Summary

Gene Name	DDX50
Specie	Homo sapiens
Full Name	DExD-box helicase 50
Also known as	GU2|GUB|RH-II/GuB|mcdrh
Coordinate	chr10:68898817-68956312
Strand	+
Gene summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. [provided by RefSeq, Jul 2008]

Retrocopy(s) from DDX50

Retroname	Coord	Strand	Genomic Region	ENSG
DDX50P1	chr2:32202632-32204218	+	Intragenic	ENSG00000229816	UCSC
DDX50P3	chr4:105678831-105680096	-	Intragenic	ENSG00000248778	UCSC
DDX50P2	chr3:154351923-154354870	-	Intragenic	ENSG00000240048	UCSC

Expression

Transcript Sequences

>NM_024045.2

CCTTTCACGCTGTCGCTGCCCGTAGGTGGTTGTGGCCACTGTGCCCGGAGGGAGGCGGCGGTGGCCAGTAATGCCTGGGAAACTCCTCTGGGGGGACATTATGGAGCTGGAAGCACCCTTGGAGGAGTCCGAGAGCCAGAAGAAGGAGAGGCAAAAGAGTGACAGAAGGAAGTCAAGGCACCATTATGACTCGGATGAGAAATCAGAAACAAGAGAAAATGGTGTTACAGATGACCTGGATGCTCCCAAGGCCAAAAAATCTAAAATGAAAGAGAAGCTAAATGGAGACACTGAAGAAGGATTTAATAGACTTTCAGATGAATTCTCCAAATCTCATAAGTCAAGAAGAAAAGATCTACCAAATGGAGATATAGATGAATATGAAAAAAAATCAAAGCGAGTATCATCTTTAGATACTTCTACTCATAAATCAAGTGATAATAAACTAGAGGAGACCTTAACACGTGAACAGAAAGAAGGAGCCTTCTCCAATTTTCCTATTTCTGAAGAGACTATAAAGCTTCTGAAAGGTCGAGGGGTAACATATCTCTTTCCTATTCAAGTTAAGACCTTTGGTCCTGTATATGAAGGAAAAGATTTAATAGCTCAAgcacggacaggaacaggaaagacattctcttttgccatccccttaattgaaaGACTCCAAAGAAATCAAGAAACAATTAAAAAAAGCCGCTCACCAAAGGTACTTGTTTTGGCTCCAACAAGGGAACTGGCAAACCAAGTAGCCAAAGACTTCAAAGATATAACTAGGAAACTCAGCGTGGCGTGTTTTTATGGTGGAACATCATATCAAAGCCAAATTAATCATATTCGAAATGGTATTGACATCTTGGTTGGAACACCTGGTCGTATCAAAGACCATCTGCAGAGTGGCCGATTGGATCTTTCTAAACTGCGACATGTTGTGCTTGATGAAGTGGATCAGATGTTAGATTTAGGTTTCGCTGAACAAGTTGAAGATATTATTCATGAATCCTACAAAACTGATTCTGAAGACAATCCTCAGACTTTACTTTTTTCTGCAACTTGCCCACAGTGGGTATACAAAGTTGCAAAAAAATACATGAAATCCAGATATGAACAGGTTGACCTTGTTGGAAAAATGACTCAAAAGGCTGCAACTACTGTGGAACATTTGGCCATCCAGTGTCATTGGTCTCAGAGGCCAGCAGTTATTGGAGATGTCCTTCAAGTCTACAGTGGGTCTGAAGGGAGGGCTATTATTTTCTGTGAGACCAAGAAGAATGTAACTGAAATGGCCATGAATCCACACATAAAACAGAATGCCCAGTGTTTACATGGGGACATTGCACAGTCACAAAGAGAAATTACACTAAAAGGCTTCAGAGAAGGTAGTTTTAAAGTTTTGGTGGCAACCAATGTGGCTGCCCGTGGTTTGGACATTCCTGAAGTTGACCTGGTGATTCAAAGTTCTCCTCCTCAGGATGTTGAGTCCTATATCCATCGCTCTGGACGCACAGGTAGAGCTGGACGGACAGGGATTTGTATATGTTTTTATCAACCAAGAGAAAGAGGTCAACTAAGATATGTGGAACAAAAAGCAGGAATTACTTTTAAACGTGTAGGTGTTCCTTCTACAATGGATTTAGTTAAATCTAAAAGCATGGATGCCATCAGGTCTCTGGCTTCCGTTTCTTACGCTGCTGTTGATTTTTTCCGACCATCAGCTCAGAGACTGATAGAAGAGAAAGGTGCAGTGGATGCATTGGCTGCAGCTTTAGCCCACATTTCTGGTGCATCAAGCTTTGAACCACGATCTTTGATCACCTCTGATAAGGGGTTTGTGACCATGACTCTGGAAAGCCTAGAGGAAATACAGGATGTCAGCTGTGCTTGGAAAGAACTTAACAGAAAGCTGAGTAGTAATGCAGTGTCTCAGATTACCAGAATGTGCCTCCTGAAAGGAAATATGGGTGTTTGCTTTGATGTTCCTACAACTGAGTCAGAAAGGTTACAGGCAGAGTGGCATGATTCCGACTGGATACTCTCAGTGCCAGCCAAATTACCTGAAATTGAAGAATATTATGATGGAAACACATCTTCTAATTCCAGACAGAGGAGTGGCTGGTCAAGTGGTCGATCAGGCCGGTCAGGCCGGTCAGGTGGTCGATCTGGCGGCCGGTCAGGTAGACAGAGTCGACAAGGAAGTCGCTCAGGAAGTCGACAAGATGGTAGAAGACGAAGTGGGAATAGAAATCGATCAAGAAGTGGGGGCCACAAACGGAGTTTTGACTGAGTATTTGATAGTTAATCTACCAGTGTGAGCTTGCCTATTTCTGCCTAATCATGTACATTATCCACCAAAAATTAGGTCATCATAGTTGAGGTATGTGTCTGCTATTTGCAAAGAAGTTGGTCGTATTTTTTTAAAAAGTATTTCACAAGAATGGAACAAATCTACTTATCCAGTTATACCTTTGAATAAAAAAACCTCCTTTTATTGTCTCTTTTCA

