Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CRADDP1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:156987874-156988739  UCSC
Coordinates (T2T) chr3:159762430-159763295  UCSC
Coordinates (hg19) chr3:156705663-156706528  UCSC
Strand -
Parental Sequence NM_003805.5
Parental seq. overlap 647 bp
Parental seq. overlap (%) 51.1%
Genomic Region Intragenic (LEKR1)
Retrocopy Summary CRADDP1, located on chr3:156987874-156988739, is a retrocopy of the parental gene CRADD. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CRADD
Full Name CASP2 and RIPK1 domain containing adaptor with death domain
Also known as MRT34|RAIDD
Coordinate chr12:93677342-93894840
Strand +
Gene summary This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CRADDP1
Bonobo Pan paniscus CRADDP1
Gorilla Gorilla gorilla CRADDP1
Orangutan Pongo abelii CRADDP1
Golden snub-nosed monkey Rhinopithecus roxellana CRADDP1
Marmoset Callithrix jacchus CRADDP1
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CRADDP1
AATGATCCTCAGATGGAAAGAGAAAACAGGGTTTCCACTTGACATTACCTGAAAGGCCAGATTACTCAGTAGATCTCCCAGATTGGTTCAACAATTCGTTGTTTTTAATTGCTTGAAGATTGCCTTGTTAcaaagatacatcaTTGTAGACTGAGAAATGGAGGCCAGAGACAAACAAGTGCTTTGCTTACTTTGCCTGAAGCTGGGTGCAGAGGCATTGGTGGAGGGACTGGTTCTTCAGTACCTTTACCAGGAAGGAATCTTGACAGGAAACCATGTCCAAGAAATTAAAGATCAAGCCACACGCCTCAAGAAAACAATGCTGCTGCTGCATAGCCTACTTTCCAGGGGTCCTAAAGCATTTGATACTTTCCTAGATTCGCTACAGGAATTTTCGTGGGTAAGGGAGAAGCTGGAGAAAGCAAGGGAAAAAGCCATGACTCAGCTGCCTGCAGGTGACACGATGACTGGGATCCCCTCGCACATCATCAGCTCCCCAACAAACTGGCAGATTAATCAGCTGACCCAGAGGCTGGGCCCTAAGTGGAAGTCCATGGTGCTGTCTTTGGTACTGTTCTAGACAGATATCTACCGCTGTAAGGCCAACCATCTCCACAATGTGCACTTGTAGGTGGTGGAGGCCTTTGTCTGTTGGTGGCAGCGCTTTGAGAAGCAGGCAACTTTCCAGAGCTTGCACAATGGGCTGCAGGCATGGAGGTAGACCTCTTGGTGTTCCTGCACATGTTGGAGTGAAAGTGCCTCTGCCAACCAGCTGAAGAGCATGTCTCCAAGTCACATGGACTGAATCCTGACTTTCAGTCAGAACAAGTGg
>NM_003805.5
GCCATTAACAAAGATGGTGCTTATGGGGCAGGTTCCCTAACAGTCAGGATTCCGGTTGCAGTTTTTCTCCCCCGCCCCAAAGATACGTGGTTGCAGACGGAGAAATGGAGGCCAGAGACAAACAAGTACTCCGCTCACTTCGCCTGGAGCTGGGTGCAGAGGTATTGGTGGAGGGACTGGTTCTTCAGTACCTCTACCAGGAAGGAATCTTGACGGAAAACCATATTCAAGAAATCAATGCTCAAACCACAGGCCTCCGGAAAACAATGCTCCTGCTGGATATCCTACCTTCCAGGGGCCCTAAAGCATTTGATACATTCCTAGATTCCCTACAGGAGTTTCCCTGGGTCAGGGAGAAGCTGAAGAAGGCAAGGGAAGAGGCCATGACCGACCTGCCTGCAGGTGACAGATTGACTGGGATCCCCTCGCACATCCTCAACAGCTCCCCATCAGACCGGCAGATTAACCAGCTGGCCCAGAGGCTGGGCCCTGAGTGGGAGCCCATGGTGCTGTCTCTGGGACTGTCCCAGACGGATATCTACCGCTGTAAGGCCAACCACCCCCACAACGTGCAGTCGCAGGTGGTGGAGGCCTTCATCCGTTGGCGGCAGCGCTTCGGGAAGCAGGCCACCTTCCAGAGCCTGCACAACGGGCTGCGGGCTGTGGAGGTGGACCCCTCGCTGCTCCTGCACATGTTGGAGTGATGGTGCCTCCAGCAACCGCTGGGGAGTGTGTCCCTGAGTCATGTGGGCTGAATCCTGACTTTCACTCAGAGCAGGTGGTTTTTTGTGTAGGTTTGTTTTTTATTTTTGATGATCTTCAGATGGAAGGAGAAAACAGGGTTTCCACTAGACATTACTTGAAAGGCCAGATTACTCAGCAGATCTCCCATGTTGGCTCAACAATTCTTTGTTTTTAATTGCTTGAAGATTGCATTGTTGTAATTGTTCAGTTTTTAAATGTGTAATGGCATTTTAATAGACTAGTAAATCACAGTGGTTCAAAatatatatccatatatatatatatccatatatatatCTCATGTCATCACATTACAGGCAGGTGTCTCATATGTAAAACATTTACCTGAATGTTGTCTGAGGACTGAACTGTGGACTTTACTATTCATAATGATAAAATAATAAAATGCGAATTACTATATATAATGTGCCTCACTCATGAGAAA

Publications

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