGATGATCGTCTGAGCCCCCCGGGCACTGGGTGGGGCAGGGCACGAGTTATTTAAAACAGTTACACTGCAGGGTTTCGCCCAATAAAGGTGGACTGACATTCCCTCTTCCAGGCCCTTGTCTCCCCAGTTGGGACGGCAGAGAGACAAGTTCTTATATCTGAAGAACTTGGAGGTTTTGGGGCATTCAGGAGTTGGAGATAGCCTCCAACTGGGTCAGCCTCTGTCTGGTGGGCATTGCTCAGGGTCTCAAACATGGACGCCCACTGTGGGGCCCCAGCAGCACTGTGGCCTGCAGGAGGGCATGGCCCCAGGTAGGGGGACTGTTCTAGCCAGCTGTGGACACATAGGAATGCTGGACCAGGGTACCAGATTTTTTCAACAAAGGGGGTGAAGTGTCCTACTAAAAAGAATAAATGTTGGCAGTGAATTAAACAATTTTTCAAATGA

Publications

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