Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DDX50P3
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:105678831-105680096  UCSC
Coordinates (T2T) chr4:108989957-108991222  UCSC
Coordinates (hg19) chr4:106599988-106601253  UCSC
Strand -
Parental Sequence NM_024045.2
Parental seq. overlap 1183 bp
Parental seq. overlap (%) 47.2%
Genomic Region Intragenic (ARHGEF38)
Retrocopy Summary DDX50P3, located on chr4:105678831-105680096, is a retrocopy of the parental gene DDX50. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DDX50
Full Name DExD-box helicase 50
Also known as GU2|GUB|RH-II/GuB|mcdrh
Coordinate chr10:68898817-68956312
Strand +
Gene summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DDX50P3
Bonobo Pan paniscus DDX50P3
Gorilla Gorilla gorilla DDX50P3
Orangutan Pongo abelii DDX50P3
Gibbon Nomascus leucogenys DDX50P1
Green monkey Chlorocebus sabaeus DDX50P1
Crab-eating macaque Macaca fascicularis DDX50P2
Rhesus Macaca mulatta DDX50P2
Baboon Papio anubis DDX50P2
Golden snub-nosed monkey Rhinopithecus roxellana DDX50P2
Marmoset Callithrix jacchus DDX50P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DDX50P3
GAGATGTCCTTCAAGTCTACAGTGGATCTGAAGGGAGGGCTATTATTTTCTGTGAGACGAAGAAGAATGTAACTGACATGGCCATGAATCCGCACAAAACAGAATGCACTGTGTTTACATGGGGACATTGCACAGTCACAAAGAGAAATTACACTAAAAGGCTTCAGAGAGGTAATTATAAAGTTTTGGTGGCAACCAATGTGGCTCCTCGTGGTTTGGACATTCCTGTAGTTGACCTGGTGATTCAAAGTTCTCCTCCTCAGGATATTGAGTCCTATATCCATCTCTCTGGATGCGTGGGTAAAGCTGGACAGACAGGGGTTTGTATATGTTTTTATCAACCAAGAGAAAGGTCAACTAAGACATGTGGAACAAAAAACACAAATTACTTTTAAATGTGTAGGTGTTCCTTCTACAATGGATTTAGTTAAATTTAAAAGCATGGATGCCATAAGGTCTCTGGCTTCCATTTCTTATGCTGCTGTTGATTTTTTTCCAACCATCAGCTCAGATACTGATAGAAGAGAAAGGGGCGATAGATGCATTGGCTGCAGCTTTAGCCCACATTTCTGGTGTATCAAGCTTTGAACCATGATCTTTAATCAACTCTGATAAGGGGTTTGTGACCATGACTCTGGAAAGCCTAGAGGAAATACAGGATGTCAGCTGTGCTTGGAAAGAACTTAGAAAGCTGAATAGTAATGCAGTGTCTCAGATTACCAGAGTGTGCCTCCTGAAAGGAAATATGGGTGTTTGCTTTGATATTCCTCCAATTGAGTCAAAGGTTACAGGCAAAGTGGCATGATTCCGGCTGGATACTCTCAGTGCCAGCTAAATTACCTGAAATTAAAGAATATTATGATGGAAACATCTTTTAATTCCAGACAGAGGAGTGGCTGGTCAGGCCAGTCAGGTTGTCGATCTGGCAATTGGTCAGGTAGAGAGAGTCGACAAAGCAGTTGCTCAGGAAAGTCGGCAAGATGGTAGAAGACGAAGTGGAACAGAAATAGATCAAGAAGTGGGGGCCACAAATGGAGTTTTGACTGAGTATTTGATAGTTAATTTAGCAGTGTGAGCTTGCCTATTTCTACCTAATCTTACATTATGGATCAAAAATTAGGTCATCATTGTTGAGGTATGTGTCTACTATTTGCAAAGAAGTTGATCGTATTTTTTTAAAAAAGTATTTCACAAGAATGATTGTAAACAAATCTACTTATCCAGTTATACCTTTGAATAAAAAAACCTCCTTTTATTGTCTCTTTa
>NM_024045.2
