Summary

Gene Name	CRADD
Specie	Homo sapiens
Full Name	CASP2 and RIPK1 domain containing adaptor with death domain
Also known as	MRT34|RAIDD
Coordinate	chr12:93677342-93894840
Strand	+
Gene summary	This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Retrocopy(s) from CRADD

Retroname	Coord	Strand	Genomic Region	ENSG
CRADDP1	chr3:156987874-156988739	-	Intragenic	ENSG00000239706	UCSC

Expression

Transcript Sequences

>NM_003805.5

GCCATTAACAAAGATGGTGCTTATGGGGCAGGTTCCCTAACAGTCAGGATTCCGGTTGCAGTTTTTCTCCCCCGCCCCAAAGATACGTGGTTGCAGACGGAGAAATGGAGGCCAGAGACAAACAAGTACTCCGCTCACTTCGCCTGGAGCTGGGTGCAGAGGTATTGGTGGAGGGACTGGTTCTTCAGTACCTCTACCAGGAAGGAATCTTGACGGAAAACCATATTCAAGAAATCAATGCTCAAACCACAGGCCTCCGGAAAACAATGCTCCTGCTGGATATCCTACCTTCCAGGGGCCCTAAAGCATTTGATACATTCCTAGATTCCCTACAGGAGTTTCCCTGGGTCAGGGAGAAGCTGAAGAAGGCAAGGGAAGAGGCCATGACCGACCTGCCTGCAGGTGACAGATTGACTGGGATCCCCTCGCACATCCTCAACAGCTCCCCATCAGACCGGCAGATTAACCAGCTGGCCCAGAGGCTGGGCCCTGAGTGGGAGCCCATGGTGCTGTCTCTGGGACTGTCCCAGACGGATATCTACCGCTGTAAGGCCAACCACCCCCACAACGTGCAGTCGCAGGTGGTGGAGGCCTTCATCCGTTGGCGGCAGCGCTTCGGGAAGCAGGCCACCTTCCAGAGCCTGCACAACGGGCTGCGGGCTGTGGAGGTGGACCCCTCGCTGCTCCTGCACATGTTGGAGTGATGGTGCCTCCAGCAACCGCTGGGGAGTGTGTCCCTGAGTCATGTGGGCTGAATCCTGACTTTCACTCAGAGCAGGTGGTTTTTTGTGTAGGTTTGTTTTTTATTTTTGATGATCTTCAGATGGAAGGAGAAAACAGGGTTTCCACTAGACATTACTTGAAAGGCCAGATTACTCAGCAGATCTCCCATGTTGGCTCAACAATTCTTTGTTTTTAATTGCTTGAAGATTGCATTGTTGTAATTGTTCAGTTTTTAAATGTGTAATGGCATTTTAATAGACTAGTAAATCACAGTGGTTCAAAatatatatccatatatatatatatccatatatatatCTCATGTCATCACATTACAGGCAGGTGTCTCATATGTAAAACATTTACCTGAATGTTGTCTGAGGACTGAACTGTGGACTTTACTATTCATAATGATAAAATAATAAAATGCGAATTACTATATATAATGTGCCTCACTCATGAGAAA