Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TPMTP4
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:86128830-86129485  UCSC
Coordinates (T2T) chrX:84560041-84560696  UCSC
Coordinates (hg19) chrX:85383834-85384489  UCSC
Strand -
Parental Sequence NM_001346817.1
Parental seq. overlap 569 bp
Parental seq. overlap (%) 15.5%
Genomic Region Intergenic
Retrocopy Summary TPMTP4, located on chrX:86128830-86129485, is a retrocopy of the parental gene TPMT. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TPMT
Full Name thiopurine S-methyltransferase
Also known as TPMTD
Coordinate chr6:18128311-18155169
Strand -
Gene summary This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TPMTP4
Bonobo Pan paniscus TPMTP4
Gorilla Gorilla gorilla TPMTP4
Orangutan Pongo abelii TPMTP4
Gibbon Nomascus leucogenys TPMTP4
Crab-eating macaque Macaca fascicularis TPMTP3
Rhesus Macaca mulatta TPMTP3
Baboon Papio anubis TPMTP2
Golden snub-nosed monkey Rhinopithecus roxellana TPMTP2
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TPMTP4
AAGCATTTGGATACTTTTCATAAAGGTGAGAGTGGACTGAGGATGTTTTTTCCTCTATATGGAAAAGTATTAATAGTTGAGATGAAATGGTTTGCAGACCAGGGACACAGTGCAGTTGGTGTGAAAATCAGTGAACTTGAGATACAAGAATTTTTTACACAGCAAATCTTTCTTACTCAGAAGAACCAATCACTAAAATTCCTGAAACCAAATATATAAGAGTTCTTCAGGGAACATTTCGTTGTACTGTTGCAGCATTTTTTATCTTCCCAGAACAAATATTGACAAATTTGACAGGATTTGGAATAGAGGAGCATTAGTTACCATTAATCCAGGTGGATTGTGAATGCTCTGCAAGTATAATGTTGTTCCTCCTGAGAAAACAGTTTCAGTACCTCATGTGTGTTCTTTCTTATGATTCAAGTAAAAACATGCAGCCCACCATTTTTATGTTCCACATGCTTAAATTGAAAGGTTATTTGGTACAATATGCAGTATTTATTGTCTTGGAAATGCTGATGCTTTTGAAGAACAACATAAAAGTTGGGGAATTGACTACATTTTTGGAAAGATAGATCTACTTACAGAAAAGTAAATGAGACATAAATAAAATCAAGTAACATTACCATGATTTTGAGCAATTGAAAATTATGCTG
>NM_001346817.1
aggcggggcgcgggcggaggcggggcgcgggcggaggcggggcgCGGAGAAGTGGCGGAGGTGGAAGCGGAGGCGTACCCGCCCCTGGGGACGTCATTGGTGGCGGAGGCAATGGCCGGCAACCAGCTGTAAGCGAGgaagctctggaggttaggcttcaccaatataagcgtggtcactaaaaaataacaacaaaaaaaagaggaagacatgaaataaagctggagattcagacaagaaggaaatctccagaatgatgatgaagagcgatcccagaaagctagctgtctaccaagattagagaataatcagggcagattccaggagagaattctccaagatgatattgatagtatagctgatgactggagagactgactgtgtactgataggaaattgggacaattggcagaatttagagttgaattaggagtaagtacaataatgcctacgtgatgaagcctacataaaaacccaagaggatggggtttggagagcctcctaatagctcaacagGCACGGAAGACATATGCTTGTGAGACAAAGGTGTCTCTGAAACTATGGATGGTACAAGAACTTCACTTGACATTGAAGAGTACTCGGATACTGAGGTACAGAAAAACCAAGTACTAACTCTGGAAGAATGGCAAGACAAGTGGGTGAACGGCAAGACTGCTTTTCATCAGGAACAAGGACATCAGCTATTAAAGAAGCATTTAGATACTTTCCTTAAAGGCAAGAGTGGACTGAGGGTATTTTTTCCTCTTTGCGGAAAAGCGGTTGAGATGAAATGGTTTGCAGACCGGGGACACAGTGTAGTTGGTGTGGAAATCAGTGAACTTGGGATACAAGAATTTTTTACAGAGCAGAATCTTTCTTACTCAGAAGAACCAATCACCGAAATTCCTGGAACCAAAGTATTTAAGAGTTCTTCGGGGAACATTTCATTGTACTGTTGCAGTATTTTTGATCTTCCCAGGACAAATATTGGCAAATTTGACATGATTTGGGATAGAGGAGCATTAGTTGCCATCAATCCAGGTGATCGCAAATGCTATGCAGATACAATGTTTTCCCTCCTGGGAAAGAAGTTTCAGTATCTCCTGTGTGTTCTTTCTTATGATCCAACTAAACATCCAGGTCCACCATTTTATGTTCCACATGCTGAAATTGAAAGGTTGTTTGGTAAAATATGCAATATACGTTGTCTTGAGAAGGTTGATGCTTTTGAAGAACGACATAAAAGTTGGGGAATTGACTGTCTTTTTGAAAAGTTATATCTACTTACAGAAAAGTAAATGAGACATAGATAAAATAAAATCACACTGACATGTTTTTGAGGAATTGAAAATTATGCTAAAGCCTGAAAATGTAATGGATGAATTTTTAAAATTGTTTATAAATCATATGATAGATCTTTACTAAAAATGGCTTTTTAGTAAAGCCATTTACTTTTTCTAAAAAAGTTTTAGAAGAAAAAGATGTAACTAAACTTTTAAAGTAGCTCCTTTGGAGAGGAGATTATGATGTGAAAGATTATGCCTATGTGTCTTGCAGATTGCAAGATATTTTACCAATCAGCATGTGTTACCTGTACAATTAAAAAAATATTTCAAAATGCAATGCATATTAAATATAATACACACAGAAAAACTGGCAtttattttgttttatttttttgagatggagtttcgttcttgttgcccaacctggagtgcaatggtgcaatctcagctcactgcaacctctgcctcccaggttcaggtgattctcctgcctcagcctcctgagtagctgggattacaggtgtgcgccaccacgcccagctaattttttgtatttttagtagagacagggtttcaccatgttggtcaggctgatctcgagctcctgacctcaggtgatctacccacctcggcctcccaaagtgctgggattacaggcgtgagccactgcacctggccTGACATTCTTTATGAAATTTAGAATTGTTGAAGAACTATAACATTTCAGTAGGGTTCAAGGTGGTCCCAAAAGTTATATAAAAGATTAGTTTTTACTATAAACCCTTGTCTTTTACTCAGATCCTAGCATCCCTTTTCACATGGTTTCTCCATGTATATAACAGAATCAAGAAACAAATTTTAATTAAACAATCTGTAACAGAATCAAGAAACAAATACATTTTAATTAAACAATCTATATGGAACAAACATTCCCAAATTCTAAGAATAAATTTTTCTTTAAGTTTTCTCTGAGTTTGGCAATTGTTGTTTTTTATAATTTAATCTGTTTAAATCATCAGGTCTTATAAAATATAATGTACTTAGAGCTGGATTCATGGCTGTTTATTATGAAAGGTTAGATTTCTCAGTTCTTCTTTAACCACATTTTGTTATATCAGACAGTCCTCTATAACTCTGTACTACCCAACAACTAAATGGTTTAGATTGTTTAGCTCATGTTAATAGGATGGTTGTGTATTATAAAAAACGAGTTACGTGTGTGTGTGCACGCATGCACGCACATGTGCTGGCTTAAAGGTTGTTAATGCAAGGtttggggtcccctttaacactggtgaaagctacggtactctccccagagatatgTCTTGTCAGCCTCTCTAGTTCCCCTTGGCCTGCATGTACAAACTTCTACCCTAGAAGCTCTCTGCCATCGATGTATTCTAATAGATTTGTAAGGCTATTAATTTGAAGCAACTCCTTGCTCACAGTGATTCTTGCTTCTCTGAGACCTGCTCCCAGTCGATACTGTGGGCTTCAGAAGCCATGACTCCCCAACTCTGCCTGTATCACCGGTTGAATGGACAACTAACCCGAGCTGGACCAACACAATTCTCTCCAGAGACTTTTGAttttacttttatgtagagacagggtctcactttgttgcccacgctgatgttgaacttgacgtgaggcctcaagcagtcctcctgtcttggccacccaaagtgctaggattacaggtatgagccattgcgctggccCTCTTCATAGGCTTTTGGACTTGGGAATAGAAAAGCaaccccgtctctactaaaaatacaaaaaaattagccaggcgtggtggcacgtgcctgtaatcccagctacttgggaggctgaggcaggagaatcacttgaacctaggaggcggaggttgcagtgagctgagatcatgccactgcacgcaagcctgggcaacagagcaagactctgtctcaaaagaaagaaaaagaaaagaaaaaaaaGAAAGGCAAGTTGACTGCTGAAAGGGGAATCTGtgtacgcctgggagctgtggggcagccacattccagcacatggatctgagaaacagaacgctgatctgcagaaagagatgagaaccaaagagaggcCACCTGCGTCCTGGGTCCATTTTCATCCTCCCTGAAGCCCAGCTGCCCAGGGTGGGGAGAAACACCCTGTGTCCATGGGATAGAGTCCTTTCCGCTTGCAGTTGTGCCCAAAGAATCTTAAATACAAATGAGATATCCTTAGGTAGTTGATCATTTATGTAATATGTGTCTTCACTGGGGAATACTGACTTCCTAAAATCTCAAGATGGAAGATATACCACATGTAAATTATTTTAGAGCAATTAAATTGTTTTCAGGATTTTCCAAAAA

Publications

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