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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Slc25a4P1
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Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr2:14642079-14642423  UCSC
Strand -
Parental Sequence NM_053515.1
Parental seq. overlap 319 bp
Parental seq. overlap (%) 24.7%
Genomic Region Intergenic
Retrocopy Summary Slc25a4P1, located on chr2:14642079-14642423, is a retrocopy of the parental gene Slc25a4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Slc25a4
Full Name solute carrier family 25 member 4
Also known as Ant1
Coordinate chr16:49266903-49270698
Strand +
Gene summary Enables enzyme binding activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; negative regulation of mitochondrial membrane permeability involved in apoptotic process; and positive regulation of cell growth involved in cardiac muscle cell development. Located in membrane raft; mitochondrial inner membrane; and mitochondrial outer membrane. Biomarker of alcoholic cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Slc25a4P1
TGTGACAGCAGTGGCAGGGCTGGTGTCCTATCCATTTGACACTGTTCACAGTAGGACGATGATGCAATCTGGCCGGAAAAGGACTGATATTATGTACACTTGACTGCTGGAGGAAGATTGCAAAGGATGAAGGAACCAAGGCTTTCTTCAAAGGTGCTGGGTCCAATGTATTGAGAGGCATGGGTGGTGCCTTTGTATTGGTATTGTATGATGAGATCAAAAAATATGTGTAATACTCAAGTTCACAGGTTCACAGATCTATTGTTTGGTTTAACAGACTATTCTTAAGGAAATAAAAAAAAAGACAGATCATGGATAAAACCAGACCATAAAGACTACCTCAGG
>NM_053515.1
CGGTCCCTTCGCGTCGTGCAGGGACGGAGACCGGGTGGCGGTGCCTGGCCGGGCGTAGGCAAGAGCAAAAGAGCGGCTCCTTGCAGACTGTGCGCGCCCGGCTTTCAGCATGGGGGATCAGGCTTTGAGCTTCCTTAAGGACTTCCTGGCAGGTGGCATCGCCGCCGCCGTCTCCAAGACCGCGGTCGCCCCGATCGAGAGGGTCAAACTGCTGCTGCAGGTCCAGCATGCCAGCAAACAGATCAGTGCAGAGAAACAGTACAAAGGCATCATTGATTGTGTCGTGAGAATCCCCAAGGAGCAGGGCTTTCTCTCCTTCTGGAGGGGTAACCTGGCCAACGTGATCCGGTACTTCCCCACCCAAGCTCTCAACTTCGCCTTCAAGGACAAGTACAAGCAGATCTTCCTGGGAGGTGTGGATCGTCATAAGCAGTTCTGGCGCTACTTCGCTGGTAACCTGGCCTCTGGTGGGGCAGCTGGGGCTACCTCCCTCTGCTTCGTCTACCCACTGGACTTTGCTAGGACCAGGCTGGCTGCCGACGTGGGCAAGGGATCTTCCCAGCGTGAGTTCAATGGGCTGGGTGACTGTCTCACCAAGATCTTCAAGTCTGATGGCCTGAAGGGTCTCTACCAGGGTTTCAGTGTCTCTGTGCAGGGCATCATCATCTACAGAGCTGCCTACTTCGGAGTCTATGACACTGCCAAGGGGATGCTGCCAGACCCCAAGAATGTGCACATTATTGTGAGCTGGATGATTGCCCAGAGTGTGACAGCCGTGGCGGGGCTGGTGTCCTATCCATTTGACACTGTCCGTCGTAGGATGATGATGCAGTCTGGCCGGAAAGGGGCTGATATTATGTACACGGGGACAGTTGACTGCTGGAGGAAGATTGCAAAAGATGAAGGAGCCAAAGCTTTCTTCAAAGGTGCTTGGTCCAACGTACTGAGAGGCATGGGGGGTGCTTTTGTATTGGTATTGTATGATGAGATCAAAAAATATGTGTAATGCTCAAGTTCACAGGTTCACAGATCCATTGTGTGGTTTAACAGACTATTCTTAAGGAAATAAAAAAAGACAGATCATGGATAAAACCAGACCATAAGGAATACCTCAGAAAAATGCTTCATTGAGTATTCATTTAACCACAAAAGTATTTTGTATTTATTTTACATTTAGATTCCCACAGCAAACAGAAGATAGCTTATCATACTTGTTCAATTAATTAACTGAAGAACTGATGCTGAATAAGTAACTCAATGTGACTCATTAATAAAGACTACTCAGTACAC

Publications

PMID - Link Title
No publications available for this retrocopy