>XM_024448162.1

aggcatgtgccaccacgccccgcgaattttctatttttagtagagatgggtttcctccatgttggtcaggctagtcttgaactcctgacctcaggtgatccgcccaccctggcttcccaaagtgctggcgtgagccaccgctcccggccCTTTTCTTTTTATATCTTAATGGTCAGTTTAAACAAGCTGAGGCAAAGGGCAAGGGAAATCTTTATAGGACCTTGTAACAGGAGTAGCAACTGAAGCACCCAACTCTTAAGTGTTGTAAAAGAAAGTACATCAGTGACTCTGGTAAGATGTTTGGAAAATAAAGATGTTCTAATAAGATTGTATCTTGAATTATTGTGCATTTTAATTATTCATGCACAGTATGCCTCCCCCTAACCCCAAATCTCATCAGACACAATCTCTTGAGATTTACAGACAGAGCAAATATGAAGAAAACAAAGTTCTCCACTCCTGCATCCCGTTCCCACGTTTTCTAGTTGATTGAGGCAAAAATGATATCCCCGGAGAACACATGTGTAATGTGGTACATATTTTTTTCAGCTAAGCCACTCCTTGGTCAAATTACTGACACATCGGTTTATACTTGCCCTTTCCATCTGACACAGACAGCAGCCAGAGATTTGGTTCAGTGAATTTAGGGCTTAGAAAGGCAGAGTCTGTAGTGTTGCAAGTCACAGAAGGTCATTCTAAAACACTCGTATACTTGTTAATCACTTGAATAGGGAGATTTGAACAGTCTACTCCTTTCTTTTTTTTCAGGCCCGCTCTTAGGACCTCTGACATACAAATGAATGCCAAAGAGTGCTCAGGAGCTCAACTTTTACTTCAGCTGTTATTAACCTTCAACCACAAGACAATAACATCTGTTCCTTTTATCCCAATTTTACGTGCGGCATTCTTAGCCATATCTACACTGTGTTTTTATGCACATCATCATACCCTGTTGTAGGGCTATAAAGACCCTACTATGGTAGAATTGGGAGTGGACTGAGGGATTAGGACAAAAGGATGTGGAAAACCGCAGATCTAGAGATGCATAGCTATTCTCATAACCTAGGAAGAGAGGTGGATTTCTCCGTCATCAATAGCTGAACACTCCTTGTGTTTCTAAGTATTGAATCCATAAAGTTACATGCAAACATACAGCCCTTGCCTTCAGGCCAAGCCGTAGTTATGCAGAAGGcttgaagcaatcacagatttaacatttgtggttccagctattcaggaccaattcccaaactccacgacatgtaacaatttgtaattttgctaggacacagtttgatgcttaggttttaaggctggtgtgcTAGACGTTATCAAGTGGTTTGTGAGAGTAGCCCTGTGTCTCCATTGGGTAGAGTAGCTGGGTCGCAAGGATCATGAAGAGATGAAGAAATGGCTGTGAAAAGCCAACTAGCCTCGGTGATAGTAAGCAAAGGTATAGAAACACTAAGGAAGTTACCCTTTGTATTGTCAAAGGTTTCAGTTTTGTGTAAGGTGGTGATTCACGGGCAGTTAATCTCCATCACTAAAATTAAATCCTTTTTTATTCATTGCAAATAGATAATCTGTGGAAGACATTTTGGCTTTTCTCGCTAGCAGAAAATGTGAGGCTTCTTCAGGTTTTTCCTGTTCATTGTTTCACGGGAGCATCTTCCCCAAAACACTGCAAAACTCAAAGTTCTcaggctgatgtggcagaaagagcattgatctcggcttcaggagctaaattctctagtcctgactgtgccactaacagactgtgggacttcagacaagtacattcctttctcgggtttcttatgtcaaatggACAGCGTGAGAAGGATCACAATGAACCAGGGATCAGCTTCACGATTAAAACCTAAGACTTAAGAGACGGACATCTGTCCGTTCCTGGCTACACCTCCGGCCCATCTGGCCCACCCCAAACTGCGCGAAGCCCCTCTCCACCGACGCCAGGCCTGTGGCCTCGCGCGAAGCTGTTGGTCGTTAACATCTCCCCCGCAATGGGCGGGATGGAGGGCTTCAGCTTCCGGCTGCAAATGGCGAGGCGGCGCGCGGCGTTGCCCACTGGCCTCGGCATGGGCCTGCCCACGCACCCGCCCAGCGCGCGCCGGACCCTGTCTACCGCCGTTGAAGGGCTTCCCAGCCCTAGCAGTGCGTACTGGGAAGCCCCCAAAAGGCTCTGCGAGGCCGAGGAGACCCGTTCGGAGTGGGGGAGGGGAAGATAAACCGAACTATTTATGTTAATCAGTGCATGCTTCCTTTATGGAGATTGGCCAGGGTTTTACTCTAGTAACCAATCACTTCAGAACAAGGGCGGGCCCGTTGATATCTCTCACACTCATTGGTTGAGAGGTTGCGGCGCAATGGAAGGTCTTAAACCGAGAGTATCCGGGATTATTTTTCCCCGCCGTGCGGTGCGTGTCCCGGAAGTGACGCATGGCCAAGGCCGGGCGGCCGCCTTGCCCCCGCTTCCTTTCACGCTGTCGCTGCCCGTAGGTGGTTGTGGCCACTGTGCCCGGAGGGAGGCGGCGGTGGCCAGTAATGCCTGGGAAACTCCTCTGGGGGGACATTATGGAGCTGGAAGCACCCTTGGAGGAGTCCGAGAGCCAGAAGAAGGAGAGGCAAAAGgtgtttattgaacctaatttgtaccatactctttgctgagtaccaaggaggttaaactaaataagtaaagaaatggtctctgctctcaaggagcctgtagAGGAGTTGTAGTCTTTCCTCCTCCCAGCCCCCTGCCCTCCaaaaaaaaaaaaaaaaaaaaaggaaaagaaaaaaCATCCTGAAACACTCAGAGGATCACAAGGTGCTGAAAAAATGCCCAGGTAAAATTATTactggagacatttgacctggaaaaaagaaatcagctgaagaggctaaggtggcagtattcgaaggctgacattcgacaaaagaatgagacttattttgtatagccttagaaagcagaaTCTACCTCTCTGACCTTATCACTAAGAGTGACAGAAGGAAGTCAAGGCACCATTATGACTCGGATGAGAAATCAGAAACAAGAGAAAATGGTGTTACAGATGACCTGGATGCTCCCAAGGCCAAAAAATCTAAAATGAAAGAGAAGCTAAATGGAGACACTGAAGAAGGATTTAATAGACTTTCAGATGAATTCTCCAAATCTCATAAGTCAAGAAGAAAAGATCTACCAAATGGAGATATAGATGAATATGAAAAAAAATCAAAGCGAGTATCATCTTTAGATACTTCTACTCATAAATCAAGTGATAATAAACTAGAGGAGACCTTAACACGTGAACAGAAAGAAGGAGCCTTCTCCAATTTTCCTATTTCTGAAGAGACTATAAAGCTTCTGAAAGGTCGAGGGGTAACATATCTCTTTCCTATTCAAGTTAAGACCTTTGGTCCTGTATATGAAGGAAAAGATTTAATAGCTCAAgcacggacaggaacaggaaagacattctcttttgccatccccttaattgaaaGACTCCAAAGAAATCAAGAAACAATTAAAAAAAGCCGCTCACCAAAGGTACTTGTTTTGGCTCCAACAAGGGAACTGGCAAACCAAGTAGCCAAAGACTTCAAAGATATAACTAGGAAACTCAGCGTGGCGTGTTTTTATGGTGGAACATCATATCAAAGCCAAATTAATCATATTCGAAATGGTATTGACATCTTGGTTGGAACACCTGGTCGTATCAAAGACCATCTGCAGAGTGGCCGATTGGATCTTTCTAAACTGCGACATGTTGTGCTTGATGAAGTGGATCAGATGTTAGATTTAGGTTTCGCTGAACAAGTTGAAGATATTATTCATGAATCCTACAAAACTGATTCTGAAGACAATCCTCAGACTTTACTTTTTTCTGCAACTTGCCCACAGTGGGTATACAAAGTTGCAAAAAAATACATGAAATCCAGATATGAACAGGTTGACCTTGTTGGAAAAATGACTCAAAAGGCTGCAACTACTGTGGAACATTTGGCCATCCAGTGTCATTGGTCTCAGAGGCCAGCAGTTATTGGAGATGTCCTTCAAGTCTACAGTGGGTCTGAAGGGAGGGCTATTATTTTCTGTGAGACCAAGAAGAATGTAACTGAAATGGCCATGAATCCACACATAAAACAGAATGCCCAGTGTTTACATGGGGACATTGCACAGTCACAAAGAGAAATTACACTAAAAGGCTTCAGAGAAGGTAGTTTTAAAGTTTTGGTGGCAACCAATGTGGCTGCCCGTGGTTTGGACATTCCTGAAGTTGACCTGGTGATTCAAAGTTCTCCTCCTCAGGATGTTGAGTCCTATATCCATCGCTCTGGACGCACAGGTAGAGCTGGACGGACAGGGATTTGTATATGTTTTTATCAACCAAGAGAAAGAGGTCAACTAAGATATGTGGAACAAAAAGCAGGAATTACTTTTAAACGTGTAGGTGTTCCTTCTACAATGGATTTAGTTAAATCTAAAAGCATGGATGCCATCAGGTCTCTGGCTTCCGTTTCTTACGCTGCTGTTGATTTTTTCCGACCATCAGCTCAGAGACTGATAGAAGAGAAAGGTGCAGTGGATGCATTGGCTGCAGCTTTAGCCCACATTTCTGGTGCATCAAGCTTTGAACCACGATCTTTGATCACCTCTGATAAGGGGTTTGTGACCATGACTCTGGAAAGCCTAGAGGAAATACAGGATGTCAGCTGTGCTTGGAAAGAACTTAACAGAAAGCTGAGTAGTAATGCAGTGTCTCAGATTACCAGAATGTGCCTCCTGAAAGGAAATATGGGTGTTTGCTTTGATGTTCCTACAACTGAGTCAGAAAGGTTACAGGCAGAGTGGCATGATTCCGACTGGATACTCTCAGTGCCAGCCAAATTACCTGAAATTGAAGAATATTATGATGGAAACACATCTTCTAATTCCAGACAGAGGAGTGGCTGGTCAAGTGGTCGATCAGGCCGGTCAGGCCGGTCAGGTGGTCGATCTGGCGGCCGGTCAGGTAGACAGAGTCGACAAGGAAGTCGCTCAGGAAGTCGACAAGATGGTAGAAGACGAAGTGGGAATAGAAATCGATCAAGAAGTGGGGGCCACAAACGGAGTTTTGACTGAGTATTTGATAGTTAATCTACCAGTGTGAGCTTGCCTATTTCTGCCTAATCATGTACATTATCCACCAAAAATTAGGTCATCATAGTTGAGGTATGTGTCTGCTATTTGCAAAGAAGTTGGTCGTATTTTTTTAAAAAGTATTTCACAAGAATGGAACAAATCTACTTATCCAGTTATACCTTTGAATAAAAAAACCTCCTTTTATTGTCTCTTTTCA