Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SRP72P1
Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr18:49495099-49496897  UCSC
Coordinates (T2T) chr18:49692844-49694642  UCSC
Coordinates (hg19) chr18:47021469-47023267  UCSC
Strand -
Parental Sequence NM_006947.4
Parental seq. overlap 1605 bp
Parental seq. overlap (%) 41.5%
Genomic Region Intergenic
Retrocopy Summary SRP72P1, located on chr18:49495099-49496897, is a retrocopy of the parental gene SRP72. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SRP72
Full Name signal recognition particle 72
Also known as BMFF|BMFS1|HEL103
Coordinate chr4:56467617-56503681
Strand +
Gene summary This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SRP72P2
Bonobo Pan paniscus SRP72P2
Gorilla Gorilla gorilla SRP72P2
Orangutan Pongo abelii SRP72P2
Gibbon Nomascus leucogenys SRP72P2
Green monkey Chlorocebus sabaeus SRP72P2
Crab-eating macaque Macaca fascicularis SRP72P2
Rhesus Macaca mulatta SRP72P2
Baboon Papio anubis SRP72P2
Golden snub-nosed monkey Rhinopithecus roxellana SRP72P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SRP72P1
GAAAGGTGGAAAAGGTAGCTGGTGATGAGAATACTCTTGTTGCAGGCTGTTTTTTAAACTAGTCTCAGAGGAATATTGCAACTACAACTGAACAGAATTAAGAATGCCTTGAAGACAATAGAAAGTGCCAACCAGCAGACAGACAAACTGAAGGAGTTTTATGGACAAGCATTACGCCGCTTGGAACGCTATGATAAATACTTAGAGTATACAGAGATCTCGCCTGAAACTCCCAAGATGATTATGATAAGGAGACGAAAACAAACCTTTCAGCAGTTGTTACTCCTCAAAGCAATTGGGAAAAAGTGGTTCCAGAGAACTTGGGCCTCCAAGAAGGTGCACATGAGCTGTGCTACAACACTGCACATGCGCTGATTGGACAAGGCCAGCTGAACCAGGTCACGACAATCCTACGAAAAGCTGAAGATCTTTGCCGCTGTTCATGATCAGAAGACTGTGATAGGACTGAGAAAGACCCACAGGCAGGACTGGCCATCATTCATGGTCAGATGGCCTATACTCTGCAGCTTCAGGGTCGAATAGAGGAGGCTTTGCAACTTTACAATCAAATAATAAAACTGAAACCAACAGATGTGGGATTACTAGCTGTAATTGCAAACAACATCATTACCATTAACAAGGACCAAAATGTCTTTGACTCCAAGAAGAAGGTGAAATTAATCAATGCAGAAAGAGTGGAGTTTGAGCTTTCCAAGAAACAACTACAAGCTATAGAATTTAACAAAGCTTTACTTGCTACGTACACAAACCAGGCCAATTAATGCCGCAAAATATCCACCAATTTATAGTCCCAAAGTCCCGAGCATCTCCCACCTATGTTAATCCAAGCTGCTCAGGTTTGCCTGGAAAGCAGCACACAAAAACAACAGAGCTGCTTCAGGAATTTTCAGATCAACATCCAGAAAATGCAGCTGAAATTAAGCTGACCATGGCACAGTTGAAAATTTCTCAAGGTAATATTTATAAGCATGTCTAATATTGAGAAGCATAGAAGAGTTAAAGCAGAAACCAGGCATGGTGTCTGCATTCGTGATCATGTATAGCCATGAAGAAGATATTGATAGTGCCATTGAGGTCTTCACACATACTATCCAGTGGTGTCAAAACCATTGGCCCAAATCTCCTGCTCATTTGTCCTTGATAAGAGAAGCTGCGAACTTCAAACTCAAATATAGACAGAAGAAGGAGGCAATTAGTGACCTAGAACAACAATGGAAACAAAATCCAAAAGATTTTCACACCCTGACACAGCTTATTTCTGCTTACTCACTTGTAGATCCAGAGAAAGACAAAGCTCTTTGTGAACACTTGTCATTATCAGATAGCATGTCTCTAAAAGTAGATGTCAAGGCTCTTGAAAATTCTCCTGGTGCTACGTACATTTGGAAGAAGGGTGGCAAAGTTACTGGAGATAGTCAACAAAAGGAGCAAGGGTGGGGAAATTTGAAAAAGAAGAAAAAGATGGGAAAATTGCCTGAGAATTATGACCCAAAAGTTACCCCAGATCCAGAAAGATGGCTACCAATGCAAGAACATTCTTATTACTGGGGAAGAAAGAAAGGTAAAAAGGATCAGGTTGGAAAAGGGATCCAGGGAGCAACTGCAGGAGCTTCATCAGAACTGGATGCCAGAAAAACTGTGAGCAGCCCGCCCCCTCCCCAAGACCTGGCAGTGCAGCGACACTATCTGCCTCTGCAAGTAACATCATACCCCCAAGACACAGAAACCTGCAGGCGCTC
>NM_006947.4
GCCCCTCGTCTCCTCCAAGATGGCGAGCGGCGGCAGCGGGGGGGTGTCAGTACCTGCGCTGTGGAGTGAAGTGAACCGGTATGGCCAGAACGGCGACTTCACGCGCGCTCTCAAGACCGTCAATAAGATACTACAGATCAACAAAGATGACGTAACTGCCCTGCATTGTAAAGTGGTATGCCTTATCCAGAATGGAAGTTTCAAGGAAGCTTTGAATGTCATCAATACTCACACCAAAGTGTTAGCCAATAACTCTCTCTCCTTTGAAAAGGCATATTGCGAGTACAGGCTGAACAGAATTGAGAATGCCTTGAAGACAATAGAAAGTGCCAACCAGCAGACAGACAAACTGAAGGAGCTTTATGGACAAGTGTTATACCGTTTGGAACGCTATGATGAATGCTTAGCAGTGTATAGAGATCTCGTCCGAAACTCCCAAGATGATTATGATGAGGAGAGGAAAACAAACCTTTCAGCAGTTGTTGCAGCTCAAAGCAATTGGGAAAAAGTGGTTCCAGAGAACCTGGGCCTCCAAGAAGGCACACATGAGCTGTGCTACAACACTGCATGTGCACTGATAGGCCAAGGCCAGCTGAACCAGGCCATGAAAATCCTACAAAAAGCTGAAGATCTTTGCCGCCGTTCATTATCAGAAGACACTGATGGGACTGAGGAAGACCCACAGGCAGAACTGGCCATCATTCATGGTCAGATGGCTTATATTCTGCAGCTTCAGGGTCGAACAGAGGAGGCTTTGCAACTTTACAATCAAATAATAAAACTAAAACCAACAGATGTGGGATTACTAGCTGTAATTGCAAATAACATCATTACCATTAACAAGGACCAAAATGTCTTTGACTCCAAGAAGAAAGTGAAATTAACCAATGCGGAAGGAGTAGAGTTTAAGCTTTCCAAGAAACAACTACAAGCTATAGAATTTAACAAAGCTTTACTTGCTATGTACACAAACCAGGCTGAACAATGCCGCAAAATATCTGCCAGTTTACAGTCCCAAAGTCCCGAGCATCTCTTACCTGTGTTAATCCAAGCTGCCCAGCTCTGCCGTGAAAAGCAGCACACAAAAGCAATAGAGCTGCTTCAGGAATTTTCAGATCAGCATCCAGAAAATGCAGCTGAAATTAAGCTGACCATGGCACAGTTGAAAATTTCTCAAGGTAATATTTCTAAAGCATGTCTAATATTGAGAAGCATAGAGGAGTTAAAGCATAAACCAGGCATGGTATCTGCATTAGTTACCATGTATAGCCATGAAGAAGATATTGATAGTGCCATTGAGGTCTTCACACAAGCTATCCAGTGGTATCAAAACCATCAGCCAAAATCTCCTGCTCATTTGTCCTTGATAAGAGAAGCTGCAAACTTCAAACTCAAATATGGGCGGAAGAAGGAGGCAATTAGTGACCTACAACAGCTGTGGAAACAAAATCCAAAAGATATTCACACCCTGGCACAGCTTATTTCTGCTTACTCACTTGTAGATCCAGAGAAAGCCAAAGCTCTTAGTAAACACTTGCCATCGTCAGATAGTATGTCTCTAAAAGTAGATGTTGAGGCTCTTGAAAATTCTGCTGGTGCTACATACATTCGGAAGAAGGGTGGAAAAGTTACTGGAGATAGTCAACCAAAGGAACAAGGACAGGGAGATTTGAAAAAGAAGAAAAAGAAAAAGAAGGGAAAATTGCCTAAGAATTATGACCCAAAAGTTACCCCAGATCCAGAAAGATGGCTGCCAATGCGAGAACGTTCTTACTACCGGGGAAGAAAGAAGGGTAAAAAGAAGGATCAGATTGGAAAAGGGACCCAGGGAGCAACTGCAGGAGCTTCATCTGAACTGGATGCCAGTAAAACTGTGAGCAGCCCACCCACCTCCCCAAGACCTGGCAGTGCTGCAACAGTATCTGCCTCTACAAGTAACATCATACCCCCAAGACACCAGAAACCTGCAGGGGCTCcagcaacaaaaaagaaacagcaacagaaaaagaaGAAAGGTGGAAAAGGTGGCTGGTGATGAGAATATTCTTGTTGCAGGCTGTTTTTAAACTAGTGTCAGTGACACTAGGAATATAATAAAGGTAACACAGCAAGAAGCACAGAACTACTCCCTCTTCATCTCCATATTTTCATAATTTCTTGTGTTTCAAATAGGGAAACATCTTCCTCAAAGTCTGCCTAGTGAGATATGGCCTACTGGTTGCCTCATAGCTTTGTACAGATTATGAGGACTGAAAATAATTGGGCATTTACCCATCTTGGTATCTGTTGTATCCTTTATCTGTGTGTGCTGATTTGATCTTTTTTCAGTTTCACATACCTTATCTAAGGTTTCCCAGGATTTAAACAGAAACTACTTCTATGATTTCAGCTGGAGTCTGAAGATACTTGTTTCTGTTCAAGTCCCACTTTAAATTATGTCTTAGGAGACTGAAAGTGGAATCTTCTGAGCATTCCTAAATATCTGCTTAGAAATATCATGTGATAAAGAGGGACCTTCTTAATACACTGATGTTCTTCACTAAATGGATGGCCACAAGAAAAATAAAGTAAATGTCTTAAATAATTTAACCATAAATTTTCTGTCATGTGATACTGGAATATGGGATACTTTTCATGTTtatatatatatatatatgtatatatatatacatatatatatatatataaacatgaaatatatatatatGGCTCCTTTGTGCCCCATGTCATTTTCAGATTATGGTAGCATGCTGATACAGCACCATGAAAGAACTCAAGGAAAATATATCAATGTAAGAAGTTCACTCTTAGACCCAGTGTTCTGAGGTCACATGGGTTTGGACTGTCTCAATCAGAAAGATTAATGACTGTTATCAAGAACATGAACATTGGCTTCCTCCATAGAGAAGAAATCAGTATCTGAGTTGCATACCAGGCAGTATTAAAATCTAACAGGTCTGTTTGGCCCATTGATAGATACTCAAATGGTGTCTCCTTCTGGTTATGGATTTTGACCATTGATTACCTTTCTCAATGTAATGAAGTATTTTACAGTCAATTTGTGGTGTAAATGTTGCTCTTGTCTTTCCTTGCTTACAAACTACTTTCACATTGAACAGCTGTGAGACAGACATATTGAGATGCCTGCCCTTGTTAGTATTCATTTTATGCTGCCCAAGATATCATTTAATTTAGACTTAACAAGTATTTCCTTGTGATTATATTACTCTGTCCTTGTTAATAAAGTGCTGCTGTGTTTGACTCTGAACATACTACCAAAACTTCTTCAAAGAGTTTTTTATGAAAGACTTTCCTCCTTTACAAGAAAGAAATGGGGTGCTGCCTTTCTGTTTAGTAAAAGCAGAATTTGCAGTGGCATCTAAAGAGATCTTTTTTAAATAAAAATTATGTATTGTGGCATAATCCTTTTTTTGAGCTCTACAGAGAACAGTCTTTTGGTAATAGTGGCAGGTATTTATTCCTTCTGAATATATACCCCATTATAGGAATAACTGTTACTTATTTAGGATTCCATCATTGAAAATTTTGACCCAAGGCACAGCAGTGAAATTTATAGTTCTCAATTTAGTTGTCATTATTGACAGGCATTGGTATTATTAGTCATTGCTAAGCAACTAAAACTTCATCAGTTCAAATAAGTTTTAATTGTCAAATGAAGTATAAACACATGAACTTTCTAGAAATATTTCCTCTTTTGGATAGGTCTTTAACCAGTTCATATATATACTTTGTCAAATATATGGATGTGTATGTGTACATTTATAAGAACCAGTATGGATACATCCATTCACTGTGGTACATTTTAAAATAAAATATTTTAGCAGTGAATATGGA

Publications

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