Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AKTIPP1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:52753409-52754764  UCSC
Coordinates (T2T) chr3:52786318-52787673  UCSC
Coordinates (hg19) chr3:52787425-52788780  UCSC
Strand +
Parental Sequence NM_001012398.3
Parental seq. overlap 928 bp
Parental seq. overlap (%) 38.2%
Genomic Region Intragenic (NEK4)
Retrocopy Summary AKTIPP1, located on chr3:52753409-52754764, is a retrocopy of the parental gene AKTIP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AKTIP
Full Name AKT interacting protein
Also known as FT1|FTS
Coordinate chr16:53491040-53504411
Strand -
Gene summary The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AKTIPP1
Bonobo Pan paniscus AKTIPP1
Gorilla Gorilla gorilla AKTIPP1
Orangutan Pongo abelii AKTIPP1
Gibbon Nomascus leucogenys AKTIPP1
Green monkey Chlorocebus sabaeus AKTIPP2
Crab-eating macaque Macaca fascicularis AKTIPP1
Rhesus Macaca mulatta AKTIPP1
Baboon Papio anubis AKTIPP1
Golden snub-nosed monkey Rhinopithecus roxellana AKTIPP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AKTIPP1
ACTCTACATTGAAGGCACAGAGGTGAGGCACAATGCCCGGAAGGCTGGTAAATTGAATGCTGAGGACGGAAGAGTCTGATGACATACTACTGAATTTCTTTGTTTGGAGTACACATTATGTACTCTTTCTGGAGCATGTCTACAAGCTCTACATGGAAACGATCTGAAGCTGAAAACATTGGCAGGGGATGCAAAAACCAGTCTTTGATGAACTATGCCAAAGAAACAGCTGCCTTCTATTCCCAAAAATGCTTTGCCCATAACTAAGCCTACGGAGCCTGTCCCAGCAGCACAGTCAACAAATGGCATGCATGCTTCCTACAGACTCGTCCACCTGAAATACTCTCTTCTTGCTGAATTTACCTTGGTTGCGGAGCAGACGTTATTAGGTGTCTATGTGCAGCCATCTTATCCCTCTGTATTAAAGTGGTTTGGACTAATATTCATAGGGCACAGACTTTATCAAGATGGCATATTTAaGATGGTGTATTTAAGTTTGCAGTTTACATCCATCCCTAATTACTATCCAGATGGTGACTATCCATGCTTGATATTTGGTATTCCCATCTTTCACCTACTAGGTGATGCCACCTCAGATGAACTGGATGTGAAGAGCATTTGGAAAATGGAGGTGGAATCATAACCAAATTTGGCAAGTACTAACAATATGCAGGGAGAGTTTTCTACAAGATTGATACAAAAAGCCCCCTAAACCCAGAGGCTGCAATACTGTATGAGAAAGATGTTCAGCTTTTTAAGAGTAAAGTGGTTGACAGTGTTAAGGTATGTATTACTCGTCTGTCTGACCAATTTAAAATAGAAGACTCATGCAATTAGCTTTTCTCCATGGAATCCTTCTGTACATGATGAAGCCAGAGAAAAGATGCTGACTCAGAAAAGCCTGAAGAACAGCACAATAAGTGTACGTGTCGCCGGCCTGTCATAGGTAAAGCCTGGCTCAGTACAATCTTTCAGTAAAGAAGAGAAAACAGTAGCAACTTAAGAGATGGTGAATCTGGTACACCATGCACTTTCCTGCTGGACTCTGGACTAGTTCAAGCTGACCAATGGCA
>NM_001012398.3
