| Gene Name | TPMT |
|
| Specie | Homo sapiens | |
| Full Name | thiopurine S-methyltransferase | |
| Also known as | TPMTD | |
| Coordinate | chr6:18128311-18155169 | |
| Strand | - | |
| Gene summary | This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| TPMTP1 | chr18:47630029-47631792 | + |
Intergenic |
ENSG00000267156 | UCSC |
| TPMTP3 | chrX:51979219-51980039 | - |
Intergenic |
ENSG00000232562 | UCSC |
| TPMTP2 | chr3:42144802-42146395 | - |
Intragenic |
ENSG00000234562 | UCSC |
| TPMTP4 | chrX:86128830-86129485 | - |
Intergenic |
ENSG00000223574 | UCSC |
| >NM_000367.5 |
| GTCATTGGTGGCGGAGGCAATGGCCGGCAACCAGCTGTAAGCGAGGCACGGAAGACATATGCTTGTGAGACAAAGGTGTCTCTGAAACTATGGATGGTACAAGAACTTCACTTGACATTGAAGAGTACTCGGATACTGAGGTACAGAAAAACCAAGTACTAACTCTGGAAGAATGGCAAGACAAGTGGGTGAACGGCAAGACTGCTTTTCATCAGGAACAAGGACATCAGCTATTAAAGAAGCATTTAGATACTTTCCTTAAAGGCAAGAGTGGACTGAGGGTATTTTTTCCTCTTTGCGGAAAAGCGGTTGAGATGAAATGGTTTGCAGACCGGGGACACAGTGTAGTTGGTGTGGAAATCAGTGAACTTGGGATACAAGAATTTTTTACAGAGCAGAATCTTTCTTACTCAGAAGAACCAATCACCGAAATTCCTGGAACCAAAGTATTTAAGAGTTCTTCGGGGAACATTTCATTGTACTGTTGCAGTATTTTTGATCTTCCCAGGACAAATATTGGCAAATTTGACATGATTTGGGATAGAGGAGCATTAGTTGCCATCAATCCAGGTGATCGCAAATGCTATGCAGATACAATGTTTTCCCTCCTGGGAAAGAAGTTTCAGTATCTCCTGTGTGTTCTTTCTTATGATCCAACTAAACATCCAGGTCCACCATTTTATGTTCCACATGCTGAAATTGAAAGGTTGTTTGGTAAAATATGCAATATACGTTGTCTTGAGAAGGTTGATGCTTTTGAAGAACGACATAAAAGTTGGGGAATTGACTGTCTTTTTGAAAAGTTATATCTACTTACAGAAAAGTAAATGAGACATAGATAAAATAAAATCACACTGACATGTTTTTGAGGAATTGAAAATTATGCTAAAGCCTGAAAATGTAATGGATGAATTTTTAAAATTGTTTATAAATCATATGATAGATCTTTACTAAAAATGGCTTTTTAGTAAAGCCATTTACTTTTTCTAAAAAAGTTTTAGAAGAAAAAGATGTAACTAAACTTTTAAAGTAGCTCCTTTGGAGAGGAGATTATGATGTGAAAGATTATGCCTATGTGTCTTGCAGATTGCAAGATATTTTACCAATCAGCATGTGTTACCTGTACAATTAAAAAAATATTTCAAAATGCAATGCATATTAAATATAATACACACAGAAAAACTGGCAtttattttgttttatttttttgagatggagtttcgttcttgttgcccaacctggagtgcaatggtgcaatctcagctcactgcaacctctgcctcccaggttcaggtgattctcctgcctcagcctcctgagtagctgggattacaggtgtgcgccaccacgcccagctaattttttgtatttttagtagagacagggtttcaccatgttggtcaggctgatctcgagctcctgacctcaggtgatctacccacctcggcctcccaaagtgctgggattacaggcgtgagccactgcacctggccTGACATTCTTTATGAAATTTAGAATTGTTGAAGAACTATAACATTTCAGTAGGGTTCAAGGTGGTCCCAAAAGTTATATAAAAGATTAGTTTTTACTATAAACCCTTGTCTTTTACTCAGATCCTAGCATCCCTTTTCACATGGTTTCTCCATGTATATAACAGAATCAAGAAACAAATTTTAATTAAACAATCTGTAACAGAATCAAGAAACAAATACATTTTAATTAAACAATCTATATGGAACAAACATTCCCAAATTCTAAGAATAAATTTTTCTTTAAGTTTTCTCTGAGTTTGGCAATTGTTGTTTTTTATAATTTAATCTGTTTAAATCATCAGGTCTTATAAAATATAATGTACTTAGAGCTGGATTCATGGCTGTTTATTATGAAAGGTTAGATTTCTCAGTTCTTCTTTAACCACATTTTGTTATATCAGACAGTCCTCTATAACTCTGTACTACCCAACAACTAAATGGTTTAGATTGTTTAGCTCATGTTAATAGGATGGTTGTGTATTATAAAAAACGAGTTACGTGTGTGTGTGCACGCATGCACGCACATGTGCTGGCTTAAAGGTTGTTAATGCAAGGtttggggtcccctttaacactggtgaaagctacggtactctccccagagatatgTCTTGTCAGCCTCTCTAGTTCCCCTTGGCCTGCATGTACAAACTTCTACCCTAGAAGCTCTCTGCCATCGATGTATTCTAATAGATTTGTAAGGCTATTAATTTGAAGCAACTCCTTGCTCACAGTGATTCTTGCTTCTCTGAGACCTGCTCCCAGTCGATACTGTGGGCTTCAGAAGCCATGACTCCCCAACTCTGCCTGTATCACCGGTTGAATGGACAACTAACCCGAGCTGGACCAACACAATTCTCTCCAGAGACTTTTGAttttacttttatgtagagacagggtctcactttgttgcccacgctgatgttgaacttgacgtgaggcctcaagcagtcctcctgtcttggccacccaaagtgctaggattacaggtatgagccattgcgctggccCTCTTCATAGGCTTTTGGACTTGGGAATAGAAAAGCaaccccgtctctactaaaaatacaaaaaaattagccaggcgtggtggcacgtgcctgtaatcccagctacttgggaggctgaggcaggagaatcacttgaacctaggaggcggaggttgcagtgagctgagatcatgccactgcacgcaagcctgggcaacagagcaagactctgtctcaaaagaaagaaaaagaaaagaaaaaaaaGAAAGGCAAGTTGACTGCTGAAAGGGGAATCTGtgtacgcctgggagctgtggggcagccacattccagcacatggatctgagaaacagaacgctgatctgcagaaagagatgagaaccaaagagaggcCACCTGCGTCCTGGGTCCATTTTCATCCTCCCTGAAGCCCAGCTGCCCAGGGTGGGGAGAAACACCCTGTGTCCATGGGATAGAGTCCTTTCCGCTTGCAGTTGTGCCCAAAGAATCTTAAATACAAATGAGATATCCTTAGGTAGTTGATCATTTATGTAATATGTGTCTTCACTGGGGAATACTGACTTCCTAAAATCTCAAGATGGAAGATATACCACATGTAAATTATTTTAGAGCAATTAAATTGTTTTCAGGATTTTCCAAAAA |
| >NM_001346817.1 |
| aggcggggcgcgggcggaggcggggcgcgggcggaggcggggcgCGGAGAAGTGGCGGAGGTGGAAGCGGAGGCGTACCCGCCCCTGGGGACGTCATTGGTGGCGGAGGCAATGGCCGGCAACCAGCTGTAAGCGAGgaagctctggaggttaggcttcaccaatataagcgtggtcactaaaaaataacaacaaaaaaaagaggaagacatgaaataaagctggagattcagacaagaaggaaatctccagaatgatgatgaagagcgatcccagaaagctagctgtctaccaagattagagaataatcagggcagattccaggagagaattctccaagatgatattgatagtatagctgatgactggagagactgactgtgtactgataggaaattgggacaattggcagaatttagagttgaattaggagtaagtacaataatgcctacgtgatgaagcctacataaaaacccaagaggatggggtttggagagcctcctaatagctcaacagGCACGGAAGACATATGCTTGTGAGACAAAGGTGTCTCTGAAACTATGGATGGTACAAGAACTTCACTTGACATTGAAGAGTACTCGGATACTGAGGTACAGAAAAACCAAGTACTAACTCTGGAAGAATGGCAAGACAAGTGGGTGAACGGCAAGACTGCTTTTCATCAGGAACAAGGACATCAGCTATTAAAGAAGCATTTAGATACTTTCCTTAAAGGCAAGAGTGGACTGAGGGTATTTTTTCCTCTTTGCGGAAAAGCGGTTGAGATGAAATGGTTTGCAGACCGGGGACACAGTGTAGTTGGTGTGGAAATCAGTGAACTTGGGATACAAGAATTTTTTACAGAGCAGAATCTTTCTTACTCAGAAGAACCAATCACCGAAATTCCTGGAACCAAAGTATTTAAGAGTTCTTCGGGGAACATTTCATTGTACTGTTGCAGTATTTTTGATCTTCCCAGGACAAATATTGGCAAATTTGACATGATTTGGGATAGAGGAGCATTAGTTGCCATCAATCCAGGTGATCGCAAATGCTATGCAGATACAATGTTTTCCCTCCTGGGAAAGAAGTTTCAGTATCTCCTGTGTGTTCTTTCTTATGATCCAACTAAACATCCAGGTCCACCATTTTATGTTCCACATGCTGAAATTGAAAGGTTGTTTGGTAAAATATGCAATATACGTTGTCTTGAGAAGGTTGATGCTTTTGAAGAACGACATAAAAGTTGGGGAATTGACTGTCTTTTTGAAAAGTTATATCTACTTACAGAAAAGTAAATGAGACATAGATAAAATAAAATCACACTGACATGTTTTTGAGGAATTGAAAATTATGCTAAAGCCTGAAAATGTAATGGATGAATTTTTAAAATTGTTTATAAATCATATGATAGATCTTTACTAAAAATGGCTTTTTAGTAAAGCCATTTACTTTTTCTAAAAAAGTTTTAGAAGAAAAAGATGTAACTAAACTTTTAAAGTAGCTCCTTTGGAGAGGAGATTATGATGTGAAAGATTATGCCTATGTGTCTTGCAGATTGCAAGATATTTTACCAATCAGCATGTGTTACCTGTACAATTAAAAAAATATTTCAAAATGCAATGCATATTAAATATAATACACACAGAAAAACTGGCAtttattttgttttatttttttgagatggagtttcgttcttgttgcccaacctggagtgcaatggtgcaatctcagctcactgcaacctctgcctcccaggttcaggtgattctcctgcctcagcctcctgagtagctgggattacaggtgtgcgccaccacgcccagctaattttttgtatttttagtagagacagggtttcaccatgttggtcaggctgatctcgagctcctgacctcaggtgatctacccacctcggcctcccaaagtgctgggattacaggcgtgagccactgcacctggccTGACATTCTTTATGAAATTTAGAATTGTTGAAGAACTATAACATTTCAGTAGGGTTCAAGGTGGTCCCAAAAGTTATATAAAAGATTAGTTTTTACTATAAACCCTTGTCTTTTACTCAGATCCTAGCATCCCTTTTCACATGGTTTCTCCATGTATATAACAGAATCAAGAAACAAATTTTAATTAAACAATCTGTAACAGAATCAAGAAACAAATACATTTTAATTAAACAATCTATATGGAACAAACATTCCCAAATTCTAAGAATAAATTTTTCTTTAAGTTTTCTCTGAGTTTGGCAATTGTTGTTTTTTATAATTTAATCTGTTTAAATCATCAGGTCTTATAAAATATAATGTACTTAGAGCTGGATTCATGGCTGTTTATTATGAAAGGTTAGATTTCTCAGTTCTTCTTTAACCACATTTTGTTATATCAGACAGTCCTCTATAACTCTGTACTACCCAACAACTAAATGGTTTAGATTGTTTAGCTCATGTTAATAGGATGGTTGTGTATTATAAAAAACGAGTTACGTGTGTGTGTGCACGCATGCACGCACATGTGCTGGCTTAAAGGTTGTTAATGCAAGGtttggggtcccctttaacactggtgaaagctacggtactctccccagagatatgTCTTGTCAGCCTCTCTAGTTCCCCTTGGCCTGCATGTACAAACTTCTACCCTAGAAGCTCTCTGCCATCGATGTATTCTAATAGATTTGTAAGGCTATTAATTTGAAGCAACTCCTTGCTCACAGTGATTCTTGCTTCTCTGAGACCTGCTCCCAGTCGATACTGTGGGCTTCAGAAGCCATGACTCCCCAACTCTGCCTGTATCACCGGTTGAATGGACAACTAACCCGAGCTGGACCAACACAATTCTCTCCAGAGACTTTTGAttttacttttatgtagagacagggtctcactttgttgcccacgctgatgttgaacttgacgtgaggcctcaagcagtcctcctgtcttggccacccaaagtgctaggattacaggtatgagccattgcgctggccCTCTTCATAGGCTTTTGGACTTGGGAATAGAAAAGCaaccccgtctctactaaaaatacaaaaaaattagccaggcgtggtggcacgtgcctgtaatcccagctacttgggaggctgaggcaggagaatcacttgaacctaggaggcggaggttgcagtgagctgagatcatgccactgcacgcaagcctgggcaacagagcaagactctgtctcaaaagaaagaaaaagaaaagaaaaaaaaGAAAGGCAAGTTGACTGCTGAAAGGGGAATCTGtgtacgcctgggagctgtggggcagccacattccagcacatggatctgagaaacagaacgctgatctgcagaaagagatgagaaccaaagagaggcCACCTGCGTCCTGGGTCCATTTTCATCCTCCCTGAAGCCCAGCTGCCCAGGGTGGGGAGAAACACCCTGTGTCCATGGGATAGAGTCCTTTCCGCTTGCAGTTGTGCCCAAAGAATCTTAAATACAAATGAGATATCCTTAGGTAGTTGATCATTTATGTAATATGTGTCTTCACTGGGGAATACTGACTTCCTAAAATCTCAAGATGGAAGATATACCACATGTAAATTATTTTAGAGCAATTAAATTGTTTTCAGGATTTTCCAAAAA |