Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PABPN1P2
Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr19:52809807-52814012  UCSC
Coordinates (hg19) chr19:53313060-53317265  UCSC
Strand +
Parental Sequence NM_004643.4
Parental seq. overlap 1492 bp
Parental seq. overlap (%) 71.6%
Genomic Region Intergenic
Retrocopy Summary PABPN1P2, located on chr19:52809807-52814012, is a retrocopy of the parental gene PABPN1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PABPN1
Full Name poly(A) binding protein nuclear 1
Also known as OPMD|PAB2|PABII|PABP-2|PABP2
Coordinate chr14:23321457-23326163
Strand +
Gene summary This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PABPN1P2
AGTAGCACTGGGCCTGCGGGCGGTCCGGGATCCAGGCCGGGGCGGCGCCATCTTGTGCCCGGGGCCGGTGGGGAGGCCGGGGAGGTTGCCCCGGGGGGCGCAGGGGACGATGGGAACGCGAAGAGGAGCCGCTCCAGCCCCGCGCCCCATGCCTGGGAGCTCCAGGACCTGGGCCTCGTTCAGGAGCCACCGGCAGCCAAGAGGAGGGGGAGGAGCCGGGACTGGTCGAGGGTGACCCGGGGCTGGAAGCTATCGAAGCTGGAGTCAGGGAGGTGGAGGAAGAAGCTGAGAAGCTAAAGGAGCTACAGAACGACGTAGAGAAGCAGAGGAATATGAGTCTACCTCCAGGCAATGCTGGCCCAGTGATCACGTCCATTGAGGAGAAGATGGAGGCTGATGCCCGTTCCATCAATGCTGGCAATGTGGACTGCGGTGCAACAGCAGAAGAGCTGGAAGCTCACTTTCATGGCTGTGGTTCAGTCAACCACGTTACCATACTCTGTGACAAATTTAGTGGCCATCCCAAAGGGTTTGCATATATAGAGTTCTCAAAGAGTCAGTGAGGACTTCCTTGGCCTTGGATGAGTCCCTATTTAGAGGAAGGCAAATCAAGGTGATCCCAAAGCGAACCAACAGACCAGGCATCAGCACAACAGACCGGGGTCTTCCACGAGCCCGCTACCGCGCCCGACCACCAACTACAGCAGTTCCTGCTCTCCATTCTACAGTGGTTTTAACAGCAGGCTCTGGGGTCGCGTCTACAGGGGCCGGGCTAGAGCGACATCACGGTATTCCCCTTACTAAAAAAAATGTGTATTAGGAGAGAGAGGAAAAAAAGAGGAAAGAAGGGGAAAAAAAAAGAATAAAAAAAAACCCAAAAAAAACAGAAGATGACCTTGATGGAAAAAAATATATATATATTTTTAAAAAAAGAGtccctctccctctccctctccaaaaaGTTTTAAGTGTGCTGTGTAGAGAGTGGCATGCTTGGATGACATAAACTGGGCAAGCCTTTGAGGAAATGCATCACCCTGATTACAGTAATAAAGTTAAACTAAACTATCACCCAATTTAAGCAATTTATACATTGTGAAAAGAGAACAATGCAACTCAGATGAAATTTTCCTAAATCTCCAGTTGTGGTAATCTTGGTTAATGCTTTATTGTCACTATACCAATACTTTTGCATGACATACTGTGGAAGGACAGAGAATCCCTAACAAACTGCTGAGGAGGGACCTGTTTTGGGCGGCTTATTCACTCTGGGGATTCGCCATGGACACGTCTCAACAGTGCAAGCTGCTCCCCGTGTTTCCCTGCCCCACTTCGCCCCCGTAGGGGCTGCTCCAGGGTAGGCGGGCGGGGGTGGTAGGAGGTTTTTTTTTTTACCCAGGGCTCTGGAAGGACACCAGACTGTTCGGCTTGTCACCTTCCCTCCGTCTTCTCCTCACCTTTCACAGTCCCCTCCTGCCTGCTCCTGTCCCTCCAGGTCTACCACCCACCCCACCCCTCTTCTCTGGCCCCCTGCCCCTCCAGATTGCCTGGTGATCTATTTTGTTTCCTTTTGTGTTTCTTTTTCTGTGTTGAGTGTCTTTGTTTACAGGTTTCTGCAGCCAGAAGATCTCCGTTCCGCTCCCAGCAGCTCCACTGTAAATTCCCCTTCCCCATGGGGAAATGCACTACCTTGTTTTGGGGGGTTTAGAGGtTCCCTTTTATTTGGAGGGAATAGGAGGAAGTGGGAACAGGGAGGTGGGAGATGGACTCTGTTTATTTTTTTAAGCTCATTTCCAGGGGTGGGAATTTTTTTTAATATGTGTCATGAATAAAGTTGTTTTTGAAAATAAAAA
>NM_004643.4
AGTCTGAgcggcgatggcggcggcggcggcggcggcagcagcagcgggggctgcgggcggtcggggctccgggccggggcggcggcgCCATCTTGTGCCCGGGGCCGGTGGGGAGGCCGGGGAGGGGGCCCCGGGGGGCGCAGGGGACTACGGGAACGgcctggagtctgaggaactggagcctgaggagctgctgctggagcccgagccggagcccgagcccgaAGAGGAGCcgccccggccccgcgcccccccgggagctccgggccctgggccTGGTTCGGGAGCCCCCGGCAGCCAAGAGGAGGAGGAGGAGCCGGGACTGGTCGAGGGTGACCCGGGGGACGGCGCCATTGAGGACCCGGAGCTGGAAGCTATCAAAGCTCGAGTCAGGGAGATGGAGGAAGAAGCTGAGAAGCTAAAGGAGCTACAGAACGAGGTAGAGAAGCAGATGAATATGAGTCCACCTCCAGGCAATGCTGGCCCGGTGATCATGTCCATTGAGGAGAAGATGGAGGCTGATGCCCGTTCCATCTATGTTGGCAATGTGGACTATGGTGCAACAGCAGAAGAGCTGGAAGCTCACTTTCATGGCTGTGGTTCAGTCAACCGTGTTACCATACTGTGTGACAAATTTAGTGGCCATCCCAAAGGGTTTGCGTATATAGAGTTCTCAGACAAAGAGTCAGTGAGGACTTCCTTGGCCTTAGATGAGTCCCTATTTAGAGGAAGGCAAATCAAGGTGATCCCAAAACGAACCAACAGACCAGGCATCAGCACAACAGACCGGGGTTTTCCACGAGCCCGCTACCGCGCCCGGACCACCAACTACAACAGCTCCCGCTCTCGATTCTACAGTGGTTTTAACAGCAGGCCCCGGGGTCGCGTCTACAGGGGCCGGGCTAGAGCGACATCATGGTATTCCCCTTACTAAAAAAAGTGTGTATTaggaggagagagaggaaaaaaagaggaaagaaggaaaaaaaaaagaattaaaaaaaaaaaaaagaaaaaCAGAAGATGACCTTGATGGAAAAAAAATATTTTTTAAAAAAAAGATATACTGTGGAAGGGGGGAGAATCCCATAACTAACTGCTGAGGAGGGACCTGCTTTGGGGAGTAGGGGAAGGCCCAGGGAGTGGGGCAGGGGGCTGCTTATTCACTCTGGGGATTCGCCATGGACACGTCTCAACTGCGCAAGCTGCTGCCCATGTTTCCCTGCCCCACTTCACCCCCTTGGGGGCTGCTCAAGGGTAGGTGGGCGTGGGTGGTAGGAGGTTTTTTTTTTTACCCAGGGCTCTGGAAGGACACCAAACTGTTCTGCTTGTTACCTTCCCTCCGTCTTCTCCTCGCCTTTCACAGTCCCCTCCTGCCTGCTCCTGTCCAGCCAGGTCTACCACCCACCCCACCCCTCTTCTCCGGCTCCCTGCCCCTCCAGATTGCCTGGTGATCTATTTTGTTTCCTTTTGTGTTTCTTTTTCTGTTTTGAGTGTCTTTCTTTGCAGGTTTCTGTAGCCGGAAGATCTCCGTTCCGCTCCCAGCGGCTCCAGTGTAAATTCCCCTTCCCCCTGGGGAAATGCACTACCTTGTTTTGGGGGGTTTAGGGGTGtttttgtttttcagttgttttgtttttttgttttttttttttttCCTTTGCCTTTTTTCCCTTTTATTTGGAgggaatgggaggaagtgggaacagggaggtgggaggtggATTTTGTTTATTTTTTTAGCTCATTTCCAGGGGTGGGAATTTTTTTTTAATATGTGTCATGAATAAAGTTGTTTTTGAAAATAAAAA

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