Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TGIF1P1
Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chr18). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr19:46136294-46137634  UCSC
Coordinates (T2T) chr19:48963697-48965037  UCSC
Coordinates (hg19) chr19:46639551-46640891  UCSC
Strand -
Parental Sequence NM_170695.5
Parental seq. overlap 1191 bp
Parental seq. overlap (%) 32.3%
Genomic Region Intragenic (IGFL2)
Retrocopy Summary TGIF1P1, located on chr19:46136294-46137634, is a retrocopy of the parental gene TGIF1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TGIF1
Full Name TGFB induced factor homeobox 1
Also known as HPE4|TGIF
Coordinate chr18:3412009-3459978
Strand +
Gene summary The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TGIF1P1
Bonobo Pan paniscus TGIF1P1
Gorilla Gorilla gorilla TGIF1P1
Orangutan Pongo abelii TGIF1P1
Gibbon Nomascus leucogenys TGIF1P1
Baboon Papio anubis TGIF1P1
Golden snub-nosed monkey Rhinopithecus roxellana TGIF1P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TGIF1P1
CAGGGTCCTGCTCCTCTGCACTGACTCATGGAAACAATGAAAGGTATTGTTGCAGCATCTGGCAGTGAGACGGAGGATGACGATTCCATGGACATTCCCTTGGACCTTCCTTCATCCTCTGGCTCAGGCAAGAGAAGGAGAAGGGGCAACCTGCCCAAGGAGTCTGTGCAGATTCTTCAAGATTGGCTGTATGAGCACCATTACAATGTCCATCCTTCCGAGCAAGAAAAAGCACTGTTGTCCCAGCAAACATATCTGTCTACACTACAGGTCTGTAACTGGTTCATCAACGCCCGCCACAAGCTTCTCAGATAAATGAGCCTACGAAGGAGATAATATTGCATGTGGTGTACGCATCCTGACATGCTGAGAAAGGATGGCAAAGATCCAAATCAGTTCACAATTACCTGCCGTGGGCCCAAGATTTCTGAAACAAGCTCTGTGAAGTTTGTGATGGGCATCAAAAACTTCATGCCAGCTCTAGAGGAGACCCCATTTCATTCCTGTACATCTGGGCCAAACCCAACCCTAGGGAGGCCATTGTCTCCTAAGCCGTCTTCCCCAGGATCAGTTTTGGCTCGTCCATCAGTGATCTGCCATGCCACTGTGACTGCATTGAAAGATGTCCCTTTCTCTGCCAGTCAGTTGGTGTGGGACAAAACACAGATATACAGCAGGTAGCAGCCAACAACTTTACAGACACCTCTCTCATGTGCCCAGAGGACATGTGTAAATCTAGACCAAGTACCAATACACAGAGTAGTCTTTTCAACACTCCTCCCCCTACTCCAATGGATCTCAACCAGGACTTTAGTGGATTTCAGCTTCTAGTGAATGTTGCACTCAAACGGGTTGGAGAGACAGAGCTTCAGCCGAAACTTACAGCTTAACCCATTTTCAAGCAAAACAGTTCTCAGAAATGTCATGATTTCTGGGGTGATGGCAAGAGATGAATTGCATTATTTTATATATTTTTTTATTAATATCTGCACATGGGATTGCTAAAACAGCCTCCTGTTACTGAGATGTCTTCAATGGAATACAGTCATTCCAAGAACTATAAACTCAAAGCTACTGCAGAAACAAAGAGTATTATTTTTTACATGTTTATTGGTAGATTATTCATAATGTGAGATGGCTCCCAATATCATGTGATTTTTTCCCCTTTCCTTCTCCTTTCTTGTTATTTTTTTACACTGTGCAATTCTTAAAGAACCTATAGCATCTTTTCATTCCCATGTGGAACAAGATGCCCACATTCTGCCTATTTAATAGATTTTCAATTCTTGTTCAAACAAGTATGAATCTAGTTAATTGATGAGTTTTTTCATGACATAATAT
>NM_170695.5
ACATTCTTTCAGACCCGGCCCGCTGCGGGGCGTTCCTGGGGGGTAGCCTCAAGGCCAGCGGGGTTCCTTCGGCTGCGTTTCTGTGGGAGGCCCTGAAACGCGCGGAGCTTCCCTCTGCCTCCAGGCTTTCCCAGCGAGAGTGAAATTAAACTTGAAACTCGGATCAACTGGCAGTCGTTGTTGGTAGAACGCCCTAAGGACCCCTCCCCGCGGGACGGAGGGAGGACTCGGGACAGGGAATTGGCCCTGGGAGAAAACGCGCGGGGGGCGTCCGAGACGCCCCGTGAAAGCCGTGCCGACCCTTGGGAGGACTGACAGGTCTAGAGACACGCGCTGTCTGTTGTGGTGGGCCTCCCGGGAATAAGTGAGGGGCTCTGTGTTTCGAGGATGGTTCTAGCGCAGAGCCGGGTGTCTGCCGGGGTGGGCTCCCCGCATTGTTCGGGCTCCGGCGGGGGCGGCTCTGATTCCTTTCCATGGCCCGCCTCCCACCCCGGGAATCCCCAGTGCTCCTTTTCCACGGCTTTTCTGGCGTCCCCCCGACTCTCCCGCGGCACTTTGGCCTACCTTCCCCCAGCGCCGTGGTCCTCCCTGGCGACCCCCTCTGCGCTCCTGGGGTCCTCCTGCGCCCCCCCTCCTCCACCGGCGCGCTGCCCACAGCCGCGTGCCCTCTCCCCGGAGCTGGGGACCAAGGCTGGGCCCCGCCGGCCGCATCGGTGGGAACTTCCGCGGTCCCCATCCCAGGGCGCACAGGGTCCAGCTCCTCGGCGCCGACTCCTGGAAACAATGAAAGGTATTGTTGCAGCATCTGGCAGTGAGACTGAGGATGAGGACAGCATGGACATTCCCTTGGACCTTTCTTCATCCGCTGGCTCAGGCAAGAGAAGGAGAAGGGGCAACCTACCCAAGGAGTCTGTGCAGATTCTTCGGGATTGGCTGTATGAGCACCGTTACAATGCCTATCCTTCAGAGCAAGAAAAAGCGTTGCTGTCCCAGCAAACACACCTGTCTACGCTACAGGTCTGTAACTGGTTCATCAACGCCCGCCGCAGGCTCCTCCCTGACATGCTGAGAAAGGATGGCAAAGATCCAAATCAGTTCACAATTTCCCGCCGTGGGGCCAAGATTTCTGAAACGAGCTCTGTGGAGTCCGTGATGGGCATCAAAAACTTCATGCCAGCTCTAGAGGAGACCCCATTTCATTCCTGTACAGCTGGGCCAAACCCAACCCTAGGGAGGCCACTGTCTCCTAAGCCGTCATCCCCGGGATCAGTTTTGGCTCGTCCATCAGTGATCTGCCATACCACTGTGACTGCATTGAAAGATGTCCCTTTCTCTCTCTGCCAGTCGGTCGGTGTGGGACAAAACACAGATATACAGCAGATAGCGGCCAAAAACTTCACAGACACCTCTCTCATGTACCCAGAGGACACTTGTAAATCTGGACCAAGTACGAATACACAGAGTGGTCTTTTCAACACTCCTCCCCCTACTCCACCGGACCTCAACCAGGACTTCAGTGGATTTCAGCTTCTAGTGGATGTTGCACTCAAACGGGCTGCAGAGATGGAGCTTCAGGCAAAACTTACAGCTTAACCCATTTTCAAGCAAAACAGTTCTCAGAAATGTCATGATTGCCGGGGTGAAGGCAAGAGATGAATTGCATTATTTTATATATTTTTTATTAATATTTGCACATGGGATTGCTAAAACAGCTTCCTGTTACTGAGATGTCTTCAATGGAATACAGTCATTCCAAGAACTATAAACTTAAAGCTACTGTAGAAACAAAGGGTTTTCTTTTTTAAATGTTTCTTGGTAGATTATTCATAATGTGAGATGGTTCCCAATATCATGTGATTTTTTTTTTCCTCCCCTTCCCTTTTTTTGTTATTTTTTCAGACTGTGCAATACTTAGAGAACCTATAGCATCTTCTCATTCCCATGTGGAACAGGATGCCCACATACTGTCTAATTAATAAATTTTCCATTTTTTTTCAAACAAGTATGAATCTAGTTGGTTGATGCCTTTTTTTTCATGACATAATAAAGTATTTTCTTTAAAAATTGTTGTAATTCAGAGTATTTCTGTTGAGGGAGGTGCTTCTTAAAAATAAGTAGGAATATAGCACCCCAGTGAGCAGGAAGCTGGGGGGGTAGGGTGCAGTGTTAGGGGGTGTCACCAGCTCTTTGAAAACCTGTGGACAACAAGCCAGTTTGCATAAACAGGATGTGTGATATTTACTCTTGATAGGAGGCATAGCAGGCCCTTAGAGCTTTACTTAAACTGCATGGCAAATTGAAATGAATCATTTTAGTGTTTAGCTAGCCACTAAATCCCTTGCTGATCTGTCCTGCGTAGTTTAAAACGTGGCCATGTTATAAAGAAAAGTCTTGAAGCATCCGGTTATTGCTGAGTTTTCAGAAGAAAACAACGCAAGCAATCTCTTGCCCTTTTTCCACGTTACCCTTTAAAATAACCTTTGTTCAGTGGTACATTTAGTTAAGGCATTTGTATTCAAATGTAGCATAGTATTTGCAGAGAAATTACCTTTTAAAACATCTCAAAAGTGTTTTCTAAAATGATGAAATAAACGGTGGGGTTCTGTCTATGGTGGGATTGTCAGTTTATTAGGTGAGTATTTTCCAAGGTCTCAGTTTGTGAAAAAATGGTGCTATGTACAAGTGGAGTTTGTTGGGATAGACAATCACTTACAAAGCCCAGATGGCCAGAAGGGAATTGGTGTTGCTCCTTTCACTTGTATGGTTGAGCAGATTTGTCACATGCCACAAAACCATTCTTTGTAGTCATGCTTAGTATGAGCTTGCTTTGTTGTTACGGTCATGTTCTTTCCAGCCCTGCCCCAGCTATGAATTGTCTAAGTGTGAGGGAGCATCAGAGCTTCAGTATTGTTTAAAGAATGTAGAAAAATACAAATTTGTCTAATTTTGAAACTATTTTAGAAAGTCCCTACTGTAGAAAGAGCTAAACTCAAAGACTTTCCTTGTAAGTGAAAGAAAAAAACTGCTGATGATTACCAAGAGGCGTAAGAAAATTAGGTGAGGGAATGTTGTGCTCTAGCCTGTGGGGTGCAGCTTCGTAGGGCACATCAGCTTAGAATGGTCTGGCCTCACCTCAGAGAGTCACAGAAATAGACAAAAACCCAAAAAGTACTAGTAAAGTAAATACAAGGAACAAAATAAACATTAATAAAAATGAATGACGCAAAGGTGATCCAGAATCATTACTTGCTCCAACAGCTAGATCAAAGGCTGAACATTTTGCTTTAGTATAGATGAGGGAAATGAGCAAGTCCTAAAAGGTTTGCCCTGTTACGGTGTTTCATCACTCATACTGGAAGGAGAAGGAAAGGAGCCATATGACTCATTTAAAAGAAAAACTGTAAGTCACCTTAAATTCCCTATGTTTTACTTCATTTTTTCCCTATTGAGGTTGTTACAGGTCATGGTTGATAATAGTTGGTGTTGAATGAATGTAATCCATTATTTAAAAACAGGTACATTTAAGTGAAAAGATAAATGTAAAAAGCTGTTCATATCAAAGCCAAATAGAAATGAtttttatgcttataatttacatggtgcaatatatctttttaatttgtttactttt

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