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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Nsmce2P2
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr10:66159382-66159852  UCSC
Strand -
Parental Sequence NM_001024876.1
Parental seq. overlap 397 bp
Parental seq. overlap (%) 37.9%
Genomic Region Intergenic
Retrocopy Summary Nsmce2P2, located on chr10:66159382-66159852, is a retrocopy of the parental gene Nsmce2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Nsmce2
Full Name NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
Also known as RGD1305156
Coordinate chr7:99677295-99900765
Strand +
Gene summary Predicted to enable SUMO ligase activity. Predicted to be involved in several processes, including DNA recombination; positive regulation of cell cycle process; and protein sumoylation. Predicted to be located in PML body and chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Mouse Mus musculus Nsmce2P1
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Nsmce2P2
TATCTTTCAGTGGTGTCCAGTCTGCCTCTCCTCCTTAAAAAACTCCCAATTTTGCATCAGCTCTGGAATGGACACGGTTTCTAATGCCTTGGACCTAGTGGACTGATGTTGAGTCGTGAGTACAGTATGGATAAGGCCCTGGTTGACTTTGCTAAAATGGGTTGGGAACTAAACCATTATGTTAAGGCTGCCCAACCTATAATAAGTCATGTAAAAGAAGGATGTCCAGAAAAAGTATGACATTTAACATGACTAGCGGAGAAGAAAGGTTTGATTTTTCAGGATAAGCATTCTGATGCCGACTTTAACGGCAGGGAGAAGTTTGTGCAGGTTAAGCAACAGCTGAAGAAGCACTGTGGTCTGTATGCAGACAGAGAGAATGATGGGACAGAAGGAGCCGATAAGGATACGATTTTGATCCAGATGCAGACCAATTTCATCTGCCCTATAACACAGATGGAAATGAAGAAA
>NM_001024876.1
TGAGGAAAGGAATCGGGGTCTGGGTGTGCGACGTTCGGCAAGATATCGCTGAGCTAGGTGGGACAGCCAGATTTCAAAGATGCCAGGACGGTCCAGTACAAATTCAGGTTCTACTCGTTACATATCCTTCAGTGGTGTAGAGTCAGCTCTCTCCTCCTTAAAAACCTTCCAGTCCTGTATCAGCTCTGGGATGGACACAGTTTCTAGTGTTGCCTTGGACCTTGTGGAGACCCAAACTGAAGTGAGTAGTGAGTACAGTATGGACAAGGCCATGGTTGAATTTGCTAAAATGGATCGAGAACTAAACCATTATGTTAAGGCTGTCCAGTCTACAATAAATCATGTAAAAGAAGAACGTCCAGAAAAAGTACCAGATTTAAAATTACTGGTGGAGAAGAAATTTTTGGCTTTACAGGATAAGAACTCTGACGCCGACTTTAAAGAGAATGAAAAGTTCGTGCAGTTTAAGCAGCAGCTGCGGGAGCTGAAGAAGCAATATGGTATTCATGCAGACAGAGAGAATGATGGGATAGAAGGAATGGATGAAGATATGATTGTGACCCAGAGCCAAACCAATTTCATCTGCCCCATAACACAGTTGGAAATGAAGAAGCCAGTGAAAAATAAAATGTGTGGCCACACATACGAAGAGGAAGCCATTGTTCGCATGATTGAATCCAAGCATAAGAGGAAGAAGAAGGCTTGTTGCCCAAAAATTGGCTGTAGCCACACAGACATGAGAATGTCAGATCTCATTCCGGATGAAGCCCTGAGAAGGGCAATCGAGAGCCACAACAAGAAGAAAAAGCGCCACTCCGAGTAGGAGCCAGCCCCCTGCCCACAGGGGTGTCAGCAGCCTACCTCCCCACAGCCACCAGAGAGTGAGCGTTCACAGCAATAGGCCCGGCAAGCTCTGCAGTGACCCTCAAGGCTAATTGTAATTGAAAGCATTTTTTAAGTTACACAATAAAAACACAAGTACATTATAGTCTTTATTTTCAAGTGCTCTGAAATTTTAAATAAAACTTTGATAATCTTCAGCACGA

Publications

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