Summary

Gene Name	AKTIP
Specie	Homo sapiens
Full Name	AKT interacting protein
Also known as	FT1|FTS
Coordinate	chr16:53491040-53504411
Strand	-
Gene summary	The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Retrocopy(s) from AKTIP

Retroname	Coord	Strand	Genomic Region	ENSG
AKTIPP1	chr3:52753409-52754764	+	Intragenic	ENSG00000271137	UCSC
AKTIPP3	chr11:96642219-96643997	-	Intergenic	ENSG00000255376	UCSC
AKTIPP2	chr5:24170238-24172277	+	Intergenic	ENSG00000226432	UCSC

Expression

Transcript Sequences

>NM_001012398.3

gggAGATGCTGTCGGGCCGCGGCGGCGCTTGGCAGCCAGGAGCTCTGCATTGAAGGCACTGGGGTGAGGCTTACTGCCCGGCAGGCTGGTGGGTAAAGTGAATGCCGAAGACAGAAGATTTGGATGATACACCACTGACTTTCTTTGTTTGGAATACACGTTATGAACCCTTTCTGGAGCATGTCTACAAGCTCTGTACGCAAACGATCTGAAGGTGAAGAGAAGACATTAACAGGGGACGTGAAAACCAGTCCTCCACGAACTGCACCAAAGAAACAGCTGCCTTCTATTCCCAAAAATGCTTTGCCCATAACTAAGCCTACATCTCCTGCCCCAGCAGCACAGTCAACAAATGGCACGCATGCGTCCTATGGACCCTTCTACCTGGAATACTCTCTTCTTGCAGAATTTACCTTGGTTGTGAAGCAGAAGCTACCAGGCGTCTATGTGCAGCCATCTTATCGCTCTGCATTAATGTGGTTTGGAGTAATATTCATACGGCATGGACTTTACCAAGATGGCGTATTTAAGTTTACagtttacatccctgataactatccagatggtgactgtccaCGCTTGGTGTTCGATATTCCTGTCTTTCACCCGCTAGTTGATCCCACCTCAGGTGAGCTGGATGTGAAGAGAGCATTTGCAAAATGGAGGCGGAACCATAATCATATTTGGCAGGTATTAATGTATGCAAGGAGAGTTTTCTACAAGATTGATACAGCAAGCCCCCTGAACCCAGAGGCTGCAGTACTGTATGAAAAAGATATTCAGCTTTTTAAAAGTAAAGTTGTTGACAGTGTTAAGGTGTGCACTGCTCGTTTGTTTGACCAACCTAAAATAGAAGACCCCTATGCAATTAGCTTTTCTCCATGGAATCCTTCTGTACATGATGAAGCCAGAGAAAAGATGCTGACTCAGAAAAAGCCTGAAGAACAGCACAATAAAAGTGTTCATGTTGCTGGCCTGTCATGGGTAAAGCCTGGCTCAGTACAGCCTTTCAGTAAAGAAGAGAAAACAGTGGCGACTTAAGAGATGGTGAATCTGGTGCACCATGCACTTTCCTGCTAGACTCTGGCCTAGTTCAAGCTGACCAATGGCAGAGGACTGCCTGAAGAGTAAAACTGTGTGAACAATGACTGACTGCCAGTGTTTTCCATGTATGCATAGGTTCTAACAGCAGGGTTTGGAAACCTGTCTCTAAGTAATGCATTACTTCTGTCAGAAGTGTCTTAGGGTGGTTATCTAGTTCAGTACTCCAAATTATTGGGGACCTTGAGGCTTAAGTAAGTATTTTTCTGAATATAATGCTAAAGGTAAGTTGCATTCATTTAAACTAATAGAGCAGACAGAATTCAGCACTACTTAATAGTTTATAAATCAGTGGTTTCAGTTGTATATATGTTAGGAAATGGAGAGGTATAGAGAGAGCAGGTTCCATAGCTCAGCACTTTTAAGTGGAAGATCATTTGAATCTCAGTCTTCAGCCTGCACTGATTTGTAGCCTGCACTGTCTTACTGATTTACAAACTGAAATCACTGAGAAATGTCTTTAGTTCAGTGAGAAGAAACCAGAACACTTGTTCCTAGTGTTGTGTTGTTTTTTTTAAGCAAATTACTTACTGTATTTTTATGGCAGGAGGGAGAAAAAGTGTTACAACGGTTTCTAATGAAGTCCGGTATTTAAATGATAAATGACTAATGTGTTTAGTAGAGACAAAATAAACCAATAAATGATTGTTCTTTGCCATTTATGCAGGAAACTACCCTTTTCTCAATATAACCAAACAAAGGCTAATTTATAAATGCTTTATTGAAAAATACACTTATCTTCATATAAAATTACAGTAGCAGTATCTTGAGAAGTTTTATAAATATTTTTGCAGAACACTATTCTAATTGAACAATGTAAGTTCCATATTTCTCTCAGCAATATGAAGTTACCTAGTAACTTTGTTTATACTGATTCAATTTACAATTGAATTTTCTCCCTAATAAGATTATTAATTTGACTTGAAAACTGCTGGAACAATAGTGATTAATAAAGATATGTATAGATAATTCAGCTGTTAAATAACATTTTCTAATTTGTATAAATGGTACTATGGTACTAATAAAAACCTAAATTCTCCAACCAATTTTTTTAAACTGCCAGGAACACCCAAAAATATTTTTAAATATATCACCTTAATAGACATTTCTTTTAGATAACTCCCTCCTAAAGGAAGAGGTCATAAGTTTTCATATTAATCCCCTCAATTCAACTTGATTAAAATCTTTTCTTAGCTGGTTGATCCCTATATAACAAAAAACTGGAGAATTTAAAACATTCCCAAAAGGTGGCTATAGGGGTTTTAACATTTTAAAAAAATATAAAAGCATTAAAGAAAATATTGGATGTTTA

