Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Hspa8P4
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr1:46453610-46456180  UCSC
Strand +
Parental Sequence NM_031165.5
Parental seq. overlap 1973 bp
Parental seq. overlap (%) 92.9%
Genomic Region Intergenic
Retrocopy Summary Hspa8P4, located on chr1:46453610-46456180, is a retrocopy of the parental gene Hspa8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Hspa8
Full Name heat shock protein 8
Also known as 2410008N15Rik|Hsc70|Hsc71|Hsc73|Hsp73|Hspa10
Coordinate chr9:40712572-40716498
Strand +
Gene summary Enables ATP hydrolysis activity; phosphatidylserine binding activity; and unfolded protein binding activity. Involved in several processes, including chaperone-mediated protein folding; late endosomal microautophagy; and positive regulation by host of viral genome replication. Acts upstream of or within several processes, including chaperone cofactor-dependent protein refolding; clathrin coat disassembly; and positive regulation of mRNA splicing, via spliceosome. Located in several cellular components, including extracellular exosome; glycinergic synapse; and photoreceptor ribbon synapse. Is active in presynapse. Is expressed in several structures, including 1st branchial arch mandibular component; alimentary system; brain; eye; and forelimb long bone. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Hspa8P4
TGCATTCGTGTGGTCTCATCATCAGCACAGCCGGGCCTACACACAAGCAACCATGTCTAAGGGACCTGCAGTTGGCATTGATCTTGGCACCACCTACTCCTGTGTGGGTGTCTTCCAGCATGGAAAGGTGGAAATTATTGCCAATGACCAGGGTAACTGCACCACGCTGAGCTATGTTGCTTTCATGGACACAGAGCGATTAACTGGGGACGGGGCCAAGAATCAGGTTGCAATGAACCTCACCAACAGTTTTTGATGCCAAACGTCTGATCGGGCGTAGGTTTGATGATGCTATTGTTCAGTCTGATATGAAGCACTGGCCCTTCATGGTGGTGAATGATGCAGGCAGACCCaaaaccCAAGGTCCAAGTGGAATACAAATAGGAGACAAAATGTTTCTACCCAGAGGAAGTGTCCTCCATGGTTCTGACAAAGATGAGGGAAATTGCAGAAGCGTACCTCAGAAAGACTGTTACCAATGCTGTGGTCACAGTGCCCACTTACTTCAATGACTCCCAGCGACAGGCAACAAAAGATGCTGGAACTATTGCTGGCCTCAATGTACTTCGAATCATCAATGAACcaactgctgctgctattgcttATGGCTTAGATAAGGTCGGAGCTGAAAGGAACGTGCTCATTTTTGACTTGGGAGGTGGCACTTTTGATGTGTCAATCCTCACTATTGAGGATGGAATTTTTGAAGTCAAATCAACAGCTAGAGACACCCACTTGGGTGGAGAAGATTTTGACAACCGAATGGTCAATCATTTCATTGCTGGGTTTAAGCGAAAGCACAAGAAAGACATCAGAGAGAACAAGATAGCTGTCTGCTGTCTTCGCACTGCCTGCAAGCAGGCCAAGTGCATCCTCTCCTCCAGCACCCAGGCCAGTATTGAGGTTGATTCTCTCTATGAGGGAATTGACTTCTATACCTCCGTTACCAGGCTCGATTTGAGGAATTGAATGCTGACCTGTTCTGTGGCACACTGGACCCTGTAGAGAAGGCCCTTCGAGATGCCAAACTGAACAAGTCACAGATCCATGATATTGTTTTGGTGGGTGGTTCTACCAGAATCCCCAAGATTCAGAAACTTCTGCAAGACTTCTTCAATGGAAAAGAACTGAACAAGAGCACTAACCCCAATGAAGCTGTTGCCAGTGGTGCAGCTGTCCAGGCAGCCATTCATTCTATCTGGAGACAAGTCTGAGAACATTAAGGATTTGCTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTGAAACTGCTGGCGGAGTCATGACTGTCCTCATCAAGTGCAATACCACCATCCCCACCAAGCAGACACAGACATTCACCACCGACTGTGATAACCAGTCTGGTGTACTCACTCAGGTGTATGAAGGTGAAAGGGCCATGACCAAGGACAACAACCTGCTTGGAAAGTTTGAGCTCACGGGCATCCCTCCAGGACCCCGTGGGGTTCCTCAGATTGAGGTTACTTTTGACATCGATGCCAAAGGCATCCTTAATGTTTCTGCTGTAGATAAGACCACAGGAAAGGAGATCAAGATCACCATCCCCAATGACAAAGGCCACTTGAGTAAGGAAGAAATTGAGCGCATGTACTTCTCCAAGAAGCTGAGAAGTACAAAGCTGAGGATGAGAAGCAGAGAGATAAGGTTTTCTTCAAGAATTCACTGGAGTCCTATGCCTTCGACATGAAAGCAACTGTTGAAGATGAGAAACTTCAAGGCAAGATCAAAGATGAAGACAAACAGAAGATTGACAAGTGCAATGAAATCATCCGCTGGCTGGATAAGAACCAGACTGCAGAGAAGGAAGAATTTGAGCATCAGCAGAAAGAACTGGAGaaagtctgcaaccctatcattACCAAGCTGTACCAGAGTGCTGGTGGCATGCCTGAGGGAATGCCTGGTGGCTTCCAAGGTGGAGGAGCTCCCCCATCTGGTGGTGCTTCTTCAGGCCCCACCATTGAAGAGGTGGATTAAATCAGTCCAAGAAGAGGATGTAGCATTGTTCCACAGGGACCCAAAACAAGTAACATGGaataataaaactatttaaattggcacca
>NM_031165.5
CTCATTGAACGCGGAGGCAGCTGCCTGGCATTTGTGTGGTCTCGTCGTCAGCGCAGCTGGGCCTACACACAAGcaACCATGTCTAAGGGACCTGCAGTTGGCATTGATCTCGGCACCACCTACTCCTGTGTGGGTGTCTTCCAGCATGGAAAGGTGGAAATTATTGCCAATGACCAGGGTAACCGCACCACGCCAAGCTATGTTGCTTTCACGGACACAGAGAGATTAATTGGGGATGCGGCCAAGAATCAGGTTGCAATGAACCCCACCAACACAGTTTTTGATGCCAAACGTCTGATCGGGCGTAGGTTTGATGATGCTGTTGTTCAGTCTGATATGAAGCACTGGCCCTTCATGGTGGTGAATGATGCAGGCAGGCCCAAGGTCCAAGTGGAATACAAAGGGGAGACAAAAAGTTTCTACCCAGAGGAAGTGTCCTCCATGGTTCTGACAAAGATGAAGGAAATTGCAGAAGCGTACCTCGgaaagaCCGTTACCAACGCTGTGGTCACAGTGCCCGCTTACTTCAATGACTCTCAGCGACAGGCAACAAAAGATGCTGGAACTATTGCTGGCCTCAATGTACTTCGAATCATCAATGAACcaactgctgctgctattgcttACGGCTTAGATAAGAAGGTCGGAGCTGAAAGGAATGTGCTCATTTTTGACTTGGGAGGTGGCACTTTTGATGTGTCAATCCTCACTATTGAGGATGGAATTTTTGAGGTCAAATCAACAGCTGGAGACACCCACTTAGGTGGAGAAGATTTTGACAACCGAATGGTCAATCATTTCATTGCTGAGTTCAAGCGAAAGCACAAGAAAGACATCAGTGAGAACAAGAGAGCTGTCCGCCGTCTCCGCACGGCCTGCGAGCGGGCCAAGCGCACCCTCTCCTCCAGCACCCAGGCCAGTATTGAGATTGATTCTCTCTATGAGGGAATTGACTTCTATACCTCCATTACCCGGGCTCGATTTGAGGAGTTGAATGCTGACCTGTTCCGTGGCACACTGGACCCTGTAGAGAAGGCCCTTCGAGATGCCAAGCTGGACAAGTCACAGATCCATGATATTGTCTTGGTGGGTGGTTCTACCAGAATCCCCAAGATTCAGAAACTTCTGCAAGACTTCTTCAATGGAAAAGAGCTGAACAAGAGCATTAACCCCGATGAAGCTGTTGCCTATGGTGCAGctgtCCAGGCAGCCATTCTATCTGGAGACAAGTCTGAGAACGTTCAGGATTTGCTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTGAAACTGCTGGCGGAGTCATGACTGTCCTCATCAAGCGCAATACCACCATCCCCACCAAGCAGACACAGACTTTCACCACCTACTCTGACAACCAGCCTGGTGTACTCATTCAGGTGTATGAAGGTGAAAGGGCCATGACCAAGGACAACAACCTGCTTGGAAAGTTCGAGCTCACAGGCATCCCTCCAGCACCCCGTGGGGTCCCTCAGATTGAGGTTACTTTTGACATCGATGCCAATGGCATCCTCAATGTTTCTGCTGTAGATAAGAGCACAGGAAAGGAGAACAAGATCACCATCACCAATGACAAGGGCCGCTTGAGTAAGGAAGATATTGAGCGCATGGTCCAAGAAGCTGAGAAGTACAAGGCTGAGGATGAGAAGCAGAGAGATAAGGTTTCCTCCAAGAACTCACTGGAGTCCTATGCCTTCAACATGAAAGCAACTGTGGAAGATGAGAAACTTCAAGGCAAGATCAATGATGAGGACAAACAGAAGATTCTTGACAAGTGCAATGAAATCATCAGCTGGCTGGATAAGAACCAGactgcagagaaggaagaatttgagcatcagcagaaagaactggagaaagtctgcaaccctatcattACCAAGCTGTACCAGAGTGCAGGTGGCATGCCTGGGGGAATGCCTGGTGGCTTCCCAGGTGGAGGAGCTCCCCCATCTGGTGGTGCTTCTTCAGGCCCCACCATTGAAGAGGTGGATTAAGTCAGTCCAAGAAGGTGTAGCTTTGTTCCACAGGGACCCAAAACAAGTAACATGGaataataaaactatttaaattggCACCATA

Publications

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