gggAGATGCTGTCGGGCCGCGGCGGCGCTTGGCAGCCAGGAGCTCTGCATTGAAGGCACTGGGGTGAGGCTTACTGCCCGGCAGGCTGGTGGGTAAAGTGAATGCCGAAGACAGAAGATTTGGATGATACACCACTGACTTTCTTTGTTTGGAATACACGTTATGAACCCTTTCTGGAGCATGTCTACAAGCTCTGTACGCAAACGATCTGAAGGTGAAGAGAAGACATTAACAGGGGACGTGAAAACCAGTCCTCCACGAACTGCACCAAAGAAACAGCTGCCTTCTATTCCCAAAAATGCTTTGCCCATAACTAAGCCTACATCTCCTGCCCCAGCAGCACAGTCAACAAATGGCACGCATGCGTCCTATGGACCCTTCTACCTGGAATACTCTCTTCTTGCAGAATTTACCTTGGTTGTGAAGCAGAAGCTACCAGGCGTCTATGTGCAGCCATCTTATCGCTCTGCATTAATGTGGTTTGGAGTAATATTCATACGGCATGGACTTTACCAAGATGGCGTATTTAAGTTTACagtttacatccctgataactatccagatggtgactgtccaCGCTTGGTGTTCGATATTCCTGTCTTTCACCCGCTAGTTGATCCCACCTCAGGTGAGCTGGATGTGAAGAGAGCATTTGCAAAATGGAGGCGGAACCATAATCATATTTGGCAGGTATTAATGTATGCAAGGAGAGTTTTCTACAAGATTGATACAGCAAGCCCCCTGAACCCAGAGGCTGCAGTACTGTATGAAAAAGATATTCAGCTTTTTAAAAGTAAAGTTGTTGACAGTGTTAAGGTGTGCACTGCTCGTTTGTTTGACCAACCTAAAATAGAAGACCCCTATGCAATTAGCTTTTCTCCATGGAATCCTTCTGTACATGATGAAGCCAGAGAAAAGATGCTGACTCAGAAAAAGCCTGAAGAACAGCACAATAAAAGTGTTCATGTTGCTGGCCTGTCATGGGTAAAGCCTGGCTCAGTACAGCCTTTCAGTAAAGAAGAGAAAACAGTGGCGACTTAAGAGATGGTGAATCTGGTGCACCATGCACTTTCCTGCTAGACTCTGGCCTAGTTCAAGCTGACCAATGGCAGAGGACTGCCTGAAGAGTAAAACTGTGTGAACAATGACTGACTGCCAGTGTTTTCCATGTATGCATAGGTTCTAACAGCAGGGTTTGGAAACCTGTCTCTAAGTAATGCATTACTTCTGTCAGAAGTGTCTTAGGGTGGTTATCTAGTTCAGTACTCCAAATTATTGGGGACCTTGAGGCTTAAGTAAGTATTTTTCTGAATATAATGCTAAAGGTAAGTTGCATTCATTTAAACTAATAGAGCAGACAGAATTCAGCACTACTTAATAGTTTATAAATCAGTGGTTTCAGTTGTATATATGTTAGGAAATGGAGAGGTATAGAGAGAGCAGGTTCCATAGCTCAGCACTTTTAAGTGGAAGATCATTTGAATCTCAGTCTTCAGCCTGCACTGATTTGTAGCCTGCACTGTCTTACTGATTTACAAACTGAAATCACTGAGAAATGTCTTTAGTTCAGTGAGAAGAAACCAGAACACTTGTTCCTAGTGTTGTGTTGTTTTTTTTAAGCAAATTACTTACTGTATTTTTATGGCAGGAGGGAGAAAAAGTGTTACAACGGTTTCTAATGAAGTCCGGTATTTAAATGATAAATGACTAATGTGTTTAGTAGAGACAAAATAAACCAATAAATGATTGTTCTTTGCCATTTATGCAGGAAACTACCCTTTTCTCAATATAACCAAACAAAGGCTAATTTATAAATGCTTTATTGAAAAATACACTTATCTTCATATAAAATTACAGTAGCAGTATCTTGAGAAGTTTTATAAATATTTTTGCAGAACACTATTCTAATTGAACAATGTAAGTTCCATATTTCTCTCAGCAATATGAAGTTACCTAGTAACTTTGTTTATACTGATTCAATTTACAATTGAATTTTCTCCCTAATAAGATTATTAATTTGACTTGAAAACTGCTGGAACAATAGTGATTAATAAAGATATGTATAGATAATTCAGCTGTTAAATAACATTTTCTAATTTGTATAAATGGTACTATGGTACTAATAAAAACCTAAATTCTCCAACCAATTTTTTTAAACTGCCAGGAACACCCAAAAATATTTTTAAATATATCACCTTAATAGACATTTCTTTTAGATAACTCCCTCCTAAAGGAAGAGGTCATAAGTTTTCATATTAATCCCCTCAATTCAACTTGATTAAAATCTTTTCTTAGCTGGTTGATCCCTATATAACAAAAAACTGGAGAATTTAAAACATTCCCAAAAGGTGGCTATAGGGGTTTTAACATTTTAAAAAAATATAAAAGCATTAAAGAAAATATTGGATGTTTA

Publications

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