Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MTCH2P2
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Macaca mulatta
Coordinates chr10:32101880-32103546  UCSC
Strand +
Parental Sequence NM_001320504.1
Parental seq. overlap 889 bp
Parental seq. overlap (%) 34.2%
Genomic Region Intergenic
Retrocopy Summary MTCH2P2, located on chr10:32101880-32103546, is a retrocopy of the parental gene MTCH2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MTCH2
Full Name mitochondrial carrier 2
Also known as -
Coordinate chr14:18111994-18139644
Strand +
Gene summary This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla MTCH2P5
Orangutan Pongo abelii MTCH2P5
Gibbon Nomascus leucogenys MTCH2P2
Green monkey Chlorocebus sabaeus MTCH2P6
Crab-eating macaque Macaca fascicularis MTCH2P2
Baboon Papio anubis MTCH2P4
Golden snub-nosed monkey Rhinopithecus roxellana LOC104668422P3
Marmoset Callithrix jacchus MTCH2P1
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MTCH2P2
TGCCAGTCAGGTGCTCCTGTTCTCAGGTCTCACCATCCTGTCCTAGCGAATCATGCACATGGAAGTGCTCATCCAGGTGGGATATGAGCCTCTTCCCCCAACAGGACGAAATATTTTGGGGTGGCAAGTATGTCAGCTTTCTCATTTCTTTTGTTATGCTCTGAACATTGCCAGCATTGACAGGAGGCATGGGTTGCTCACAGGCTTAACTCCATGACTGCATTTGGGGGTCCTTGGAACTGTGGTCCATGGTAAAGcCCATGGTAAAGTTTTATAGCATTACCAGGAGTGTGACAAGGGTGAGAAGTTAGGACCTGGATATGAACAAAAAGAAATCTCATCTTCCTTTGACCAAATCATCAAGGAAACAACTCAAGAGATGATCGTTTGTTCAGCTGCTGCCCTTATCACGTCCCTTCCATGTGCTCACTCTAAGATCTATGGCACAATTCACTGGGAAAGAATCCAAGTTCTGTGGACTTTGTGACACCATACTAACCATTTATCAGAAAGAGGGTATCCTAGGATTTTTCCCAGGTCTTGTTCCTCACCTCCTAGGTGACGACATTTCTTTGTGGCTGTGTGACTCACTAGCCTACCACCTTGTTGATACCCATGCAATGGACAGTGGGGTTTCTATCATGAATGAAATGAAGAGTTATTCTCAAGCTGTCACAGGATTTTTTTTGCCAGTATGTTGACCTATCCCTTTGTGATTGTCTCCCATCTTATGGCTGTTAACAACTGTGGTCTTGCTGGTGGATGCCCTCCTTACTCCCCAATATATACTTCTTGGATAGATTGCTGAGGTATGCTACGAAGAGAAGAAATATGAGCCTAGGAAATAGCTTGTTTTTCCAGATACAAGCCCTTTGGGAAGAGAAGACTTATTGTTGTGACCTGAGAATGTTAATATGAAGATGTGGGGCAGGGACTGTGACATTTCTATAGTTTCAGATGCACAGGATTATGGGAGAGAATGTTGATTTGTATATAATTTGGCATGCTTTCGAAATAATCATTTACTCTTGGG
>NM_001320504.1
