Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Olfm1P1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr5:117758864-117759711  UCSC
Strand -
Parental Sequence XM_006233876.3
Parental seq. overlap 750 bp
Parental seq. overlap (%) 66.8%
Genomic Region Intragenic (Dock7)
Retrocopy Summary Olfm1P1, located on chr5:117758864-117759711, is a retrocopy of the parental gene Olfm1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Olfm1
Full Name olfactomedin 1
Also known as D2Sut1e|Noe1
Coordinate chr3:6761031-6798739
Strand +
Gene summary Predicted to enable amyloid-beta binding activity and identical protein binding activity. Predicted to be involved in several processes, including heart development; neuronal signal transduction; and regulation of gene expression. Predicted to act upstream of or within negative regulation of amyloid-beta formation and negative regulation of neuron migration. Predicted to be located in several cellular components, including axonal growth cone; neuronal cell body; and synaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in glutamatergic synapse. Predicted to be extrinsic component of synaptic membrane. Orthologous to human OLFM1 (olfactomedin 1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Olfm1P1
GCCTGGTCACCTCCTGGCACCGAGGCGGCGCGGGGATGTCCAGGGCGCACAGACGGGCGGGCGCGGCGGGCAGAGGGGGATCCGAGATGAAGCCAGGCGCCCCTGCCCGCTGTGGTACTCGCGGTCTAAGGCTGCCCGGGGTGCAGGAGCCGGCGCCGTGCAGCGCAGGCACAGGAGGCGCAATGTCGGTGCTGCTGCTGAAGATCGGAGTTGTGCTAAGCACCATGGTCAGGATCACCAACTGCATGTTCCAAACACTGCTCTCCCTGATGGGCCTTAATACCACCCGGCTCTTGGCCGCCAGCAGCGGGATGTTGGACCGCAGCCGGTGTGTTGCCCACCAACCCCGAGGTGAGCTGCAGCTCTGCCCAGGACAGTGAGGGCAAGTGTATCTGCACGGTGGTCACCCCCCAGCAGACCATGCCAGCACAAAATAGCAGCTACTGGAAAAGGTGCAAAACATGTCTCAATCCATAGAAGTCTTGGGCATGCGGACTCAGAGAGTCCTGCAGTATGTGGAGAAGATGGAGAACCAGATGAAAGGCCTGGAGTCCAAGTTCAGGCAGGTTCAGGAGAGCCATAAGCAGCATCTGGCCAGGCTAGCTTAAAGAGTTTTTTCAATGTGCCGCTGACTGAAGAAGCAGCCTCTCTGCCCCCTTGTAACCATGAGAGAGCCAGAGAGCTTTTTGCACCATGAATTTTTACGATTCTTTTCCAATCCTTAATGCCATTTCACTAAGGAACCTTGAATCCAACCAGGATCCTCCTTTTGTGTGTGACTCTAGATGCATCCCAAGAATAGTTTGAACCCTTCTCAATGCGCTTTTTGa
>XM_006233876.3
GCCGCGGCCCCCGCGCACATCCCGCGCCGTGCTCAGAACCTGGTGGCCCTTCTCGACAGCGGAGCGCGCGGGGACGCTGCAGCGGCGGGCAACGCGGGCAGGCAGCGCGCTCCAGGCAGGGCCGCCTGGTCACCTCCCGGCGCCGGGGCGGCGCGGCGATGGCCAGGGCGCAGAGGGAGGCAGAGACGGGCGGGCGGCGGCGGGCGGAGGGGGCGCGGGGACGCGGCCGGGCGCCCCTGCCCGCCCTGGTGCCCGCCGCCTAAGGCTGCCCGGGGCGCGGGAGCCGGCGCCGGCGCGGCGCGGGCGCAGGAGACCACTCGAGGCGCGATGTCGGTGCCGCTGCTGAAGATCGGGGTCGTGCTAAGCACCATGGCCATGATCACCAACTGGATGTCCCAGACGCTGCCCTCGCTGGTGGGCCTCAATACCACCCGGCTCTCGGCCGCCAGCGGCGGGACGCTGGACCGCAGCACCGGCGTGTTGCCCACCAACCCCGAGGAGAGCTGGCAGGTGTACAGCTCTGCCCAGGACAGTGAGGGCAGGTGTATCTGCACGGTGGTCGCCCCCCAGCAGACCATGTGTTCACGGGATGCCCGCACAAAACAGCTGAGGCAGCTACTGGAGAAGGTGCAAAACATGTCTCAATCCATAGAAGTCTTGGACAGGCGGACTCAGAGAGACCTGCAGTACGTGGAGAAGATGGAGAACCAGATGAAAGGCCTGGAGTCCAAGTTCAGGCAGGTGGAGGAGAGCCATAAGCAGCATCTGGCCAGGCAGTTCAAGGGCTAACTTAAAGAGTTTTTTCAATGCGCCAGTGACTGAAGAAGCAGTCCCCCCATGTAACCATGAGAGAGCCAGAGAGCTTTTTGCACCATGCATTTTTATGATTCTTTTCCAATCCTTAGCGCCATTTCACTAAGGAACCTTGAATCCAGCCAGGATCCTCCTTTTGCATGCGACTCTAGATGCATCCCATGAATAGTTTGAACCCTTCCTTGTCAATGCACTTTTTGAAAGAGAAAGAAAAAAAAACCCACAAACTTTGTGTATGTGACCTAAAGCATGTAACTTTAAGATGCTGCATTCTCAACTGACTAATAAAGGCCTTTCCCAAATA

Publications

PMID - Link Title