Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Eef1a1P5
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr3:1260419-1262086  UCSC
Strand -
Parental Sequence NM_175838.1
Parental seq. overlap 1540 bp
Parental seq. overlap (%) 89%
Genomic Region Intergenic
Retrocopy Summary Eef1a1P5, located on chr3:1260419-1262086, is a retrocopy of the parental gene Eef1a1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Eef1a1
Full Name eukaryotic translation elongation factor 1 alpha 1
Also known as EEF-1|EEF1A|EF1A|Eef1a2|Eef1a2l1|SI
Coordinate chr8:85838594-85841816
Strand -
Gene summary Enables identical protein binding activity and mRNA binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of reactive oxygen species biosynthetic process; and positive regulation of neuron projection development. Located in cytosol and nucleus. Orthologous to human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens EEF1A1P21
Crab-eating macaque Macaca fascicularis EEF1A1P21
Rhesus Macaca mulatta EEF1A1P22
Sloth Choloepus didactylus EEF1A1P29
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Eef1a1P5
AACAGGTTTGCTGTCAGAACACAGGTGTTGTGAAAGCCACCGCTAATTCAAAGCAAAAATGGGCAAGGAAAAGACTTACATAGTTGTAATTGGACACGTAGATTCGGGCAAGTCCACCACAACCAGGCACCTGATCCACAAATGTAGTGGAATCGACAAAAGAACCACTGAAAAGTTTGAAAAGGAAACTGCCGAGATGGGAAAAGGCTCCTTTAACTATGCCTGGGTCTTGGACAAACTGAAAGCTAAGCGTGAGCATGATATCATTATTAACATCTCATATGGAAATTTGAGAACAATAAGTACTATGTGACACAGGACACAGAGATTTCATCAAGAACATGATTATAGGCACATCTCAGGCTGACTGTGCTGTCCTAATTGTTGCTGCTGGTGTTGGAGAATTTGAAGCTGGTATCTCCAAGAATGGGCAGACCCATGAGCGTGCTTTTCTGGTGAAACAGCTAATTGTTGGTGTCAACAAAATGGATTTCACTGAGTCACCATGCAGTCAGAAGAGATATGAGGAAATCGTTAAGGAAGTCAGTACCTACATTAAGAAAATTGGCTACAACGCTGACACATTAGCATTTGTGCCAATTTCTGGTTGGAATGGTGACAACATGCTGGAGCCAAGTGCTTATATGCCTTGGTTCAACGGATGGAAAGTCACCCGCAAAGATGGCAGTGCCAGTGGTACCACACTGCTGGACGCTTTGGACTGCATTCTGCTGCCAACTCGTCCAACTGACAAGCCTCTGCGACTGCCCCTCCAGGATGTCTATAAAATTGGGGGCATTGGCACTGTCCCCATGGGCTGAGTGGAAACTGGTGTTCTCAAACCTGGCATGGTGGTTACCTTTGCTCCAGTCAATGTAACAACTGAAGTCAAGTCTGTGGAAATGCACCATGAAGCTTTGAGTGAAGCTCTGCCTGGAGACAATGTGGCCTTCAATGTAAAGAACATGTCTGTCAAAGATGTTAGATGTGCCAATGTTGCTGGTGACAGCAAAAATGACCCACCAATGGTGGCAGCTGGCTTCACTGATTATCCTGATTATCCTGAACCATTCAGGCCAAATTAGTGCTGGCTATGCTCCTAGTCTGGATTGTCACGTGGCTCACATAGCATGCAAGTTTGCCGAGCTTAAAGAGAAGATAGATCATTGTTCTGGTAAGAAACTAGAAGATTGCCCCAAATTCTTGAAGTCTGGTGATGCTGCCATTGTTGACATGGTCCCTGGAAAGCCCATGTGTGTTGAGAGCTTCTCTGATGATCCTCTACTTGGTCATTTTGCTGTTTGTGACATGAAGCAGACAGTTGCTGTGGGTGTCATCAAAGCTGTGGAAGAAGGCTGCAGTAGCTGGCAAAGTCACCAAGTCCACCCAGAAAGCTCAGAAGGCTAAATGAATATTATCCCTAACACCTGCCACCCTAGTCTTAATTAGTGGTGGAAGAACGGTTTCAGAAGTGTTTGTCTCAATTGGCCTTTTAAGTTTAATAGTAAAAGACTGGTTAATGATAACAATGCATCGTAAAACCGTCAGAAGGAAAGAATGTGTTGTGGGCCAATTTTTTTGGTGTGTGGCAGTTTTAAGTTATTAGTTTTCAAAATCAGTACTTTTAAATGGAAACAACTTGACCAAAAATCTGTCACAT
>NM_175838.1
TTTTTCGCAACGGGTTTGCCGTCAGAACGCAGGTGTTGTGAAAGCCACCGCTAATTCAAAGCAAAAATGGGAAAGGAAAAGACTCACATCAACATCGTCGTAATTGGACACGTAGATTCCGGCAAGTCCACCACAACCGGCCACCTGATCTACAAATGTGGTGGAATCGACAAAAGAACCATTGAAAAGTTTGAGAAGGAGGCTGCGGAGATGGGAAAAGGCTCCTTCAAGTATGCCTGGGTCCTGGACAAACTGAAAGCTGAGCGTGAGCGTGGTATCACTATTGACATCTCCCTGTGGAAGTTTGAGACCAGCAAGTACTATGTGACTATCATTGATGCCCCAGGACACAGAGACTTCATCAAGAACATGATTACGGGCACATCTCAGGCTGACTGCGCTGTCCTGATTGTTGCTGCTGGTGTTGGGGAATTTGAAGCTGGTATCTCCAAGAACGGGCAGACCCGTGAGCATGCTCTTCTGGCTTACACTTTGGGTGTGAAACAGCTAATTGTTGGTGTCAACAAAATGGATTCCACCGAGCCACCATACAGTCAGAAGAGATACGAGGAAATCGTTAAGGAAGTCAGCACCTACATTAAGAAAATTGGCTACAACCCTGACACAGTAGCATTTGTGCCAATTTCTGGTTGGAATGGTGACAACATGCTGGAGCCAAGTGCTAATATGCCGTGGTTCAAGGGATGGAAAGTCACCCGCAAAGATGGCAGTGCCAGTGGCACCACGCTGCTGGAAGCTTTGGACTGCATTCTGCCGCCAACTCGTCCAACTGACAAGCCTCTGCGACTGCCCCTCCAGGATGTCTATAAAATTGGCGGCATTGGCACTGTCCCTGTGGGCCGAGTGGAAACTGGTGTTCTCAAACCTGGTATGGTGGTTACCTTTGCTCCAGTCAATGTAACAACTGAAGTCAAGTCTGTGGAAATGCACCATGAAGCTTTGAGTGAAGCTCTGCCTGGGGACAATGTAGGCTTCAACGTAAAGAACGTGTCTGTCAAAGACGTTAGACGTGGCAATGTTGCTGGGGACAGCAAAAATGACCCACCAATGGAAGCAGCTGGCTTCACTGCTCAGGTGATTATCCTGAACCATCCAGGCCAGATCAGTGCTGGCTATGCCCCTGTTCTGGACTGCCACACGGCCCACATAGCATGCAAGTTTGCCGAGCTTAAAGAGAAGATCGATCGTCGTTCTGGTAAGAAGCTGGAAGATGGCCCCAAATTCTTGAAGTCTGGTGATGCTGCCATTGTTGACATGGTCCCTGGCAAGCCCATGTGTGTTGAAAGCTTCTCTGACTACCCTCCACTTGGTCGTTTTGCTGTTCGTGACATGAGGCAGACAGTTGCTGTGGGTGTCATCAAAGCCGTGGACAAGAAGGCTGCAGGAGCTGGCAAAGTCACCAAGTCTGCCCAGAAAGCTCAGAAGGCTAAATGAATATTATCCCTAACACCTGCCACCCCAGTCTTAATCAGTGGTGGAAGAACGGTCTCAGAACTGTTTGTCTCAATTGGCCATTTAAGTTTAATAGTAAAAGACTGGTTAATGATAACAATGCATCGTAAAACCTTCAGAAGGAAAGAATGTTTTGTGGACCATTTTTTTTTGTGTGTGGCAGTTTTAAGTTATTAGTTTTCAAAATCAGTACTTTTTAATGGAAACAACTTGACCAAAAATCTGTCACAGAATTTTGAGACCATTAAAACAAGTTT

Publications

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