Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SKP2P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:96620617-96622051  UCSC
Coordinates (T2T) chrX:95059873-95061307  UCSC
Coordinates (hg19) chrX:95875616-95877050  UCSC
Strand +
Parental Sequence NM_005983.4
Parental seq. overlap 1231 bp
Parental seq. overlap (%) 32.9%
Genomic Region Intergenic
Retrocopy Summary SKP2P1, located on chrX:96620617-96622051, is a retrocopy of the parental gene SKP2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SKP2
Full Name S-phase kinase associated protein 2
Also known as FBL1|FBXL1|FLB1|p45
Coordinate chr5:36152067-36184319
Strand +
Gene summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SKP2P1
Bonobo Pan paniscus SKP2P1
Gorilla Gorilla gorilla SKP2P1
Orangutan Pongo abelii SKP2P1
Gibbon Nomascus leucogenys SKP2P1
Green monkey Chlorocebus sabaeus SKP2P1
Crab-eating macaque Macaca fascicularis SKP2P1
Rhesus Macaca mulatta SKP2P1
Baboon Papio anubis SKP2P1
Golden snub-nosed monkey Rhinopithecus roxellana SKP2P1
Marmoset Callithrix jacchus SKP2P3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SKP2P1
ACCAAAGCGGGAATCCAGGAGGCAGGCAGCTGTGCAATTAACGCATGTACTTAAAACTCCCAAACCTGCAGATGCCATGCACAAGAACCACCTTTAAGAGATTCCAGACCAGAGTAGCAATGTTACCACCAGCTTCATGTGGGGATAGGATTCCAGCAAGACTTCTGAACTACTGGCAGGCATCGGGGTCTCTGCCCTGGAGAAGGAGGAGGCAGACAGTGAGAATATCCCCAAGGAACTGCTCTAAAACCTGGGCCAATCACACAGCCACCCAAGGAAATGGCTGAATAGCAAAAGGAATGACAAAGACTGTGATCATCAACAGGCCTAAACTAAATGGAGAGAACTTTCCAGGTGTTTCATGGGACTCCCTTCCAGATGAGCTGCTCTTGGGGATATTTTCCTGTCTGCACCTCACTGAGCTGCTAAAGGCCTCCGATGTTTTAAGAGATGGTACTGCCCTAGCATTTGTTGAGTCTCTGTGGCAGACTTTATACCTCACAGGTAAAAATCTGAAGCCAGATGTGATTAGTGTGGGCCGGTTGCCTTCCACTGCCAACAATCATTTATGACCAACCATTGGTTGAACATTTCAGCCCTCTGCATATACAGCAGAGGGATGTGTTGAACTCAGTTATAGATGTGTCTGCCCTACATGGCATTCTGTCTCAGGGCTCCAAGCTGCAGAATCTAAGCTTTCTGGAAGACCTATGGCTTTCAGAACCCATTTTCAATAATCTTGCACAGAACTCAAATTTAGTGCAACTGGGTGTTCTGGGTTCTCCTAATCCAGCTGTTCCAGACTTGATGAGCTAAATCTCTGCTGGTGATATGACTTCACTGAAAAAACATGTGCAAGTGGCTGTTGCGCATTTGTCAGAGAGCATCACCCAGCTGAATCTCAGTGGCTGCCGAAAGAATATCCTGAAATCCAATGTCTCTACTTTAGTTAGAAGATCCTCCAATGAGGGTCTAGATGTCCACCTAAACGTAAGTGATAATGTCATGCTAAAGCTAAAGAATGACTGCTTTCAGATATTTTCCAGCTCAACTACCTCCAATACGTATCACGCAGTCGGTGCTATGATATACCCAAAACTTTACTTGAACTCGAAGCAATTCCCACTCTAAAAACACTACAAGTCTTTGGAATCCTGCCAGACAGCACCCTTCAACTGTTAAAGGAAGCCCTTCCTCATCTACAGATTAATTGCTCCAAGTTAACTACAACTGCCAGGCCAACTATTGGCAACAAAAAGAATTAGGAGATATGGGACATCAAATGCTGACTGACATTGCAAAAGTCCAATTGTCTATAAAGTATTTATTGCAAGATGGTGTCTCCCTTTTCTTTGGGACAGGGAAAATAGGCAGGAAGCCCAATTGCTGGAGTGCTTGGCTAGTTTTATTCTCGGTTTTCTCTTTGCCTTCATTC
>NM_005983.4
AGTGGGGATGGAACGTTGCTAGGCTTAGCGGGTCTGGCTGCTGGGGGCCCGAGCAGCACGCTCGGAGCCGCCGCGCGCCAAAGCGGGAATCTGGGAGGCGAGCAGCTCTGCAGTTAATGCACGTATTTTAAACTCCCGGGCCTGCGGACGCTATGCACAGGAAGCACCTCCAGGAGATTCCAGACCTGAGTAGCAACGTTGCCACCAGCTTCACGTGGGGATGGGATTCCAGCAAGACTTCTGAACTGCTGTCAGGCATGGGGGTCTCCGCCCTGGAGAAAGAGGAGCCCGACAGTGAGAACATCCCCCAGGAACTGCTCTCAAACCTGGGCCACCCGGAGAGCCCCCCACGGAAACGGCTGAAGAGCAAAGGGAGTGACAAAGACTTTGTGATTGTCCGCAGGCCTAAGCTAAATCGAGAGAACTTTCCAGGTGTTTCATGGGACTCCCTTCCGGATGAGCTGCTCTTGGGAATCTTTTCCTGTCTGTGCCTCCCTGAGCTGCTAAAGGTCTCTGGTGTTTGTAAGAGGTGGTATCGCCTAGCGTCTGATGAGTCTCTATGGCAGACCTTAGACCTCACAGGTAAAAATCTGCACCCGGATGTGACTGGTCGGTTGCTGTCTCAAGGGGTGATTGCCTTCCGCTGCCCACGATCATTTATGGACCAACCATTGGCTGAACATTTCAGCCCTTTTCGTGTACAGCACATGGACCTATCGAACTCAGTTATAGAAGTGTCCACCCTCCACGGCATACTGTCTCAGTGTTCCAAGTTGCAGAATCTAAGCCTGGAAGGCCTGCGGCTTTCGGATCCCATTGTCAATACTCTCGCAAAAAACTCAAATTTAGTGCGACTTAACCTTTCTGGGTGTTCTGGATTCTCTGAATTTGCCCTGCAGACTTTGCTAAGCAGCTGTTCCAGACTGGATGAGCTGAACCTCTCCTGGTGTTTTGATTTCACTGAAAAGCATGTACAGGTGGCTGTTGCGCATGTGTCAGAGACCATCACCCAGCTGAATCTTAGCGGCTACAGAAAGAATCTCCAGAAATCAGATCTCTCTACTTTAGTTAGAAGATGCCCCAATCTTGTCCATCTAGACTTAAGTGATAGTGTCATGCTAAAGAATGACTGCTTTCAGGAATTTTTCCAGCTCAACTACCTCCAACACCTATCACTCAGTCGGTGCTATGATATAATACCTGAAACTTTACTTGAACTTGGAGAAATTCCCACACTAAAAACACTACAAGTTTTTGGAATCGTGCCAGATGGTACCCTTCAACTGTTAAAGGAAGCCCTTCCTCATCTACAGATTAATTGCTCCCATTTCACCACCATTGCCAGGCCAACTATTGGCAACAAAAAGAACCAGGAGATATGGGGCATCAAATGCCGACTGACACTGCAAAAGCCCAGTTGTCTATGAAGTATTTATTGCAGGATGGTGTCTCTTCTTTAGAACAGGGAAAATAGGCAGGAAGCCCAATTGCTGGAGTACTTAGCTAGTTTTATTCTTGGTTTTCCCTTTGCCTTCATTCTGCAAGTATACTAGGGAGCCATTTGAGAGGGAAAACTATGAAATCTTGCTTTTTGAAATGATTCTAAAAGCTTCTATCACTGCTTTGCTCTTAAGAGCCAAAGTTGTAGGCCTTTTGAAATTTTAGGAGAGTGAGCCTATAATTTCAAGATACCTTAAAGAGCAAAATTTGAGCCACCTCTTCCAAGTGCCCTTCTTACTAAGTCTATTCAGAATCAAGCTTAAAAATTACCACCAGCAAACAATCTTCATAGCCCATATAACTTTTATCTATTTAATTTTATAGTATTGCTTTATAAGACAGCTTAGAAGAACAATAAGCTATTTGTATTATGAGCTGAACAAAAAGAGAATCATAGGATAGTAGCGTCTGAGGCCATCTTTTCTAGGAATAGGAAAGAGAAAAATGTATTTGAATTTTGCCTTTAGATTTGAAATTAGGTTAATAGAAATAAGTAACCCCATGTAATTCACCTTAAAACTTAACAAAAGACCAAACATTACAAAACCCAGAGATATAGAATCAATATAGGATTTGAAGGCCCAGCAGACAGTTTTCTATGACAGGTTAATCTGAAGTATCCTGTAATGTTCATTAAGTTACTGTGTTTCCAGAATCTAAATTAGATGAGAAATATAATTGTGGTTTTCTAACTTGATAATCAAATTATGTTAACATGGGTCCTTTAGCTTTTAAAATGACTTGCTTTGTTTTAGAAAGGTGGTATTAATCCACTCTCTATTCTTGAAAATTTGGATGGGAGAATTCTGAAGTTGCCTGCTGTTTTCCTTTAGCGCTGAGGTTCTTAAGGTTACTTTTATATTACTCTGGAATCAAGTATTTTAAATTGTATTTTTTTTTTAAATGATCTCTCAGCAATAATTGTTTGAAACTATCCATATATAAGGTTATCAGACCTACAGTTCCCTAAGAGGAACTGCATGTTCTCTTCAATCAGAAATATACAGTAGAAGCAGGTATATCTTCCATGCAGTTTCAGTAGTAAGCACTACTTATACCTACATAAGAGTTAAAATCCAGATGTGGGACCTTTTGATACCATCAGTGATATATATTTTTTTAAACTGGTACAGAGAAGTGAAAAGATTAAATTCTACTTCTAttttttttttttttttttgagacggagtctcgctctgtcaccaaggccggagtgcagtggtgcgatctcggctcactgcaagctccgcctcccaggttcacgtcattctcctgcctcagcctcccgactagctgggactacaggcgcccaccaccacgcccggctaatttttttgtatttttagtagagacggggtttcaccatgttagccaggatggtctcaatctcctgacctcatgatccgcccgtcttggcctcccaaagtgctgggattacaggcatgagcaactgcgcccagccAAATTCTACTTCTTAAAAATCACAAAAACTAGTTTAAATTGATGACTTGTTCGTATGTTCAAAATGTAACAACAAAAAAAGCTAACACCAGTCATTTATATTAACTTTTTTTTTTTAAATCAAAAATTGTTAATGTTAGAAACATACTATGAAGTGCCTTTATCTGCTTAGACCTAAGGAAGATTTTAAAGTTGGGTTGCACAGGAAATGATGATGCTTCAATTTCTTAATAGTTAAAAAGTGCTAAATACTACTTGAAATTATTGTTTACAGATTAGTGACAAGAGCTGGGGTTAGGATCCGGTTGGACTCTGACATCGGATGCCCTCAAACATACAGAACTTCCAAACTCAAGTCCAGCCATAAGCTATTTTGCCAACATGTCAGAGTAATCTGTATTTTTGTATGTGATTTCTACTTTTATAGACTTGTTTTAAAACAATAAAACACATTTTTATAAAAATGAGTGCTTAAACTAAGTTGTATTCCTTTTTTCTTTCTCTTTTTTTAAGTGCTGTGGTTAAAATTTGAAAGCATTTAGTGTGGTATGCCATTTGGCTTAGATACCTCTAAATAAGACTCTTCAAAACAGAGCCCTGAGATGGTCCTTTTTGACCCATCTACTTCATATGCTTGTCACATTAAAAAAAAAAGTTTATAATGCCTTTATAAAAGGGGCTAATACAGTCTTGTTATCtttttttttaaattatactttaagttctagggtacatgtgcacaacgtgcaggttt

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