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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Cks1bP1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr1:191724785-191725492  UCSC
Strand +
Parental Sequence NM_016904.1
Parental seq. overlap 680 bp
Parental seq. overlap (%) 89.8%
Genomic Region Intragenic (Rd3)
Retrocopy Summary Cks1bP1, located on chr1:191724785-191725492, is a retrocopy of the parental gene Cks1b. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Cks1b
Full Name CDC28 protein kinase 1b
Also known as 2410005G18Rik|2610005D03Rik|Cks1|sid1334
Coordinate chr3:89322779-89325598
Strand -
Gene summary Predicted to enable several functions, including cyclin-dependent protein serine/threonine kinase activator activity; histone binding activity; and ubiquitin binding activity. Acts upstream of or within cell population proliferation; mitotic cell cycle phase transition; and regulation of transcription, DNA-templated. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including 1st branchial arch; cerebral cortex ventricular layer; limb; and neural retina. Orthologous to human CKS1B (CDC28 protein kinase regulatory subunit 1B). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Cks1bP1
TCGGCGCGGGACTGAGCGCCCTCCGACAGAGCAATCATGTCCCACAAACAAATCTACTATTCGGACATATACGACGACGAGGAGTTCGAGTACCGGCATGTCATGTTGCCCAAGGACATAGCCAAGCTGGTCCCTAAAACCCATCTGATGTCTGAATCTGAATGGAGGAAGCTCGGTGTTCAGCAGAGTCAGGGATGGCTCCACTATATGATCCATGAACCAGAACCTCACTGTTCCGGTGGCCACTGCCCAAGAAGCCAAAGAAATGAAGCCAGCGAACCGCCTTCCGGCCTCGAGCTTTCCACAGCTGTCCTCACTCCCTACCATCTTTCTGATCTTGTGATCATGTCGCTTTCTTATTTCTCACTTTGATATGTAAAGGATACACTGTTTGAATGTGCTGGTATCTGCTTTGCTTCTGGAGTTGAGCCACCAGTGCCACAGCCCTGTCAGATGAGTGTGACCTCAAAGCCCCCGTGTGCTCGGGATCCAGCAGGCCATATTAGTCATTTGGCAGAAGCATGTGAAATCTAGATCATGGCTGTTACAAGGATGGTGTGAATTTGCTGATGTGTTTTTTACTATTGGGTATTATATTTATGATGACTTATGGATTTATGTTTCAATGTattggaaactttgcattttgtCTGACAGATCTCTTCCATGTTACAAGCCTTGATTAAAGAAAGTtttttataatcttaa
>NM_016904.1
AGAGGGTGGGAGCGCGTGCTGCTGGGAGTTGTCTGGAGGCCTGCGGCGCGGGGCTGAGCGCCCTCGGACAGAGCAATCATGTCCCACAAACAAATCTACTATTCGGACAAATACGACGACGAGGAGTTCGAATACCGGCATGTCATGTTGCCCAAGGACATAGCCAAGCTGGTCCCGAAAACCCATCTGATGTCTGAATCTGAATGGAGGAACCTCGGCGTTCAGCAGAGTCAGGGATGGGTCCACTATATGATCCATGAACCAGAACCTCACATCTTACTGTTCCGACGGCCACTGCCCAAGAAGCCAAAGAAATGAAGCCGGCGAACCGCCTTCCGGCCTCGAGCGGTCCACAGCTGTCCTCACTCCCTGCCATCTTTCTGATCGCGTGACCATGTTGCTTTCTTATTTCTCACTTTGATATGTAAAGGATACACTGTTTGAATGTGCTGGTACCTGCTTTGCTTCTGGAGTTGAGCCACCAGTGCCACAGCCCTGTCAGATGAGTGTGACCTCAAAGCCCTCGTGTGCGCGGGACCCAGCAGGCCATATTAGTCATTTGGCAGAAGCATGTGAAATCTAGATCATGGCTGTTACAAGGATGGTGTGAATTTGCTGACGTGTTTTTTACTATTGGGTATTGTATTTATGATGACTTATGGATTTATGTTTCAATGTATTGGAAATTTTGCATTTTATCTGACAGATCTCTTCCATGTTACAAGCCTTGATTAAAGGAAGTTTTTTATAATCTTAA

Publications

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