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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Birc5P1
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Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr3:80497649-80498452  UCSC
Strand +
Parental Sequence NM_022274.1
Parental seq. overlap 693 bp
Parental seq. overlap (%) 77.4%
Genomic Region Intragenic (Ckap5)
Retrocopy Summary Birc5P1, located on chr3:80497649-80498452, is a retrocopy of the parental gene Birc5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Birc5
Full Name baculoviral IAP repeat-containing 5
Also known as AP14
Coordinate chr10:106856097-106864419
Strand +
Gene summary Predicted to enable several functions, including chaperone binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and protein dimerization activity. Involved in several processes, including cellular response to ethanol; cellular response to stem cell factor stimulus; and response to glucocorticoid. Located in apical plasma membrane; cytoplasm; and nucleus. Used to study endometriosis and pulmonary hypertension. Biomarker of acute pancreatitis (multiple); artery disease (multiple); congestive heart failure; high grade glioma; and stomach carcinoma. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Birc5P1
ACTCCGGCGCTGCCCCCGACCTGGCAGCTAGCTGTACCTCAAGGACCACCTCATCTCCACCTTAAGAACTGGCCCTTCCTGGAGGGCTGTTCCTGCATCCCATAGTGGATGGCGGAGGCTGGCTTTGTCCACTGCCCTACAGAGAATGAACCCAGTGTTTTAAGGAATTGAAAGGCTGGGAACCAGATGACAGCCCTTTAGAGGAGCATAGGAAGCACTCACCTAGCTATGCCTCCCTTACTGTCAGTGAATTTTTGAAACTGGGCAAACAGCCAAGAACAGAATTGCAAAGGAGACCAACAACAAGCAGAAAGAGTTTGAAGAGCCTTGAAGACTGTCCATCAGTCAGTTGAGCAACTGCTGCCTTGCCGAGCCTTTGCTGGGACAACCTGGACCTGAGTGACACACCATGGCTAAGCCACTCATCCCAGCTTTCCCAGCCCAGGCCTCCTTAATAGTGTCTTAGAGAAGGAAGTGGTGTTATTTTGAAACTGGATGTCAAATATTTTTGGTTTTGCTTTAAAGTGGCTTAGCCTCTGTGGCCACCTCTCTGTGGTTTTGTGGCTTTGCTCTATTGTGACCTGGACTTAAGCAATGAGGAAAGGAGTAGATGAGGGGACAGTTTTCTCTTGACAGGACCTATGGGGGTCAGGGTGCCTGTGCAAGACCTTTCTTGCCTTGATATTTCCATACCTGGTAGCTGTTGCGGCCCATGCGTAGGTGTGGTTATATATGTTTGCGCTAATAATTCTTCTGCCCTTCTGATGAGTCTTCCTACCACAGAGTAGTGGAATAAAATCACTT
>NM_022274.1
ATCATGGGTGCTCCGGCGCTGCCCCCGACCTGGCAGCTGTACCTTAAGGACCACCGCATCTCCACCTTCAAGAACTGGCCCTTCCTGGAGGATTGCTCCTGCACCCCAGAGCGGATGGCGGAGGCTGGCTTCATCCACTGCCCTACCGAGAATGAGCCTGATTTGGCCCAGTGTTTTTTCTGCTTTAAGGAACTGGAAGGCTGGGAACCGGATGACAACCCTATAGAGGAGCATAGGAAGCACTCCCCTGGCTGCGCCTTCCTTACAGTCAAGAAGCAGGTGGAAGAACTGACCGTCAGCGAGTTTTTGAAACTGGACAAACAAAGAGCCAAGAACAAAATTGCAAAGGAGACCAACAACAAACAGAAAGAGTTCGAGGAGACCGCGAGGACGGTCCGCCAGTCCATTGAGCAGCTGGCTGCCTTACGCTGAGCCTTTGCTGGGCAACCTGGACCTGAGTGACATGCCACGGCTAAGCCACTTGTCCCAGCTTTCCAGGCCTGCCTGGCCGCCTTGGTGTCTTACAGGAGACCGTGACATTTCGAAACTGGACATCAGATGATTTGGGGTTTTGCTTTAAAGGGGCTCAGCCTGCGTGGCCACCTCTCTTTGGTTTTGTGGCTTTGCTCTATTGTGACCTGGACTTAAGCACTGAGGAAGGGAGTGGATGAGGGACAGGATTCTCTGACAGGATCTATGGGGTGGGGAGGGGGGTGAAGGGAGGGTTGTGCAAGGCCTTTCTGGTCTTGATGTTTCCATGCCTGGCAGCTGTCGCAGCCCATGTGTAGGTGTGGTTTATATATGTTTGTGCTGATAATTCTTCTGTCCTTCTGATGAGTCCTCCTACCATGGGGTAATGGAATAAAATAACTTAACAAA

Publications

PMID - Link Title
No publications available for this retrocopy