Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Gene Name PABPN1
Plot displaying the genomic locations of a parental gene (in chr14) and its retrocopy(ies). Each line represents a retrocopy.
Specie Homo sapiens
Full Name poly(A) binding protein nuclear 1
Also known as OPMD|PAB2|PABII|PABP-2|PABP2
Coordinate chr14:23321457-23326163
Strand +
Gene summary This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]

Retrocopy(s) from PABPN1

Retroname Coord Strand Genomic Region ENSG
PABPN1P2 chr19:52809807-52814012 + Intergenic
 ENSG00000255875 UCSC
PABPN1P1 chrX:71419231-71420966 - Intragenic
 ENSG00000213018 UCSC

Expression

Transcript Sequences

>NM_004643.4
AGTCTGAgcggcgatggcggcggcggcggcggcggcagcagcagcgggggctgcgggcggtcggggctccgggccggggcggcggcgCCATCTTGTGCCCGGGGCCGGTGGGGAGGCCGGGGAGGGGGCCCCGGGGGGCGCAGGGGACTACGGGAACGgcctggagtctgaggaactggagcctgaggagctgctgctggagcccgagccggagcccgagcccgaAGAGGAGCcgccccggccccgcgcccccccgggagctccgggccctgggccTGGTTCGGGAGCCCCCGGCAGCCAAGAGGAGGAGGAGGAGCCGGGACTGGTCGAGGGTGACCCGGGGGACGGCGCCATTGAGGACCCGGAGCTGGAAGCTATCAAAGCTCGAGTCAGGGAGATGGAGGAAGAAGCTGAGAAGCTAAAGGAGCTACAGAACGAGGTAGAGAAGCAGATGAATATGAGTCCACCTCCAGGCAATGCTGGCCCGGTGATCATGTCCATTGAGGAGAAGATGGAGGCTGATGCCCGTTCCATCTATGTTGGCAATGTGGACTATGGTGCAACAGCAGAAGAGCTGGAAGCTCACTTTCATGGCTGTGGTTCAGTCAACCGTGTTACCATACTGTGTGACAAATTTAGTGGCCATCCCAAAGGGTTTGCGTATATAGAGTTCTCAGACAAAGAGTCAGTGAGGACTTCCTTGGCCTTAGATGAGTCCCTATTTAGAGGAAGGCAAATCAAGGTGATCCCAAAACGAACCAACAGACCAGGCATCAGCACAACAGACCGGGGTTTTCCACGAGCCCGCTACCGCGCCCGGACCACCAACTACAACAGCTCCCGCTCTCGATTCTACAGTGGTTTTAACAGCAGGCCCCGGGGTCGCGTCTACAGGGGCCGGGCTAGAGCGACATCATGGTATTCCCCTTACTAAAAAAAGTGTGTATTaggaggagagagaggaaaaaaagaggaaagaaggaaaaaaaaaagaattaaaaaaaaaaaaaagaaaaaCAGAAGATGACCTTGATGGAAAAAAAATATTTTTTAAAAAAAAGATATACTGTGGAAGGGGGGAGAATCCCATAACTAACTGCTGAGGAGGGACCTGCTTTGGGGAGTAGGGGAAGGCCCAGGGAGTGGGGCAGGGGGCTGCTTATTCACTCTGGGGATTCGCCATGGACACGTCTCAACTGCGCAAGCTGCTGCCCATGTTTCCCTGCCCCACTTCACCCCCTTGGGGGCTGCTCAAGGGTAGGTGGGCGTGGGTGGTAGGAGGTTTTTTTTTTTACCCAGGGCTCTGGAAGGACACCAAACTGTTCTGCTTGTTACCTTCCCTCCGTCTTCTCCTCGCCTTTCACAGTCCCCTCCTGCCTGCTCCTGTCCAGCCAGGTCTACCACCCACCCCACCCCTCTTCTCCGGCTCCCTGCCCCTCCAGATTGCCTGGTGATCTATTTTGTTTCCTTTTGTGTTTCTTTTTCTGTTTTGAGTGTCTTTCTTTGCAGGTTTCTGTAGCCGGAAGATCTCCGTTCCGCTCCCAGCGGCTCCAGTGTAAATTCCCCTTCCCCCTGGGGAAATGCACTACCTTGTTTTGGGGGGTTTAGGGGTGtttttgtttttcagttgttttgtttttttgttttttttttttttCCTTTGCCTTTTTTCCCTTTTATTTGGAgggaatgggaggaagtgggaacagggaggtgggaggtggATTTTGTTTATTTTTTTAGCTCATTTCCAGGGGTGGGAATTTTTTTTTAATATGTGTCATGAATAAAGTTGTTTTTGAAAATAAAAA