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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SELENOWP1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Macaca mulatta
Coordinates chr1:193560017-193560586  UCSC
Strand +
Parental Sequence NM_001042737.2
Parental seq. overlap 497 bp
Parental seq. overlap (%) 57%
Genomic Region Intergenic
Retrocopy Summary SELENOWP1, located on chr1:193560017-193560586, is a retrocopy of the parental gene SELENOW. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SELENOW
Full Name N/A
Also known as SEPW1
Coordinate chr19:47798144-47805122
Strand +
Gene summary This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A pseudogene of this locus has been identified on chromosome 1. [provided by RefSeq, Aug 2017]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens SELENOWP1
Chimpanzee Pan troglodytes SELENOWP1
Orangutan Pongo abelii SELENOWP1
Golden snub-nosed monkey Rhinopithecus roxellana SELENOWP1
Marmoset Callithrix jacchus SELENOWP2
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SELENOWP1
TTGGATATCTGCAGTGAGAGAACACCCCAGGCCACTGGGTTCTTTAAAGTAATGGTAGCCGGGAAGTTGATTCACTCTAAGAAGCAAGATGATGGCTACGTGGACACAGAAAACAAGTTTCTGAAGCTGGTGGCCGCCATCAAAGCCACCTTGACTCACGGCTAATGTGCCCTGAAGGCAGAGTCCAAGGACCTTGACCTGGCTCCTCGCAGCAGACACTTCATGACAGGAAGGACTGAAATGTCTCGAGGACGCCTGGTCTCCCCCTGTTCTTGCAGCTGCTGTTGGGGGCAGAGGTTGATGCCCCTGGTCGTTGCCTCTGTGTGGGAGAGTCTGTTAGTATGTGTCTTCCCCAGAATCCACACCGCCCTACCCTTGTTCCCTGATTTCATCAGATCTCTGTGCATACCCCATGTTTCCCCGGTTGTCTACCAGAGTTTGTGGGATGTCCCACCTCAGGCTTCCTTCTCAAAGGGAAGCCAAAAGAGGCGTCAGCATAGGTGAGTCTCTGATTGCGGCAACGTTTGCAACTGTTCACGATTCAATAAATATTGGACGAATTTAACCGAA
>NM_001042737.2
GCCGTTCCCTTGTCCCCCGCCTCGGCGCCTCTCCGCCCACCACCCCTCCCTGGCATTGGTTGACGCCAGAGGAAGCCGAGGCTCCATCCTTTCTGCGCAGGTTCCCGCCGCACTCGCGCAGACCTAGGGCGTCCAGCTGGGAGAGCGGTGTGGTCCGGGCGTCCGCTCCTCAGCGGATGTGGCGGCCCCGAGCCATGGCTCTCGCCGTGCGAGTCGTTTATTGTGGCGCTTGAGGCTACAAGTCCAAGTATCTTCAGCTCAAGAAGAAGTTAGAAGATGAGTTCCCCGGCCGCCTGGACATCTGCGGCGAGGGAACTCCCCAGGCCACCGGGTTCTTTGAAGTGATGGTAGCCGGGAAGTTGATTCACTCTAAGAAGAAAGGCGATGGCTACGTGGACACAGAAAGCAAGTTTCTGAAGCTGGTGGCCGCCATCAAAGCCGCCTTGGCCCAGGGCTAATGCGCCCTGAAGGCAGAGTCCAGCGACCTTGACCCAGCCCCTCTCAGCAGACGCTTCATGATAGGAAGGACTGAAAAGTCTTGTGGACGCCTGGTCTTTCCCTGATGTTCTCGTGGCTGCTGTTGGGGGCAGAGATTGACGCCGCTGGTCTTTGCCTCTGTGTGGGAGTCTGTGTGTATGTGTCTTCCCCGGAATCCACACCACCCCACCCTCCTCCTGTCCCCTGGTTTCATCGTCTCTCTTTGCATACCCCATGTCTTCCCCAGTTGTCCCCTGGAGTTTGGGGGACGTCCCGCCTCAGGCATCCTTCTCAAGGGGAAGCCAAGAGAGGCATCAGGATGGGTGAATTTCTGATTGCGGCGACGTTTGCAACCATTCACGATTCAATAAATACTGGAGGAATTGAACCGAA

Publications

PMID - Link Title