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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MSRB1P1
Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chr20). Each line represents a retrocopy.
Species Macaca mulatta
Coordinates chr19:38502670-38503612  UCSC
Strand -
Parental Sequence NM_001346686.1
Parental seq. overlap 789 bp
Parental seq. overlap (%) 55.7%
Genomic Region Intergenic
Retrocopy Summary MSRB1P1, located on chr19:38502670-38503612, is a retrocopy of the parental gene MSRB1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MSRB1
Full Name methionine sulfoxide reductase B1
Also known as SEPX1
Coordinate chr20:1964370-1970332
Strand -
Gene summary The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 19. [provided by RefSeq, Aug 2017]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens MSRB1P1
Chimpanzee Pan troglodytes MSRB1P1
Bonobo Pan paniscus MSRB1P1
Gorilla Gorilla gorilla MSRB1P1
Orangutan Pongo abelii MSRB1P1
Gibbon Nomascus leucogenys MSRB1P1
Green monkey Chlorocebus sabaeus MSRB1P1
Crab-eating macaque Macaca fascicularis MSRB1P1
Baboon Papio anubis MSRB1P1
Golden snub-nosed monkey Rhinopithecus roxellana MSRB1P1
Marmoset Callithrix jacchus MSRB1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MSRB1P1
ATTGGTTCTTGGGAGGCGTGGGGAGGTGGGCGCGGGTCCCAGCGGTCATGGGGTCGGCGGCCTTGGGTCTGTTGGAGGGGCAAGTGCACGGTGGTCCTGGCAGTGCCATGTTGTTCTGCAGCTTCTTCAGGGGCGAGGTTTTCCAGAATCACTTTGAGCCAAGCGACTATATCTGTGCCAAGTGTGGCTATGAGCTGTTCCCCGGCCGCTCAAAGTGCGCATACTCATTCCCCTGACCGGCGTTCACCAAGACCATCCACTCTGACAGCGTGGCCAAGCGCCCAGAGCGTAATCGTCCTGAAGTCTTGAAGGTGTCCTGTGGCAAGTGTGGCAATGCATCGAGCCACGAGTCCCTGAACCGTGGCCCCAAGCTGTAGCAGTGCCGATTCTGAATGAATATTCAGCAGCTCGCTGAAGTTTGTCCCTAAAGGCAAAGAAACTTCTGCTTCCAAGGGGCACTAGGCGGGCAGCCCACATCCACCCCAGATGGCCACGGCACTAAGGCCACACGCTGGCCATTCTACCATGGAATCAGAGCCCTGGACACTGAGACAGGAAGGCAGGGCACAATGGCTGAAACATCAAGAAGGCTCCCAAGGCCCCAGCTCTGAACAAGATCTTGTTTCTTGGAAAAGTCACTCTTGCTGATGGTTCCTGCCTTCTGGTTCCTGGGCTGTGCGGCCACCCTGTCAGCTGACTCAGCCTCCTGCTCACTCAATAAGGCATCTCAGGGGTGTGGTCTGGGTGCAGTTGGTCTTTGAATGATGTTACGCCCCAACCTTCGACCTTTTCTTCCTGGTCCTGCCTCTGGACTCATCCCTGTGGGGCCCAATTCCAAGACAGACTCTCATCCTCACCAAAGCTTAGGCCCACATCTCCCAGGCTGCTTACGAGACAGAATGGAAATGGAGGCTGCCCCTGACAGCTGCCCCGGCTCTGGTCG
>NM_001346686.1
GCCCTCAGGAGGGGCGGGGCCTCCCGAAGGCGGAAGCCGGGATTCGCACTCCGGGGAGCTATTGGTCCTCGGGAGGGGCGGGGAGGCGGACGCGGGTCCTGGCCGTCGTCGGGTCGGCAGCCTTGGGTCAGTTGGCTGCGGCAAGTGCGCTGCGGTTCCAGCGGCGCCATGTCGTTCTGCAGCTTCTTCGGGGGCGAGGTTTTCCAGAATCACTTTGAGCCCGGCGTTTATGCGTGTGCCAAGTGTGGCTATGAGCTGTTCTCCAGCCGCTCGAAGTACGCACACTCATCCCCATGGCCGGCATTCACTGAGACCATTCACACCGACAGCGTGGCCAAGCGTCCGGAGCACAATCGACCTGGAGCCTTGAAGGTGTCCTGTGGCAAGTGTGGCAACGGGTTGGGCCACGAGTTCCTGAACGATGGCCCCAAGCCGGGGCAGTCCCGATTCTGAATATTCAGCAGCTCGCTGAAGTTTGTCCCTAAAGGCAAAGAAACTTCTACCTCCCAGGGGCACTAGGCGGGCAGCCCACACCCACCCCAGATGGCCACCTCACCAAGGCCACACGCTGGCCGTTCCACCTTGGAGTTGGAACCCTGGGCATCGAGACAGGAAGCCAGGGCGCAGTGGCTGAAACATCAGGGTGCTCCCAAGGCCCCAGCTCTGAACAAGACCTTCTCGTTTCTTGGAAAAGACCCTCATTTGCTGATGGTTCATGCCTTCTGCTGGGACAGGCCTGGGCTGCACAGCCACACTGTCGGCTGACTGAGCCCCCTGCTCACTCCAGATGCCTCCAGGAGGTGATCCCTGGGTGCAGCTGGTCTCTGAATGACGTTACACCTTCTTTTCCTGGCCCTGTCTGTGGACTCTGCCCCGTGAGCCCCAATTCCAAGACAGAGTGTTGTCCTCACTGAAGCTTAGGCCCACGTCTCCCAGGCTGCTTAGGAGACAGAATGGAAATGGAGGCCGCCCCTGCCAGCCGCCCTGGCCCTGGTCACTGCATGATCTGCTCTGGTCAAACCCTTCCAGGCCAGCCAGCGTGGGGATGGTCTGTGACCTGCTGGGAAGGCGGGCTGATGGGGCAGACCCCTGGCCTCTCGTCCACGAGGGAAGAAACCTAAACCCTGTTTCACAATCTGTGCGGAAGCAGCTTGCTTCACTCGTGCTGAGGAAAGCGGCTGTTGCTCCATGACTAACCAGCACAGGGCTGGGGCCTGCAGTTCACACCCGCAGGGACGCCCTTCCCAAGGTGTGGCGACTGTGCCTCACTGTACATGCTCAGAGGCCTGGCCATACAGGAGGGTGGGTGATGCTGAAGTCAGTCCCCATCTTAAGTAATTACTTTCTGTAATAATGAGGTGGAAATCAATAAACAAATGAAACATTCAGATGTA

Publications

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