Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Ezh2P1
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Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr18:15277363-15277989  UCSC
Strand -
Parental Sequence NM_001134979.1
Parental seq. overlap 510 bp
Parental seq. overlap (%) 18.1%
Genomic Region Intragenic (Mapre2)
Retrocopy Summary Ezh2P1, located on chr18:15277363-15277989, is a retrocopy of the parental gene Ezh2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Ezh2
Full Name enhancer of zeste 2 polycomb repressive complex 2 subunit
Also known as -
Coordinate chr4:77284404-77347011
Strand -
Gene summary Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including histone H3-K27 methylation; negative regulation of macromolecule metabolic process; and positive regulation of dendrite development. Located in cytoplasm and nucleus. Used to study endometriosis. Biomarker of leiomyoma; non-alcoholic fatty liver disease; and pancreatic cancer. Human ortholog(s) of this gene implicated in Weaver syndrome; bone cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Ezh2P1
ATTCAGTGGGGCTCTAAAGGCACTTACTGCCGGCACCATCTAATGTGGCATGCTGGGGGAGCTTCATCAAAGGCCCTGTGCAGAAGACAATGAATTTGCCCCAGTATTCTGTGGAGAGATTATTCTCAGGATGAAGCCAACAGAAGACAGGGACCGACAAATACACACGCAACTTCCTGTTCAACCCGAGCAATGAATGCAATCCACAAAGGCAAAACACAATCATTTTGCTAATCATTCAGTATATCCAAATGCCATGCAAGAGCTATGTTGGTTAACCATGATCACCAGATAGGCAACTTTGCTAAGAGAGCCATCCAGAATGGTGAAGAGCCATTTTTTTTATTCCAGATAGAGGCAGGCAGATGCCCTGAAGTGTGTGGGCACTGAAAGAGAAAGAGAAATTCCTTGACATGTCCACCCCTTCCCCCCTTCTCTGAAGCAACCACTTCAGCCTCAGAAACCTTGAGTAATTTTTTTTTTAGAAAAAGAAAACGCAGTTTGAAATTGTGAATTTGCAAAGTCAGCACTATAACAGCACTTCATAGAAATGAGCTTGAAAATCAACTTTCCATGCCTTCTCCCCACTGCAAGGTGTTTTGTGCCAGTGAATGTTTGCAATAATGT
>NM_001134979.1
GCTGCTGCGTTTGGCGCTCGGTCCGGTCGCGTCCGACACCCAGTGGGACATCGAAGGCAGTGGAGTCCcggcggcggcggcggcggcggcgcgttggggcggcgcgcgggagaagcgcgggctggcgcgcggGACGAAGAATAATCATGGGCCAGACTGGGAAGAAATCTGAGAAGGGACCGGTTTGTTGGCGGAAGCGTGTAAAGTCAGAGTACATGAGACTGAGACAGCTCAAGAGGTTCAGAAGAGCTGACGAAGTAAAGACTATGTTTAGTTCCAATCGTCAGAAAATTTTGGAAAGAACTGAAACCTTAAATCAAGAATGGAAGCAGCGAAGGATACAGCCTGTGCACATCATGACTTCTGTGAGCTCATTACGCGGGACTAGGGAGTGTTCAGTGACCAGTGACTTGGATTTTCCAGCACAAGTCATCCCGTTAAAGACCCTAAATGCTGTCGCATCGGTGCCCATAATGTATTCTTGGTCTCCCTTACAACAGAATTTTATGGTGGAAGATGAAACTGTTTTACATAACATTCCTTATATGGGGGATGAAGTTCTGGATCAGGATGGCACTTTCATTGAAGAATTAATAAAAAATTATGATGGAAAAGTGCATGGAGACAGAGAATGTGGATTTATAAATGATGAAATTTTTGTGGAGTTGGTAAATGCTCTTGGTCAATataatgatgatgacgatgatgatgatggagacgatcctgatgaAAGAGAAGAAAAACAGAAAGATCTAGACGATAGTCGAGATGATAAAGAAACTTGCCCACCTCGGAAATTTCCTGCTGATAAAATATTTGAAGCCATTTCCTCAATGTTTCCAGATAAGGGCACAGCAGAAGAACTGAAAGAAAAGTATAAAGAACTCACGGAGCAGCAGCTCCCCGGTGCTCTACCTCCTGAATGTACCCCAAACATCGATGGACCAAATGCCAAATCTGTTCAGAGGGAGCAAAGTTTACATTCATTTCATACGCTCTTTTGTCGACGATGTTTTAAGTATGACTGCTTCCTACATCCCTTTCATGCAACACCCAACACATATAAGAGGAAGAACACAGAAACAGCTCTGGACAACAAGCCTTGTGGACCACAGTGTTATCAGCATCTGGAGGGAGCTAAGGAGTTTGCTGCTGCCCTTACTGCTGAGCGGATAAAGACACCACCTAAACGTCCAGGGGGCCGCAGAAGAGGAAGACTTCCGAATAACAGTAGCAGACCCAGCACCCCCACCATCAGTGTGCTGGAGTCAAAGGATACAGACAGTGACAGAGAAGCAGGGACTGAAACCGGGGGAGAGAACAACGATAAAGAAGAAGAAGAGAAAAAAGATGAGACTTCCAGTTCCTCTGAAGCAAATTCTCGGTGTCAAACACCAATAAAGATGAAGCCAAATATTGAACCTCCTGAGAATGTGGAGTGGAGTGGTGCTGAAGCCTCCATGTTTAGAGTCCTCATTGGTACTTACTACGATAACTTTTGTGCCATTGCTAGGCTAATTGGGACCAAAACATGTAGACAGGTGTATGAGTTTAGAGTCAAAGAGTCCAGTATCATAGCACCTGTTCCCACTGAGGATGTGGACACTCCTCCAAGAAAGAAGAAAAGAAAACATCGGTTGTGGGCTGCACACTGCAGAAAGATCCAACTGAAAAAGGACGGCTCCTCTAACCATGTTTACAACTATCAACCCTGTGACCATCCACGGCAGCCTTGTGACAGTTCGTGCCCTTGTGTGATAGCACAAAATTTTTGTGAAAAGTTTTGTCAATGTAGTTCAGAGTGTCAAAACCGCTTTCCTGGATGCCGGTGCAAAGCACAATGCAACACCAAGCAGTGTCCGTGCTACCTGGCTGTCCGAGAGTGTGATCCTGACCTCTGTCTCACTTGTGGAGCTGCTGACCACTGGGACAGTAAAAATGTGTCCTGCAAGAACTGTAGCATTCAGCGGGGCTCTAAAAAGCACTTACTGCTGGCACCGTCTGATGTGGCAGGCTGGGGCATCTTTATCAAAGATCCAGTACAGAAAAATGAATTCATCTCAGAATACTGTGGAGAGATTATTTCTCAGGATGAAGCAGACAGAAGAGGGAAAGTGTATGACAAATACATGTGCAGCTTTCTGTTCAACTTGAACAATGATTTTGTGGTGGATGCAACCCGCAAGGGCAACAAAATTCGTTTTGCTAATCATTCAGTAAATCCAAACTGCTATGCAAAAGTTATGATGGTTAATGGTGACCACAGGATAGGCATCTTTGCTAAGAGAGCTATCCAGACTGGTGAAGAGTTGTTCTTTGATTACAGATACAGCCAGGCTGATGCCCTGAAGTATGTGGGCATCGAACGAGAAATGGAAATCCCTTGAAATCTACTACCTCTTCCCCTCCTCTCAAACAGCTGCCTTAGCTTCAGGAACCTTGAGTACTGTGGGCAATTTAGAAAAAGGAAATGCAGTTTGAAATTTTGAATTTGCAAAGTACTGTAACAGTAATTTATAGTAATGAGTTTTAAAATCAACTTTTTATTGCCTTCTCACCAGCTGCAAAGTGTTTTGTACCAGTGAATTTTTGCAATAATGCAGTATGGTACATTTTTCAAATTTGAATAAAGAATACTTGAACTTGTTGTTGAGTCACTTGTTACAGAACATCACCAACTGATTCTAGAAAGACTATATCCAGTGGGAAAACACAACTCCTCTTTGTTTTTCCAGCTGTCTGTGAATATTTAATAACTAATAAACATACTGGCATAGTGTTTACCTAGATCCAG

Publications

PMID - Link Title
No publications available for this retrocopy