Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PTTG1P5
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Macaca mulatta
Coordinates chr14:11165315-11165912  UCSC
Strand +
Parental Sequence NM_001195222.1
Parental seq. overlap 514 bp
Parental seq. overlap (%) 74.7%
Genomic Region Intragenic (LOC106993208)
Retrocopy Summary PTTG1P5, located on chr14:11165315-11165912, is a retrocopy of the parental gene PTTG1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PTTG1
Full Name PTTG1 regulator of sister chromatid separation, securin
Also known as securin
Coordinate chr6:157808201-157814786
Strand +
Gene summary N/A

Homology

Species Scientific Name Retrocopy
Human Homo sapiens PTTG1P3
Chimpanzee Pan troglodytes PTTG1P5
Bonobo Pan paniscus PTTG1P5
Gorilla Gorilla gorilla PTTG1P5
Orangutan Pongo abelii PTTG1P5
Gibbon Nomascus leucogenys PTTG1P2
Crab-eating macaque Macaca fascicularis PTTG1P5
Baboon Papio anubis PTTG1P6
Golden snub-nosed monkey Rhinopithecus roxellana PTTG1P6
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PTTG1P5
TCTGATCTATATTGATAAGGAGAATGGAGAACCAGGTATCCATGCAGCTCCTAAAGATAGGCTGAAGCTGGGATCTGGACCTTCAATCAAAGGCTTAAAGGGGAGATCTCAAGTTTCAACACCATGTGTTGGCAAAATGTCCGGTGCTTTACCAGCCTTACCTAAAGCTACCAGAAAGGCTTTTGGAACTGTCGACAGGGCTACAGAAACGCGAGTGAAGACCAACAGACTCCTCAAACTAAAACACCGAAATTTCTCTGCCAAAAAGATGACCAGGGAGACTGTTAAAGCAAAAAGCTCTGTTCCTGCCTCAGATAATGTTATCCAGAAATAGAAAAATTCTTTCACTTCAGTCTTCTAGATTTTGAGAGTTTTAACCAACCTGAAGAGCACCAGATTACAGGCCTCCCCTTGAGTGGAATGCCTCTTATGATCCTTGATAAGGAGAGAGAGCTTGAAAAGCTGTTTCAGCTGGGCCTGCCTCCACCTGTGAAGATGCCCTCTCCATCATGGGAGCCCAATCTGTTGTAGTCTCCTTCAACCCTTCTGTTGACCCTGGATGTGGAATTGCCACCTGTTTGCTATGACATAA
>NM_001195222.1
ACCGCCGCCTTAGACGAATGTGGCTGTTGGAAGCTGCGTGAGTGAACTGGAGGGTTGCGGCTGGTTAGAATAATCCAGAATGGCTACTCTAATCTATGTTGATAAGGAAAATGGAGAACCAGGCACCCGTGTGGCTGCTAAGGATGGGCTGAAGTTGGGGTCTGGACCTTCAATCAAAGCCTTAGATGGGAGATCTCAAGTTTCAACACCACGTTTTGGCAAAACGTTCGATGCTCCACCAGCCTTACCTAAAGCTACAAGAAAGGCTTTGGGAACCGTCAACAGAGCTACAGAAAAGTCTGTAAAGACCAAGGGACCCCTCAAACAAAAACAGCCAAACTTTTCTGCCAAAAAGATGACTGAGAAGACTGTTAAAACAAAAAGTTCTGTTCCTGCCTCAGACGATGCCTATCCAGAAATAGAAAAATTCTTTCCCTTCAATCCTCTAGACTTTGAGAGTTTTGACCTGCCTGAAGAGCACCAGATTGCGCACCTCCCCTTGAGTGGAGTGCCTCTCATGATCCTTGACGAGGAGAGAGAGCTTGAAAAGCTGTTTCAGCTGGGCCCCCCTTCACCTGTGAAGATGCCCTCTCCACCATGGGAATCCAATCTGTTGCAGTCTCCTTCAAGCATTCTGTCGACCCTGGATGTTGAATTGCCACCTGTTTGCTGTGACATAGATATTTAA

Publications

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