| Gene Name | TGIF1 |
|
| Specie | Homo sapiens | |
| Full Name | TGFB induced factor homeobox 1 | |
| Also known as | HPE4|TGIF | |
| Coordinate | chr18:3412009-3459978 | |
| Strand | + | |
| Gene summary | The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| TGIF1P1 | chr19:46136294-46137634 | - |
Intragenic |
ENSG00000259339 | UCSC |
| >NM_170695.5 |
| ACATTCTTTCAGACCCGGCCCGCTGCGGGGCGTTCCTGGGGGGTAGCCTCAAGGCCAGCGGGGTTCCTTCGGCTGCGTTTCTGTGGGAGGCCCTGAAACGCGCGGAGCTTCCCTCTGCCTCCAGGCTTTCCCAGCGAGAGTGAAATTAAACTTGAAACTCGGATCAACTGGCAGTCGTTGTTGGTAGAACGCCCTAAGGACCCCTCCCCGCGGGACGGAGGGAGGACTCGGGACAGGGAATTGGCCCTGGGAGAAAACGCGCGGGGGGCGTCCGAGACGCCCCGTGAAAGCCGTGCCGACCCTTGGGAGGACTGACAGGTCTAGAGACACGCGCTGTCTGTTGTGGTGGGCCTCCCGGGAATAAGTGAGGGGCTCTGTGTTTCGAGGATGGTTCTAGCGCAGAGCCGGGTGTCTGCCGGGGTGGGCTCCCCGCATTGTTCGGGCTCCGGCGGGGGCGGCTCTGATTCCTTTCCATGGCCCGCCTCCCACCCCGGGAATCCCCAGTGCTCCTTTTCCACGGCTTTTCTGGCGTCCCCCCGACTCTCCCGCGGCACTTTGGCCTACCTTCCCCCAGCGCCGTGGTCCTCCCTGGCGACCCCCTCTGCGCTCCTGGGGTCCTCCTGCGCCCCCCCTCCTCCACCGGCGCGCTGCCCACAGCCGCGTGCCCTCTCCCCGGAGCTGGGGACCAAGGCTGGGCCCCGCCGGCCGCATCGGTGGGAACTTCCGCGGTCCCCATCCCAGGGCGCACAGGGTCCAGCTCCTCGGCGCCGACTCCTGGAAACAATGAAAGGTATTGTTGCAGCATCTGGCAGTGAGACTGAGGATGAGGACAGCATGGACATTCCCTTGGACCTTTCTTCATCCGCTGGCTCAGGCAAGAGAAGGAGAAGGGGCAACCTACCCAAGGAGTCTGTGCAGATTCTTCGGGATTGGCTGTATGAGCACCGTTACAATGCCTATCCTTCAGAGCAAGAAAAAGCGTTGCTGTCCCAGCAAACACACCTGTCTACGCTACAGGTCTGTAACTGGTTCATCAACGCCCGCCGCAGGCTCCTCCCTGACATGCTGAGAAAGGATGGCAAAGATCCAAATCAGTTCACAATTTCCCGCCGTGGGGCCAAGATTTCTGAAACGAGCTCTGTGGAGTCCGTGATGGGCATCAAAAACTTCATGCCAGCTCTAGAGGAGACCCCATTTCATTCCTGTACAGCTGGGCCAAACCCAACCCTAGGGAGGCCACTGTCTCCTAAGCCGTCATCCCCGGGATCAGTTTTGGCTCGTCCATCAGTGATCTGCCATACCACTGTGACTGCATTGAAAGATGTCCCTTTCTCTCTCTGCCAGTCGGTCGGTGTGGGACAAAACACAGATATACAGCAGATAGCGGCCAAAAACTTCACAGACACCTCTCTCATGTACCCAGAGGACACTTGTAAATCTGGACCAAGTACGAATACACAGAGTGGTCTTTTCAACACTCCTCCCCCTACTCCACCGGACCTCAACCAGGACTTCAGTGGATTTCAGCTTCTAGTGGATGTTGCACTCAAACGGGCTGCAGAGATGGAGCTTCAGGCAAAACTTACAGCTTAACCCATTTTCAAGCAAAACAGTTCTCAGAAATGTCATGATTGCCGGGGTGAAGGCAAGAGATGAATTGCATTATTTTATATATTTTTTATTAATATTTGCACATGGGATTGCTAAAACAGCTTCCTGTTACTGAGATGTCTTCAATGGAATACAGTCATTCCAAGAACTATAAACTTAAAGCTACTGTAGAAACAAAGGGTTTTCTTTTTTAAATGTTTCTTGGTAGATTATTCATAATGTGAGATGGTTCCCAATATCATGTGATTTTTTTTTTCCTCCCCTTCCCTTTTTTTGTTATTTTTTCAGACTGTGCAATACTTAGAGAACCTATAGCATCTTCTCATTCCCATGTGGAACAGGATGCCCACATACTGTCTAATTAATAAATTTTCCATTTTTTTTCAAACAAGTATGAATCTAGTTGGTTGATGCCTTTTTTTTCATGACATAATAAAGTATTTTCTTTAAAAATTGTTGTAATTCAGAGTATTTCTGTTGAGGGAGGTGCTTCTTAAAAATAAGTAGGAATATAGCACCCCAGTGAGCAGGAAGCTGGGGGGGTAGGGTGCAGTGTTAGGGGGTGTCACCAGCTCTTTGAAAACCTGTGGACAACAAGCCAGTTTGCATAAACAGGATGTGTGATATTTACTCTTGATAGGAGGCATAGCAGGCCCTTAGAGCTTTACTTAAACTGCATGGCAAATTGAAATGAATCATTTTAGTGTTTAGCTAGCCACTAAATCCCTTGCTGATCTGTCCTGCGTAGTTTAAAACGTGGCCATGTTATAAAGAAAAGTCTTGAAGCATCCGGTTATTGCTGAGTTTTCAGAAGAAAACAACGCAAGCAATCTCTTGCCCTTTTTCCACGTTACCCTTTAAAATAACCTTTGTTCAGTGGTACATTTAGTTAAGGCATTTGTATTCAAATGTAGCATAGTATTTGCAGAGAAATTACCTTTTAAAACATCTCAAAAGTGTTTTCTAAAATGATGAAATAAACGGTGGGGTTCTGTCTATGGTGGGATTGTCAGTTTATTAGGTGAGTATTTTCCAAGGTCTCAGTTTGTGAAAAAATGGTGCTATGTACAAGTGGAGTTTGTTGGGATAGACAATCACTTACAAAGCCCAGATGGCCAGAAGGGAATTGGTGTTGCTCCTTTCACTTGTATGGTTGAGCAGATTTGTCACATGCCACAAAACCATTCTTTGTAGTCATGCTTAGTATGAGCTTGCTTTGTTGTTACGGTCATGTTCTTTCCAGCCCTGCCCCAGCTATGAATTGTCTAAGTGTGAGGGAGCATCAGAGCTTCAGTATTGTTTAAAGAATGTAGAAAAATACAAATTTGTCTAATTTTGAAACTATTTTAGAAAGTCCCTACTGTAGAAAGAGCTAAACTCAAAGACTTTCCTTGTAAGTGAAAGAAAAAAACTGCTGATGATTACCAAGAGGCGTAAGAAAATTAGGTGAGGGAATGTTGTGCTCTAGCCTGTGGGGTGCAGCTTCGTAGGGCACATCAGCTTAGAATGGTCTGGCCTCACCTCAGAGAGTCACAGAAATAGACAAAAACCCAAAAAGTACTAGTAAAGTAAATACAAGGAACAAAATAAACATTAATAAAAATGAATGACGCAAAGGTGATCCAGAATCATTACTTGCTCCAACAGCTAGATCAAAGGCTGAACATTTTGCTTTAGTATAGATGAGGGAAATGAGCAAGTCCTAAAAGGTTTGCCCTGTTACGGTGTTTCATCACTCATACTGGAAGGAGAAGGAAAGGAGCCATATGACTCATTTAAAAGAAAAACTGTAAGTCACCTTAAATTCCCTATGTTTTACTTCATTTTTTCCCTATTGAGGTTGTTACAGGTCATGGTTGATAATAGTTGGTGTTGAATGAATGTAATCCATTATTTAAAAACAGGTACATTTAAGTGAAAAGATAAATGTAAAAAGCTGTTCATATCAAAGCCAAATAGAAATGAtttttatgcttataatttacatggtgcaatatatctttttaatttgtttactttt |