Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MAPK8IP1P1
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:46243604-46245786  UCSC
Coordinates (T2T) chr17:47105636-47107818  UCSC
Coordinates (hg19) chr17:44320970-44323152  UCSC
Strand +
Parental Sequence NM_005456.4
Parental seq. overlap 2060 bp
Parental seq. overlap (%) 67.5%
Genomic Region Intergenic
Retrocopy Summary MAPK8IP1P1, located on chr17:46243604-46245786, is a retrocopy of the parental gene MAPK8IP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MAPK8IP1
Full Name mitogen-activated protein kinase 8 interacting protein 1
Also known as IB1|JIP-1|JIP1|PRKM8IP
Coordinate chr11:45885651-45906465
Strand +
Gene summary This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla MAPK8IP1P1
Orangutan Pongo abelii MAPK8IP1P1
Gibbon Nomascus leucogenys MAPK8IP1P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MAPK8IP1P1
GCTCTGCGGGCGGCGGCGGCGCGGGGAGCCGGTTGCAGGCCGAGATGCTGCAGATGGACCTGATCGACGCGACGGGGGACACTCCCGGGGCCGAGGAGGACGACGACGAGGAGCGCGCGGCCCGGCGGCCGGGAGCGGGGCCGCCCAAGGCCGAGTCCcAGCGGGGACACGTACCGGCCCAAGCGGCCCACCACGCTCAACCTCTTTCCGCAGGTGCAGTTGTCTCAGGACACACTGAATAATAATTCTCTGGGCAAAAAGTACAGTTGGCAGGATCGGGTGTCTCGATCATCCTCACCCCTGAAGACAGGGGAGCAGACACCACCGCATGAACCCATTTGCCTGAGCGATGAGCTGCCCCCCCAGAGCAGCCCCGCCCCCACCACAGATCGAGGCACCTCCACCAACAGCCCACGCTGCTGGAGCTGGTGAGCCTGCGGCCGTGCTTCAGAGACTACAGTGACGAGAGTGACTCGGCCATCGTCTACGACAACTGTGCCTCCGTCTCCTCGCCCTATGAGTCAGCCATCGGAGAGGAATATGAGGAGGCCTCCCGGCCCCAGCCTCCTGCCTGCCTCTCCAAGGACTCCACGCCTGACGAACCCGACGTCCATTTCTCCAAGAAGTTCCTGAACATCTTCATGAGTGGCCGCTCCCGCTCCTCCAGTGCCGAGTCCTTCGGGCTGTTCTCCTGCATCATCAACCGGGAGGAGCAGGAGCAGACCCACCGGACCATATTCAGGTTTGTGCCTCGACACGAAGACGAACCTGAGCTGGAAGTGGATGACCCTCTGCTAGTGGAGCTCCAGGCTGAAGACTACTGGTACGAGGCCTACAACATGCGCACTGGTGCCCGGGGCATCTTTACTGCCTATTACGCCATCGAGGTCACCAAGGAGCCCGAGCACATGGCAGCCCTGGCTAAAAACAGTGACTGGGTGGACCAGTTCCGGGTGAAGTTCCTGGGCTCAGTCCAGGTTCCCTATCACAAGGGCGATGTCGTCCTCTCTGCCGCTATGCAAAAGATTGCCACCACCCGCCGGCTAACCGTGCACTTTAACCCGCCCTCCAGCTGTGTCCTGGAGATCAGCGTGCGGGGTGTGAAGATAGGTATCAAGGCCGATGACTCCCAGGAGGCCAAGGGGAATAAATGTAGCCACTTTTTCCAGTTAAAAAACATCTCTTTCCGCGGATATCATCCAAAGAACAACAAGTACTTTGGGTTCATCACCAAGCACCTCGCCGACCACCGGTTTGCCTGCCACGTCTTTGTGTCTGAAGACTCCACCAAAGCCCTGGCAGAGTCCGTGGGGAGAGCATTCCAGCAGTTTCACAAGCAGTTTGTGGAGTACACCTGCCCCACAGAAAATATCTACCTGGAGTAGCCGCGCAGCCCCGCCCTCTGCGTCCCCCGGCCCTCAGGCCAGTGCCAGGACAGCTGGCTGCTGACAGGATGTGGCACTGCTTGAGGAGGGGCACCTGCCACCGCCAGGGGATGAGGAAGTGGGGGCCGCTGGCTCAGGGTAGGGGAGGGTGGGGCAATGGGGAGAGGCAAATGCAGTTTATTGTAATATATGGGATTAGATTCATCTATGGAGGGCAGAGTGGGCTGCCTGGGGATTGGGAGGGACAGGGCTTGGGGAGCAGGTCTCTGGCAGAGAAGGATGTCCGTTCCAGGAGCACACGGCCCTGCCCCATCCTGGGCCATACCTCCCCTGCCAGGGCTCGGGTGCTCTGGCTCCTGCCTTGATGAAGCCCATGTCCTGCCTTGATGAAGCCTGTGCCACCTGCAAGTGCCCGCCCTGCCCCTGTCCCAACACCCACCGAAGAGCCCTGAGCTCAGGCTGAGCCCAGCCACCTCCCAAGGACTTTCCAGTGAGGAAATGGCAACACATGGAAGTGAAGTCCCTGTTCTCAGCTCTGTCATCTGCAGGGCTTCTGGGTGGCTCCTGCCACTGACCTCACTGGCATGCTAGCCTGTGGCAGGCCTAGGACCTCAGCGGGGAGGAGGAGCTGCTGCAAGGCCCTATCCCAGCAGGAGAGGGAGGCTTCCTGACTGACACAGGCTAGCCCCATCTTGGTCCTGTCACCCTGGCCCCAACTATTAAAGTGCCATTTCCTGTC
>NM_005456.4
AGTCCCGCGGGCCGTGCGCGGTGCTGTGCCGCGCCCTGCCAGACACAGGTGCGCCCGCCTAGCCCGAACTccgcggcggcggctgccctctcgccgcgcctccgcctccttcgcagccgccgcctcctccgcgccgcgctccgccCGGATGGCCAGGGCTGTGCCCGAGAATGGCGGAGCGAGAAAGCGGCGGCCTGGGAGGGGGGGCCGCGTCCCCGCCCGCCGCCTCCCCGTTCCTGGGGCTGCACATCGCTTCGCCTCCCAATTTCAGGCTCACCCATGACATCAGCCTGGAGGAGTTTGAGGATGAAGACCTCTCGGAGATCACTGATGAGTGTGGCATCAGCTTACAGTGCAAAGACACCCTGTCCTTACGGCCCCCGCGCGCCGGGCTGCTCTCTGCGGGCGGCGGCGGCGCGGGGAGCCGGTTGCAGGCCGAGATGCTGCAGATGGACCTGATCGACGCGACGGGGGACACTCCCGGGGCcgaggacgacgaggaggacgacgacgaggaGCGCGCGGCCCGGCGGCCGGGAGCGGGGCCGCCCAAGGCCGAGTCCggccaggagccggcgtcccgcggccagggccagagccaaggccagagccagggcccgggcAGCGGGGACACGTACCGGCCCAAGCGGCCCACCACGCTCAACCTCTTTCCGCAGGTGCCGCGGTCTCAGGACACACTGAATAATAATTCTCTGGGCAAAAAGCACAGTTGGCAGGATCGGGTGTCTCGATCATCCTCACCCCTGAAGACAGGGGAGCAGACACCACCGCATGAACACATCTGCCTGAGCGATGAGCTGCCCCCCCAGAGCGGCCCCGCCCCCACCACAGATCGAGGCACCTCCACCGACAGCCCTTGCCGCCGCAGCACAGCCACCCAGATGGCACCTCCGGGTGGTCCCCCTGCTGCCCCGCCTGGGGGTCGGGGCCACTCGCATCGAGACCGAATCCACTACCAGGCCGATGTGCGACTAGAGGCCACTGAGGAGATCTACCTGACCCCAGTGCAGAGGCCCCCAGACGCTGCAGAGCCCACCTCCGCCTTCCTGCCGCCCACTGAGAGCCGGATGTCAGTCAGCTCCGATCCAGACCCTGCCGCCTACCCCTCCACGGCAGGGCGGCCGCACCCCTCCATCAGTGAAGAGGAAGAGGGCTTCGACTGCCTGTCGTCCCCAGAGCGGGCTGAGCCCCCAGGCGGAGGGTGGCGGGGGAGCCTGGGGGAGCCGCCGCCACCTCCACGGGCCTCTCTGAGCTCGGACACCAGCGCCCTGTCCTATGACTCTGTCAAGTACACGCTGGTGGTAGATGAGCATGCACAGCTGGAGCTGGTGAGCCTGCGGCCGTGCTTCGGAGACTACAGTGACGAGAGTGACTCTGCCACCGTCTATGACAACTGTGCCTCCGTCTCCTCGCCCTATGAGTCGGCCATCGGAGAGGAATATGAGGAGGCCCCGCGGCCCCAGCCCCCTGCCTGCCTCTCCGAGGACTCCACGCCTGATGAACCCGACGTCCATTTCTCCAAGAAATTCCTGAACGTCTTCATGAGTGGCCGCTCCCGCTCCTCCAGTGCTGAGTCCTTCGGGCTGTTCTCCTGCATCATCAACGGGGAGGAGCAGGAGCAGACCCACCGGGCCATATTCAGGTTTGTGCCTCGACACGAAGACGAACTTGAGCTGGAAGTGGATGACCCTCTGCTAGTGGAGCTCCAGGCTGAAGACTACTGGTACGAGGCCTACAACATGCGCACTGGTGCCCGGGGTGTCTTTCCTGCCTATTACGCCATCGAGGTCACCAAGGAGCCCGAGCACATGGCAGCCCTGGCCAAAAACAGTGACTGGGTGGACCAGTTCCGGGTGAAGTTCCTGGGCTCAGTCCAGGTTCCCTATCACAAGGGCAATGACGTCCTCTGTGCTGCTATGCAAAAGATTGCCACCACCCGCCGGCTCACCGTGCACTTTAACCCGCCCTCCAGCTGTGTCCTGGAGATCAGCGTGCGGGGTGTGAAGATAGGCGTCAAGGCCGATGACTCCCAGGAGGCCAAGGGGAATAAATGTAGCCACTTTTTCCAGTTAAAAAACATCTCTTTCTGCGGATATCATCCAAAGAACAACAAGTACTTTGGGTTCATCACCAAGCACCCCGCCGACCACCGGTTTGCCTGCCACGTCTTTGTGTCTGAAGACTCCACCAAAGCCCTGGCAGAGTCCGTGGGGAGAGCATTCCAGCAGTTCTACAAGCAGTTTGTGGAGTACACCTGCCCCACAGAAGATATCTACCTGGAGTAGCTGTGCAGCCCCGCCCTCTGCGTCCCCCAGCCCTCAGGCCAGTGCCAGGACAGCTGGCTGCTGACAGGATGTGGCACTGCTTGAGGAGGGGCACCTGCCACCGCCAGAGGACAAGGAAGTGGGGGCCGCTGGCCCAGGGTAGGGGAGGGTGGGGCAATGGGGAGAGGCAAATGCAGTTTATTGTAATATATGGGATTAGATTCATCTATGGAGGGCAGAGTGGGCTGCCTGGGGATTGGGAGGGACAGGGCTTGGGGAGCAGGTCTCTGGCAGAGAAGGATGTCCGTTCCAGGAGCACACGGCCCTGCCCCATCCTGGGCCTTACCTCCCCTGCCAGGGCTCGGGCGCTGTGGCTCCTGCCTTGATGAAGCCCGTGTCCTGCCTTGATGAAGCCTGtgccacctgcaagtgcccgccctgcccctgccccaaccccCACCGAAGAGCCCTGAGCTCAGGCTGAGCCCAGCCACCTCCCAAGGACTTTCCAGTGAGGAAATGGCAACACGTGGAGGTGAAGTCCCTGTTCTCAGCTCCGTCATCTGCGGGGCTTCTGGGTGGCTCCTGCCACTGACCTCACCGGCATGCTGGCCTGTGGCAGGCCTAGGACCTCAGGCGGGGAGGAGGAGCTGCCGCAAGGCCCTGTCCCAGCAGAAGAGGGAGGCTTCCTGACTGACACAGGCCAGCCCCATCTTGGTCCTGTCACCCTGGCCCCAACTATTAAAGTGCCATTTCCTGTCTGGA

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