Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Ppp2r2bP1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr18). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr1:211232818-211233080  UCSC
Strand +
Parental Sequence NM_022209.3
Parental seq. overlap 216 bp
Parental seq. overlap (%) 10.8%
Genomic Region Intragenic (Ppp2r2d)
Retrocopy Summary Ppp2r2bP1, located on chr1:211232818-211233080, is a retrocopy of the parental gene Ppp2r2b. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Ppp2r2b
Full Name protein phosphatase 2, regulatory subunit B, beta
Also known as Pppr2b2
Coordinate chr18:36985709-37421383
Strand -
Gene summary Predicted to enable protein phosphatase regulator activity. Involved in several processes, including mitochondrion organization; nervous system development; and positive regulation of neuron apoptotic process. Located in cytosol and mitochondrial outer membrane. Part of protein phosphatase type 2A complex. Colocalizes with cytoskeleton. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Mouse Mus musculus Ppp2r2cP1
Chinese hamster Cricetulus griseus Ppp2r2c_1P1
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Ppp2r2bP1
GTTTTTGAAGAGCCAGAAGATCCCAGCAGTAGATCCTTTTTCTCAGAAATAATCTCATCTATATCTGATGTCAAGTTCAGCCACAGTGGTCGATACATGATGACCAGAGACTATCTGTCGGTGAAGGTATGGGACCTCAACATGGAGGGCAGGCCTGTCGAGACCCACCAGGTACATGAGTACCTACGAAGCAAGCTCTGCTCCTTGTATGAGAATGACTGCATCTTTGACAAGTTCGAGTGCTGCTGGAATGGTTCAGACAG
>NM_022209.3
TGTAAGGCATTGCTTCCTAGCGCTGATGGCAAAATGGGACCCATCTCCAGTTATTCCTTGGGCTTCCCAGCTCTGCAGATCTGGGAGAGAACCTACATAAACATATTGGTGATGTAGCCAGCTTTCAAGGCTGAGAGAATCCTTATGGATTCGGGAGACTGGTTTTTCATTTAGAATTTTCTTTTTCCTTTGGAAGATGAAATGCTTCTCTCGTTACCTGCCTTATATCTTCAGACCTCCAAATACCATCCTCTCTTCCAGCTGCCACACTGAAGCTGACATTATCTCTACGGTAGAATTCAACCACACTGGAGAGTTACTAGCGACGGGGGACAAGGGGGGTAGGGTTGTAATATTTCAGCGAGAACAGGAGAGTAAAAATCAGGTTCATCGTAGGGGTGAATACAATGTTTACAGCACATTCCAGAGCCATGAACCCGAGTTCGATTACCTGAAAAGTTTAGAAATAGAAGAAAAAATCAATAAAATAAGATGGCTCCCTCAACAAAATGCAGCTTACTTTCTTCTGTCTACCAACGATAAAACTGTGAAGCTATGGAAAGTTAGTGAGCGTGATAAGAGGCCAGAAGGCTACAACCTGAAAGATGAGGAGGGCCGGCTCCGGGATCCTGCCACCATCACAACCCTGCGGGTGCCTGTCCTGAGACCCATGGACTTGATGGTGGAGGCCACCCCACGAAGAGTGTTTGCCAATGCGCACACATACCACATCAACTCCATATCTGTCAACAGCGACTATGAGACCTACATGTCTGCTGATGACCTGAGGATTAACCTGTGGAACTTTGAGATAACCAATCAGAGTTTTAATATCGTGGACATCAAGCCAGCCAACATGGAGGAGCTCACAGAAGTGATCACAGCAGCCGAGTTCCACCCCCACCACTGCAACACCTTTGTATACAGCAGCAGCAAGGGGACAATCCGGCTGTGTGACATGCGGGCATCTGCGCTGTGTGACAGGCACACCAAGTTTTTTGAAGAGCCAGAAGATCCAAGCAATAGATCGTTTTTCTCTGAAATTATCTCTTCAATTTCGGATGTGAAGTTCAGCCACAGTGGGAGGTATATCATGACCAGAGACTATCTGACCGCGAAAGTCTGGGATCTCAACATGGAAAATCGCCCCGTAGAGACATACCAGGTTCATGACTACCTCCGTAGCAAGTTGTGCTCCCTCTACGAAAATGACTGCATTTTTGATAAATTCGAGTGTGTGTGGAATGGGTCAGACAGCGTCATCATGACGGGCTCCTACAATAACTTCTTCAGGATGTTCGACCGAAACACCAAGCGTGATGTGACCCTTGAGGCCTCAAGGGAAAACAGCAAACCCCGGGCTATCCTCAAACCCCGAAAAGTGTGCGTCGGGGGCAAGCGAAGAAAAGATGAGATCAGTGTTGACAGTCTGGACTTTAGCAAAAAGATCTTGCATACAGCTTGGCATCCTTCAGAAAATATTATAGCAGTGGCGGCTACAAATAACTTATATATATTCCAGGACAAGGTTAATTAGGAGGACAAGTTACTACTTAGTCTCACATACTGAATACTAGTCAAACAAGTTTTTAAATGTTTCTTTGGGTCTTCATTTTGATGCATTGACTTTCATTTCCCTCTGCATAAAACAATTGGAATAGAACTTAAAAGGAGTTCAATGTTCTCAACTCCCCAATTCTAAGAAACGTCTGTCAAACTCGGTAGGCTTGGGACACTTCTGTTTAGAGTTGAGAGCTGCCAACGGCAGTAACTCTTCCACAGTCCACTGAATGTCTGATGCGTTCGTTCATTGCCCAGTTCTCTCTGGTGGGTTCTGTGTTTTGTTTCTAGGTGTCTGCTGCGATAAAATGAGATTGTCTGTAGTATTTAAGGAGAAAAAGAGATAAGGTTTTTTTTTTAATTAAGCAATTCCATTTGTTTGAAAAAAATCAACAACAAAAAAATAAACACTGTTTACTCTTAAGAA

Publications

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