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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Taldo1P2
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr10:96604496-96604663  UCSC
Strand -
Parental Sequence NM_011528.4
Parental seq. overlap 137 bp
Parental seq. overlap (%) 10.7%
Genomic Region Intergenic
Retrocopy Summary Taldo1P2, located on chr10:96604496-96604663, is a retrocopy of the parental gene Taldo1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Taldo1
Full Name transaldolase 1
Also known as -
Coordinate chr7:140972073-140982889
Strand +
Gene summary This gene encodes a key enzyme of the nonoxidative pentose phosphate pathway that provides ribose-5-phosphate for nucleic acid synthesis and nicotinamide adenine dinucleotide phosphate (NADPH) for lipid biosynthesis. The encoded protein is important for maintaining structure and function of mitochondria. Studies in knockout mice identify that deficiency of this gene product is a cause of sperm dysmotility and male infertility. Deficiency of this protein has also been identified as a cause of hepatocarcinogenesis in mice. Two related pseudogenes have been identified on chromosome 10. [provided by RefSeq, Mar 2010]

Homology

Species Scientific Name Retrocopy
Rat Rattus norvegicus Taldo1P1
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Taldo1P2
GCCCAGGCCAGTGACTTGAAGAATACACATCTGGAGAGAAGACCTTCCATTGGCTGCACACTCAAGACCAAATGGTTATAGAGAAGCTCACATGGGATCTGCAGGTTTGCTGGTGATGCCATAAAGTGAGAGAGGATGCTCATGCAACAAATGCTCAGGGCTAAGAAT
>NM_011528.4
GACGCGCGGGGCATTGTGGGTTAGCACGCACCGGCTACCGCCTCAGCTGTTCGCGTTTCGCCATGTCGGGGTCCCCGGTAAAGCGCCAGAGGATGGAGTCCGCCTTGGACCAGCTCAAGCAGTTCACCACCGTGGTGGCCGACACGGGTGATTTCAATGCCATCGATGAATACAAGCCCCAAGATGCCACCACCAACCCATCCCTGATCCTGGCTGCAGCCCAGATGCCTGCCTACCAAGAGCTGGTAGAGGAGGCCATTGCCTACGGCAAGAAGCTGGGTGGGCCTCAAGAGGAGCAGATTAAAAATGCCATTGACAAACTTTTTGTGCTGTTTGGAGCAGAAATATTAAAGAAGATTCCAGGCCGTGTATCCACAGAAGTTGATGCAAGGCTTTCCTTTGATAAGGATGCCATGGTGGCCCGAGCCAGGCGCCTCATCGAGCTTTACAAAGAAGCTGGGGTCGGCAAGGACAGAATTCTCATCAAGTTATCATCAACCTGGGAGGGGATTCAGGCTGGAAAGGAGCTGGAGGAACAGCATGGCATCCACTGCAACATGACACTGCTTTTCTCCTTCGCCCAGGCTGTGGCCTGTGCTGAGGCGGGCGTGACGCTCATCTCTCCCTTTGTGGGGCGCATCCTTGATTGGCATGTGGCAAACACAGACAAGAAATCCTATGAACCCCAGGAGGACCCTGGGGTCAAGAGTGTCACCAAAATCTACAACTACTACAAGAAGTTCGGCTACAAGACCATTGTCATGGGCGCCTCCTTCCGCAACACGGGCGAGATCAAAGCACTGGCGGGCTGTGACTTCCTCACCATCTCCCCGAAGCTCCTGGGGGAGCTGCTCAAGGATAACAGCAAGCTGGCGCCTGCGCTCTCTGTCAAGGCGGCCCAGACCAGTGACTCGGAGAAGATACATCTGGACGAGAAGGCCTTCCGTTGGCTGCACAACGAAGACCAAATGGCCGTGGAGAAGCTCTCCGACGGCATCCGCAAATTTGCtgctgatgccataaagttggAGCGGATGCTCACGGAACGAATGTTCAGCGCTGAGAACGGGAAGTAGTGCAACACCCGAGGCCCCAGTCCTGCACCGAGGCTGACCCCAGACCTGCACTGCCTTTGAGCTGGGTCCTAATTGCACATGGCTTGTGACGAATGAATCTTGCATTTTTTAGTGATCGGAGAAGGGATGGATCATAGgattctgattttatgtgaaattTTGTCTAATTCATTAAAGCAGTTGCTTTTCCTATGCTGTTT

Publications

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