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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ELOBP1
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:25365762-25366179  UCSC
Coordinates (T2T) chr13:24575451-24575868  UCSC
Coordinates (hg19) chr13:25939900-25940317  UCSC
Strand -
Parental Sequence NM_007108.4
Parental seq. overlap 385 bp
Parental seq. overlap (%) 39.5%
Genomic Region Intergenic
Retrocopy Summary ELOBP1, located on chr13:25365762-25366179, is a retrocopy of the parental gene ELOB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ELOB
Full Name elongin B
Also known as SIII|TCEB2
Coordinate chr16:2771414-2777280
Strand -
Gene summary This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ELOBP3
Bonobo Pan paniscus ELOBP3
Gorilla Gorilla gorilla ELOBP2
Gibbon Nomascus leucogenys ELOBP1
Marmoset Callithrix jacchus ELOBP3
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ELOBP1
TCGAGGGGAGAGGCAGCCGCCGGGATGGAAGTGTTCCTCACCATCCGGCGCCACAAGACCAGCATCTTCACGGACGCCAAGGAGTCCAGCGCGGTGTTCGAGCTGAAGCGCATCGTTGAGGCCATCCTCAAGCTGCTGCCAGATGAGCAGTGGCTGTGCTAGGACGACCAACTCTTGGATGATGGCAAGACACTGGGTGAGTGTGGCTTCACCAGCCAAACAGCACGGCCACAGGCCCCAGCCACAGTGGGGCTCGCCTTCCGCGCAGACGACAGCTTTGAGACCCTGTGCATCGAGCCGTTTTCCAGCCCGCCTGAGCTGCCCGACGTGATGAAGCCCCAGGACTCGGGAAGCAGTGCCAATGAACAAGCCGTGCAGTGAGGACGCCCGAGTTCCCCCCAATAGAAGAGATTTGGGG
>NM_007108.4
GCGGCTGCGCCGGCGCGTCGAGGGGAGAGGCAGCAGCCGCGATGGACGTGTTCCTCATGATCCGGCGCCACAAGACCACCATCTTCACGGACGCCAAGGAGTCCAGCACGGTGTTCGAACTGAAGCGCATCGTCGAGGGCATCCTCAAGCGGCCTCCTGACGAGCAGCGGCTGTACAAGGATGACCAACTCTTGGATGATGGCAAGACACTGGGCGAGTGTGGCTTCACCAGTCAAACAGCACGGCCACAGGCCCCAGCCACAGTGGGGCTGGCCTTCCGGGCAGATGACACCTTTGAGGCCCTGTGCATCGAGCCGTTTTCCAGCCCGCCAGAGCTGCCCGATGTGATGAAGCCCCAGGACTCGGGAAGCAGTGCCAATGAACAAGCCGTGCAGTGAGGACCCCCAAGAGGCCCATTTCCCCCAATAAAAGAGATTTGGGAGTCTGCCTGGTTGCTGCCTCTTTTTCCCGCCCCTCCCTGGGATGGGTCCCACTCCCTGTGGGCTCCTTTTGGGGCTTGTGCTTGGCAGTTCCTGTGCTGTCCTGTCTCCCAGATCCTGAGACCCTGGCTGAGAACTTGGCCCAGCCTGCTGCTTAAAGGCACCATGGGGACCTGGGTTGCCCTGAGACCCAAGCCATTGTTAGCAGCTAGCCAGCCACACCAACCACGCCAGGGGGAGGAAAGGGAAGGACTGGGAGAGACACAAAGACCAGAGCCAGCCTCAGGGACAAGAGATTCCAGTTTTAGGCCTTTCTCCTTCTAAGTGCCCCCCACCCCCATAGCCTGCATGTCCACTCCCAGACGATGGCCAAGAGCAGAAACACAAGCTGGAGCCAGTGTCCTGGTTTGACAGCATGTTCAACGAGGGAACCCCAAGACGGACCCACACAGGTCCACCCACGCTGGGGGCTGTAATCACGGAGGGAAGTGGCTGCCCCCTTAACACACCTTTAATAAACAGTCTACAGACCCA

Publications

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