ggactgggcggagaggcgcgcgctggtgcgtgcgtgcgcgcgcgccgcgggcgggcCAGTGAAACCGGCGGCCCTGGCACGTGACCCAGGACCGGCTCACCGGGTCGCTTGGTGGCTCAGTCTGTCTGTCCGTCCGCGGGTGCCATCATGGCGGACGCGGCCAGTCAGGTGCTCCTGGGCTCCGGTCTCACCATCCTGTCCCAGCCGCTTATGTACGTGAAAGTGCTCATCCAGGTGGGTTATGAGCCTCTTCCTCCAACAATAGGACGAAATATTTTTGGGCGGCAAGTGTGTCAGCTTCCTGGACTCTTTAGTTATGCTCAGCACATTGCCAGTATCGATGGGAGGCGTGGGTTGTTCACAGGCTTAACTCCAAGACTGTGTTCGGGAGTCCTTGGAACTGTGGTCCATGGTAAAGTTTTACAGCATTACCAGGAGAGTGACAAGGGTGAGGAGTTAGGACCTGGAAATGTACAGAAAGAAGTCTCATCTTCCTTTGACCGCGTTATCAAGGAGACAACTCGAGAGATGATCGCTCGTTCTGCTGCTACCCTCATCACACATCCCTTCCATGTGATCACTCTGAGATCTATGGTACAGTTCATTGGCAGAGAATCCAAGTACTGTGGACTTTGTGATTCCATAGTAACCATCTATCGGGAAGAGGGCATTCTAGGATTTTTCGCGGGTCTTGTTCCTCGCCTTCTAGGTGACATCCTTTCTTTGTGGCTGTGTAACTCACTGGCCTACCTCGTCAATACCTATGCACTGGACAGTGGGGTTTCTACCATGAATGAAATGAAGAGTTATTCTCAAGCTGTCACAGGATTTTTTGCGAGTATGTTGACCTATCCCTTTGTGCTTGTCTCCAATCTTATGGCTGTCAACAACTGTGGTCTTGCTGGTGGATGCCCTCCTTACTCCCCAATATATACGTCTTGGATAGATTGTTGGTGCATGCTACAAAAAGAGGGGAATATGAGCCGAGGAAATAGCTTGTTTTTCCGGAAGGTCCCCTTTGGGAAGACTTATTGTTGTGACCTGAAAATGTTAATTTGAAGATGTGGGGCAGGGACAGTGACATTTCTGTAGTCCCAGATGCACAGAATTATGGGAGAGAATGTTGATTTCTATACAGTGTGGCGCGCTTTTTTAATAATCATTTAATCTTGGGAAAATTGAGGTGTTTGGTGTCTGCCTTTTTTGTTCTTTTTTCCAGCACAACATAACTTACCACTGATAATCCCCTTTTAGTTATTCTGAATTAGGATATTTTTGCTCCAAATTCTTATTTTACTTAACCAGAAGGGAAAAAAAAGTTGTATTTTCCTGAAGCTACAGGCACTTTGTCATGTGATTTTTGAGTCTCAATTTCAGGCTTTGTAAAATGAAGAGTGGAATTCCAAGAAGAATGAGAAATAATTCTGTAAAACTTGACAAAATCACTAAATTAAACTATATGGGAGGTTATGAATTACCTTTTCTTAGGTAGACCCTAAAAAGTCAGTAGCATGCACCAGAATCTGACTCCCATTATGCTTCTAAGCACATTTCGTTGACCTTGTCTCTCATACTTCAAGAAAAGGACAGTACGTGGCTACATTATCCTAGAAAGTCTGTGTGAGGATCTACCCCTTCAGTCTGTTATTGCAGAGTAATAAAATGTCACCGACAGggagcctctgagcctactctagttcaacaggctgcctaaAAAAAATAAATAAGATAAAGGGTCAGCAACAACAAAGAAAAAGGACAGTTACAGAAAATAAGCAAGATTTGGAAAGGAAGTATAATGGCATTTTTTTCTCAAAGGAAGTTCTTGTTTTCACGTCAAATACGAAAAGCAGATCCTGCAGGAGTAATCCCCTTCTTTAAGAGCCAAGTATTCGCCCGTGCTTAAATTACACCATACAGTTCTAATTGTATATAATCttttgttcttcagttttttgttttgtttcctttttgttattgttGCCGAAGGTGAGTAGTTTTGCATTTCTGATGATAGCCTTGGAAAGTATATTTGTAACTCCATGTCTGGTAATGCCAACCCAAGTCCATATGGGTCTTAGGACACTGACCGCCTCACATGCCATACCCTCAGTTAAGCATGTTAACATTTATAGGAGGAAAAAAATCACTTTAGGAGAAAATAAAATTCAACTCAAGCATAAAGCTTCTATTTACTCAGGCCTTTTAAAAAGCAGGTTAAAATGCTCTAAAATGAGAAAGCCTGGTTTCACTTATTTATATAATTCACTGGGACATTGCCAAATGAGTAAGCACTTAATTTGCtgcttctgagacttctctatcaaaacagccccactaataatgttagaatgagaatgcaggggtctcttccctccccctggggtttaggaagctcatgaggagctcggcttaaaatgtctttgatgtctcttcctttgtctcaaaaagtaatgtcaattttatatactattcaatattactatctgcatttgttttaatataaaaatgtttgctgcctacctttttctcccaaaaaatctttaagtaaagatgatctgggaaaatgtg

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