Summary

Gene Name	SKP2
Specie	Homo sapiens
Full Name	S-phase kinase associated protein 2
Also known as	FBL1|FBXL1|FLB1|p45
Coordinate	chr5:36152067-36184319
Strand	+
Gene summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]

Retrocopy(s) from SKP2

Retroname	Coord	Strand	Genomic Region	ENSG
SKP2P1	chrX:96620617-96622051	+	Intergenic	ENSG00000229693	UCSC

Expression

Transcript Sequences

>NM_005983.4

AGTGGGGATGGAACGTTGCTAGGCTTAGCGGGTCTGGCTGCTGGGGGCCCGAGCAGCACGCTCGGAGCCGCCGCGCGCCAAAGCGGGAATCTGGGAGGCGAGCAGCTCTGCAGTTAATGCACGTATTTTAAACTCCCGGGCCTGCGGACGCTATGCACAGGAAGCACCTCCAGGAGATTCCAGACCTGAGTAGCAACGTTGCCACCAGCTTCACGTGGGGATGGGATTCCAGCAAGACTTCTGAACTGCTGTCAGGCATGGGGGTCTCCGCCCTGGAGAAAGAGGAGCCCGACAGTGAGAACATCCCCCAGGAACTGCTCTCAAACCTGGGCCACCCGGAGAGCCCCCCACGGAAACGGCTGAAGAGCAAAGGGAGTGACAAAGACTTTGTGATTGTCCGCAGGCCTAAGCTAAATCGAGAGAACTTTCCAGGTGTTTCATGGGACTCCCTTCCGGATGAGCTGCTCTTGGGAATCTTTTCCTGTCTGTGCCTCCCTGAGCTGCTAAAGGTCTCTGGTGTTTGTAAGAGGTGGTATCGCCTAGCGTCTGATGAGTCTCTATGGCAGACCTTAGACCTCACAGGTAAAAATCTGCACCCGGATGTGACTGGTCGGTTGCTGTCTCAAGGGGTGATTGCCTTCCGCTGCCCACGATCATTTATGGACCAACCATTGGCTGAACATTTCAGCCCTTTTCGTGTACAGCACATGGACCTATCGAACTCAGTTATAGAAGTGTCCACCCTCCACGGCATACTGTCTCAGTGTTCCAAGTTGCAGAATCTAAGCCTGGAAGGCCTGCGGCTTTCGGATCCCATTGTCAATACTCTCGCAAAAAACTCAAATTTAGTGCGACTTAACCTTTCTGGGTGTTCTGGATTCTCTGAATTTGCCCTGCAGACTTTGCTAAGCAGCTGTTCCAGACTGGATGAGCTGAACCTCTCCTGGTGTTTTGATTTCACTGAAAAGCATGTACAGGTGGCTGTTGCGCATGTGTCAGAGACCATCACCCAGCTGAATCTTAGCGGCTACAGAAAGAATCTCCAGAAATCAGATCTCTCTACTTTAGTTAGAAGATGCCCCAATCTTGTCCATCTAGACTTAAGTGATAGTGTCATGCTAAAGAATGACTGCTTTCAGGAATTTTTCCAGCTCAACTACCTCCAACACCTATCACTCAGTCGGTGCTATGATATAATACCTGAAACTTTACTTGAACTTGGAGAAATTCCCACACTAAAAACACTACAAGTTTTTGGAATCGTGCCAGATGGTACCCTTCAACTGTTAAAGGAAGCCCTTCCTCATCTACAGATTAATTGCTCCCATTTCACCACCATTGCCAGGCCAACTATTGGCAACAAAAAGAACCAGGAGATATGGGGCATCAAATGCCGACTGACACTGCAAAAGCCCAGTTGTCTATGAAGTATTTATTGCAGGATGGTGTCTCTTCTTTAGAACAGGGAAAATAGGCAGGAAGCCCAATTGCTGGAGTACTTAGCTAGTTTTATTCTTGGTTTTCCCTTTGCCTTCATTCTGCAAGTATACTAGGGAGCCATTTGAGAGGGAAAACTATGAAATCTTGCTTTTTGAAATGATTCTAAAAGCTTCTATCACTGCTTTGCTCTTAAGAGCCAAAGTTGTAGGCCTTTTGAAATTTTAGGAGAGTGAGCCTATAATTTCAAGATACCTTAAAGAGCAAAATTTGAGCCACCTCTTCCAAGTGCCCTTCTTACTAAGTCTATTCAGAATCAAGCTTAAAAATTACCACCAGCAAACAATCTTCATAGCCCATATAACTTTTATCTATTTAATTTTATAGTATTGCTTTATAAGACAGCTTAGAAGAACAATAAGCTATTTGTATTATGAGCTGAACAAAAAGAGAATCATAGGATAGTAGCGTCTGAGGCCATCTTTTCTAGGAATAGGAAAGAGAAAAATGTATTTGAATTTTGCCTTTAGATTTGAAATTAGGTTAATAGAAATAAGTAACCCCATGTAATTCACCTTAAAACTTAACAAAAGACCAAACATTACAAAACCCAGAGATATAGAATCAATATAGGATTTGAAGGCCCAGCAGACAGTTTTCTATGACAGGTTAATCTGAAGTATCCTGTAATGTTCATTAAGTTACTGTGTTTCCAGAATCTAAATTAGATGAGAAATATAATTGTGGTTTTCTAACTTGATAATCAAATTATGTTAACATGGGTCCTTTAGCTTTTAAAATGACTTGCTTTGTTTTAGAAAGGTGGTATTAATCCACTCTCTATTCTTGAAAATTTGGATGGGAGAATTCTGAAGTTGCCTGCTGTTTTCCTTTAGCGCTGAGGTTCTTAAGGTTACTTTTATATTACTCTGGAATCAAGTATTTTAAATTGTATTTTTTTTTTAAATGATCTCTCAGCAATAATTGTTTGAAACTATCCATATATAAGGTTATCAGACCTACAGTTCCCTAAGAGGAACTGCATGTTCTCTTCAATCAGAAATATACAGTAGAAGCAGGTATATCTTCCATGCAGTTTCAGTAGTAAGCACTACTTATACCTACATAAGAGTTAAAATCCAGATGTGGGACCTTTTGATACCATCAGTGATATATATTTTTTTAAACTGGTACAGAGAAGTGAAAAGATTAAATTCTACTTCTAttttttttttttttttttgagacggagtctcgctctgtcaccaaggccggagtgcagtggtgcgatctcggctcactgcaagctccgcctcccaggttcacgtcattctcctgcctcagcctcccgactagctgggactacaggcgcccaccaccacgcccggctaatttttttgtatttttagtagagacggggtttcaccatgttagccaggatggtctcaatctcctgacctcatgatccgcccgtcttggcctcccaaagtgctgggattacaggcatgagcaactgcgcccagccAAATTCTACTTCTTAAAAATCACAAAAACTAGTTTAAATTGATGACTTGTTCGTATGTTCAAAATGTAACAACAAAAAAAGCTAACACCAGTCATTTATATTAACTTTTTTTTTTTAAATCAAAAATTGTTAATGTTAGAAACATACTATGAAGTGCCTTTATCTGCTTAGACCTAAGGAAGATTTTAAAGTTGGGTTGCACAGGAAATGATGATGCTTCAATTTCTTAATAGTTAAAAAGTGCTAAATACTACTTGAAATTATTGTTTACAGATTAGTGACAAGAGCTGGGGTTAGGATCCGGTTGGACTCTGACATCGGATGCCCTCAAACATACAGAACTTCCAAACTCAAGTCCAGCCATAAGCTATTTTGCCAACATGTCAGAGTAATCTGTATTTTTGTATGTGATTTCTACTTTTATAGACTTGTTTTAAAACAATAAAACACATTTTTATAAAAATGAGTGCTTAAACTAAGTTGTATTCCTTTTTTCTTTCTCTTTTTTTAAGTGCTGTGGTTAAAATTTGAAAGCATTTAGTGTGGTATGCCATTTGGCTTAGATACCTCTAAATAAGACTCTTCAAAACAGAGCCCTGAGATGGTCCTTTTTGACCCATCTACTTCATATGCTTGTCACATTAAAAAAAAAAGTTTATAATGCCTTTATAAAAGGGGCTAATACAGTCTTGTTATCtttttttttaaattatactttaagttctagggtacatgtgcacaacgtgcaggttt