Summary

Gene Name	SRP72
Specie	Homo sapiens
Full Name	signal recognition particle 72
Also known as	BMFF|BMFS1|HEL103
Coordinate	chr4:56467617-56503681
Strand	+
Gene summary	This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Retrocopy(s) from SRP72

Retroname	Coord	Strand	Genomic Region	ENSG
SRP72P1	chr18:49495099-49496897	-	Intergenic	ENSG00000265182	UCSC
SRP72P2	chr6:158236474-158242784	-	Intragenic	ENSG00000188451	UCSC

Expression

Transcript Sequences

>NM_006947.4

GCCCCTCGTCTCCTCCAAGATGGCGAGCGGCGGCAGCGGGGGGGTGTCAGTACCTGCGCTGTGGAGTGAAGTGAACCGGTATGGCCAGAACGGCGACTTCACGCGCGCTCTCAAGACCGTCAATAAGATACTACAGATCAACAAAGATGACGTAACTGCCCTGCATTGTAAAGTGGTATGCCTTATCCAGAATGGAAGTTTCAAGGAAGCTTTGAATGTCATCAATACTCACACCAAAGTGTTAGCCAATAACTCTCTCTCCTTTGAAAAGGCATATTGCGAGTACAGGCTGAACAGAATTGAGAATGCCTTGAAGACAATAGAAAGTGCCAACCAGCAGACAGACAAACTGAAGGAGCTTTATGGACAAGTGTTATACCGTTTGGAACGCTATGATGAATGCTTAGCAGTGTATAGAGATCTCGTCCGAAACTCCCAAGATGATTATGATGAGGAGAGGAAAACAAACCTTTCAGCAGTTGTTGCAGCTCAAAGCAATTGGGAAAAAGTGGTTCCAGAGAACCTGGGCCTCCAAGAAGGCACACATGAGCTGTGCTACAACACTGCATGTGCACTGATAGGCCAAGGCCAGCTGAACCAGGCCATGAAAATCCTACAAAAAGCTGAAGATCTTTGCCGCCGTTCATTATCAGAAGACACTGATGGGACTGAGGAAGACCCACAGGCAGAACTGGCCATCATTCATGGTCAGATGGCTTATATTCTGCAGCTTCAGGGTCGAACAGAGGAGGCTTTGCAACTTTACAATCAAATAATAAAACTAAAACCAACAGATGTGGGATTACTAGCTGTAATTGCAAATAACATCATTACCATTAACAAGGACCAAAATGTCTTTGACTCCAAGAAGAAAGTGAAATTAACCAATGCGGAAGGAGTAGAGTTTAAGCTTTCCAAGAAACAACTACAAGCTATAGAATTTAACAAAGCTTTACTTGCTATGTACACAAACCAGGCTGAACAATGCCGCAAAATATCTGCCAGTTTACAGTCCCAAAGTCCCGAGCATCTCTTACCTGTGTTAATCCAAGCTGCCCAGCTCTGCCGTGAAAAGCAGCACACAAAAGCAATAGAGCTGCTTCAGGAATTTTCAGATCAGCATCCAGAAAATGCAGCTGAAATTAAGCTGACCATGGCACAGTTGAAAATTTCTCAAGGTAATATTTCTAAAGCATGTCTAATATTGAGAAGCATAGAGGAGTTAAAGCATAAACCAGGCATGGTATCTGCATTAGTTACCATGTATAGCCATGAAGAAGATATTGATAGTGCCATTGAGGTCTTCACACAAGCTATCCAGTGGTATCAAAACCATCAGCCAAAATCTCCTGCTCATTTGTCCTTGATAAGAGAAGCTGCAAACTTCAAACTCAAATATGGGCGGAAGAAGGAGGCAATTAGTGACCTACAACAGCTGTGGAAACAAAATCCAAAAGATATTCACACCCTGGCACAGCTTATTTCTGCTTACTCACTTGTAGATCCAGAGAAAGCCAAAGCTCTTAGTAAACACTTGCCATCGTCAGATAGTATGTCTCTAAAAGTAGATGTTGAGGCTCTTGAAAATTCTGCTGGTGCTACATACATTCGGAAGAAGGGTGGAAAAGTTACTGGAGATAGTCAACCAAAGGAACAAGGACAGGGAGATTTGAAAAAGAAGAAAAAGAAAAAGAAGGGAAAATTGCCTAAGAATTATGACCCAAAAGTTACCCCAGATCCAGAAAGATGGCTGCCAATGCGAGAACGTTCTTACTACCGGGGAAGAAAGAAGGGTAAAAAGAAGGATCAGATTGGAAAAGGGACCCAGGGAGCAACTGCAGGAGCTTCATCTGAACTGGATGCCAGTAAAACTGTGAGCAGCCCACCCACCTCCCCAAGACCTGGCAGTGCTGCAACAGTATCTGCCTCTACAAGTAACATCATACCCCCAAGACACCAGAAACCTGCAGGGGCTCcagcaacaaaaaagaaacagcaacagaaaaagaaGAAAGGTGGAAAAGGTGGCTGGTGATGAGAATATTCTTGTTGCAGGCTGTTTTTAAACTAGTGTCAGTGACACTAGGAATATAATAAAGGTAACACAGCAAGAAGCACAGAACTACTCCCTCTTCATCTCCATATTTTCATAATTTCTTGTGTTTCAAATAGGGAAACATCTTCCTCAAAGTCTGCCTAGTGAGATATGGCCTACTGGTTGCCTCATAGCTTTGTACAGATTATGAGGACTGAAAATAATTGGGCATTTACCCATCTTGGTATCTGTTGTATCCTTTATCTGTGTGTGCTGATTTGATCTTTTTTCAGTTTCACATACCTTATCTAAGGTTTCCCAGGATTTAAACAGAAACTACTTCTATGATTTCAGCTGGAGTCTGAAGATACTTGTTTCTGTTCAAGTCCCACTTTAAATTATGTCTTAGGAGACTGAAAGTGGAATCTTCTGAGCATTCCTAAATATCTGCTTAGAAATATCATGTGATAAAGAGGGACCTTCTTAATACACTGATGTTCTTCACTAAATGGATGGCCACAAGAAAAATAAAGTAAATGTCTTAAATAATTTAACCATAAATTTTCTGTCATGTGATACTGGAATATGGGATACTTTTCATGTTtatatatatatatatatgtatatatatatacatatatatatatatataaacatgaaatatatatatatGGCTCCTTTGTGCCCCATGTCATTTTCAGATTATGGTAGCATGCTGATACAGCACCATGAAAGAACTCAAGGAAAATATATCAATGTAAGAAGTTCACTCTTAGACCCAGTGTTCTGAGGTCACATGGGTTTGGACTGTCTCAATCAGAAAGATTAATGACTGTTATCAAGAACATGAACATTGGCTTCCTCCATAGAGAAGAAATCAGTATCTGAGTTGCATACCAGGCAGTATTAAAATCTAACAGGTCTGTTTGGCCCATTGATAGATACTCAAATGGTGTCTCCTTCTGGTTATGGATTTTGACCATTGATTACCTTTCTCAATGTAATGAAGTATTTTACAGTCAATTTGTGGTGTAAATGTTGCTCTTGTCTTTCCTTGCTTACAAACTACTTTCACATTGAACAGCTGTGAGACAGACATATTGAGATGCCTGCCCTTGTTAGTATTCATTTTATGCTGCCCAAGATATCATTTAATTTAGACTTAACAAGTATTTCCTTGTGATTATATTACTCTGTCCTTGTTAATAAAGTGCTGCTGTGTTTGACTCTGAACATACTACCAAAACTTCTTCAAAGAGTTTTTTATGAAAGACTTTCCTCCTTTACAAGAAAGAAATGGGGTGCTGCCTTTCTGTTTAGTAAAAGCAGAATTTGCAGTGGCATCTAAAGAGATCTTTTTTAAATAAAAATTATGTATTGTGGCATAATCCTTTTTTTGAGCTCTACAGAGAACAGTCTTTTGGTAATAGTGGCAGGTATTTATTCCTTCTGAATATATACCCCATTATAGGAATAACTGTTACTTATTTAGGATTCCATCATTGAAAATTTTGACCCAAGGCACAGCAGTGAAATTTATAGTTCTCAATTTAGTTGTCATTATTGACAGGCATTGGTATTATTAGTCATTGCTAAGCAACTAAAACTTCATCAGTTCAAATAAGTTTTAATTGTCAAATGAAGTATAAACACATGAACTTTCTAGAAATATTTCCTCTTTTGGATAGGTCTTTAACCAGTTCATATATATACTTTGTCAAATATATGGATGTGTATGTGTACATTTATAAGAACCAGTATGGATACATCCATTCACTGTGGTACATTTTAAAATAAAATATTTTAGCAGTGAATATGGA