Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Hmga2P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr1:176663091-176666638  UCSC
Strand +
Parental Sequence NM_010441.3
Parental seq. overlap 3243 bp
Parental seq. overlap (%) 86.8%
Genomic Region Intragenic (Sdccag8)
Retrocopy Summary Hmga2P1, located on chr1:176663091-176666638, is a retrocopy of the parental gene Hmga2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Hmga2
Full Name high mobility group AT-hook 2
Also known as 9430083A20Rik|HMGI-C|Hmgic|pg|pygmy
Coordinate chr10:120197173-120312374
Strand -
Gene summary Enables DNA-binding transcription activator activity, RNA polymerase II-specific and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including negative regulation of cellular senescence; positive regulation of angiogenesis; and positive regulation of cell proliferation in bone marrow. Acts upstream of or within several processes, including animal organ development; negative regulation of astrocyte differentiation; and positive regulation of cell population proliferation. Located in nuclear chromosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; leiomyoma; lipoma; and ovarian cancer. Orthologous to human HMGA2 (high mobility group AT-hook 2). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Hmga2P1
GGATGGTGGCAGCGGCGGCAGCCTAAGCAGCAGCAGTCCCAGGCGCACACGCCAGCTCGCCTGCTCTCGCTGCTCTTGCCCTCTCCAGCTCTCTCCATCCCGTCTACCGAAAGGTGCTGGGAGGCAGGATGAGCGCACGCGGTGAGGGCGCCGGGCAGCCTTCCACATCAGCCCAGGGGCAACCTGCCGCCCAGGTGCCACAGAAGCGAGGACGCGGCCGACCCAGGAAGCAGCAGCAAGAGCCAACCTCCTAAGCTCCTGTGAGCCCTCTCCTAAGAGACCCAGAGGAAGACCCAAAGGCAGCAAAAACAAGAGTCCCTCTAAAGCAGCCCAGAAGAAAGCAGAGACCATTGGAGAAAAAACGGCCAAGAGGCAGACCTAGGAAATGGCCACAACAAGTCGTTCAGAAGAAGCCTGCTCAGGAGACTGAAGAGACATCCTCCCAAGAGTCCGCAGAGGAGGATTAGGGGGCGCCGACATTCAATTTCTACCTCAGCATCAGTTGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTTAACTGCCACGATCTTTCTACTTTCTGGAGAAATCGCATAACCTTGAGAAGGACTATATTAATCACTTTGTAATCCCTTCACAGTCCCAGGTTTAGTGAAAAACTGCTGTAAACACGGGGAACACAGTTTAACAATgcaacttttaatgactgttttctttttccttaactTACTAATAGTATGTGGATCTGATAAGCAAGGGTGTGTGGTTGAAGAAAACCTCTGTGGTGGGCTTAATCAGTCACTACATGCAAACCCTAAACCGGCACCCTGGTGACCGGGGGCATTCGTATAAGAAAAGCattgtgtgtgactctgtgtccaCTCAGATGCCACCCCCACCATGATCATAGAAAATCTGCTTAGGACACCAAAGATGAGAACTAGACACTACTCTCCTTTGTGTATAATCTTGTAGAcacttacttgatttttttttctttttttacttttcaatTCTGAATGAGACAAAATGCTGGTGTATCTTTTAATACAGCTAGCAAACCAGAATAAGTTATGCtcgttttttgtcttgttttgtttttttcaaaaaggGAAGTAAACGAGAACCGTTGACTCCTCCGTTTATGGActcacacacagcagcaggagtgATAAGCCCACAAGCTCTCTTTCCCGCCTCGGGAAATCTACACAGCCAAAAGCCACTTAGCCATAAATGACACTTGTCAGCCTTGAAGCATCCGAGATAACTAGCTGAGTAAAATGATCCttttttggaatttaatgaaaaggtTAACAGTACCCAATGAACCCACCCAAGTGATGACGTGGGAGGAGCGAAACCGAAATCTCTCTTGCTATATAAAggacactattttttaaaaaataataataaaaacagctcCCGCtcgctctcctctctccctcccttctctccctcgcctctctctcctctctatatTCTCTGTTCTTCATTGTGTACCAGTGTCCGTGAAAGACCGCAGTACCACTTACCTCAGATGAAGCCTGCGTGTTACGTCCTGTAACACCTTTCGTTTTGACATAAGATGGCTAGCCCGGGTGCATTATCTTGGTTCGGACTGCCATCTCTGCATTCACGCTGCACTTTTAGCCAGAGATGCAATAATCCCTACACTCAATACTACCTCTGAATGCTACAGTTAATTTACAGCCCTGCCCTTGTTACACGCTGCTAGACACAAGCCCTGcaagagaaaggggggaaaaaaacccaccaaaaccaaaccaaaccttacTGGGTCGGCATCTCAGCCATCCCCAGTTCTCGACCATTCTTGTCTGTACTCTTACTCCGTCTCTGCAGGCTATGCATGtttctatgacttttttttttttaaaattaaaatgttacaaaTGCTTGTGGCAGCTTTCCTGCTAGATTGTTACATTAATTTGAAACAGTTTTGAGTCAAGTTGCTCCTAGGTTCTTAAggagaatttatttttcagtggcACTActttgtatcatctgtagtgTTCAAATATAAGTCTCCAAGTTTGTACCTCAAATGAATtattgaaacaaatggacttccTGATTTGCAAGGAACTACCTCCACACTTCCAAAGGAACAAACTTGCAGCCTATATCGCTCATTGATTTCCTTCCCCCATGTTTGAAGGAGTTCAAACCTCACCTCTCCCTCATCGAAACTATTTTTTTGTAAAATACACTTGATAGAAACACAATTTTTTTACATACTtttgcaaaaataaatgaattaaaatcaaGCCAACCTTCAAAGAAACTTGAAATTTTGCTACAACCAGCTCAGCCTTTTGCCTAAtgcaatgaaaaaggaaaaaaaatagatttctaAGATTAGTTGCCTAGAAGAATATGCTTGACCGatattttttcatgtattttacaCAATGTGATTTTTGTAAAAAAATGTCTCAAGCAGATTTGTTTTGGACGCTTCTTGTGTAGAGTTTCTATGCCTTTCTCTCCTATTAAGTGTGCTGACTTTCCAGAGTGTTACCCACTGGGCCAGGAGGTGGTTTCTCATAGTGGCTTGTGTCAGTATAAGTTAATACTGAAgccaaatgaatgtCTCTTTCAGCTGTTTTCAGGGAGGTCACTTCAAAGGCCACGTGCCGCTCTGAGACTGGCAGATGGCTCACTGTCGTGAGTTGCCAAAGGAGCTATGGAGAGATTAAAACTCAACGTGACTATTAACAATGcattaaataatcaaataaacaaTGGCTTATAAATATCAGATTCTCATTCCAGGTCTTCGGATGTGCCTTACAGAAACCTCATTTTGGCCAGCTCATAAAAACTGAAGCAGTTTCTCGTGTTGGCCAGACTGGGCACACTGAGCAATTTCCATCTCTGATGAAGTTATTCCTTATTTCCTGTATGTTGTACAATCAAAACACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTcatactgaggcttCTGTCCAATGGAACAGTGAGAACatcataaaatttttatatatatagtttatttttatggGAGATAAATTTTATAAGACTGTTTTTTACTGTTGTTGGTCACAGCTAAGTAAAACTGGACATCTAACTTCTCTACCATTTCTGTGAGCTAAGTATGTTTGCAGGAAAAACTTATCAAGACGATTAACTGCATCCAACCTTCTCCCTGTTCCTTTGTGCGCCCTCTGACTTATTTCTCTGTTCCTTGTGTAGAGTCGCTGTCTGTGATTGTGCTTGGATGGCTTGCTTGTGGCAATACCTTCTCTAGTGGATTATCACTGTCTGCACAATAAACATAACAGCctctgtggg
>NM_010441.3
CGCAACTCCCGAGCCTTTGCGGAGAGAGCAACCCTCTCCGCCTCcaactcttccctctccttcgCTTCCCGCCTCCTCTCCCTACCTCCACCTCTACCTCCGCCACCCACTGCCCGCAGcgcctcctcctttcctcctcctcctctcctcctcctctcttcctcctcccctctctctttttggcAGCCGCTGGACGTCCGGTGTTGATGGTGGCAGCGGCGGCAGCCTAAGCAGCAGCAGTAGTCCCCGGCGCACTCGCCAGCTCGCCTGCTCTCGCCGCTCTTGCCCTCTCCAGCTCTCTACATCCCGTCTCCCGAAAGGTGCTGGGCGGATTCGGGGCGGCGGAGGCCGAGCGGCTGCAGCGGCGGTACCGGTAGAGGCAGTGGTAGCGGCGGCGGGAGGCAGGATGAGCGCACGCGGTGAGGGCGCCGGGCAGCCGTCCACATCAGCCCAGGGACAACCTGCCGCCCCGGTGCCACAGAAGCGAGGACGCGGCCGACCCAGGAAGCAGCAGCAAGAGCCAACCTGTGAGCCCTCTCCTAAGAGACCCAGAGGAAGACCCAAAGGCAGCAAAAACAAGAGCCCCTCTAAAGCAGCCCAGAAGaAAGCAGAGACCATTGGAGAAAAACGGCCAAGAGGCAGACCTAGGAAATGGCCACAACAAGTCGTTCAGAAGAAGCCTGCTCAGGAGACTGAAGAGACATCCTCGCAAGAGTCCGCAGAGGAGGATTAGGGGGCGCCGACATTCAATTTCTACCTCAGCATCAGTTGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCAGTTATTCTTAACTGCCACGGTCTTTCTACTTCCtgcggggtggggcgggggcggggctgggCGAGGGGCGGGGCCGGGGTGGGCGAAATCGCATAACCTTGAGAAGGACTATATTAATCACTTTGTAATCCCTTCACAGTCCCAGGTTTAGTGAAAAACTGCTGTAAACACGGGGGACACAGTTTAACAATgcaacttttaatgactgttttctttttccttaactTACTAATAGTTTGTGGATCTGATAAGCAAGGGTGTGTGGTTGAAGAAAACCTCTGTGGTGGGCTTAATCAGTCACTACATGCAAACCCTAAACCGGCACCCTGGTGACCGGGGGCATTCGTATAAGAAAAGCattgtgtgtgactctgtgtccaCTCAGATGCCACCCCCACCATGATCATAGAAAATCTGCTTAGGACACCAAAGATGAGAACTAGACACTACTCTCCTTTCTTTGTGTATAATCTTGTAGAcacttacttgatttttttttctttttttacttttcaatTCTGAATGAGACAAAATGCTGGTGTATCTTTTCATACAGCTAGCAAACCAGAATAGGTTATGCtcgttttttgctttgttttgtttttcaaaaagggAAGTAAACGAGAACCGTTGACTCCTCCATTTATGGACTCATACACAGCAGCAGGAGTGATAAGCCCACAAGCTCTCTTTCCCGCCTCGGGAAATCTACACAGCCAAAAGCCACTTAGCCATAAATGACACTTGTCAGCCTTGAAGCATCGGAGATAACTAGCTGAGTAAAATGATCCtgttttggaatttaatgaaaaggtTAACAGTACCCAATGAACCCACCCAAGTGATGACATGGGAGGAGCGAAACCGAAATCTCTTTTGCTATATAAAggacactattttttaaaaaaaaataataaaaacagctcccgctctctgtcctctctccctcccttctctccctcgcctctctctcctctctatatTCCCTGTTCTTCATTGTGTACCAGTGTCCGTGAAAGACCGCAGTACCACTTACCTCAGATGAAGCCTGCGTGTTACATCCTGTAACACCTTTCATTTTGACATAAGATGGCTAGCCGAGGTGCATTATCTTGGTTCGGACTGCCATCTCTGCATTCACGCTGCACTTTTAGCCAGAGATGCAATAATCCCCACTCCTCAATACTACCTCTGAATGCTACAGTGAATTTACAGCCCTGCACTTGTTACACGCTGCTAGACACAAGCCCtgcaagagaaaggaaaaaaaaaagcccaccaaaaccaaaccaaaccttacTGGGTCGGCATCTCAGCCATCCCCAGTTCTCGACCATTCTTCTCTGTACTCTTACTCCGTCTCAGCAGGCTATGCATGtttctatgactttttttttttttaattaaaatgttacaaATGCTTGTGGCAGCTTTCCTGCTAGATTGTTACATTAATTTGAAACAGTTTTGAGTCAAGTTGCTCCTAGGTTCttaaggagaatttttttttcagtgacactactttgtatcacacacacacatctgtagtgTTCAAATATAAGTCTCCAAGTTTGTACCTCAAATGAATtattgaaacaaatggacttccTGATTTGCAAGGAACTACCTCCACACTTCCAAAGGAACGAACTTGCAGCCTATATCACTCATTGATTTCCTTCCCCCATGTTTGAAGGAGCTCAAACCTCACCTCTCCCtcattgaaacattttttttggtAAAAGACACTTGATAGAAACACAATTTTTTTACATACTtttgcaaaaataaatgaattaaaatcaaGCCAACCTTCAAAGAAACTTGAAATTTTGCTACAACCAGCTCAGCCTTTTGCCTAAtgcaatgaaaaaggaaaaaaatagatttcTAAGATTTGTTGCCTAGAAGAATATGCTTGACCGatattttttcatgtattttacaCAATGTGATTTTTGTAAAAAAATGTCTCAAGCAGATTTGTTTTGGACGCTTCTTGTGTAGAGTTTCTATGCCTTTCTCTCCTATTAAGTGTGCTGACTTTCCAGAGTGTTACCCACTGGGCCAGGAGGTAGTTTCTCATAGTGGCTTGTGTCAGTATAAGTTAATACTGAAgccaaatgaaacaaacaaacaaccatgtCTCTTCCAGCTGTTTTCAGGGAGGTTACTTCAAAGGCCACGTGCCGCTCTGAGACTGGCAGATGGCTCACTGTTGTGAGTCGCCAAAGGAGCTATGGAGAGATTAAAATTCAACATGACTGTTAACAATGcattaaataatcaaataaacagTGGCTTATAAATATCAGATTCTCATTCCGGGTCTTCGGATGGGCCTTACAGAAACCTCATTTTGGCCAGCTCATAAAAACTGAAGCAGCTTCTCGTGTTGGCCAGACTCGGCACACCGAGCAATTTCCATCTCTGATGAAGTTATTCCTTATTTCCTGTATGTTGTACAATCAAAACACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTcatactgaaaaaaaagaaaaaaaagagaaaaaaaaaggcttgtgTCCAATGGAACAGTGAGAACatcataaaatttttatatatatagtttatttttgTGGGAGATAAATTTTATAAGACTGTTTTTTACTGTTGTTGGTCACAGCTAAGTAAGACTGGACATCTAACTTCTCTACCATTTCTGCAAGCTAAGTATGTTTGCAGGAGAAACTTATCAAGACGATTAACTGCATCCAACTTTCTCCCCGTTCCTTTGTGTGCCCTCTGACTTCGTTCTCTGTTCCTTGTGTAGAGTCGCTGTCTGTGATTGTACTTGGACGGCTTGCTTGTGGCAATACCTTCTCTAGTGGATTATCACTGTCTGCACAATAAACATAACAGCCTCTGTGGGCCCCgtgg

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