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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Pla2g10P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr1:86692282-86693088  UCSC
Strand -
Parental Sequence NM_011987.4
Parental seq. overlap 709 bp
Parental seq. overlap (%) 73.9%
Genomic Region Intragenic (Dis3l2)
Retrocopy Summary Pla2g10P1, located on chr1:86692282-86693088, is a retrocopy of the parental gene Pla2g10. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Pla2g10
Full Name phospholipase A2, group X
Also known as GX sPLA2|PLA2GX|sPLA2-X
Coordinate chr16:13532921-13548863
Strand -
Gene summary This gene encodes a member of the phospholipase A2 family of lipolytic enzymes that hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. The encoded protein undergoes proteolytic processing to generate a calcium-dependent enzyme that plays pivotal roles in the liberation of arachidonic acid from membrane phospholipids leading to the production of various inflammatory lipid mediators, such as prostaglandins. In response to myocardial ischemia/reperfusion, mice lacking the encoded protein display a reduction in myocardial infarct size partly through the suppression of neutorphil cytotoxic activities. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2015]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Pla2g10P1
AGCAACCAGGAGGTCACATGTATACAAGCATGGACTCCTGGAACTGGCAGGGACCTTGGATTGTGTTGGTCCTCGATCTCCGATGGCTTACGTAAACTATGGCTGTTATTGTGGCCTTGGTGGCCATGGAGAGCCACATGACGAACACCATTGACTGCTATAGTCTGCCCACTCTCACCTTCAGGTGCTGCCACCACCATGACTGCTGCTACTCTCAGGCTCAGGATGCCGGCTGCAGCCCTAAGTTAGACTGCTATCCATGGAAGTACATGGACCATGGCATCCTGTTTGGACCAGCAGAGAACAAATGTGTGCAGGTGTGACGAGGAGCTCGCTTACTGCCTGGCAGCAACCGAGTACCACTGGAGATACTTCTTCTTCCCCTCTATTTTATGTGAGAAAGACTCACCCAAGTGCGACTGACAGGCTACATGTCCCTTCACACATGGCAATGCAGTTCGCTTTCAGTCATGCAGCATGCAATTTATGCATAAGAATCCCTGGAGGCCAAGTTCAACAGCCTGCATTTGCTTTCTCCCTCCATTCAGGAACTCACAACTATGAGCCTGTGGAGTTGCCAGTCTGATGAAGGTTCAAAGTCCTGGGCCTGTTTTATACAAATACCACTGTGTTGGGCTTGGTATAATTTTTGAAGTTCAACCTTTATGAAACGCTGTACTATCTTCTACCTGTTGCAGAGGGTTGGTGGTCAAATGTGGATGAACACCTGCTTAGGCTTGGCTGTAGTAATAACATTGCCACATGATACATCTAAGAATTGTAACTGTAATAAAATATGTTCCCTAC
>NM_011987.4
GTATACTGGCCCTTCTGGTCAGTCCTACACCTGTCACTCTCCTATGTGTGGGCCACCTCTGTGACGGGCAATaatgctgctgctactgctgctgttgctgctgggaCCTGGACCCGGATTCAGCGAAGCAACCAGGAGGTCACATGTATACAAGCGTGGACTCCTGGAGCTGGCAGGGACCTTGGATTGTGTTGGGCCTCGATCTCCGATGGCTTACATGAACTATGGCTGTTATTGTGGCCTTGGTGGCCATGGAGAGCCACGTGACGCCATTGACTGGTGCTGCTACCACCACGACTGCTGCTACTCTCGGGCTCAGGACGCTGGCTGCAGCCCTAAGTTAGACCGCTACCCATGGAAGTGCATGGACCATCACATCCTGTGTGGACCAGCAGAGAACAAATGCCAAGAACTTTTGTGCAGGTGTGACGAGGAGCTGGCTTACTGCCTGGCAGGGACCGAGTACCACCTGAAATacctcttcttcccctccatTTTATGTGAGAAGGACTCTCCCAAGTGCAATTGACAGGCTCACATGTCCCTTTGCACATGGAAACGCACTTCACTTTCAGTGATCACCAACAGCATGCAATTTGTGCAGGAGAGTCACCGGAGGCCAAGTGCTAAAGCCACCTGCGTTTGCTTTCTCCTTCCATTCAGGAACTCACAACTATGAGCCTGTGGAGTTGCCAGTCTGATGAAGGTTCAAAGTCCTGGGCCTGTTTTATACAAATAGCGCTGTGTTGGGCGTGGTATACTTTTTGAAATTCAGCCTTTATGAGAAGCTGTACTATCTTGTACCTGCTGCAGGGCTGCTGGTCAGATGTGGGTGAACACCTGCTTAGGCTTGGCTGTGGTAATAACATTGCCACATGATACATCTAAGAATTGTAACTGTAATAAAAAAATGTTCCCTAACTGGC

Publications

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