>NM_001308325.2

gggAGATGCTGTCGGGCCGCGGCGGCGCTTGGCAGCCAGGAGCTCTGCATTGAAGGCACTGGGGTAAAGTGAATGCCGAAGACAGAAGATTTGGATGATACACCACTGACTTTCTTTGTTTGGAATACACGTTATGAACCCTTTCTGGAGCATGTCTACAAGCTCTGTACGCAAACGATCTGAAGGTGAAGAGAAGACATTAACAGGGGACGTGAAAACCAGTCCTCCACGAACTGCACCAAAGAAACAGCTGCCTTCTATTCCCAAAAATGCTTTGCCCATAACTAAGCCTACATCTCCTGCCCCAGCAGCACAGTCAACAAATGGCACGCATGCGTCCTATGGACCCTTCTACCTGGAATACTCTCTTCTTGCAGAATTTACCTTGGTTGTGAAGCAGAAGCTACCAGGCGTCTATGTGCAGCCATCTTATCGCTCTGCATTAATGTGGTTTGGAGTAATATTCATACGGCATGGACTTTACCAAGATGGCGTATTTAAGTTTACagtttacatccctgataactatccagatggtgactgtccaCGCTTGGTGTTCGATATTCCTGTCTTTCACCCGCTAGTTGATCCCACCTCAGGTGAGCTGGATGTGAAGAGAGCATTTGCAAAATGGAGGCGGAACCATAATCATATTTGGCAGGTATTAATGTATGCAAGGAGAGTTTTCTACAAGATTGATACAGCAAGCCCCCTGAACCCAGAGGCTGCAGTACTGTATGAAAAAGATATTCAGCTTTTTAAAAGTAAAGTTGTTGACAGTGTTAAGGTGTGCACTGCTCGTTTGTTTGACCAACCTAAAATAGAAGACCCCTATGCAATTAGCTTTTCTCCATGGAATCCTTCTGTACATGATGAAGCCAGAGAAAAGATGCTGACTCAGAAAAAGAAGCCTGAAGAACAGCACAATAAAAGTGTTCATGTTGCTGGCCTGTCATGGGTAAAGCCTGGCTCAGTACAGCCTTTCAGTAAAGAAGAGAAAACAGTGGCGACTTAAGAGATGGTGAATCTGGTGCACCATGCACTTTCCTGCTAGACTCTGGCCTAGTTCAAGCTGACCAATGGCAGAGGACTGCCTGAAGAGTAAAACTGTGTGAACAATGACTGACTGCCAGTGTTTTCCATGTATGCATAGGTTCTAACAGCAGGGTTTGGAAACCTGTCTCTAAGTAATGCATTACTTCTGTCAGAAGTGTCTTAGGGTGGTTATCTAGTTCAGTACTCCAAATTATTGGGGACCTTGAGGCTTAAGTAAGTATTTTTCTGAATATAATGCTAAAGGTAAGTTGCATTCATTTAAACTAATAGAGCAGACAGAATTCAGCACTACTTAATAGTTTATAAATCAGTGGTTTCAGTTGTATATATGTTAGGAAATGGAGAGGTATAGAGAGAGCAGGTTCCATAGCTCAGCACTTTTAAGTGGAAGATCATTTGAATCTCAGTCTTCAGCCTGCACTGATTTGTAGCCTGCACTGTCTTACTGATTTACAAACTGAAATCACTGAGAAATGTCTTTAGTTCAGTGAGAAGAAACCAGAACACTTGTTCCTAGTGTTGTGTTGTTTTTTTTAAGCAAATTACTTACTGTATTTTTATGGCAGGAGGGAGAAAAAGTGTTACAACGGTTTCTAATGAAGTCCGGTATTTAAATGATAAATGACTAATGTGTTTAGTAGAGACAAAATAAACCAATAAATGATTGTTCTTTGCCATTTATGCAGGAAACTACCCTTTTCTCAATATAACCAAACAAAGGCTAATTTATAAATGCTTTATTGAAAAATACACTTATCTTCATATAAAATTACAGTAGCAGTATCTTGAGAAGTTTTATAAATATTTTTGCAGAACACTATTCTAATTGAACAATGTAAGTTCCATATTTCTCTCAGCAATATGAAGTTACCTAGTAACTTTGTTTATACTGATTCAATTTACAATTGAATTTTCTCCCTAATAAGATTATTAATTTGACTTGAAAACTGCTGGAACAATAGTGATTAATAAAGATATGTATAGATAATTCAGCTGTTAAATAACATTTTCTAATTTGTATAAATGGTACTATGGTACTAATAAAAACCTAAATTCTCCAACCAATTTTTTTAAACTGCCAGGAACACCCAAAAATATTTTTAAATATATCACCTTAATAGACATTTCTTTTAGATAACTCCCTCCTAAAGGAAGAGGTCATAAGTTTTCATATTAATCCCCTCAATTCAACTTGATTAAAATCTTTTCTTAGCTGGTTGATCCCTATATAACAAAAAACTGGAGAATTTAAAACATTCCCAAAAGGTGGCTATAGGGGTTTTAACATTTTAAAAAAATATAAAAGCATTAAAGAAAATATTGGATGTTTA