Summary

Gene Name	MAPK8IP1
Specie	Homo sapiens
Full Name	mitogen-activated protein kinase 8 interacting protein 1
Also known as	IB1|JIP-1|JIP1|PRKM8IP
Coordinate	chr11:45885651-45906465
Strand	+
Gene summary	This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

Retrocopy(s) from MAPK8IP1

Retroname	Coord	Strand	Genomic Region	ENSG
MAPK8IP1P2	chr17:45600130-45602341	-	Intergenic	ENSG00000263503	UCSC
MAPK8IP1P1	chr17:46243604-46245786	+	Intergenic	ENSG00000262500	UCSC

Expression

Transcript Sequences

>NM_005456.4

AGTCCCGCGGGCCGTGCGCGGTGCTGTGCCGCGCCCTGCCAGACACAGGTGCGCCCGCCTAGCCCGAACTccgcggcggcggctgccctctcgccgcgcctccgcctccttcgcagccgccgcctcctccgcgccgcgctccgccCGGATGGCCAGGGCTGTGCCCGAGAATGGCGGAGCGAGAAAGCGGCGGCCTGGGAGGGGGGGCCGCGTCCCCGCCCGCCGCCTCCCCGTTCCTGGGGCTGCACATCGCTTCGCCTCCCAATTTCAGGCTCACCCATGACATCAGCCTGGAGGAGTTTGAGGATGAAGACCTCTCGGAGATCACTGATGAGTGTGGCATCAGCTTACAGTGCAAAGACACCCTGTCCTTACGGCCCCCGCGCGCCGGGCTGCTCTCTGCGGGCGGCGGCGGCGCGGGGAGCCGGTTGCAGGCCGAGATGCTGCAGATGGACCTGATCGACGCGACGGGGGACACTCCCGGGGCcgaggacgacgaggaggacgacgacgaggaGCGCGCGGCCCGGCGGCCGGGAGCGGGGCCGCCCAAGGCCGAGTCCggccaggagccggcgtcccgcggccagggccagagccaaggccagagccagggcccgggcAGCGGGGACACGTACCGGCCCAAGCGGCCCACCACGCTCAACCTCTTTCCGCAGGTGCCGCGGTCTCAGGACACACTGAATAATAATTCTCTGGGCAAAAAGCACAGTTGGCAGGATCGGGTGTCTCGATCATCCTCACCCCTGAAGACAGGGGAGCAGACACCACCGCATGAACACATCTGCCTGAGCGATGAGCTGCCCCCCCAGAGCGGCCCCGCCCCCACCACAGATCGAGGCACCTCCACCGACAGCCCTTGCCGCCGCAGCACAGCCACCCAGATGGCACCTCCGGGTGGTCCCCCTGCTGCCCCGCCTGGGGGTCGGGGCCACTCGCATCGAGACCGAATCCACTACCAGGCCGATGTGCGACTAGAGGCCACTGAGGAGATCTACCTGACCCCAGTGCAGAGGCCCCCAGACGCTGCAGAGCCCACCTCCGCCTTCCTGCCGCCCACTGAGAGCCGGATGTCAGTCAGCTCCGATCCAGACCCTGCCGCCTACCCCTCCACGGCAGGGCGGCCGCACCCCTCCATCAGTGAAGAGGAAGAGGGCTTCGACTGCCTGTCGTCCCCAGAGCGGGCTGAGCCCCCAGGCGGAGGGTGGCGGGGGAGCCTGGGGGAGCCGCCGCCACCTCCACGGGCCTCTCTGAGCTCGGACACCAGCGCCCTGTCCTATGACTCTGTCAAGTACACGCTGGTGGTAGATGAGCATGCACAGCTGGAGCTGGTGAGCCTGCGGCCGTGCTTCGGAGACTACAGTGACGAGAGTGACTCTGCCACCGTCTATGACAACTGTGCCTCCGTCTCCTCGCCCTATGAGTCGGCCATCGGAGAGGAATATGAGGAGGCCCCGCGGCCCCAGCCCCCTGCCTGCCTCTCCGAGGACTCCACGCCTGATGAACCCGACGTCCATTTCTCCAAGAAATTCCTGAACGTCTTCATGAGTGGCCGCTCCCGCTCCTCCAGTGCTGAGTCCTTCGGGCTGTTCTCCTGCATCATCAACGGGGAGGAGCAGGAGCAGACCCACCGGGCCATATTCAGGTTTGTGCCTCGACACGAAGACGAACTTGAGCTGGAAGTGGATGACCCTCTGCTAGTGGAGCTCCAGGCTGAAGACTACTGGTACGAGGCCTACAACATGCGCACTGGTGCCCGGGGTGTCTTTCCTGCCTATTACGCCATCGAGGTCACCAAGGAGCCCGAGCACATGGCAGCCCTGGCCAAAAACAGTGACTGGGTGGACCAGTTCCGGGTGAAGTTCCTGGGCTCAGTCCAGGTTCCCTATCACAAGGGCAATGACGTCCTCTGTGCTGCTATGCAAAAGATTGCCACCACCCGCCGGCTCACCGTGCACTTTAACCCGCCCTCCAGCTGTGTCCTGGAGATCAGCGTGCGGGGTGTGAAGATAGGCGTCAAGGCCGATGACTCCCAGGAGGCCAAGGGGAATAAATGTAGCCACTTTTTCCAGTTAAAAAACATCTCTTTCTGCGGATATCATCCAAAGAACAACAAGTACTTTGGGTTCATCACCAAGCACCCCGCCGACCACCGGTTTGCCTGCCACGTCTTTGTGTCTGAAGACTCCACCAAAGCCCTGGCAGAGTCCGTGGGGAGAGCATTCCAGCAGTTCTACAAGCAGTTTGTGGAGTACACCTGCCCCACAGAAGATATCTACCTGGAGTAGCTGTGCAGCCCCGCCCTCTGCGTCCCCCAGCCCTCAGGCCAGTGCCAGGACAGCTGGCTGCTGACAGGATGTGGCACTGCTTGAGGAGGGGCACCTGCCACCGCCAGAGGACAAGGAAGTGGGGGCCGCTGGCCCAGGGTAGGGGAGGGTGGGGCAATGGGGAGAGGCAAATGCAGTTTATTGTAATATATGGGATTAGATTCATCTATGGAGGGCAGAGTGGGCTGCCTGGGGATTGGGAGGGACAGGGCTTGGGGAGCAGGTCTCTGGCAGAGAAGGATGTCCGTTCCAGGAGCACACGGCCCTGCCCCATCCTGGGCCTTACCTCCCCTGCCAGGGCTCGGGCGCTGTGGCTCCTGCCTTGATGAAGCCCGTGTCCTGCCTTGATGAAGCCTGtgccacctgcaagtgcccgccctgcccctgccccaaccccCACCGAAGAGCCCTGAGCTCAGGCTGAGCCCAGCCACCTCCCAAGGACTTTCCAGTGAGGAAATGGCAACACGTGGAGGTGAAGTCCCTGTTCTCAGCTCCGTCATCTGCGGGGCTTCTGGGTGGCTCCTGCCACTGACCTCACCGGCATGCTGGCCTGTGGCAGGCCTAGGACCTCAGGCGGGGAGGAGGAGCTGCCGCAAGGCCCTGTCCCAGCAGAAGAGGGAGGCTTCCTGACTGACACAGGCCAGCCCCATCTTGGTCCTGTCACCCTGGCCCCAACTATTAAAGTGCCATTTCCTGTCTGGA