Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Dynll1P2
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr1:247316424-247316976  UCSC
Strand -
Parental Sequence NM_053319.3
Parental seq. overlap 498 bp
Parental seq. overlap (%) 75.1%
Genomic Region Intergenic
Retrocopy Summary Dynll1P2, located on chr1:247316424-247316976, is a retrocopy of the parental gene Dynll1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Dynll1
Full Name dynein light chain LC8-type 1
Also known as 8kDLC|Dlc8|Dnclc1|Pin
Coordinate chr12:47074200-47076573
Strand +
Gene summary Enables several functions, including identical protein binding activity; nitric-oxide synthase regulator activity; and scaffold protein binding activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus and spermatid development. Acts upstream of or within negative regulation of nitric oxide biosynthetic process. Located in axon cytoplasm; nucleus; and secretory granule. Part of cytoplasmic dynein complex. Colocalizes with mitochondrion. Used to study hypertension and impotence. Biomarker of cardiac arrest; congestive heart failure; and middle cerebral artery infarction. Orthologous to human DYNLL1 (dynein light chain LC8-type 1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Dynll1P2
CTGTCCTCTGCTGCTTGAGCAGTGCCAGCACCTTCCCTAGGAACAGCCCGCTGGCCCCTGCTCCACGGTAACCACGTGTGACCTGAAGGCAGTGATCAAAAACGCAGACGTGTCATGCCCAAAGAGAGGCAACAGGACTCGGTGGAGCGTGCTACTCAGGAGTTGGAGAAGTACAACATAGAGAAGGATGTTGCGGCCCACATCAAGAAGGAATTTGACAAGAAGCACAACTAACTCCACCTGGCACTGCGTTGTGGACCGGAACTTTCCGTAGTTATGTGACACACGAAACCAAACACTTTATCTTCTACCTGGGTGGCCATTCGTCTGTTCAAATCTGGGAAAAGCATGGACTGCGCCAAACACCCCATGATCCATCCCAAAACAAGGACTGCATCCTAAATTCCAAATACCAGAGACTGAATCTTCAGCCTTGCTAAGGAAACACCTCGTTAGAATCTGTTGTGTTTTGCACAGGGCACCATTCTCTGTACACCTCTGTGGTTATAAAATTAGTAAAACATATTTATTTTCTAGTCCATACTTCTGTACT
>NM_053319.3
AGATGCGCCACGGCTTCGGTAGCGACCGGCTGTCCACTGCTGCTTGAGCGGCGCCAGCACCTTCCCTAGGAGCTCGCAGCAGCCGGCTGGCCCCTGCTCCACGGTAACCATGTGCGACCGGAAGGCGGTGATCAAAAATGCAGACATGTCGGAAGAGATGCAACAGGACTCGGTGGAGTGCGCTACTCAGGCGTTGGAGAAGTACAACATAGAGAAGGATATCGCGGCCCATATCAAGAAGGAGTTTGACAAGAAGTACAACCCCACCTGGCACTGCATCGTGGGCCGGAACTTCGGTAGCTACGTGACACACGAGACCAAACACTTCATCTACTTCTACCTGGGTCAGGTGGCCATTCTCCTGTTCAAATCTGGTTAATAGCATGGACTGTGCCAAACACCCAGTGATCCATCCAAAAACAAGGACTGCATCCTAAATTCCAAATACCAGAGACTGAATCTTCAGCCTTGCTAAGGGAACACCTCGTTTGAATCTGTTGTGTTTTGTACAGGGCACCATTCTCTGTACACGTTTGTGGTTATAAAATTAGTAAAACAGCTTACATTTGTATTTATTTTCTAGTCCATACTTCTGTACCCCCATTTTTTTCTCCCTTAGGTCATTCCTTTAAAATAAATCTGTTGGAGATGTA

Publications

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