Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Fgfr3P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr1:180919182-180921307  UCSC
Strand +
Parental Sequence NM_008010.5
Parental seq. overlap 1906 bp
Parental seq. overlap (%) 44.9%
Genomic Region Intragenic (Nvl)
Retrocopy Summary Fgfr3P1, located on chr1:180919182-180921307, is a retrocopy of the parental gene Fgfr3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Fgfr3
Full Name fibroblast growth factor receptor 3
Also known as CD333|FR3|Fgfr-3|Flg-2|HBGFR|Mfr3|sam3
Coordinate chr5:33879068-33894412
Strand +
Gene summary This gene encodes a member of the fibroblast growth factor receptor family. Members of this family are highly conserved proteins that differ from one another in their ligand affinities and tissue distribution. A representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene may be associated with craniosynostosis and multiple types of skeletal dysplasia. A pseudogene of this gene is located on chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Fgfr3P1
ACTGCAGGCTGCCAGGAGAACAGCTTACCTGCAAGGATCTAGTGTTCTGTGCCTACCAGGTAACATGGAGCACAGAATACTTGGCTTCCCAGAAGTGTATTCAGAGACTTGGCTGCCAGAAATGTCCTGGTTACCTCGGACAATGTGATGAAGATTACAGACTTTGGCCTGGCCCAAGACGTGCACAACCTGGATTACTACAAGAAGACCACAAGTGGCCTGCTACCTGTGAAGTGGATGGAATCAGAGGCCCTTTTTTACAGAGTCTTCACCCACCAGAGTGATGTCTGGTTCTTTGGTGTCCTCCGCTAGGACATCTCACCGTATCCTGGCATCCCAGTGGAAGAGCTTTTCAAGCTACTTACAGAGGGCCACTGCATGGACAAGCCCCACAACTGCACACGTGGCCTGTACATGGTCACGTGGGGATATTGgcatgcagtgtcttcagaggccCACCTTCAAGCAGTAGGTAGAGGATTTAGACCGCATCCTCACTGTGACATCAACTGACAAGTACTTGGACCTCTCCGTGCCATTTGAGCAGTCCTCTCCAGGTGGTTGGGACACTCCTAGCTCCAGCCTGTCCAGGGATGACAGGGTGTTCACCCATGAGTTGCTACCCCCACCCAATAATGGGGGACCTCGGATGTGAAAGGCCTGCAGTCCCACAGACCAAGCCCCAGCCAATGTTTCTGTGGACCCTAACCCGCCCTGCTACTGCTGGTGTGCAGTGGACCCTAGCCAGCCCAGTGCAATGGGTCAACAATAGACAAGACTTCCTGCATGTTTATCcttagctcctgggtgcagaggCCCCTGCCCCTTGGGAACATGCACTGCTGTATAGTGATCTCCTGAgtggccagggccaggaagaccAAATGAGAACGTTAAGAGGCCCACCCTGTGCAACCCTGGGGTTCTGGCCCTCTCATTTCTCACTGCTACCTTACAGGGACCATTGTAGAGAGTGGGCCTTGGCCTCTTTGGTGCCCCAAGCTGAGCTTGCAGGGAGGCTCTGCTCTGTGTGGCAAGCCTCTCTCCTACATGGCACCTTATATCTAGGGGGTGTCATAGCTCGACATCTCCAGGCTGCCTGCTTCCCACCCTGCCTCTCAGACACAAATTACAGGTACctgaaaaaggggggggggagataatGTCTATCAGAAAGGTGTATTCCAGaggaaaatgtatatttatataaatagatgttgtgtatctatatgaaAAAAGGCAAAGCTGAAGCCCAAGGGAGCAAGATACTCCATGGGGCTCACTAGTAAACTGGCAAGAACAGGCTGAGAAGCAAGGGACTTTTCTGGCATGGCAGTTTTGTTTGTACTGGACCTGTATATTTGTAAAGCTATATTTATCAACTCCCAGAGCTCCAGTCCCCAACCTCAGGGTACAGCATTTAGTCCCAGGGTATTTCAGACATTTTAAGTTGTAACTTATTAACAGTGAAAGAGGTTCATGCTGGATTTAGGGAGTTGCTGAGACCGTGAGTCTGGCCTCTGCCAGGCTGGACATAGCCCCTTGGCGCATGAGCAGCTAGCTCTCCTAGTTAGTAATGGCGCCAGAGAGCGTTTCCTGTTGCCTTCGGCCCTCTTTTGTGAGGGATTAGATTTATATAGGAACTTTCTTTAGGAGATGTTTAAAAATTTCAAGGTGAACTGGTATTTTTCATACAGATTATTCTAATTGCTATGTATTCCAGGCAGGAGCCTGTGCCCAGGGAGGGACTGATCCTGTAAGAAGGTTCAGATGTTAATAGATATCTGTTACAAGTCTATCTATAATTTATTGAGTTTTTACAAGTTGTTTTGCTGCAGGCTTAACACTCCCTATGCAGAGCTTCTAGACTTTTATAGCCTAGACTGCTACCTTTCAAAGCCTGGGAGACAGTGGTGAAtgcaattttgctactttttTTACTCCTCTTATTGGGCTTGGGTGGCTGTCCCTTGCCTGTCAGTCAGCAGGGTCAGGACAGTGGCTCAGGGTTCTTGGGGCCTAGCACATGGTTTATCAGCCCACACTAGCAGATGTGGTTTTACTAACACAGCCAACTTACTTtccaaaaaataaagagataactggttc
>NM_008010.5
TCGGGGCGTGGCGGGagcaccccccaacccccgcccggGCTGCTGCGCGCCGGGCAGCCCCAGTTCAGTGCACTGTGGCAGCGGGGGTGGCGGGAGCAGCTGGCGCCGTGCGATCCACTCCGGCGGGGGGACTCAGTGGTGGGCGGCCGGCCACTGGGACAGAGGAGACCCTGGAAAAGCGGGCCGAGAGACGGAGCCGCGCGTGTCTCCACAGAGGCGTTCTCCCACCGGCGCCGGAGCCGGGCGTGGGGGGTTGCAGCATGCCCGCGCGCGCTGCTTGAGGACGCCGCGGCCCCCGCTCTGGAGCCATGGTAGTCCCGGCCTGCGTGCTAGTGTTCTGCGTGGCGGTCGTGGCTGGAGCTACTTCCGAGCCTCCTGGTCCAGAGCAGCGAGTTGTGCGGAGAGCGGCAGAGGTTCCAGGGCCTGAACCTAGCCAGCAGGAGCAGGTGGCCTTCGGCAGTGGGGACACCGTGGAGCTGAGCTGCCATCCTCCTGGAGGTGCCCCCACAGGGCCCACGGTCTGGGCTAAGGATGGTACAGGTCTGGTGGCCTCCCACCGCATCCTGGTGGGGCCTCAGAGGCTGCAAGTGCTAAATGCCTCCCACGAAGATGCAGGGGTCTACAGCTGCCAGCACCGGCTCACTCGGCGTGTGCTGTGCCACTTCAGTGTGCGTGTAACAGATGCTCCATCCTCAGGAGATGACGAAGATGGGGAGGACGTGGCTGAAGACACAGGGGCTCCTTATTGGACTCGCCCGGAGCGAATGGATAAGAAACTGCTGGCTGTGCCAGCCGCAAACACTGTCCGCTTCCGCTGCCCAGCTGCTGGCAACCCTACCCCCTCCATCTCCTGGCTGAAGAATGGCAAAGAATTCCGAGGGGAGCATCGCATTGGGGGCATCAAGCTCCGGCACCAGCAGTGGAGCTTGGTCATGGAAAGTGTGGTACCCTCCGATCGTGGCAACTATACCTGTGTAGTTGAGAACAAGTTTGGCAGCATCCGGCAGACATACACACTGGATGTGCTGGAGCGCTCCCCACACCGGCCCATCCTGCAGGCTGGGCTGCCGGCCAACCAGACAGCCATTCTAGGCAGTGACGTGGAGTTCCACTGCAAGGTGTACAGCGATGCACAGCCACACATCCAGTGGCTGAAGCACGTGGAAGTGAACGGCAGCAAGGTGGGCCCTGACGGCACGCCCTACGTCACTGTACTCAAGACTGCAGGCGCTAACACCACCGACAAGGAGCTAGAGGTTCTGTCCTTGCACAATGTCACCTTTGAGGACGCGGGGGAGTACACCTGCCTGGCGGGCAATTCTATTGGGTTTTCCCATCACTCTGCGTGGCTGGTGGTGCTGCCAGCTGAGGAGGAGCTGATGGAAACTGATGAGGCTGGCAGCGTGTACGCAGGCGTCCTCAGCTACGGGGtggtcttcttcctcttcatcctggtGGTGGCAGCTGTGATACTCTGCCGCCTGCGCAGTCCCCCAAAGAAGGGCTTGGGCTCGCCCACCGTGCACAAGGTCTCTCGCTTCCCGCTTAAGCGACAGGTGTCCTTGGAATCTAACTCCTCTATGAACTCCAACACACCCCTTGTCCGGATTGCCCGGCTGTCCTCAGGAGAAGGTCCTGTTCTGGCCAATGTTTCTGAACTTGAGCTGCCTGCTGACCCCAAGTGGGAGCTATCCAGGACCCGGCTGACACTTGGTAAGCCTCTTGGAGAAGGCTGCTTTGGACAGGTGGTCATGGCAGAAGCTATTGGCATCGACAAGGACCGTACTGCCAAGCCTGTCACCGTGGCCGTGAAGATGCTGaaagATgatgcgactgacaaggacctgTCGGACCTGGTATCTGAGATGGAGATGATGAAAATGAttggcaagcacaagaacatcaTTAACCTGCTGGGGGCGTGCACACAGGGTGGGCCCCTGTATGTGCTGGTGGAGTACGCAGCCAAGGGCAATCTCCGGGAGTTCCTTCGGGCGCGGCGGCCTCCAGGCATGGACTACTCCTTTgatgcctgcaggctgccagagGAACAGCTCACCTGCAAGGATCTAGTGTCCTGTGCCTACCAGGTGGCACGGGGCATGGAATACTTGGCTTCTCAGAAGTGTATTCACAGAGACTTGGCTGCCAGAAACGTCCTGGTGACCGAGGACAATGTGATGAAGATTGCGGACTTTGGCCTGGCTCGAGATGTGCACAACCTGGACTACTACAAGAAGACCACAAATGGCCGGCTACCTGTGAAGTGGATGGCACCAGAGGCCCTTTTTGACCGAGTCTACACCCACCAGAGTGATGTTTGGTCTTTTGGTGTCCTCCTCTGGGAGATCTTTACGCTGGGGGGCTCACCGTATCCTGGCATCCCAGTGGAAGAGCTTTTCAAGCTGTTGAAAGAGGGCCACCGCATGGACAAGCCAGCCAGCTGCACACATGACCTGTACATGATCATGCGGGAATGTTGGCATGCGGTGCCTTCACAGAGGCCCACCTTCAAGCAGTTGGTAGAGGATTTAGACCGCATCCTCACTGTGACATCAACCGACGAGTACTTGGACCTCTCCGTGCCGTTTGAGCAGTACTCGCCAGGTGGCCAGGACACGCCTAGCTCCAGCTCGTCCGGAGATGACTCGGTGTTCACCCATGACCTGCTACCCCCAGGTCCACCCAGTAACGGGGGACCTCGGACGTGAAGGGCCAACAGTCCCACAGACCAAGCCCCAGGCAATGTTTACGCGGACCCTAGCCCGCCCTGCTACTGCTGGTGTGCAGTGGACCCTAGCCAGCCCAGTGCAATGGGCCAACAGTAGACAAGACTTCCTGCGTGTTTATCCTTGGCTCCTGGGTGCAGAGGCCCCTTGGGAACATGCACTGCTGTAGAGTAATCTCCTGACTGGCCAGGGCCAGGAGCACCAAACAAGAATGTAAGAGGCCCACCCTGTGCAACCCTGGGGTTCTGGCCCTCTCATTTCCCACTGCTACCTTCCAGGGACCATTGTGGAGAGGGCTAGACTCCATGTCCAGAGTGGGCCTTGGCCTTCTTGGTGCCCCAAGCTGAGCCTACAGGGAGGCTCTGCTCTGTGTGGCAAACCTCTCTCCTACATGGCACCTTGTGCCTGGGGGTGTCATAGCTCGACATCTCcaggctgcctgctttccaccCTGCCCCTCAGAGACAAATTACGGGTACCTGAAGGGGGGGCATAATGTCTATCAGAAAGGTTTATTCCAGaggaaaatgtacatttatataaataGATGTTGtgtatgatataaatatatacatacatatatataagaaTATCTATATGGAAAAAGGCAAAGTTGAGGCCCAAGGGAGCAAGATACTCCATGGGTCTCACTAGGAAACTGGCAAGAGCAGGCTGAGAAGCAAGGGGCTTTTCTGGCACGGCAGTTTTGTTTGTACTGGACCTGTATATTTGTAAAGCTATTTATCAACCCCCAGAGCGCCAGTCCCCGACCCCAGGTTCATAGCGTTTAGTCCCAGGGTATTGCAGCCATCTTAAGTTGTAACTTATTAACAGCGGAAGAGGTTCATGCTGGATTTAGGGAATTGCTGAGAACGTGCGTCTGGCCTCCACCAGGCTGGCCGTGGCCCCTTGGCGCTTGAATGGCTCTCCTAGTCAGAGCTGGCTCCAGGGAGCATTTTCTGTTGCCTTTGGCCCTCTTTTGTGGGGGATTAGATTTATATAGGAACTTTCTTTAGGAgatgtttaaaaattttaaggtgAACTGGTATTTTTCATACAGATTATTCTAATTGCTATGTATTCCAGGCAGGAGCCTGTGCCCAGGGAAGGGCTGGCCCTGCAAGAAGGTTCAGATGTTAATAGTTATCTGTTACAAGtttatctatctataatttattgAGTTTTTACAAGTTGTTTTGCTGTAGGCTTAACACTTCCTATGCAGTGCTTCTAGACTTTTATAGCCTAGACTGCTACCTTTCAAAGCTTGGGAGACAGTGGTGAATGCAATTTTGTTACTTTTGTACTGTCACTGGGCCCTAGGCTTGGGTGGCTGTCCCTTGCCTGTCAACCAGCAGGGTCAGGACAGTGGCTCAGGGTGACTTTCTTGGGGCCTAGCACATGGTTTGTCAGCCCACACTGGCAGATGTGGTTTTGTTAACACAACCAACTTACTTtccaaaaaataaagagataacTGGTTCCATGAG

Publications

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