CCTTTCACGCTGTCGCTGCCCGTAGGTGGTTGTGGCCACTGTGCCCGGAGGGAGGCGGCGGTGGCCAGTAATGCCTGGGAAACTCCTCTGGGGGGACATTATGGAGCTGGAAGCACCCTTGGAGGAGTCCGAGAGCCAGAAGAAGGAGAGGCAAAAGAGTGACAGAAGGAAGTCAAGGCACCATTATGACTCGGATGAGAAATCAGAAACAAGAGAAAATGGTGTTACAGATGACCTGGATGCTCCCAAGGCCAAAAAATCTAAAATGAAAGAGAAGCTAAATGGAGACACTGAAGAAGGATTTAATAGACTTTCAGATGAATTCTCCAAATCTCATAAGTCAAGAAGAAAAGATCTACCAAATGGAGATATAGATGAATATGAAAAAAAATCAAAGCGAGTATCATCTTTAGATACTTCTACTCATAAATCAAGTGATAATAAACTAGAGGAGACCTTAACACGTGAACAGAAAGAAGGAGCCTTCTCCAATTTTCCTATTTCTGAAGAGACTATAAAGCTTCTGAAAGGTCGAGGGGTAACATATCTCTTTCCTATTCAAGTTAAGACCTTTGGTCCTGTATATGAAGGAAAAGATTTAATAGCTCAAgcacggacaggaacaggaaagacattctcttttgccatccccttaattgaaaGACTCCAAAGAAATCAAGAAACAATTAAAAAAAGCCGCTCACCAAAGGTACTTGTTTTGGCTCCAACAAGGGAACTGGCAAACCAAGTAGCCAAAGACTTCAAAGATATAACTAGGAAACTCAGCGTGGCGTGTTTTTATGGTGGAACATCATATCAAAGCCAAATTAATCATATTCGAAATGGTATTGACATCTTGGTTGGAACACCTGGTCGTATCAAAGACCATCTGCAGAGTGGCCGATTGGATCTTTCTAAACTGCGACATGTTGTGCTTGATGAAGTGGATCAGATGTTAGATTTAGGTTTCGCTGAACAAGTTGAAGATATTATTCATGAATCCTACAAAACTGATTCTGAAGACAATCCTCAGACTTTACTTTTTTCTGCAACTTGCCCACAGTGGGTATACAAAGTTGCAAAAAAATACATGAAATCCAGATATGAACAGGTTGACCTTGTTGGAAAAATGACTCAAAAGGCTGCAACTACTGTGGAACATTTGGCCATCCAGTGTCATTGGTCTCAGAGGCCAGCAGTTATTGGAGATGTCCTTCAAGTCTACAGTGGGTCTGAAGGGAGGGCTATTATTTTCTGTGAGACCAAGAAGAATGTAACTGAAATGGCCATGAATCCACACATAAAACAGAATGCCCAGTGTTTACATGGGGACATTGCACAGTCACAAAGAGAAATTACACTAAAAGGCTTCAGAGAAGGTAGTTTTAAAGTTTTGGTGGCAACCAATGTGGCTGCCCGTGGTTTGGACATTCCTGAAGTTGACCTGGTGATTCAAAGTTCTCCTCCTCAGGATGTTGAGTCCTATATCCATCGCTCTGGACGCACAGGTAGAGCTGGACGGACAGGGATTTGTATATGTTTTTATCAACCAAGAGAAAGAGGTCAACTAAGATATGTGGAACAAAAAGCAGGAATTACTTTTAAACGTGTAGGTGTTCCTTCTACAATGGATTTAGTTAAATCTAAAAGCATGGATGCCATCAGGTCTCTGGCTTCCGTTTCTTACGCTGCTGTTGATTTTTTCCGACCATCAGCTCAGAGACTGATAGAAGAGAAAGGTGCAGTGGATGCATTGGCTGCAGCTTTAGCCCACATTTCTGGTGCATCAAGCTTTGAACCACGATCTTTGATCACCTCTGATAAGGGGTTTGTGACCATGACTCTGGAAAGCCTAGAGGAAATACAGGATGTCAGCTGTGCTTGGAAAGAACTTAACAGAAAGCTGAGTAGTAATGCAGTGTCTCAGATTACCAGAATGTGCCTCCTGAAAGGAAATATGGGTGTTTGCTTTGATGTTCCTACAACTGAGTCAGAAAGGTTACAGGCAGAGTGGCATGATTCCGACTGGATACTCTCAGTGCCAGCCAAATTACCTGAAATTGAAGAATATTATGATGGAAACACATCTTCTAATTCCAGACAGAGGAGTGGCTGGTCAAGTGGTCGATCAGGCCGGTCAGGCCGGTCAGGTGGTCGATCTGGCGGCCGGTCAGGTAGACAGAGTCGACAAGGAAGTCGCTCAGGAAGTCGACAAGATGGTAGAAGACGAAGTGGGAATAGAAATCGATCAAGAAGTGGGGGCCACAAACGGAGTTTTGACTGAGTATTTGATAGTTAATCTACCAGTGTGAGCTTGCCTATTTCTGCCTAATCATGTACATTATCCACCAAAAATTAGGTCATCATAGTTGAGGTATGTGTCTGCTATTTGCAAAGAAGTTGGTCGTATTTTTTTAAAAAGTATTTCACAAGAATGGAACAAATCTACTTATCCAGTTATACCTTTGAATAAAAAAACCTCCTTTTATTGTCTCTTTTCA

Publications

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