| Gene Name | ELOB |
|
| Specie | Homo sapiens | |
| Full Name | elongin B | |
| Also known as | SIII|TCEB2 | |
| Coordinate | chr16:2771414-2777280 | |
| Strand | - | |
| Gene summary | This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| ELOBP2 | chr11:130032814-130033261 | - |
Intergenic |
ENSG00000255262 | UCSC |
| ELOBP1 | chr13:25365762-25366179 | - |
Intergenic |
ENSG00000234152 | UCSC |
| >NM_007108.4 |
| GCGGCTGCGCCGGCGCGTCGAGGGGAGAGGCAGCAGCCGCGATGGACGTGTTCCTCATGATCCGGCGCCACAAGACCACCATCTTCACGGACGCCAAGGAGTCCAGCACGGTGTTCGAACTGAAGCGCATCGTCGAGGGCATCCTCAAGCGGCCTCCTGACGAGCAGCGGCTGTACAAGGATGACCAACTCTTGGATGATGGCAAGACACTGGGCGAGTGTGGCTTCACCAGTCAAACAGCACGGCCACAGGCCCCAGCCACAGTGGGGCTGGCCTTCCGGGCAGATGACACCTTTGAGGCCCTGTGCATCGAGCCGTTTTCCAGCCCGCCAGAGCTGCCCGATGTGATGAAGCCCCAGGACTCGGGAAGCAGTGCCAATGAACAAGCCGTGCAGTGAGGACCCCCAAGAGGCCCATTTCCCCCAATAAAAGAGATTTGGGAGTCTGCCTGGTTGCTGCCTCTTTTTCCCGCCCCTCCCTGGGATGGGTCCCACTCCCTGTGGGCTCCTTTTGGGGCTTGTGCTTGGCAGTTCCTGTGCTGTCCTGTCTCCCAGATCCTGAGACCCTGGCTGAGAACTTGGCCCAGCCTGCTGCTTAAAGGCACCATGGGGACCTGGGTTGCCCTGAGACCCAAGCCATTGTTAGCAGCTAGCCAGCCACACCAACCACGCCAGGGGGAGGAAAGGGAAGGACTGGGAGAGACACAAAGACCAGAGCCAGCCTCAGGGACAAGAGATTCCAGTTTTAGGCCTTTCTCCTTCTAAGTGCCCCCCACCCCCATAGCCTGCATGTCCACTCCCAGACGATGGCCAAGAGCAGAAACACAAGCTGGAGCCAGTGTCCTGGTTTGACAGCATGTTCAACGAGGGAACCCCAAGACGGACCCACACAGGTCCACCCACGCTGGGGGCTGTAATCACGGAGGGAAGTGGCTGCCCCCTTAACACACCTTTAATAAACAGTCTACAGACCCA |